Macrophages and post-burn immune dysfunction

Burns

Volumn 29, Issue 1, 2003, Pages 1-14

  Schwacha, Martin G ^a  

^a UNIVERSITY OF ALABAMA SCHOOL OF MEDICINE   (United States)

Author keywords

Burns; Immune dysfunction; Inflammation; Macrophages

Indexed keywords

CYCLOOXYGENASE 2; CYTOKINE; INTERLEUKIN 1; INTERLEUKIN 6; NITRIC OXIDE SYNTHASE; PROSTAGLANDIN SYNTHASE; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR ALPHA;

BURN; BURN EXCISION; CELL ACTIVITY; CELL FUNCTION; CYTOKINE RELEASE; HUMAN; IMMUNE RESPONSE; IMMUNOPATHOLOGY; INFLAMMATION; MACROPHAGE; NONHUMAN; REVIEW; SIGNAL TRANSDUCTION; SKIN GRAFT; T LYMPHOCYTE; TH1 CELL; TH2 CELL; THERMAL INJURY;

BURNS; CYCLOOXYGENASE 2; CYTOKINES; HUMANS; ISOENZYMES; MACROPHAGE ACTIVATION; MACROPHAGES; MEMBRANE PROTEINS; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE II; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; RECEPTORS, ANTIGEN, T-CELL, GAMMA-DELTA; SIGNAL TRANSDUCTION; T-LYMPHOCYTES; TH1 CELLS; TH2 CELLS;

EID: 0037306984     PISSN: 03054179     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0305-4179(02)00187-0     Document Type: Review

References (194)

1. Teodorczyk-Injeyan J.A., Sparkes B.G., Mills G.B., Peters W.J., Falk R.E. Impairment of T cell activation in burn patients: a possible mechanism of thermal injury induced immunosuppression. Clin. Exp. Immunol. 65:1986;570-581.
2. Saffle J.R., Sullivan J.J., Tuohig G.M., Larson C.M. Multiple organ failure in patients with thermal injury. Crit. Care Med. 21:1993;1673-1683.
3. Baue A.E., Durham R., Faist E. Systemic inflammatory response syndrome (SIRS), multiple organ dysfunction syndrome (MODS), multiple organ failure (MOF): are we winning the battle? Shock. 10:1998;79-89.
4. Nguyen T.T., Gilpin D.A., Meyer N.A., Herndon D.N. Current treatment of severely burned patients. Ann. Surg. 223:1996;14-25.
5. Harris B.H., Gelfand J.A. The immune response to trauma. Semin. Pediatr. Surg. 4:1995;77-82.
6. Still J.M.J., Belcher K., Law E.J. Experience with polymicrobial sepsis in a regional burn unit. Burns. 19:1993;434-436.
7. Meakins J.L. Etiology of multiple organ failure. J. Trauma. 30:1990;S165-S168.
8. Remick DG, Friedland DS. Cytokines in health and disease. New York: Marcel Dekker; 1992.
9. MacMicking J., Xie Q.-W., Nathan C. Nitric oxide and macrophage function. Ann. Rev. Immunol. 15:1997;323-350.
10. Schwacha M.G., Somers S.D. Thermal injury induced immunosuppression in mice: the role of macrophage derived reactive nitrogen intermediates. J. Leukoc. Biol. 63:1998;51-58.
11. 2 by macrophages isolated after thermal injury and bacterial translocation. Circ. Shock. 42:1994;154-162.
12. 2 and immunomodulation by indomethacin. J. Immunol. 151:1993;2142-2149.
13. Durbin E.A., Gregory M.S., Messingham K.A., Fontanilla C.V., Duffner L.A., Kovacs E.J. The role of interleukin 6 in interferon-γ production in thermally injured mice. Cytokine. 12:2000;1669-1675.
14. Schwacha M.G., Somers S.D. Thermal injury induces macrophage hyperactivity through pretussis toxin-sensitive and -insensitive pathways. Shock. 9:1998;249-255.
15. Moss N.M., Gough D.B., Jordan A.L., Grbic J.T., Wood J.J., Rodrick M.L.et al. Temporal correlation of impaired immune response after thermal injury with susceptibility to infection in a murine model. Surgery. 104:1988;882-887.
16. Sparkes B.G. Mechanisms of immune failure in burn injury. Vaccine. 11:1993;504-510.
17. O'Sullivan S.T., Lederer J.A., Horgan A.F., Chin D.H.L., Mannick J.A., Rodrick M.L. Major injury leads to predominance of the T helper-2 lymphocyte phenotype and diminished interleukin-12 production associated with decreased resistance to infection. Ann. Surg. 222:1995;482-492.
18. 2 by isolated enterocytes and gut macrophages: effect of lipopolysaccaride and thermal injury. J. Burn Care Rehabil. 15:1994;470-477.
19. Rumbaugh K.P., Colmer J.A., Griswold J.A., Hamood A.N. The effects of infection of thermal injury by pseudomonas aeruginosa pao1 on the murine cytokine response. Cytokine. 16:2001;160-168. [JID 9005353].
20. Masson I., Mathieu J., Nolland X.B., Sousa M.D., Chanaud B., Stralko S.et al. Role of nitric oxide in depressed lymphproliferative responses and altered cytokine production following thermal injury in rats. Cell Immunol. 186:1998;121-132.
