Mast cells in the promotion and limitation of chronic inflammation

Immunological Reviews

Volumn 217, Issue 1, 2007, Pages 304-328

  Metz, Martin ^a   Grimbaldeston, Michele A ^a   Nakae, Susumu ^a,b   Piliponsky, Adrian M ^a   Tsai, Mindy ^a   Galli, Stephen J ^a  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b Natl Childrens Med Res Ctr   (Japan)

Author keywords

Acquired immunity; Cytokines; IgE; Inflammation; Innate immunity; T cells

Indexed keywords

BLEOMYCIN; CALCITONIN GENE RELATED PEPTIDE; COMPLEMENT COMPONENT C3A; COMPLEMENT COMPONENT C4B; COMPLEMENT COMPONENT C5A; CYTOKINE; FLUORESCEIN ISOTHIOCYANATE; IMMUNOGLOBULIN E; IMMUNOGLOBULIN G1; MONOCROTALINE; NERVE GROWTH FACTOR; PHOSPHOLIPASE A2; SARAFOTOXIN; STEM CELL FACTOR; SUBSTANCE P; VENOM;

CARDIOVASCULAR DISEASE; CELL ACTIVATION; CELL FUNCTION; CELL INTERACTION; CELL MATURATION; CHRONIC INFLAMMATION; CONTACT ALLERGY; CYTOLOGY; ELECTRON MICROSCOPY; GENETIC MODEL; GRAFT VERSUS HOST REACTION; HUMAN; IMMUNE RESPONSE; IMMUNOMODULATION; INNATE IMMUNITY; KNOCKOUT MOUSE; LUNG DISEASE; LUNG RESECTION; MAST CELL; MICROSCOPY; NEOVASCULARIZATION (PATHOLOGY); NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PULMONARY HYPERTENSION; REVIEW; T LYMPHOCYTE; ULTRAVIOLET RADIATION;

ACUTE DISEASE; ANIMALS; CHRONIC DISEASE; DISEASE MODELS, ANIMAL; IMMUNITY, NATURAL; IMMUNOGLOBULIN E; INFLAMMATION; MAST CELLS; MICE; PROTO-ONCOGENE PROTEINS C-KIT;

EID: 34248185984     PISSN: 01052896     EISSN: 1600065X     Source Type: Journal    
DOI: 10.1111/j.1600-065X.2007.00520.x     Document Type: Review

References (257)

1. von Recklinghausen F. Ueber Eiter- und Bindegewebskörperchen. Virchows Arch Path Anat 1863 28 : 157 197.
2. Ehrlich P. Beiträge zur Kenntniss der Anilinfärbungen und ihrer Verwendung in der mikroskopischen Technik. Arch Mikr Anat 1877 13 : 263 278.
3. Ehrlich P. Beiträge zur Theorie und Praxis der histologischen Färbung. I. Teil: Die chemische Auffassung der Färbung. II. Teil: Die Anilinfarben in chemischer, technologischer und histologischer Beziehung. PhD Thesis, University of Leipzig, 1878.
4. Ehrlich P. Beiträge zur Kenntniss der granulirten Bindegewebszellen und der eosinophilen Leukocythen. Arch Anat Physiol 1879 3 : 166 169.
5. Waldeyer W. Über Bindegewebszellen. Arch f mikroskop Anat 1875 11 : 176 194.
6. Dvorak AM. New aspects of mast cell biology. Int Arch Allergy Immunol 1997 114 : 1 9.
7. Metcalfe DD, Baram D, Mekori YA. Mast cells. Physiol Rev 1997 77 : 1033 1079.
8. Theoharides TC, Cochrane DE. Critical role of mast cells in inflammatory diseases and the effect of acute stress. J Neuroimmunol 2004 146 : 1 12.
9. Theoharides TC, Conti P. Mast cells: the Jekyll and Hyde of tumor growth. Trends Immunol 2004 25 : 235 241.
10. Dvorak AM. Ultrastructural analysis is necessary and sufficient for identification of basophils and mast cells. Chem Immunol Allergy 2005 85 : 10 67.
11. Dvorak AM. Ultrastructural studies of human basophils and mast cells. J Histochem Cytochem 2005 53 : 1043 1070.
12. Galli SJ, Kalesnikoff J, Grimbaldeston MA, Piliponsky AM, Williams CM, Tsai M. Mast cells as "tunable" effector and immunoregulatory cells: recent advances. Annu Rev Immunol 2005 23 : 749 786.
13. Galli SJ, Nakae S, Tsai M. Mast cells in the development of adaptive immune responses. Nat Immunol 2005 6 : 135 142.
14. Marone G, Triggiani M, Genovese A, Paulis AD. Role of human mast cells and basophils in bronchial asthma. Adv Immunol 2005 88 : 97 160.
15. Bradding P, Walls AF, Holgate ST. The role of the mast cell in the pathophysiology of asthma. J Allergy Clin Immunol 2006 117 : 1277 1284.
16. Gallin JI, Snyderman R, eds. Inflammation: Basic Principles and Clinical Correlates, 3rd edn. Philadelphia : Lippincott Williams & Wilkins, 1999.
17. Kumar V, Abbas AK, Fausto N, eds. Robbins and Cotran Pathologic Basis of Disease, 7th edn. Philadelphia : Elsevier Saunders, 2005.
18. Karin M, Lawrence T, Nizet V. Innate immunity gone awry: linking microbial infections to chronic inflammation and cancer. Cell 2006 124 : 823 835.
19. Fort MM, Leach MW, Rennick DM. A role for NK cells as regulators of CD4+ T cells in a transfer model of colitis. J Immunol 1998 161 : 3256 3261.
20. Erdman SE, et al. CD4+ CD25+ regulatory T lymphocytes inhibit microbially induced colon cancer in Rag2-deficient mice. Am J Pathol 2003 162 : 691 702.
21. Huang C, Sali A, Stevens RL. Regulation and function of mast cell proteases in inflammation. J Clin Immunol 1998 18 : 169 183.
22. Marshall JS. Mast-cell responses to pathogens. Nat Rev Immunol 2004 4 : 787 799.
23. Theoharides TC, Donelan JM, Papadopoulou N, Cao J, Kempuraj D, Conti P. Mast cells as targets of corticotropin-releasing factor and related peptides. Trends Pharmacol Sci 2004 25 : 563 568.
24. Gurish MF, Austen KF. The diverse roles of mast cells. J Exp Med 2001 194 : F1 F5.
25. Boyce JA. Mast cells: beyond IgE. J Allergy Clin Immunol 2003 111 : 24 32.
26. Grimbaldeston MA, Metz M, Yu M, Tsai M, Galli SJ. Effector and potential immunoregulatory roles of mast cells in IgE-associated acquired immune responses. Curr Opin Immunol 2006 18 : 751 760.
