Enhanced regulatory T cell activity is an element of the host response to injury

Journal of Immunology

Volumn 176, Issue 1, 2006, Pages 225-236

  Choileain, Niamh Ni ^a   MacConmara, Malcolm ^a   Zang, Yan ^a   Murphy, Thomas J ^a   Mannick, John A ^a   Lederer, James A ^a  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD28 ANTIGEN; CD4 ANTIGEN; CD45 ANTIGEN; CD45RB ANTIGEN; CD69 ANTIGEN; INTERLEUKIN 10; INTERLEUKIN 2 RECEPTOR ALPHA; PADGEM PROTEIN; TRANSFORMING GROWTH FACTOR BETA RECEPTOR 1; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; AUTOIMMUNE DISEASE; CELL FUNCTION; CELL PROLIFERATION; CELL SURFACE; CONTROLLED STUDY; CYTOKINE PRODUCTION; HOMEOSTASIS; IMMUNE RESPONSE; IMMUNOPATHOLOGY; IMMUNOREACTIVITY; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; REGULATORY T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION; T LYMPHOCYTE SUBPOPULATION; TH1 CELL; THERMAL INJURY;

EID: 29644441715     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.176.1.225     Document Type: Article

References (53)

1. Moss, N. M., D. B. Gough, A. L. Jordan, J. T. Grbic, J. J. Wood, M. L. Rodrick, and J. A. Mannick. 1988. Temporal correlation of impaired immune response after thermal injury with susceptibility to infection in a murine model. Surgery 104: 882-887.
2. Cheadle, W. G., M. Mercer-Jones, M. Heinzelmann, and H. C. Polk, Jr. 1996. Sepsis and septic complications in the surgical patient: who is at risk? Shock 6(Suppl. 1): S6-S9.
3. Moore, F. A., A. Sauaia, E. E. Moore, J. B. Haenel, J. M. Burch, and D. C. Lezotte. 1996. Postinjury multiple organ failure: a bimodal phenomenon. J. Trauma 40: 501-510.
4. Ninnemann, J. L., J. C. Fisher, and H. A. Frank. 1978. Prolonged survival of human skin allografts following thermal injury. Transplantation 25: 69-72.
5. Lederer, J. A., M. L. Rodrick, and J. A. Mannick. 1999. The effects of injury on the adaptive immune response. Shock 11: 153-159.
6. Faist, E., C. Schinkel, and S. Zimmer. 1996. Update on the mechanisms of immune suppression of injury and immune modulation. World J. Surg. 20: 454-459.
7. Kelly, J. L., C. B. O'Suilleabhain, C. C. Soberg, J. A. Mannick, and J. A. Lederer. 1999. Severe injury triggers antigen-specific T-helper cell dysfunction. Shock 12: 39-45.
8. Baker, C. C., C. L. Miller, and D. D. Trunkey. 1979. Predicting fatal sepsis in burn patients. J. Trauma 19: 641-648.
9. Angele, M. K., and E. Faist. 2002. Clinical review: immunodepression in the surgical patient and increased susceptibility to infection. Crit. Care 6: 298-305.
10. O'Suilleabhain, C., S. T. O'Sullivan, J. L. Kelly, J. Lederer, J. A. Mannick, and M. L. Rodrick. 1996. Interleukin-12 treatment restores normal resistance to bacterial challenge after burn injury. Surgery 120: 290-296.
11. Lyons, A., A. Goebel, J. A. Mannick, and J. A. Lederer. 1999. Protective effects of early interleukin 10 antagonism on injury-induced immune dysfunction. Arch. Surg. 134: 1317-1323.
12. + , Ly-1 T suppressor inducer cells and Ly-2 T suppressor effector cells following thermal trauma in mice. J. Immunol. 133: 3047-3053.
13. Singh, H., D. N. Herndon, and M. D. Stein. 1986. Kinetics of lymphoproliferative responses following scald injury in a rat burn model. Clin. Immunol. Immunopathol. 40: 476-484.
14. Teodorczyk-Injeyan, J. A., B. G. Sparkes, R. E. Falk, and W. J. Peters. 1986. Polyclonal immunoglobulin production in burned patients: kinetics and correlations with T-cell activity. J. Trauma 26: 834-839.
15. Jeffries, M. K., and M. L. Vance. 1992. Growth hormone and cortisol secretion in patients with burn injury. J. Burn Care Rehabil. 13: 391-395.
16. Schrader, K. A. 1996. Stress and immunity after traumatic injury: the mind-body link. AACN Clin. Issues 7: 351-358.
17. Ninnemann, J. L., and A. E. Stockland. 1984. Participation of prostaglandin E in immunosuppression following thermal injury. J. Trauma 24: 201-207.
18. 2 after trauma attenuates pro-inflammatory cytokines and improves survival. Shock 14: 374-379.
19. Goebel, A., E. Kavanagh, A. Lyons, I. B. Saporoschetz, C. Soberg, J. A. Lederer, J. A. Mannick, and M. L. Rodrick. 2000. Injury induces deficient interleukin-12 production, but interleukin-12 therapy after injury restores resistance to infection. Ann. Surg. 231: 253-261.
20. Schwacha, M. G., C. S. Chung, A. Ayala, K. I. Bland, and I. H. Chaudry. 2002. Cyclooxygenase 2-mediated suppression of macrophage interleukin-12 production after thermal injury. Am. J. Physiol. 282: C263-C270.
21. Dorf, M. E., and B. Benacerraf. 1984. Suppressor cells and immunoregulation. Annu. Rev. Immunol. 2: 127-157.