21. 2 production in severely injured patients. Arch. Surg. 123:1988;293-299.
22. 2, cytokines, ecosinoids in patients with burns. Burns. 21:1995;422-426.
23. Marano M.A., Fong Y., Moldawer L.L., Wei H., Calvano S.E., Tracey K.J.et al. Serum cachectin/tumor necrosis factor in critically ill patients with burns correlates with infection and mortality. Surg. Gynecol. Obstet. 170:1990;32-37.
24. Gamelli R.L., George M., Sharp-Pucci M., Dries D.J., Radisazljevic Z. Burn-induced nitric oxide release in humans. J. Trauma. 39:1995;869-878.
25. Prieser J., Reper P., Vlasselaer D., Vray B., Zang H., Metz G.et al. Nitric oxide production is increased in patients after burn injury. J. Trauma. 40:1996;368-371.
26. Yang L., Hsu B. The role of macrophages (Mφ) and PGE-2 in postburn immunosuppression. Burns. 18:1992;132-136.
27. O'Riordain M., Collins K.H., Pitz M., Saporoschetz I.B., Mannick J.A., Rodrick M.L. Modulation of macrophage hyperactivity improves survival in a burn-sepsis model. Arch. Surg. 127:1992;152-157.
28. Deitch E.A. Multiple organ failure: pathophysiology and potential future therapy. Ann. Surg. 216:1992;117-134.
29. Mackrell P.J., Daly J.M., Mestre J.R., Stapleton P.P., Howe L.R., Subbaramaiah K.et al. Elevated expression of cyclooxygenase-2 contributes to immune dysfunction in a murine model of trauma. Surgery. 130:2001;826-833. [JID 0417347].
30. 2 after trauma attenuates pro-inflammatory cytokines and improves survival. Shock. 14:2000;374-379.
31. McCarter M.D., Mack V.E., Daly J.M., Naama H.A., Calvano S.E. Trauma-induced alterations in macrophage function. Surgery. 123:1998;96-101. [JID 0417347].
32. Zellweger R., Ayala A., Zhu X.L., Morrison M.H., Chaudry I.H. Effect of surgical trauma on splenocyte and peritoneal macrophage immune function. J. Trauma. 39:1995;645-650. [JID 0376373].
33. Schwacha M.G., Knoferl M.W., Samy T.S., Ayala A., Chaudry I.H. The immunologic consequences of hemorrhagic shock. Crit. Care Shock. 2:1999;42-64.
34. Bendtzen K. Interleukin-1, interleukin-6, and tumor necrosis factor in infection, inflammation and immunity. Immunol. Lett. 19:1988;183-192.
35. Ertel W., Morrison M.H., Wang P., Ba Z.F., Ayala A., Chaudry I.H. The complex pattern of cytokines in sepsis. Association between prostaglandins, cachectin and interleukins. Ann. Surg. 214:1991;141-148.
36. Piguet P.F., Grau G.E., Vassalli P. Tumor necrosis factor and immunopathology. Immunol. Res. 10:1991;122-140.
37. Marano M.A., Moldawer L.L., Fong Y., Wei H., Minei J., Yurt R.et al. Cachectin/TNF production in experimental burns and Pseudomonas infection. Arch. Surg. 123:1988;1383-1388.
38. Drost A.C., Burleson D.G., Cioffi W.G., Mason A.D., Pruitt B.A. Jr. Plasma cytokines after thermal injury and their relationship to infection. Ann. Surg. 218:1993;74-78.
39. Yamada Y., Endo S., Inada K. Plasma cytokine levels in patients with severe burn injury - with reference to the relationship between infection and prognosis. Burns. 22:1996;587-593. [JID 8913178].
40. de Bandt J.P., Chollet-Martin S., Hernvann A., Lioret N., Du R.L., Lim S.K.et al. Cytokine response to burn injury: relationship with protein metabolism. J. Trauma. 36:1994;624-628. [JID 0376373].
41. Vindenes H.A., Ulvestad E., Bjerknes R. Concentrations of cytokines in plasma of patients with large burns: their relation to time after injury, burn size, inflammatory variables, infection, and outcome. Eur. J. Surg. 164:1998;647-656. [JID 9105264].
42. Abraham E., Wunderink R., Silverman H., Perl T.M., Nasraway S., Levy H.et al. Efficacy and safety of monoclonal antibody to human tumor necrosis factor alpha in patients with sepsis syndrome. A randomized, controlled, double-blind, multicenter clinical trial. TNF-alpha MAb Sepsis Study Group. JAMA. 273:1995;934-941. [JID 7501160 3-22].
43. Reinhart K., Wiegand-Lohnert C., Grimminger F., Kaul M., Withington S., Treacher D.et al. Assessment of the safety and efficacy of the monoclonal anti-tumor necrosis factor antibody-fragment, MAK 195F, in patients with sepsis and septic shock: a multicenter, randomized, placebo-controlled, dose-ranging study. Crit. Care Med. 24:1996;733-742. [JID 0355501].
44. Dinarello C.A., Cannon J.G., Wolff S.M., Bernheim H.A., Beutler B., Cerami A.et al. Tumor necrosis factor is an endogenous pyrogen and induces the production of interleukin 1. J. Exp. Med. 163:1986;1433-1450.
45. Faunce D.E., Gregory M.S., Kovacs E.J. Acute ethanol exposure prior to thermal injury results in decreased T cell responses mediated in part by increases in IL-6 production. Shock. 10:1998;135-150.