27. Kitamura Y. Heterogeneity of mast cells and phenotypic change between subpopulations. Annu Rev Immunol 1989 7 : 59 76.
28. Arinobu Y, et al. Developmental checkpoints of the basophil/mast cell lineages in adult murine hematopoiesis. Proc Natl Acad Sci USA 2005 102 : 18105 18110.
29. Chen CC, Grimbaldeston MA, Tsai M, Weissman IL, Galli SJ. Identification of mast cell progenitors in adult mice. Proc Natl Acad Sci USA 2005 102 : 11408 11413.
30. Kawakami T, Galli SJ. Regulation of mast-cell and basophil function and survival by IgE. Nat Rev Immunol 2002 2 : 773 786.
31. Lu LF, et al. Mast cells are essential intermediaries in regulatory T-cell tolerance. Nature 2006 442 : 997 1002.
32. Bienenstock J, Befus AD, Denburg J, Goodacre R, Pearce F, Shanahan F. Mast cell heterogeneity. Monogr Allergy 1983 18 : 124 128.
33. Galli SJ. New insights into "the riddle of the mast cells": microenvironmental regulation of mast cell development and phenotypic heterogeneity. Lab Invest 1990 62 : 5 33.
34. Enerbäck L. The differentiation and maturation of inflammatory cells involved in the allergic response: mast cells and basophils. Allergy 1997 52 : 4 10.
35. Rivera J, Gilfillan AM. Molecular regulation of mast cell activation. J Allergy Clin Immunol 2006 117 : 1214 1225.
36. Kinet J-P. The high-affinity IgE receptor (FcεRI): from physiology to pathology. Annu Rev Immunol 1999 17 : 931 972.
37. Daëron M, Prouvost-Danon A, Voisin GA. Mast cell membrane antigens and Fc receptors in anaphylaxis. II. Functionally distinct receptors for IgG and for IgE on mouse mast cells. Cell Immunol 1980 49 : 178 189.
38. Tkaczyk C, Okayama Y, Metcalfe DD, Gilfillan AM. Fcgamma receptors on mast cells: activatory and inhibitory regulation of mediator release. Int Arch Allergy Immunol 2004 133 : 305 315.
39. Finkelman FD, Rothenberg ME, Brandt EB, Morris SC, Strait RT. Molecular mechanisms of anaphylaxis: lessons from studies with murine models. J Allergy Clin Immunol 2005 115 : 449 457.
40. Galli SJ, Maurer M, Lantz CS. Mast cells as sentinels of innate immunity. Curr Opin Immunol 1999 11 : 53 59.
41. Malaviya R, Abraham SN. Mast cell modulation of immune responses to bacteria. Immunol Rev 2001 179 : 16 24.
42. Maurer M, et al. Mast cells promote homeostasis by limiting endothelin-1-induced toxicity. Nature 2004 432 : 512 516.
43. Metz M, et al. Mast cells can enhance resistance to snake and honeybee venoms. Science 2006 313 : 526 530.
44. Männel DN, Echtenacher B. TNF in the inflammatory response. Chem Immunol 2000 74 : 141 161.
45. Jutel M, et al. Histamine regulates T-cell and antibody responses by differential expression of H1 and H2 receptors. Nature 2001 413 : 420 425.
46. Ott VL, Cambier JC, Kappler J, Marrack P, Swanson BJ. Mast cell-dependent migration of effector CD8+ T cells through production of leukotriene B4. Nat Immunol 2003 4 : 974 981.
47. Kabashima K, Sakata D, Nagamachi M, Miyachi Y, Inaba K, Narumiya S. Prostaglandin E2-EP4 signaling initiates skin immune responses by promoting migration and maturation of Langerhans cells. Nat Med 2003 9 : 744 749.
48. Jutel M, Blaser K, Akdis CA. Histamine in allergic inflammation and immune modulation. Int Arch Allergy Immunol 2005 137 : 82 92.
49. Miller HR, Pemberton AD. Tissue-specific expression of mast cell granule serine proteinases and their role in inflammation in the lung and gut. Immunology 2002 105 : 375 390.
50. McDermott JR, Bartram RE, Knight PA, Miller HR, Garrod DR, Grencis RK. Mast cells disrupt epithelial barrier function during enteric nematode infection. Proc Natl Acad Sci USA 2003 100 : 7761 7766.
51. Hallgren J, Pejler G. Biology of mast cell tryptase. An inflammatory mediator. FEBS J 2006 273 : 1871 1895.
52. Gordon JR, Galli SJ. Promotion of mouse fibroblast collagen gene expression by mast cells stimulated via the FcεRI. Role for mast cell-derived transforming growth factor β and tumor necrosis factor α. J Exp Med 1994 180 : 2027 2037.
53. Kendall JC, Li XH, Galli SJ, Gordon JR. Promotion of mouse fibroblast proliferation by IgE-dependent activation of mouse mast cells: role for mast cell tumor necrosis factor-α and transforming growth factor-β 1. J Allergy Clin Immunol 1997 99 : 113 123.
54. Li MO, Wan YY, Sanjabi S, Robertson AK, Flavell RA. Transforming growth factor-β regulation of immune responses. Annu Rev Immunol 2006 24 : 99 146.
55. Mekori YA, Metcalfe DD. Mast cell-T cell interactions. J Allergy Clin Immunol 1999 104 : 517 523.
56. Robbie-Ryan M, Tanzola MB, Secor VH, Brown MA. Cutting edge: both activating and inhibitory Fc receptors expressed on mast cells regulate experimental allergic encephalomyelitis disease severity. J Immunol 2003 170 : 1630 1634.
57. Kashiwakura J, Yokoi H, Saito H, Okayama Y. T cell proliferation by direct cross-talk between OX40 ligand on human mast cells and OX40 on human T cells: comparison of gene expression profiles between human tonsillar and lung-cultured mast cells. J Immunol 2004 173 : 5247 5257.
58. Nakae S, Suto H, Kakurai M, Sedgwick JD, Tsai M, Galli SJ. Mast cells enhance T cell activation: importance of mast cell-derived TNF. Proc Natl Acad Sci USA 2005 102 : 6467 6472.
59. Gregory GD, Raju SS, Winandy S, Brown MA. Mast cell IL-4 expression is regulated by Ikaros and influences encephalitogenic Th1 responses in EAE. J Clin Invest 2006 116 : 1327 1336.
60. Nakae S, et al. Mast cells enhance T cell activation: importance of mast cell costimulatory molecules and secreted TNF. J Immunol 2006 176 : 2238 2248.