22. Dorf, M. E., V. K. Kuchroo, and M. Collins. 1992. Suppressor T cells: some answers but more questions. Immunol. Today 13: 241-243.
23. Kupper, T. S., C. C. Baker, T. A. Ferguson, and D. R. Green. 1985. A burn induced Ly-2 suppressor T cell lowers resistance to bacterial infection. J. Surg. Res. 38: 606-612.
24. Asano, M., M. Toda, N. Sakaguchi, and S. Sakaguchi. 1996. Autoimmune disease as a consequence of developmental abnormality of a T cell subpopulation. J. Exp. Med. 184: 387-396.
25. + T cells inhibit both the induction and effector function of autoreactive T cells and represent a unique lineage of immunoregulatory cells. J. Immunol. 160: 1212-1218.
26. + regulatory T cells is mediated by cell surface-bound transforming growth factor β. J. Exp. Med. 194: 629-644.
27. + T-regulatory cell subset has optimal suppressive and proliferative potential. Am. J. Transplant. 4: 65-78.
28. Caramalho, I., T. Lopes-Carvalho, D. Ostler, S. Zelenay, M. Haury, and J. Demengeot. 2003. Regulatory T cells selectively express Toll-like receptors and are activated by lipopolysaccharide. J. Exp. Med. 197: 403-411.
29. + regulatory T cells. Nat. Immunol. 4: 330-336.
30. Hori, S., T. Nomura, and S. Sakaguchi. 2003. Control of regulatory T cell development by the transcription factor Foxp3. Science 299: 1057-1061.
31. + T(R) cells suppress innate immune pathology through cytokine-dependent mechanisms. J. Exp. Med. 197: 111-119.
32. + regulatory T cell activity in both humans and mice. J. Immunol. 172: 834-842.
33. + regulatory T cells. Int. Immunol. 16: 249-256.
34. + regulatory T cells control innate immune reactivity after injury. J. Immunol. 174: 2957-2963.
35. Guo, Z., E. Kavanagh, Y. Zang, S. M. Dolan, S. J. Kriynovich, J. A. Mannick, and J. A. Lederer. 2003. Burn injury promotes antigen-driven Th2-type responses in vivo. J. Immunol. 171: 3983-3990.
36. Levings, M. K., R. Bacchetta, U. Schulz, and M. G. Roncarolo. 2002. The role of IL-10 and TGF-β in the differentiation and effector function of T regulatory cells. Int. Arch. Allergy Immunol. 129: 263-276.
37. Mack, V. E., M. D. McCarter, H. A. Naama, S. E. Calvano, and J. M. Daly. 1996. Dominance of T-helper 2-type cytokines after severe injury. Arch. Surg. 131: 1303-1308.
38. + T cells through TGF-β-TGF-β receptor interactions in type 1 diabetes. Proc. Natl. Acad. Sci. USA 100: 10878-10883.
39. + regulatory T cells responsible for protection against diabetes. Proc. Natl. Acad. Sci. USA 101: 4572-4577.
40. Powrie, F., S. Read, C. Mottet, H. Uhlig, and K. Maloy. 2003. Control of immune pathology by regulatory T cells. Novartis Found. Symp. 252: 92-98.
41. Shelley, O., T. Murphy, H. Paterson, J. A. Mannick, and J. A. Lederer. 2003. Interaction between the innate and adaptive immune systems is required to survive sepsis and control inflammation after injury. Shock 20: 123-129.
42. Kobayashi, M., H. Takahashi, A. P. Sanford, D. N. Herndon, R. B. Pollard, and F. Suzuki. 2002. An increase in the susceptibility of burned patients to infectious complications due to impaired production of macrophage inflammatory protein 1a. J. Immunol. 169: 4460-4466.
43. Oberholzer, A., C. Oberholzer, and L. L. Moldawer. 2001. Sepsis syndromes: understanding the role of innate and acquired immunity. Shock 16: 83-96.
44. + regulatory T cells can mediate suppressor function in the absence of transforming growth factor β1 production and responsiveness. J. Exp. Med. 196: 237-246.
45. Asseman, C., S. Mauze, M. W. Leach, R. L. Coffman, and F. Powrie. 1999. An essential role for interleukin 10 in the function of regulatory T cells that inhibit intestinal inflammation. J. Exp. Med. 190: 995-1004.
46. + T regulatory cells. Novartis Found. Symp. 252: 115-127.
47. + T cells in the control of inflammation. J. Immunol. 171: 5018-5026.
48. Pasare, C., and R. Medzhitov. 2004. Toll-dependent control mechanisms of CD4 T cell activation. Immunity 21: 733-741.
49. + regulatory T cells by TGF-β induction of transcription factor Foxp3. J. Exp. Med. 198: 1875-1886.
50. + cells with CD3 and CD46 induces a T-regulatory cell 1 phenotype. Nature 421: 388-392.
51. - T cells through Foxp3 induction and down-regulation of Smad7. J. Immunol. 172: 5149-5153.
52. Shi, Y., J. E. Evans, and K. L. Rock. 2003. Molecular identification of a danger signal that alerts the immune system to dying cells. Nature 425: 516-521.
53. Beg, A. A. 2002. Endogenous ligands of Toll-like receptors: implications for regulating inflammatory and immune responses. Trends Immunol. 23: 509-512.