46. Kowal-Vern A., Walanga J.M., Hoppensteadt D., Sharp-Pucci M., Gamelli R.L. Interleukin-2 and interleukin-6 in relation to burn wound size in the acute phase of thermal injury. J. Am. Coll. Surg. 178:1994;357-362.
47. Biffl W.L., Moore E.E., Moore F.A., Peterson V.M. Interleukin-6 in the injured patient: marker of injury or mediator of inflammation. Ann. Surg. 224:1996;647-664.
48. Song Q.H., Singh R.P., Richardson T.P., Nugent M.A., Trinkaus-Randall V. Transforming growth factor-beta1 expression in cultured corneal fibroblasts in response to injury. J. Cell. Biochem. 77:2000;186-199. [JID 8205768].
49. Letterio J.J., Roberts A.B. Regulation of immune responses by TGF-beta. Annu. Rev. Immunol. 16:1998;137-161. [JID 8309206].
50. Kulkarni A.B., Huh C.G., Becker D., Geiser A., Lyght M., Flanders K.C.et al. Transforming growth factor beta 1 null mutation in mice causes excessive inflammatory response and early death. Proc. Natl. Acad. Sci. U.S.A. 90:1993;770-774. [JID 7505876].
51. Wahl S.M., Hunt D.A., Wakefield L.M., McCartney-Francis N., Wahl L.M., Roberts A.B.et al. Transforming growth factor type beta induces monocyte chemotaxis and growth factor production. Proc. Natl. Acad. Sci. U.S.A. 84:1987;5788-5792. [JID 7505876].
52. Ranges G.E., Figari I.S., Espevik T., Palladino M.A.J. Inhibition of cytotoxic T cell development by transforming growth factor beta and reversal by recombinant tumor necrosis factor alpha. J. Exp. Med. 166:1987;991-998. [JID 2985109R].
53. Meert K.L., Ofenstein J.P., Genyea C., Sarnaik A.P., Kaplan J. Elevated transforming growth factor-beta concentration correlates with posttrauma immunosuppression. J. Trauma. 40:1996;901-906. [JID 0376373].
54. Varedi M., Jeschke M.G., Englander E.W., Herndon D.N., Barrow R.E. Serum TGF-beta in thermally injured rats. Shock. 16:2001;380-382. [JID 9421564].
55. Nishimura T., Nishiura T., deSerres S., Nakagawa T., Meyer A.A. Transforming growth factor-beta1 and splenocyte apoptotic cell death after burn injuries. J. Burn Care Rehabil. 21:2000;128-134. [JID 8110188].
56. Nishimura T., Yamamoto H., deSerres S., Meyer A.A. Transforming growth factor-beta impairs postburn immunoglobulin production by limiting B-cell proliferation, but not cellular synthesis. J. Trauma. 46:1999;881-885. [JID 0376373].
57. Polo M., Ko F., Busillo F., Cruse C.W., Krizek T.J., Robson M.C. The 1997 Moyer Award. Cytokine production in patients with hypertrophic burn scars. J. Burn Care Rehabil. 18:1997;477-482. [JID 8110188].
58. Ono I., Gunji H., Zhang J.Z., Maruyama K., Kaneko F. A study of cytokines in burn blister fluid related to wound healing. Burns. 21:1995;352-355. [JID 8913178].
59. Szabo C., Thiemermann C. Role of nitric oxide in hemorrhagic, traumatic, and anaphylactic shock and thermal injury. Shock. 2:1994;145-155.
60. Kwon N.S., Stuehr D.J., Nathan C.F. Inhibition of tumor cell ribonucleotide reductase by macrophage derived nitric oxide. J. Exp. Med. 174:1991;761-767.
61. Moncada S., Palmer R.M., Higgs E.A. Nitric oxide physiology, pathophysiology, and pharmacology. Pharmacol. Rev. 43:1991;109-142.
62. Cui S., Reichner J.S., Mateo R.B., Albina J.E. Activated macrophages induce apoptosis in tumor cells through nitric oxide dependent or independent mechanisms. Cancer Res. 54:1994;2462-2467.
63. Langrehr J.M., Hoffman R.A., Lancaster J.R. Jr., Simmons R.L. Nitric oxide - a new endogenous immunomodulator. Transplantation. 55:1993;1205-1212.
64. Eisenstein TK, Huang D, Meissler Jr JJ, Schwacha MG. Attenuated Salmonella used as vaccines are immunosuppressive by macrophage-mediated production of nitric oxide. In: Keusch GT, Kawakami M, editors. Cytokines cholera and the gut. Burke (VA): IOS Press Inc.; 1997.
65. Albina J.E., Abate J.A., Henry W.L. Jr. Nitric oxide production is required for murine resident peritoneal macrophages to suppress mitogen-stimulated T cell proliferation. J. Immunol. 147:1991;144-148.
66. Liew F.Y. Regulation of lymphocyte functions by nitric oxide. Curr. Opin. Immunol. 7:1995;396-399.
67. Szabo C. The pathophysiological role of peroxynitrite in shock, inflammation, and ischemia-reperfusion injury. Shock. 6:1996;79-88.
68. Becker W.K., Shippee R.L., McManus A.T., Mason A.D., Pruitt B.A. Jr. Kinetics of nitrogen oxide production following experimental thermal injury in rats. J. Trauma. 34:1993;855-862.
69. Carter E.A., Derojas-Walker T., Tamir S., Tannebaum S.R., Yu Y., Tompkins R.G. Nitric oxide production is intensely and persistently increased in tissue by thermal injury. Biochem. J. 304:1994;201-204.
70. 2 regulates inducible nitric oxide synthase in the murine macrophage cell line J774. Prostaglandins. 49:1995;105-115.
71. 2 and of agents that raise cAMP levels on macrophage activation induced by IFN-gamma and TNF-alpha. J. Leukoc. Biol. 58:1995;217-224.
72. Salvemini D., Seibert K., Masferrer J.L., Settle S.L., Misko T.P., Currie M.G.et al. Nitric oxide and the cyclooxygenase pathway. Adv. Prostaglandin Thromboxane Leukoc. Res. 23:1995;491-493.
73. 2 and cyclic nucleotides. J. Immunol. 141:1988;2388-2393.
74. Jobin N., Garrel D.R., Champoux J., Bernier J. Improved immune functions with administration of a low-fat diet in a burn animal model. Cell Immunol. 206:2000;71-84.
75. Inoue H., Ando K., Wakisaka N., Matsuzaki K., Aihara M., Kumagai N. Effects of nitric oxide synthase inhibitors on vascular hyperpermeability with thermal injury in mice. Nitric Oxide. 5:2001;334-342.
76. Chen L.W., Hsu C.M., Cha M.C., Chen J.S., Chen S.C. Changes in gut mucosal nitric oxide synthase (NOS) activity after thermal injury and its relation with barrier failure. Shock. 11:1999;104-110.
77. Soejima K., Traber L.D., Schmalstieg F.C., Hawkins H., Jodoin J.M., Szabo C.et al. Role of nitric oxide in vascular permeability after combined burns and smoke inhalation injury. Am. J. Resp. Crit. Care Med. 163:2001;745-752.
78. Heggers J.P., Loy G.L., Robson M.C., Del Beccaro E.J. Histological demonstration of prostaglandins and thromboxanes in burned tissue. J. Surg. Res. 28:1980;110-117.
79. Waymack J.P., Miskell P., Gonce S.J., Alexander J.W. Effect of two new immunomodulators on normal and burn injury neutrophils and macrophages. J. Burn Care Rehabil. 8:1987;9-14.
80. Faist E., Mewes A., Strasser T., Walz A., Alkan S., Baker C.et al. Alteration of monocyte function following major injury. Arch. Surg. 123:1988;287-292.
81. 2 release in experimental trauma. J. Trauma. 29:1989;1152-1156.
82. Stenson W.F., Parker C.W. Monohydroxyeicosatetraenoic acids (HETEs) induce degranulation of human neutrophils. J. Immunol. 124:1980;2100-2104.
83. Bomalaski J.S., Williamson P.K., Zurier R.B. Prostaglandins and the inflammatory response. Clin. Lab. Med. 3:1983;695-717.
84. Mitchell J.A., Akarasereenont P., Thiemermann C., Flower R.J., Vane J.R. Selectivity of nonsteroidal antiinflammatory drugs as inhibitors of constitutive and inducible cyclooxygenase. Proc. Natl. Acad. Sci. U.S.A. 90:1993;11693-11697.
85. Liu S.F., Newton R., Evans T.W., Barnes P.J. Differential regulation of cyclo-oxygenase-1 and cyclo-oxygenase-2 gene expression by lipopolysaccharide treatment in vivo in the rat. Clin. Sci. (Colch.). 90:1996;301-306.
86. Kulkarni S.K., Jain N.K., Singh A. Cyclooxygenase isoenzymes and newer therapeutic potential for selective COX-2 inhibitors. Methods. Find Exp. Clin. Pharmacol. 22:2000;291-298.
87. O'Neill G.P., Ford-Hutchinson A.W. Expression of mRNA for cyclooxygenase-1 and cyclooxygenase-2 in human tissues. FEBS Lett. 330:1993;156-160.
88. Fu J.Y., Masferrer J.L., Seibert K., Raz A., Needleman P. The induction and suppression of prostaglandin H2 synthase (cyclooxygenase) in human monocytes. J. Biol. Chem. 265:1990;16737-16740.
89. Niiro H., Otsuka T., Izuhara K., Yamaoka K., Ohshima K., Tanabe T.et al. Regulation by interleukin-10 and interleukin-4 of cyclooxygenase-2 expression in human neutrophils. Blood. 89:1997;1621-1628.
90. Hla T., Neilson K. Human cyclooxygenase-2 cDNA. Proc. Natl. Acad. Sci. U.S.A. 89:1992;7384-7388.
91. 2 primes naive T cells for the production of anti-inflammatory cytokines. Eur. J. Immunol. 27:1997;3526-3531.
92. 2 in immune suppression following injury. Ann. Surg. 214:1991;253-263.
93. Schwacha M.G., Chung C.-S., Ayala A., Bland K.I., Chaudry I.H. Cyclooxygenase-2-mediated suppression of macrophage interleukin-12 production following thermal injury. Am. J. Physiol., Cell Physiol. 282:2002;C263-C270.
94. 2) in severely burned patients. Burns. 22:1996;298-302.
95. Schwacha M.G., Ayala A., Chaudry I.H. Insights into the role of γδ T-lymphocytes in the immunopathogenic response to thermal injury. J. Leukoc. Biol. 67:2000;644-650.
96. Shoup M., He L.K., Liu H., Shankar R., Gamelli R. Cyclooxygenase-2 inhibitor NS-398 improves survival and restores leukocyte counts in burn infection. J. Trauma. 45:1998;215-220.
97. Salvemini D., Currie M.G., Mollace V. Nitric oxide-mediated cyclooxygenase activation. A key event in the antiplatelet effects of nitrovasodilators. J. Clin. Invest. 97:1996;2562-2568.
98. Tetsuka T., Daphna-Iken D., Miller B.W., Guan Z., Baier L.D., Morrison A.R. Nitric oxide amplifies interleukin 1-induced cyclooxygenase-2 expression in rat mesangial cells. J. Clin. Invest. 97:1996;2051-2066.
99. Salvemini D., Settle S.L., Masferrer J.L., Seibert K., Currie M.G., Needleman P. Regulation of prostaglandin production by nitric oxide; an in vivo analysis. Br. J. Pharmacol. 114:1995;1171-1178.
100. Sautebin L., Ialenti A., Ianaro A., Di Rosa M. Modulation by nitric oxide of prostaglandin biosynthesis in the rat. Br. J. Pharmacol. 114:1995;323-328.
101. Mullet D., Fertel R.H., Kniss D., Cox G.W. An increase in intracellular cyclic AMP modulates nitric oxide production in IFN-gamma-treated macrophages. J. Immunol. 158:1997;897-904.
102. Snyder D.S., Beller D.I., Unanue E. Prostaglandins modulate macrophage Ia expression. Nature. 299:1982;163-165.
103. Tannenbaum C.S., Hamilton T.A. Lipopolysaccaride induced gene expression in murine peritoneal macrophages is selectively suppressed by agents that elevate intracellular cAMP. J. Immunol. 142:1989;1274-1282.
104. 2: contribution to the enhancement of inducible nitric oxide synthase activity. J. Leukoc. Biol. 64:1998;740-746.
105. Horgan A.F., O'Riordain D.S., Chin D.H., Mannick J.A., Rodrick M.L. The role of cyclic adenosine monophosphate in the suppression of cellular immunity after thermal injury. Arch. Surg. 129:1994;1284-1289.
106. Bjornson A.B., Somers S.D., Knippenberg R.W., Bjornson H.S. Circulating factors contribute to elevation of intracellular cyclic-3′,5′-adenosine monophosphate and depression of superoxide anion production in polymorphonuclear leukocytes following thermal injury. J. Leukoc. Biol. 52:1992;407-414.
107. Tremblay P., Houde M., Arbour N., Rochefort D., Masure S., Mandeville R.et al. Differential effects of PKC inhibitors on gelatinase B and interleukin 6 production in the mouse macrophage. Cytokine. 7:1995;130-136.
108. 2-induced T-lymphocyte proliferative suppression in sepsis. Infect. Immun. 63:1995;3101-3105.
109. 2 inhibitory effect by the tumor promotor 12.0 tetradecanoyl phorbol-13 acetate. J. Clin. Invest. 80:1987;333-340.
110. Ayala A., Ertel W., Chaudry I.H. Trauma-induced suppression of antigen presentation and expression of major histocompatibility class II antigen complex in leukocytes. Shock. 5:1996;79-90.
111. Ayala A., Wang P., Chaudry I.H. Insights into the mechanism by which interferon-gamma improves macrophage function following hemorrhage and resuscitation. J. Surg. Res. 54:1993;322-327.
112. Sabeh F., Hockberger P., Sayeed M.M. Signaling mechanisms of elevated neutrophil O2-generation after burn injury. Am. J. Physiol. 274:1998;R476-R485.
113. Szabo C., Hasko G., Zingarelli B., Nemeth Z.H., Salzman A.L., Kvetan V.et al. Isoproterenol regulates tumour necrosis factor, interleukin-10, interleukin-6 and nitric oxide production and protects against the development of vascular hyporeactivity in endotoxaemia. Immunology. 90:1997;95-100.
114. Abraham E. Alterations in transcriptional regulation of proinflammatory and immunoregulatory cytokine expression by hemorrhage, injury, and critical illness. New Horiz. 4:1996;184-193.
115. Xie Q.-W., Kashiwabara Y., Nathan C. Role of transcription factor NF-kappa B/Rel in induction of nitric oxide synthase. J. Biol. Chem. 269:1994;4705-4708.
116. Martin E., Nathan C., Xie Q.-W. Role of interferon regulatory factor 1 in induction of nitric oxide synthase. J. Exp. Med. 180:1994;977-984.
117. Tebo J.M., Chaoqun W., Ohmori Y., Hamilton T.A. Murine inhibitory protein-kappa B alpha negatively regulates kappa B-dependent transcription in lipopolysaccharide-stimulated RAW 264.7 macrophages. J. Immunol. 153:1994;4713-4720.
118. de Martin R., Vanhove B., Cheng Q., Hofer E., Csizmadia V., Winkler H.et al. Cytokine-inducible expression in endothelial cells of an I kappa B alpha-like gene is regulated by NF kappa B. EMBO J. 12:1993;2773-2779.
119. Tzen C.Y., Cox R.L., Scott R.E. Coordinate induction of I kappa B alpha and NF kappa B genes. Exp. Cell Res. 211:1994;12-16.
120. Meyer T.E., Habener J.F. Cyclic adenosine 3′,5′-monophosphate response element binding protein (CREB) and related transcription-activating deoxyribonucleic acid-binding proteins. Endocr. Rev. 14:1993;269-290.
121. Xie Q.-W., Herschman H.R. Transcriptional regulation of prostaglandin synthase 2 gene expression by platelet-derived growth factor and serum. J. Biol. Chem. 271:1996;31742-31748.
122. Inoue H., Nanayama T., Hara S., Yokoyama C., Tanabe T. The cyclic AMP response element plays an essential role in the expression of the human prostaglandin-endoperoxide synthase 2 gene in differentiated U937 monocytic cells. FEBS Lett. 350:1994;51-54.
123. Montminy M. Transcriptional regulation by cyclic AMP. Annu. Rev. Biochem. 66:1997;807-822.
124. Greenberg S.S., Jie O., Zhao X., Wang J.F. Role of PKC and tyrosine kinase in ethanol-mediated inhibition of LPS-inducible nitric oxide synthase. Alcohol. 16:1998;167-175.
125. Zagariya A., Mungre S., Lovis R., Birrer M., Ness S., Thimmapaya B.et al. Tumor necrosis factor alpha gene regulation: enhancement of C/EBPbeta-induced activation by c-Jun. Mol. Cell Biol. 18:1998;2815-2824.
126. Tran-Thi T.A., Decker K., Baeuerle P.A. Differential activation of transcription factors NF-kappa B and AP-1 in rat liver macrophages. Hepatology. 22:1995;613-619.
127. Bodor J., Habener J.F. Role of transcriptional repressor ICER in cyclic AMP-mediated attenuation of cytokine gene expression in human thymocytes. J. Biol. Chem. 273:1998;9544-9551.
128. Tamir A., Isakov N. Cyclic AMP inhibits phosphatidylinositol-coupled. J. Immunol. 152:1994;3391-3399.
129. Brunda M.J. Interleukin-12. J. Leukoc. Biol. 55:1994;280-288.
130. Trinchieri G., Gerosa F. Immunoregulation by interleukin-12. J. Leukoc. Biol. 59:1996;505-511.
131. O'Suilleabhain C., O'Sullivan S.T., Kelly J.L., Lederer J., Mannick J.A., Rodrick M.L. Interleukin-12 treatment restores normal resistance to bacterial challenge after burn injury. Surgery. 120:1996;290-296.
132. Goebel A., Kavanagh E., Lyons A., Saporoschetz I.B., Soberg C., Lederer J.A.et al. Injury induces deficient interleukin-12 production, but interleukin-12 therapy after injury restores resistance to infection. Ann. Surg. 231:2000;253-261.
133. 2 is a potent inhibitor of human interleukin 12 production. J. Exp. Med. 181:1995;775-779.
134. 2) regulate differently IL-12 production in human intestinal lamina propria mononuclear cells (LPMC). Clin. Exp. Immunol. 117:1999;469-475.
135. Procopio D.O., Teixeira M.M., Camargo M.M., Travassos L.R., Ferguson M.A., Almeida I.C.et al. Differential inhibitory mechanism of cyclic AMP on TNF-alpha and IL-12 synthesis by macrophages exposed to microbial stimuli. Br. J. Pharmacol. 127:1999;1195-1205.
136. Utsunomiya T., Kobayashi M., Herndon D.N., Pollard R.B., Suzuki F. A mechanism of interleukin-12 unresponsiveness associated with thermal injury. J. Surg. Res. 96:2001;211-217.
137. 2. J. Exp. Med. 180:1994;2365-2370.
138. 2 among mouse strains: a possible mechanism to polarize Th2 type response in BALB/c mice. J. Immunol. 164:2000;2386-2395.
139. 2 and IL-4 provide naive CD4+ T cells with distinct inhibitory signals for the priming of IFN-gamma production. Cell Immunol. 181:1997;86-92.
140. Van der Pouw-Kraan T.C., Van Kooten C., Rensink I., Aarden L. Interleukin (IL)-4 production by human T cells: differential regulation of IL-4 vs. IL-2 production. Eur. J. Immunol. 22:1992;1237-1241.
141. 2 differentially modulates cytokine secretion profiles of human T helper lymphocytes. J. Immunol. 150:1993;5321-5329.
142. 2 inhibits production of Th1 lymphokines but not of Th2 lymphokines. J. Immunol. 146:1991;108-113.
143. Phipps R.P., Stein S.H., Roper R.L. A new view of prostaglandin E regulation of the immune response. Immunol. Today. 12:1991;349-352.
144. Cavaillon J.M. Cytokines and macrophages. Biomed. Pharmacother. 48:1999;445-453.
145. Cunha F.Q., Moncada S., Liew F.Y. Interleukin-10 (IL-10) inhibits the induction of nitric oxide synthase by interferon-gamma in murine macrophages. Biochem. Biophys. Res. Commun. 182:1992;1155-1159.
146. Cenci E., Romani L., Mencacci A., Spaccapelo R., Schiaffella E., Puccetti P.et al. Interleukin-4 and interleukin-10 inhibit nitric oxide-dependent macrophage killing of Candida albicans. Eur. J. Immunol. 23:1993;1034-1038.
147. de Waal Malefyt R., Abrams J., Bennett B., Figdot C.G., de Vries J. Interleukin-10 (IL-10) inhibits cytokine synthesis by human monocytes: and autoregulatory role of IL-10 produced by monocytes. J. Exp. Med. 174:1991;1209-1220.
148. Lyons A., Kelly J.L., Rodrick M.L., Mannick J.A., Lederer J.A. Major injury induces increased production of interleukin-10 by cells of the immune system with a negative impact on resistance to infection. Ann. Surg. 226:1997;450-458.
149. Kelly J.L., Lyons A., Soberg C.C., Mannick J.A., Lederer J.A. Anti-interleukin-10 antibody restores burn-induced defects in T-cell function. Surgery. 122:1997;146-152.
150. Friedman G., Jankowski S., Marchant A., Goldman M., Kahn R.J., Vincent J.L. Blood interleukin 10 levels parallel the severity of septic shock. J. Crit. Care. 12:1997;183-187.
151. van der Poll T., Marchant A., Buurman W.A., Berman L., Keogh C.V., Lazarus D.D.et al. Endogenous IL-10 protects mice from death during septic peritonitis. J. Immunol. 155:1995;5397-5401.
152. Schwacha M.G., Schneider C.P., Bland K.I., Chaudry I.H. Resistance of macrophages to the suppressive effect of interleukin-10 following thermal injury. Am. J. Physiol., Cell Physiol. 281:2001;C1180-C1187.
153. Metzger Z., Hoffeld J.T., Oppenheim J.J. Macrophage-mediated suppression. I. Evidence for participation of both hydrogen peroxide and prostaglandins in suppression of murine lymphocyte proliferation. J. Immunol. 124:1980;983-988.
154. Allison A.C. Mechanisms by which activated macrophages inhibit lymphocyte responses. Immunol. Rev. 40:1978;3-27.
155. Mills C.D. Molecular basis of "suppressor" macrophages. Arginine metabolism via the nitric oxide synthase pathway. J. Immunol. 146:1991;2719-2723.
156. Schwacha M.G., Ayala A., Cioffi W.G., Bland K.I., Chaudry I.H. Role of protein kinase C in cyclic AMP-mediated suppression of T-lymphocyte activation following burn injury. Biochim. Biophys. Acta. 1455:1999;45-53.
157. Skeen M.J., Ziegler H.K. Intracellular interactions and cytokine responsiveness of peritoneal α/β and γ/δ T cells from Listeria-infected mice: synergistic effects of interleukin 1 and 7 on γ/δ T cells. J. Exp. Med. 178:1993;985-996.
158. Haas W., Pereira P., Tonegawa S. Gamma/delta cells. Ann. Rev. Immunol. 11:1993;637-685.
159. Hisaeda H., Sakai T., Nagasawa H., Ishikawa H., Yasutomo K., Maekawa Y.et al. Contribution of extrathymic gamma delta T cells to the expression of heat-shock protein and to protective immunity in mice infected with Toxoplasma gondii. Immunology. 88:1996;551-557.
160. Nishimura H., Hiromatsu K., Kobayashi N., Grabstein K.H., Paxton R., Sugamura K.et al. IL-15 is a novel growth factor for murine gamma delta T cells induced by Salmonella infection. J. Immunol. 156:1996;663-669.
161. Takano M., Nishimura H., Kimura Y., Mokuno Y., Washizu J., Itohara S.et al. Protective roles of gamma delta T cells and interleukin-15 in Escherichia coli infection in mice. Infect. Immun. 66:1998;3270-3278.
162. Tanaka Y., Morita C.T., Nieves E., Brenner M.B., Bloom B.R. Natural and synthetic non-peptide antigens recognized by human γδ T cells. Nature. 375:1995;155-158.
163. Chien Y.-H., Jores R., Crowley M.P. Recognition by γ/δ T cells. Ann. Rev. Immunol. 14:1996;511-532.
164. Boismenu R., Feng L., Xia Y.Y., Chang J.C., Havran W.L. Chemokine expression by intraepithelial γδ T cells. Implications for the recruitment of inflammatory cells to damaged epithelia. J. Immunol. 157:1996;985-992.
165. Fu Y.-Y., Roark C.E., Kelly K., Drevets D., Campbell P., O'Brien R.et al. Immune protection and control of inflammatory tissue necrosis by γδ T cells. J. Immunol. 153:1994;3101-3115.
166. Boismenu R., Havran W.L. Modulation of epithelial cell growth by intraepithelial gamma delta T cells. Science. 266:1994;1253-1255.
167. Ueta C., Kawasumi H., Fujiwara H., Miyagawa T., Kida H., Ohmoto Y.et al. Interleukin-12 activates human gamma delta T cells: synergistic effect of tumor necrosis factor-alpha. Eur. J. Immunol. 26:1996;3066-3073.
168. Follows G.A., Munk M.E., Gatrill A.J., Conradt P., Kaufmann S.H.E. Gamma-interferon and interleukin 2, but not interleukin 4, are detectable in γ/δ T cell cultures after activation with bacteria. Infect. Immun. 60:1992;1229-1231.
169. Skeen M.J., Ziegler H.K. Activation of γδ T cells for production of IFN-γ is mediated by bacteria via macrophage derived cytokines IL-1 and IL-12. J. Immunol. 154:1995;5832-5841.
170. Ferrick D.A., Schrenzel M.D., Mulvania T., Hsieh B., Ferlin W.G., Lepper H. Differential production of interferon-γ and interleukin-4 in response to Th1 and Th2 stimulating pathogens by γδ T cells in vivo. Nature. 373:1995;255-257.
171. Kobayashi M., Herndon D.N., Pollard R.B., Suzuki F. CD4+ contrasuppressor T cells improve the resistance of thermally injured mice infected with HSV. J. Leukoc. Biol. 58:1995;159-167.
172. Kupper T.S., Baker C.C., Ferguson T.A., Green D.R. A burn induced Ly-2 suppressor T cell lowers resistance to bacterial infection. J. Surg. Res. 38:1985;606-612.
173. Suzuki F., Pollard R.B. Suppressor Lyt2+ T-cells demonstrated in mice late after thermal injury. Immunol. Lett. 19:1988;33-39.
174. Yao Y.M., Yu Y., Sheng Z.Y., Tian H.M., Wang Y.P., Lu L.R. Role of gut-derived endotoxaemia and bacterial translocation in rats after thermal injury: effects of selective decontamination of the digestive tract. Burns. 21:1995;580-585.
175. Nishimura H., Emoto M., Hiromatsu K., Yamamoto S., Matsuura K., Gomi H.et al. The role of γδ T cells in priming macrophages to produce tumor necrosis factor-α Eur. J. Immunol. 25:1995;1465-1468.
176. Lahn M., Kalataradi H., Mittelstadt P., Pflum E., Vollmer M., Cady C.et al. Early preferential stimulation of gamma delta T cells by TNF-alpha. J. Immunol. 160:1998;5221-5230.
177. Deitch E.A. Intestinal permeability is increased in burn patients shortly after injury. Surgery. 107:1990;411-416.
178. Ryan C.M., Yarmush M.L., Burke J.F., Tompkins R.G. Increased gut permeability early after burns correlates with the extent of burn injury. Crit. Care Med. 20:1992;1508-1512.
179. Herndon D.N., Zeigler S.T. Bacterial translocation after thermal injury. Crit. Care Med. 21:1993;S50-S54.
180. Eaves-Pyles T., Alexander J.W. Rapid and prolonged impairment of gut barrier function after thermal injury in mice. Shock. 9:1998;95-100.
181. Van Leeuwen P.A., Boermeester M.A., Houdijk A.P., Ferwerda C.C., Cuesta M.A., Meyer S.et al. Clinical significance of translocation. Gut. 35:1994;S28-S34.
182. Lemaire L.C., van Lanschot J.J., Stoutenbeek C.P., van Deventer S.J., Wells C.L., Gouma D.J. Bacterial translocation in multiple organ failure: cause or epiphenomenon still unproven. Br. J. Surg. 84:1997;1340-1350.
183. Deitch E.A. The management of burns. N. Engl. J. Med. 323:1990;1249-1253.
184. Burke J.F., Quinby W.C. Jr., Bondoc C.C. Primary excision and prompt grafting as routine therapy for the treatment of thermal burns in children, 1976. Hand Clin. 6:1990;305-317.
185. Tompkins R.G., Burke J.F., Schoenfeld D.A., Bondoc C.C., Quinby W.C. Jr., Behringer G.C.et al. Prompt eschar excision: a treatment system contributing to reduced burn mortality. A statistical evaluation of burn care at the Massachusetts General Hospital (1974-1984). Ann. Surg. 204:1986;272-281.
186. Tompkins R.G., Remensnyder J.P., Burke J.F., Tompkins D.F., Hilton J.F., Schoenfeld D.A.et al. Significant reductions in mortality for children with burn injury through the use of prompt eschar excision. Ann. Surg. 208:1988;577-585.
187. Wolf S.E., Rose J.K., Desai M.H., Mileski J.P., Barrow R.E., Herndon D.N. Mortality determinants in massive pediatric burns. An analysis of 103 children with > or = 80% TBSA burns (> or = 70% full-thickness). Ann. Surg. 225:1997;554-565.
188. Ho W.S., Ying S.Y., Chan H.H. A study of burn injuries in the elderly in a regional burn centre. Burns. 27:2001;382-385. [JID 8913178].
189. Herd B.M., Herd A.N., Tanner N.S. Burns to the elderly: a reappraisal. Br. J. Plast. Surg. 40:1987;278-282. [JID 2984714R].
190. Kirn D.S., Luce E.A. Early excision and grafting versus conservative management of burns in the elderly. Plast. Reconst. Surg. 102:1998;1013-1017. [JID 1306050].
191. Hultman C.S., Cairns B.A., deSerres S., Frelinger J.A., Meyer A.A. Early, complete burn wound excision partially restores cytotoxic T lymphocyte function. Surgery. 118:1995;421-429.
192. Yamamoto H., Siltharm S., deSerres S., Hultman C.S., Meyer A.A. Immediate burn wound excision restores antibody synthesis to bacterial antigen. J. Surg. Res. 63:1996;157-162.
193. Cetinkale O., Ulualp K.M., Ayan F., Duren M., Cizmeci O., Pusane A. Early wound excision and skin grafting restores cellular immunity after severe burn trauma. Br. J. Surg. 80:1993;1296-1298.
194. Schwacha M.G., Knoferl M.W., Chaudry I.H. Does burn wound excision after thermal injury attenuate subsequent macrophage hyperactivity and immunosuppression? Shock. 14:2000;623-628.