61. Kitamura Y, Go S, Hatanaka K. Decrease of mast cells in W/Wv mice and their increase by bone marrow transplantation. Blood 1978 52 : 447 452.
62. Nakano T, et al. Fate of bone marrow-derived cultured mast cells after intracutaneous, intraperitoneal, and intravenous transfer into genetically mast cell-deficient W/Wv mice. Evidence that cultured mast cells can give rise to both connective tissue type and mucosal mast cells. J Exp Med 1985 162 : 1025 1043.
63. Tsai M, Tam S-Y, Wedemeyer J, Galli SJ. Mast cells derived from embryonic stem cells: a model system for studying the effects of genetic manipulations on mast cell development, phenotype, and function in vitro and in vivo. Int J Hematol 2002 75 : 345 349.
64. Lyon MF, Glenister PH. A new allele sash (Wsh) at the W-locus and a spontaneous recessive lethal in mice. Genet Res 1982 39 : 315 322.
65. Grimbaldeston MA, Chen CC, Piliponsky AM, Tsai M, Tam S-Y, Galli SJ. Mast cell-deficient W-sash c-kit mutant KitW-sh/W-sh mice as a model for investigating mast cell biology in vivo. Am J Pathol 2005 167 : 835 848.
66. Wolters PJ, et al. Tissue-selective mast cell reconstitution and differential lung gene expression in mast cell-deficient KitW-sh/KitW-sh sash mice. Clin Exp Allergy 2005 35 : 82 88.
67. Wershil BK, Furuta GT, Wang ZS, Galli SJ. Mast cell-dependent neutrophil and mononuclear cell recruitment in immunoglobulin E-induced gastric reactions in mice. Gastroenterology 1996 110 : 1482 1490.
68. Otsu K, et al. Phenotypic changes of bone marrow-derived mast cells after intraperitoneal transfer into W/Wv mice that are genetically deficient in mast cells. J Exp Med 1987 165 : 615 627.
69. Tsai M, Grimbaldeston MA, Yu M, Tam SY, Galli SJ. Using mast cell knock-in mice to analyze the roles of mast cells in allergic responses in vivo. Chem Immunol Allergy 2005 87 : 179 197.
70. Sonoda S, Nakano T, Kanakura Y, Sonoda T, Asai H, Kitamura Y. Hybrid resistance to parental mast cell precursors in the skin of (WB × C57BL/6)F1-W/Wv mice. J Immunol 1986 137 : 2152 2155.
71. Tanzola MB, Robbie-Ryan M, Gutekunst CA, Brown MA. Mast cells exert effects outside the central nervous system to influence experimental allergic encephalomyelitis disease course. J Immunol 2003 171 : 4385 4391.
72. Echtenacher B, Männel DN, Hültner L. Critical protective role of mast cells in a model of acute septic peritonitis. Nature 1996 381 : 75 77.
73. Jippo T, Morii E, Ito A, Kitamura Y. Effect of anatomical distribution of mast cells on their defense function against bacterial infections: demonstration using partially mast cell-deficient tg/tg mice. J Exp Med 2003 197 : 1417 1425.
74. Malaviya R, Navara C, Uckun FM. Role of Janus kinase 3 in mast cell-mediated innate immunity against gram-negative bacteria. Immunity 2001 15 : 313 321.
75. Supajatura V, et al. Differential responses of mast cell Toll-like receptors 2 and 4 in allergy and innate immunity. J Clin Invest 2002 109 : 1351 1359.
76. Wershil BK, Mekori YA, Murakami T, Galli SJ. 125I-fibrin deposition in IgE-dependent immediate hypersensitivity reactions in mouse skin. Demonstration of the role of mast cells using genetically mast cell-deficient mice locally reconstituted with cultured mast cells. J Immunol 1987 139 : 2605 2614.
77. Wershil BK, Murakami T, Galli SJ. Mast cell-dependent amplification of an immunologically nonspecific inflammatory response. Mast cells are required for the full expression of cutaneous acute inflammation induced by phorbol 12-myristate 13-acetate. J Immunol 1988 140 : 2356 2360.
78. Yano H, Wershil BK, Arizono N, Galli SJ. Substance P-induced augmentation of cutaneous vascular permeability and granulocyte infiltration in mice is mast cell dependent. J Clin Invest 1989 84 : 1276 1286.
79. Wershil BK, Wang Z-S, Gordon JR, Galli SJ. Recruitment of neutrophils during IgE-dependent cutaneous late phase reactions in the mouse is mast cell-dependent. Partial inhibition of the reaction with antiserum against tumor necrosis factor-alpha. J Clin Invest 1991 87 : 446 453.
80. Chen R, et al. Mast cells play a key role in neutrophil recruitment in experimental bullous pemphigoid. J Clin Invest 2001 108 : 1151 1158.
81. Jawdat DM, Albert EJ, Rowden G, Haidl ID, Marshall JS. IgE-mediated mast cell activation induces Langerhans cell migration in vivo. J Immunol 2004 173 : 5275 5282.
82. Kakurai M, Monteforte R, Suto H, Tsai M, Nakae S, Galli SJ. Mast cell-derived tumor necrosis factor can promote nerve fiber elongation in the skin during contact hypersensitivity in mice. Am J Pathol 2006 169 : 1713 1721.
83. Metz M, Lammel V, Gibbs BF, Maurer M. Inflammatory murine skin responses to UV-B light are partially dependent on endothelin-1 and mast cells. Am J Pathol 2006 169 : 815 822.
84. Weller K, Foitzik K, Paus R, Syska W, Maurer M. Mast cells are required for normal healing of skin wounds in mice. FASEB J 2006 20 : 2366 2368.
85. Martin TR, Takeishi T, Katz HR, Austen KF, Drazen JM, Galli SJ. Mast cell activation enhances airway responsiveness to methacholine in the mouse. J Clin Invest 1993 91 : 1176 1182.
86. Williams CMM, Galli SJ. Mast cells can amplify airway reactivity and features of chronic inflammation in an asthma model in mice. J Exp Med 2000 192 : 455 462.
87. Yu M, Tsai M, Tam SY, Jones C, Zehnder J, Galli SJ. Mast cells can promote the development of multiple features of chronic asthma in mice. J Clin Invest 2006 116 : 1633 1641.
88. Wershil BK, Tsai M, Geissler EN, Zsebo KM, Galli SJ. The rat c-kit ligand, stem cell factor, induces c-kit receptor-dependent mouse mast cell activation in vivo. Evidence that signaling through the c-kit receptor can induce expression of cellular function. J Exp Med 1992 175 : 245 255.
89. Alizadeh H, Murrell KD. The intestinal mast cell response to Trichinella spiralis infection in mast cell-deficient w/wv mice. J Parasitol 1984 70 : 767 773.
90. Galli SJ, Arizono N, Murakami T, Dvorak AM, Fox JG. Development of large numbers of mast cells at sites of idiopathic chronic dermatitis in genetically mast cell-deficient WBB6F1-W/Wv mice. Blood 1987 69 : 1661 1666.
91. Gordon JR, Galli SJ. Phorbol 12-myristate 13-acetate-induced development of functionally active mast cells in W/Wv but not Sl/Sld genetically mast cell-deficient mice. Blood 1990 75 : 1637 1645.
92. Khan AI, Horii Y, Tiuria R, Sato Y, Nawa Y. Mucosal mast cells and the expulsive mechanisms of mice against Strongyloides venezuelensis. Int J Parasitol 1993 23 : 551 555.
93. Theoharides TC, el-Mansoury M, Letourneau R, Boucher W, Rozniecki JJ. Dermatitis characterized by mastocytosis at immunization sites in mast-cell-deficient W/Wv mice. Int Arch Allergy Immunol 1993 102 : 352 361.
94. Lantz CS, et al. Role for interleukin-3 in mast-cell and basophil development and in immunity to parasites. Nature 1998 392 : 90 93.
95. Gu H, Marth JD, Orban PC, Mossmann H, Rajewsky K. Deletion of a DNA polymerase beta gene segment in T cells using cell type-specific gene targeting. Science 1994 265 : 103 106.
96. Rajewsky K, et al. Conditional gene targeting. J Clin Invest 1996 98 : 600 603.
97. Nagy A. Cre recombinase: the universal reagent for genome tailoring. Genesis 2000 26 : 99 109.
98. Mak TW, Penninger JM, Ohashi PS. Knockout mice: a paradigm shift in modern immunology. Nat Rev Immunol 2001 1 : 11 19.
99. Mikkola HK, Orkin SH. Gene targeting and transgenic strategies for the analysis of hematopoietic development in the mouse. Methods Mol Med 2005 105 : 3 22.
100. Forsberg E, et al. Abnormal mast cells in mice deficient in a heparin-synthesizing enzyme. Nature 1999 400 : 773 776.
101. Humphries DE, et al. Heparin is essential for the storage of specific granule proteases in mast cells. Nature 1999 400 : 769 772.
102. Feyerabend TB, et al. Loss of histochemical identity in mast cells lacking carboxypeptidase A. Mol Cell Biol 2005 25 : 6199 6210.
103. Henningsson F, Wolters P, Chapman HA, Caughey GH, Pejler G. Mast cell cathepsins C and S control levels of carboxypeptidase A and the chymase, mouse mast cell protease 5. Biol Chem 2003 384 : 1527 1531.
104. Malaviya R, Ikeda T, Ross E, Abraham SN. Mast cell modulation of neutrophil influx and bacterial clearance at sites of infection through TNF-α. Nature 1996 381 : 77 80.
105. Prodeus AP, Zhou X, Maurer M, Galli SJ, Carroll MC. Impaired mast cell-dependent natural immunity in complement C3-deficient mice. Nature 1997 390 : 172 175.
106. Maurer M, et al. The c-kit ligand, stem cell factor, can enhance innate immunity through effects on mast cells. J Exp Med 1998 188 : 2343 2348.
107. Malaviya R, Abraham SN. Role of mast cell leukotrienes in neutrophil recruitment and bacterial clearance in infectious peritonitis. J Leukoc Biol 2000 67 : 841 846.
108. Gommerman JL, et al. A role for CD21/CD35 and CD19 in responses to acute septic peritonitis: a potential mechanism for mast cell activation. J Immunol 2000 165 : 6915 6921.
109. Malaviya R, Twesten NJ, Ross EA, Abraham SN, Pfeifer JD. Mast cells process bacterial Ags through a phagocytic route for class I MHC presentation to T cells. J Immunol 1996 156 : 1490 1496.
110. Di Nardo A, Vitiello A, Gallo RL. Cutting edge: mast cell antimicrobial activity is mediated by expression of cathelicidin antimicrobial peptide. J Immunol 2003 170 : 2274 2278.
111. McLachlan JB, et al. Mast cell-derived tumor necrosis factor induces hypertrophy of draining lymph nodes during infection. Nat Immunol 2003 4 : 1199 1205.
112. Echtenacher B, Weigl K, Lehn N, Männel DN. Tumor necrosis factor-dependent adhesions as a major protective mechanism early in septic peritonitis in mice. Infect Immun 2001 69 : 3550 3555.
113. Holmdahl L, Ivarsson ML. The role of cytokines, coagulation, and fibrinolysis in peritoneal tissue repair. Eur J Surg 1999 165 : 1012 1019.
114. Wanecek M, Weitzberg E, Rudehill A, Oldner A. The endothelin system in septic and endotoxin shock. Eur J Pharmacol 2000 407 : 1 15.
115. Kakizoe E, Shiota N, Tanabe Y, Shimoura K, Kobayashi Y, Okunishi H. Isoform-selective upregulation of mast cell chymase in the development of skin fibrosis in scleroderma model mice. J Invest Dermatol 2001 116 : 118 123.
116. Sommerhoff CP. Mast cell tryptases and airway remodeling. Am J Respir Crit Care Med 2001 164 : S52 S58.
117. Janicki JS, et al. Cardiac mast cell regulation of matrix metalloproteinase-related ventricular remodeling in chronic pressure or volume overload. Cardiovasc Res 2006 69 : 657 665.
118. Kloog Y, Ambar I, Sokolovsky M, Kochva E, Wollberg Z, Bdolah A. Sarafotoxin, a novel vasoconstrictor peptide: phosphoinositide hydrolysis in rat heart and brain. Science 1988 242 : 268 270.
119. Lu Q, Clemetson JM, Clemetson KJ. Snake venoms and hemostasis. J Thromb Haemost 2005 3 : 1791 1799.
120. Favreau P, et al. Mass spectrometry strategies for venom mapping and peptide sequencing from crude venoms: case applications with single arthropod specimen. Toxicon 2006 47 : 676 687.
121. Grassi-Kassisse DM, Ribeiro-DaSilva G. Canatoxin triggers histamine secretion from rat peritoneal mast cells. Agents Actions 1992 37 : 204 209.
122. Stassen M, et al. The streptococcal exotoxin streptolysin O activates mast cells to produce tumor necrosis factor alpha by p38 mitogen-activated protein kinase- and protein kinase C-dependent pathways. Infect Immun 2003 71 : 6171 6177.
123. Weisel-Eichler A, Libersat F. Venom effects on monoaminergic systems. J Comp Physiol A Neuroethol Sens Neural Behav Physiol 2004 190 : 683 690.
124. Rylander R. Endotoxin and occupational airway disease. Curr Opin Allergy Clin Immunol 2006 6 : 62 66.
125. Silinsky EM, Searl TJ. Phorbol esters and neurotransmitter release: more than just protein kinase C? Br J Pharmacol 2003 138 : 1191 1201.
126. Wershil BK, Mekori YA, Murakami T, Galli SJ. Diminished croton oil-induced acute inflammation in mast cell-deficient (W/WV and Sl/SId) mice. Fed Proc 1986 45 : 1104.
127. Jawdat DM, Rowden G, Marshall JS. Mast cells have a pivotal role in TNF-independent lymph node hypertrophy and the mobilization of Langerhans cells in response to bacterial peptidoglycan. J Immunol 2006 177 : 1755 1762.
128. Ha TY, Reed ND, Crowle PK. Immune response potential of mast cell-deficient W/Wv mice. Int Arch Allergy Appl Immunol 1986 80 : 85 94.
129. Yamashita H, Michibata Y, Mizukami H, Ogihara Y, Morita A, Nose M. Dermal mast cells play a central role in the incidence of scratching behavior in mice induced by multiple application of the hapten, 2,4,6-trinitrochlorobenzene. Exp Dermatol 2005 14 : 438 444.
130. Suto H, Nakae S, Kakurai M, Sedgwick JD, Tsai M, Galli SJ. Mast cell-associated TNF promotes dendritic cell migration. J Immunol 2006 176 : 4102 4112.
131. Bryce PJ, Miller ML, Miyajima I, Tsai M, Galli SJ, Oettgen HC. Immune sensitization in the skin is enhanced by antigen-independent effects of IgE. Immunity 2004 20 : 381 392.
132. Matsuda K, et al. Monomeric IgE enhances human mast cell chemokine production: IL-4 augments and dexamethasone suppresses the response. J Allergy Clin Immunol 2005 116 : 1357 1363.
133. Nigo YI, et al. Regulation of allergic airway inflammation through Toll-like receptor 4-mediated modification of mast cell function. Proc Natl Acad Sci USA 2006 103 : 2286 2291.
134. Kalinski P, Hilkens CM, Snijders A, Snijdewint FG, Kapsenberg ML. IL-12-deficient dendritic cells, generated in the presence of prostaglandin E2, promote type 2 cytokine production in maturing human naive T helper cells. J Immunol 1997 159 : 28 35.
135. Kaser A, et al. A role for IL-16 in the cross-talk between dendritic cells and T cells. J Immunol 1999 163 : 3232 3238.
136. Cumberbatch M, Dearman RJ, Griffiths CE, Kimber I. Langerhans cell migration. Clin Exp Dermatol 2000 25 : 413 418.
137. Mazzoni A, Young HA, Spitzer JH, Visintin A, Segal DM. Histamine regulates cytokine production in maturing dendritic cells, resulting in altered T cell polarization. J Clin Invest 2001 108 : 1865 1873.
138. Caron G, et al. Histamine polarizes human dendritic cells into Th2 cell-promoting effector dendritic cells. J Immunol 2001 167 : 3682 3686.
139. Cumberbatch M, Dearman RJ, Antonopoulos C, Groves RW, Kimber I. Interleukin (IL)-18 induces Langerhans cell migration by a tumour necrosis factor-α- and IL-1β-dependent mechanism. Immunology 2001 102 : 323 330.
140. Faveeuw C, et al. Prostaglandin D2 inhibits the production of interleukin-12 in murine dendritic cells through multiple signaling pathways. Eur J Immunol 2003 33 : 889 898.
141. Depinay N, Hacini F, Beghdadi W, Peronet R, Mecheri S. Mast cell-dependent down-regulation of antigen-specific immune responses by mosquito bites. J Immunol 2006 176 : 4141 4146.
142. Hart PH, Grimbaldeston MA, Swift GJ, Jaksic A, Noonan FP, Finlay-Jones JJ. Dermal mast cells determine susceptibility to ultraviolet B-induced systemic suppression of contact hypersensitivity responses in mice. J Exp Med 1998 187 : 2045 2053.
143. Dombrowicz D, Flamand V, Miyajima I, Ravetch JV, Galli SJ, Kinet J-P. Absence of FcεRIα chain results in upregulation of FcγRIII-dependent mast cell degranulation and anaphylaxis. Evidence of competition between FcεRI and FcγRIII for limiting amounts of FcR β and γ chains. J Clin Invest 1997 99 : 915 925.
144. Miyajima I, Dombrowicz D, Martin TR, Ravetch JV, Kinet JP, Galli SJ. Systemic anaphylaxis in the mouse can be mediated largely through IgG1 and FcγRIII. Assessment of the cardiopulmonary changes, mast cell degranulation, and death associated with active or IgE- or IgG1-dependent passive anaphylaxis. J Clin Invest 1997 99 : 901 914.
145. Strait RT, Morris SC, Yang M, Qu XW, Finkelman FD. Pathways of anaphylaxis in the mouse. J Allergy Clin Immunol 2002 109 : 658 668.
146. Mukai K, et al. Basophils play a critical role in the development of IgE-mediated chronic allergic inflammation independently of T cells and mast cells. Immunity 2005 23 : 191 202.
147. Choi IH, et al. Immunoglobulin E-dependent active fatal anaphylaxis in mast cell-deficient mice. J Exp Med 1998 188 : 1587 1592.
148. Williams CMM, Galli SJ. The diverse potential effector and immunoregulatory roles of mast cells in allergic disease. J Allergy Clin Immunol 2000 105 : 847 859.
149. Kay AB. Allergy and allergic diseases. First of two parts. N Engl J Med 2001 344 : 30 37.
150. Benoist C, Mathis D. Mast cells in autoimmune disease. Nature 2002 420 : 875 878.
151. Furuta GT, et al. Mast cell-dependent tumor necrosis factor α production participates in allergic gastric inflammation in mice. Gastroenterology 1997 113 : 1560 1569.
152. Taube C, et al. Mast cells, FcεRI, and IL-13 are required for development of airway hyperresponsiveness after aerosolized allergen exposure in the absence of adjuvant. J Immunol 2004 172 : 6398 6406.
153. Miyazaki D, Nakamura T, Toda M, Cheung-Chau KW, Richardson RM, Ono SJ. Macrophage inflammatory protein-1α as a costimulatory signal for mast cell-mediated immediate hypersensitivity reactions. J Clin Invest 2005 115 : 434 442.
154. Gerard NP, Gerard C. Complement in allergy and asthma. Curr Opin Immunol 2002 14 : 705 708.
155. Zaidi AK, Amrani Y, Panettieri RA, Ali H. Response to C3a, mast cells, and asthma. FASEB J 2006 20 : 199.
156. Matsuda H, et al. Necessity of IgE antibodies and mast cells for manifestation of resistance against larval Haemaphysalis longicornis ticks in mice. J Immunol 1990 144 : 259 262.
157. Miller HR. Mucosal mast cells and the allergic response against nematode parasites. Vet Immunol Immunopathol 1996 54 : 331 336.
158. Pedotti R, De Voss JJ, Steinman L, Galli SJ. Involvement of both 'allergic' and 'autoimmune' mechanisms in EAE, MS and other autoimmune diseases. Trends Immunol 2003 24 : 479 484.
159. Wintroub BU, Mihm MC Jr., Goetzl EJ, Soter NA, Austen KF. Morphologic and functional evidence for release of mast-cell products in bullous pemphigoid. N Engl J Med 1978 298 : 417 421.
160. Mican JM, Metcalfe DD. Arthritis and mast cell activation. J Allergy Clin Immunol 1990 86 : 677 683.
161. Secor VH, Secor WE, Gutekunst CA, Brown MA. Mast cells are essential for early onset and severe disease in a murine model of multiple sclerosis. J Exp Med 2000 191 : 813 822.
162. Gregory GD, Brown MA. Mast cells in allergy and autoimmunity: implications for adaptive immunity. Methods Mol Biol 2006 315 : 35 50.
163. Lee DM, Friend DS, Gurish MF, Benoist C, Mathis D, Brenner MB. Mast cells: a cellular link between autoantibodies and inflammatory arthritis. Science 2002 297 : 1689 1692.
164. Askenase PW, et al. Defective elicitation of delayed-type hypersensitivity in W/Wv and SI/SId mast cell-deficient mice. J Immunol 1983 131 : 2687 2694.
165. Galli SJ, Hammel I. Unequivocal delayed hypersensitivity in mast cell-deficient and beige mice. Science 1984 226 : 710 713.
166. Biedermann T, et al. Mast cells control neutrophil recruitment during T cell-mediated delayed-type hypersensitivity reactions through tumor necrosis factor and macrophage inflammatory protein 2. J Exp Med 2000 192 : 1441 1452.
167. Kraneveld AD, et al. Key role for mast cells in nonatopic asthma. J Immunol 2002 169 : 2044 2053.
168. Rijnierse A, Koster AS, Nijkamp FP, Kraneveld AD. Critical role for mast cells in the pathogenesis of 2,4-dinitrobenzene-induced murine colonic hypersensitivity reaction. J Immunol 2006 176 : 4375 4384.
169. Haynes DC, Gershwin ME. The immunopathology of progressive systemic sclerosis (PSS). Semin Arthritis Rheum 1982 11 : 331 351.
170. Claman HN, Choi KL, Sujansky W, Vatter AE. Mast cell " disappearance" in chronic murine graft-vs-host disease (GVHD)- ultrastructural demonstration of "phantom mast cells". J Immunol 1986 137 : 2009 13.
171. Yamamoto T. Bleomycin and the skin. Br J Dermatol 2006 155 : 869 875.
172. Yamamoto T, Takahashi Y, Takagawa S, Katayama I, Nishioka K. Animal model of sclerotic skin. II. Bleomycin induced scleroderma in genetically mast cell deficient WBB6F1-W/Wv mice. J Rheumatol 1999 26 : 2628 2634.
173. Mekori YA. The mastocyte: the "other" inflammatory cell in immunopathogenesis. J Allergy Clin Immunol 2004 114 : 52 57.
174. Stopfer P, Männel DN, Hehlgans T. Lymphotoxin-β receptor activation by activated T cells induces cytokine release from mouse bone marrow-derived mast cells. J Immunol 2004 172 : 7459 7465.
175. Weaver CT, Harrington LE, Mangan PR, Gavrieli M, Murphy KM. Th17: an effector CD4 T cell lineage with regulatory T cell ties. Immunity 2006 24 : 677 688.
176. Nakae S, et al. Antigen-specific T cell sensitization is impaired in IL-17-deficient mice, causing suppression of allergic cellular and humoral responses. Immunity 2002 17 : 375 387.
177. Nakae S, Nambu A, Sudo K, Iwakura Y. Suppression of immune induction of collagen-induced arthritis in IL-17-deficient mice. J Immunol 2003 171 : 6173 6177.
178. Nakae S, Saijo S, Horai R, Sudo K, Mori S, Iwakura Y. IL-17 production from activated T cells is required for the spontaneous development of destructive arthritis in mice deficient in IL-1 receptor antagonist. Proc Natl Acad Sci USA 2003 100 : 5986 5990.
179. Langrish CL, et al. IL-23 drives a pathogenic T cell population that induces autoimmune inflammation. J Exp Med 2005 201 : 233 240.
180. Komiyama Y, et al. IL-17 plays an important role in the development of experimental autoimmune encephalomyelitis. J Immunol 2006 177 : 566 573.
181. Nakae S, Suto H, Berry GJ, Galli SJ. Mast cell-derived TNF can promote Th17 cell-dependent neutrophil recruitment in ovalbumin-challenged OTII mice. Blood 2006 Dec 29 Epub ahead of print L, Elias JA, Chupp GL. Asthma: mechanisms of disease persistence and progression. Annu Rev Immunol 2004 22 : 789 815.
182. Storms W. Allergens in the pathogenesis of asthma: potential role of anti-immunoglobulin E therapy. Am J Respir Med 2002 1 : 361 368.
183. Shakoory B, Fitzgerald SM, Lee SA, Chi DS, Krishnaswamy G. The role of human mast cell-derived cytokines in eosinophil biology. J Interferon Cytokine Res 2004 24 : 271 281.
184. Amin K, et al. Inflammation and structural changes in the airways of patients with atopic and nonatopic asthma. BHR Group. Am J Respir Crit Care Med 2000 162 : 2295 2301.
185. Fahy JV, Kim KW, Liu J, Boushey HA. Prominent neutrophilic inflammation in sputum from subjects with asthma exacerbation. J Allergy Clin Immunol 1995 95 : 843 852.
186. Wenzel SE, Szefler SJ, Leung DY, Sloan SI, Rex MD, Martin RJ. Bronchoscopic evaluation of severe asthma. Persistent inflammation associated with high dose glucocorticoids. Am J Respir Crit Care Med 1997 156 : 737 743.
187. Douwes J, Gibson P, Pekkanen J, Pearce N. Non-eosinophilic asthma: importance and possible mechanisms. Thorax 2002 57 : 643 648.
188. Caramori G, Pandit A, Papi A. Is there a difference between chronic airway inflammation in chronic severe asthma and chronic obstructive pulmonary disease? Curr Opin Allergy Clin Immunol 2005 5 : 77 83.
189. Kamath AV, Pavord ID, Ruparelia PR, Chilvers ER. Is the neutrophil the key effector cell in severe asthma? Thorax 2005 60 : 529 530.
190. Yasui K, et al. Neutrophilic inflammation in childhood bronchial asthma. Thorax 2005 60 : 704 705.
191. Thomas PS, Yates DH, Barnes PJ. Tumor necrosis factor-α increases airway responsiveness and sputum neutrophilia in normal human subjects. Am J Respir Crit Care Med 1995 152 : 76 80.
192. Halasz A, Cserhati E, Magyar R, Kovacs M, Cseh K. Role of TNF-α and its 55 and 75 kDa receptors in bronchial hyperreactivity. Respir Med 2002 96 : 262 267.
193. Basyigit I, Yildiz F, Ozkara SK, Boyaci H, Ilgazli A. Inhaled corticosteroid effects both eosinophilic and non-eosinophilic inflammation in asthmatic patients. Mediators Inflamm 2004 13 : 285 291.
194. Bradding P, et al. Interleukin-4, -5, and -6 and tumor necrosis factor-α in normal and asthmatic airways: evidence for the human mast cell as a source of these cytokines. Am J Respir Cell Mol Biol 1994 10 : 471 480.
195. Howarth PH, et al. Tumour necrosis factor (TNFα) as a novel therapeutic target in symptomatic corticosteroid dependent asthma. Thorax 2005 60 : 1012 1018.
196. Babu KS, Davies DE, Holgate ST. Role of tumor necrosis factor alpha in asthma. Immunol Allergy Clin North Am 2004 24 : 583 597, v-vi.
197. Berry MA, et al. Evidence of a role of tumor necrosis factor alpha in refractory asthma. N Engl J Med 2006 354 : 697 708.
198. Rouhani FN, Meitin CA, Kaler M, Miskinis-Hilligoss D, Stylianou M, Levine SJ. Effect of tumor necrosis factor antagonism on allergen-mediated asthmatic airway inflammation. Respir Med 2005 99 : 1175 1182.
199. Wong CK, et al. Proinflammatory cytokines (IL-17, IL-6, IL-18 and IL-12) and Th cytokines (IFN-γ, IL-4, IL-10 and IL-13) in patients with allergic asthma. Clin Exp Immunol 2001 125 : 177 183.
200. Molet S, et al. IL-17 is increased in asthmatic airways and induces human bronchial fibroblasts to produce cytokines. J Allergy Clin Immunol 2001 108 : 430 438.
201. Linden A. Role of interleukin-17 and the neutrophil in asthma. Int Arch Allergy Immunol 2001 126 : 179 184.
202. Weill H, McDonald JC. Exposure to crystalline silica and risk of lung cancer: the epidemiological evidence. Thorax 1996 51 : 97 102.
203. Jindal SK, Aggarwal AN, Gupta D. Dust-induced interstitial lung disease in the tropics. Curr Opin Pulm Med 2001 7 : 272 277.
204. Hamada H, Vallyathan V, Cool CD, Barker E, Inoue Y, Newman LS. Mast cell basic fibroblast growth factor in silicosis. Am J Respir Crit Care Med 2000 161 : 2026 2034.
205. Suzuki N, et al. Mast cells are essential for the full development of silica-induced pulmonary inflammation: a study with mast cell-deficient mice. Am J Respir Cell Mol Biol 1993 9 : 475 483.
206. Brown JM, Swindle EJ, Kushnir-Sukhov NM, Holian A, Metcalfe DD. Silica-directed mast cell activation is enhanced by scavenger receptors. Am J Respir Cell Mol Biol 2007 36 : 43 52.
207. Hunt LW, Colby TV, Weiler DA, Sur S, Butterfield JH. Immunofluorescent staining for mast cells in idiopathic pulmonary fibrosis: quantification and evidence for extracellular release of mast cell tryptase. Mayo Clin Proc 1992 67 : 941 948.
208. Pesci A, Bertorelli G, Gabrielli M, Olivieri D. Mast cells in fibrotic lung disorders. Chest 1993 103 : 989 996.
209. Inoue Y, King TE Jr., Tinkle SS, Dockstader K, Newman LS. Human mast cell basic fibroblast growth factor in pulmonary fibrotic disorders. Am J Pathol 1996 149 : 2037 2054.
210. Shimabukuro DW, Sawa T, Gropper MA. Injury and repair in lung and airways. Crit Care Med 2003 31 : S524 S531.
211. Okazaki T, et al. Increase of mast cells in the liver and lung may be associated with but not a cause of fibrosis: demonstration using mast cell-deficient Ws/Ws rats. Lab Invest 1998 78 : 1431 1438.
212. Tomimori Y, et al. Involvement of mast cell chymase in bleomycin-induced pulmonary fibrosis in mice. Eur J Pharmacol 2003 478 : 179 185.
213. Beller TC, Maekawa A, Friend DS, Austen KF, Kanaoka Y. Targeted gene disruption reveals the role of the cysteinyl leukotriene 2 receptor in increased vascular permeability and in bleomycin-induced pulmonary fibrosis in mice. J Biol Chem 2004 279 : 46129 46134.
214. Galli SJ, Wershil BK, Mekori YA. Analysis of mast cell function in biological responses not involving IgE. Int Arch Allergy Appl Immunol 1987 82 : 269 271.
215. Mori H, Kawada K, Zhang P, Uesugi Y, Sakamoto O, Koda A. Bleomycin-induced pulmonary fibrosis in genetically mast cell-deficient WBB6F1-W/Wv mice and mechanism of the suppressive effect of tranilast, an antiallergic drug inhibiting mediator release from mast cells, on fibrosis. Int Arch Allergy Appl Immunol 1991 95 : 195 201.
216. Ebi Y, Kasugai T, Seino Y, Onoue H, Kanemoto T, Kitamura Y. Mechanism of mast cell deficiency in mutant mice of mi/mi genotype: an analysis by co-culture of mast cells and fibroblasts. Blood 1990 75 : 1247 1251.
217. Stechschulte DJ, et al. Effect of the mi allele on mast cells, basophils, natural killer cells, and osteoclasts in C57Bl/6J mice. J Cell Physiol 1987 132 : 565 570.
218. O'Brien-Ladner AR, Wesselius LJ, Stechschulte DJ. Bleomycin injury of the lung in a mast-cell-deficient model. Agents Actions 1993 39 : 20 24.
219. Heath D, Yacoub M. Lung mast cells in plexogenic pulmonary arteriopathy. J Clin Pathol 1991 44 : 1003 1006.
220. Mitani Y, et al. Mast cell chymase in pulmonary hypertension. Thorax 1999 54 : 88 90.
221. Kay JM, Waymire JC, Grover RF. Lung mast cell hyperplasia and pulmonary histamine-forming capacity in hypoxic rats. Am J Physiol 1974 226 : 178 184.
222. Zhu YJ, Kradin R, Brandstetter RD, Staton G, Moss J, Hales CA. Hypoxic pulmonary hypertension in the mast cell-deficient mouse. J Appl Physiol 1983 54 : 680 686.
223. Vaszar LT, et al. Longitudinal transcriptional analysis of developing neointimal vascular occlusion and pulmonary hypertension in rats. Physiol Genomics 2004 17 : 150 156.
224. Ghanem NS, Assem ES, Leung KB, Pearce FL. Cardiac and renal mast cells: morphology, distribution, fixation and staining properties in the guinea pig and preliminary comparison with human. Agents Actions 1988 23 : 223 226.
225. Kovanen PT. Chymase-containing mast cells in human arterial intima: implications for atherosclerotic disease. Heart Vessels 1997 Suppl. 12 125 127.
226. Patella V, et al. Stem cell factor in mast cells and increased mast cell density in idiopathic and ischemic cardiomyopathy. Circulation 1998 97 : 971 978.
227. Lindstedt KA, Kovanen PT. Mast cells in vulnerable coronary plaques: potential mechanisms linking mast cell activation to plaque erosion and rupture. Curr Opin Lipidol 2004 15 : 567 573.
228. Vanderlaan PA, Reardon CA. Thematic review series: the immune system and atherogenesis. The unusual suspects: an overview of the minor leukocyte populations in atherosclerosis. J Lipid Res 2005 46 : 829 838.
229. Hara M, et al. Evidence for a role of mast cells in the evolution to congestive heart failure. J Exp Med 2002 195 : 375 381.
230. Bader M. Role of the local renin-angiotensin system in cardiac damage: a minireview focussing on transgenic animal models. J Mol Cell Cardiol 2002 34 : 1455 1462.
231. Urata H, Kinoshita A, Misono KS, Bumpus FM, Husain A. Identification of a highly specific chymase as the major angiotensin II-forming enzyme in the human heart. J Biol Chem 1990 265 : 22348 22357.
232. Li M, et al. Involvement of chymase-mediated angiotensin II generation in blood pressure regulation. J Clin Invest 2004 114 : 112 120.
233. Lundequist A, Tchougounova E, Abrink M, Pejler G. Cooperation between mast cell carboxypeptidase A and the chymase mouse mast cell protease 4 in the formation and degradation of angiotensin II. J Biol Chem 2004 279 : 32339 32344.
234. Jin D, Takai S, Shiota N, Miyazaki M. Roles of vascular angiotensin converting enzyme and chymase in two-kidney, one clip hypertensive hamsters. J Hypertens 1998 16 : 657 664.
235. Miyazaki M, Takai S, Jin D, Muramatsu M. Pathological roles of angiotensin II produced by mast cell chymase and the effects of chymase inhibition in animal models. Pharmacol Ther 2006 112 : 668 676.
236. Matsumoto T, Wada A, Tsutamoto T, Ohnishi M, Isono T, Kinoshita M. Chymase inhibition prevents cardiac fibrosis and improves diastolic dysfunction in the progression of heart failure. Circulation 2003 107 : 2555 2558.
237. Silver RB, et al. Mast cells: a unique source of renin. Proc Natl Acad Sci USA 2004 101 : 13607 13612.
238. Mackins CJ, et al. Cardiac mast cell-derived renin promotes local angiotensin formation, norepinephrine release, and arrhythmias in ischemia/reperfusion. J Clin Invest 2006 116 : 1063 1070.
239. Constantinides P. Mast cells and susceptibility to experimental atherosclerosis. Science 1953 117 : 505 506.
240. Kovanen PT. The mast cell - a potential link between inflammation and cellular cholesterol deposition in atherogenesis. Eur Heart J 1993 14 (Suppl 105 117.
241. Lindstedt KA, Leskinen MJ, Kovanen PT. Proteolysis of the pericellular matrix: a novel element determining cell survival and death in the pathogenesis of plaque erosion and rupture. Arterioscler Thromb Vasc Biol 2004 24 : 1350 1358.
242. Tsuruda T, et al. Adrenomedullin in mast cells of abdominal aortic aneurysm. Cardiovasc Res 2006 70 : 158 164.
243. Schmidt-Weber CB, Blaser K. The role of TGF-β in allergic inflammation. Immunol Allergy Clin North Am 2006 26 : 233 244, vi-vii.
244. Steinke JW, Negri J, Enelow R, Baramki DF, Borish L. Proinflammatory effects of IL-4 antagonism. J Allergy Clin Immunol 2006 118 : 756 758.
245. Akdis CA, Blaser K. Mechanisms of interleukin-10-mediated immune suppression. Immunology 2001 103 : 131 136.
246. Hart PH, Grimbaldeston MA, Finlay-Jones JJ. Sunlight, immunosuppression and skin cancer: role of histamine and mast cells. Clin Exp Pharmacol Physiol 2001 28 : 1 8.
247. Gilfillan AM, Tkaczyk C. Integrated signalling pathways for mast-cell activation. Nat Rev Immunol 2006 6 : 218 230.
248. Moormann C, et al. Functional characterization and expression analysis of the proteinase-activated receptor-2 in human cutaneous mast cells. J Invest Dermatol 2006 126 : 746 755.
249. Fischer M, et al. Mast cell CD30 ligand is upregulated in cutaneous inflammation and mediates degranulation-independent chemokine secretion. J Clin Invest 2006 116 : 2748 2756.
250. Varsani M, Pearce FL. Role of phospholipase A2 in mast cell activation. Inflamm Res 1997 46 (Suppl S9 S10.
251. Ziai MR, Russek S, Wang HC, Beer B, Blume AJ. Mast cell degranulating peptide: a multi-functional neurotoxin. J Pharm Pharmacol 1990 42 : 457 461.
252. Graham C, Richter SC, McClean S, O'Kane E, Flatt PR, Shaw C. Histamine-releasing and antimicrobial peptides from the skin secretions of the dusky gopher frog, Rana sevosa. Peptides 2006 27 : 1313 1319.
253. Lind NK. Mechanism of action of fire ant (Solenopsis) venoms. I. Lytic release of histamine from mast cells. Toxicon 1982 20 : 831 840.
254. Takei M, Nakagawa H, Endo K. