Both percentage of γδ T lymphocytes and CD3 expression are reduced during septic shock

Critical Care Medicine

Volumn 33, Issue 12, 2005, Pages 2836-2840

  Venet, Fabienne ^a   Bohé, Julien ^a   Debard, Anne Lise ^a   Bienvenu, Jacques ^a   Lepape, Alain ^a   Monneret, Guillaume ^a,b  

^a CENTRE HOSPITALIER LYON SUD   (France)

^b HÔPITAL NEUROLOGIQUE   (France)

Author keywords

CD3 expression; Human leukocyte antigen DR; T cells; T lymphocytes

Indexed keywords

CD3 ANTIGEN; T LYMPHOCYTE RECEPTOR ALPHA CHAIN; T LYMPHOCYTE RECEPTOR BETA CHAIN; T LYMPHOCYTE RECEPTOR DELTA CHAIN; T LYMPHOCYTE RECEPTOR GAMMA CHAIN; LYMPHOCYTE ANTIGEN RECEPTOR;

ADULT; AGED; ANTIGEN DETECTION; ANTIGEN EXPRESSION; ARTICLE; CELL LINEAGE; CLINICAL ARTICLE; COMPARATIVE STUDY; CONTROLLED STUDY; DOWN REGULATION; FEMALE; FLUORESCENCE ANALYSIS; HUMAN; INTENSIVE CARE UNIT; MALE; PRIORITY JOURNAL; SEPTIC SHOCK; T LYMPHOCYTE ACTIVATION; UNIVERSITY HOSPITAL; BLOOD; IMMUNOLOGICAL TOLERANCE; IMMUNOLOGY; LYMPHOCYTE COUNT; MIDDLE AGED; REGULATORY T LYMPHOCYTE;

AGED; ANTIGENS, CD3; HUMANS; IMMUNE TOLERANCE; LYMPHOCYTE COUNT; MALE; MIDDLE AGED; RECEPTORS, ANTIGEN, T-CELL, ALPHA-BETA; RECEPTORS, ANTIGEN, T-CELL, GAMMA-DELTA; SHOCK, SEPTIC; T-LYMPHOCYTES, REGULATORY;

EID: 29144514677     PISSN: 00903493     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.CCM.0000189745.66585.AE     Document Type: Article

References (15)

1. Annane D, Bellissant E, Cavaillon JM: Septic shock. Lancet 2005; 365:63-78
2. Munford RS, Pugin J: Normal responses to injury prevent systemic inflammation and can be immunosuppressive. Am J Respir Crit Care Med 2001; 163:316-321
3. Hotchkiss RS, Karl EI: The pathophysiology and treatment of sepsis. N Engl J Med 2003; 348:138-150
4. Matsushima A, Ogura H, Fujita K, et al: Early activation of γδ T lymphocytes in patients with severe systemic inflammatory response syndrome. Shock 2004; 22:11-15
5. Kalyan S, Chow AW: Human peripheral gammadelta T cells potentiate the early proinflammatory cytokine response to staphylococcal toxic shock syndrome toxin-1. J Infect Dis 2004; 189:1892-1896
6. Jameson J, Witherden D, Havran DL: T-cell effector mechanisms: γδ and CD1d-restricted subsets. Curr Opin Immunol 2003; 15:349-353
7. Thibault G, Bardos P: Compared TCR and CD3 epsilon expression on alpha beta and gamma delta T cells. Evidence for the association of two TCR heterodimers with three CD3 epsilon chains in the TCR/CD3 complex. J Immunol 1995; 154:3814-3820
8. Nicolas L, Monneret G, Debard AL, et al: Human γδ T cells express a higher TCR/CD3 complex density than αβ T cells. Clin Immunol 2001; 3:358-363
9. Monneret G, Elmenkouri N, Bohe J, et al: Analytical requirements for measuring monocytic HLA-DR by flow cytometry: Application to the monitoring of patients with septic shock. Clin Chem 2002; 48:1589-1592
10. Monneret G, Finck ME, Venet F, et al: The anti-inflammatory response dominates after septic shock: Association of low monocyte HLA-DR expression and high interleukin-10 concentration. Immunol Lett 2004; 95:193-198
11. Bone RC, Balk RA, Cerra FB, et al: Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. The ACCP/SCCM Consensus Conference Committee. American College of Chest Physicians/Society of Critical Care Medicine. Chest 1992; 101:1644-1655
12. Lepape A, Debard AL, Bohé J, et al: Monitoring of sepsis-induced immunoparalysis by measuring monocytic HLA-DR in patients with septic shock. Abstract. Shock 2004; 21:S109
13. Le Gall JR, Lemeshow S, Saulnier F: A new Simplified Acute Physiology Score [SAPS II] based on a European/North American multicenter study. JAMA 1993; 270:2957-2963
14. Colonna-Romano G, Aquino A, Bulati M, et al: Impairment of gamma/delta T lymphocytes in elderly: Implications for immunosenescence. Exp Gerontol 2004; 39:1439-1446
15. Manjuck J, Saha DC, Astiz M, et al: Decreased response to recall antigens is associated with depressed costimulatory receptor expression in septic critically ill patients. J Lab Clin Med 2000; 135:153-160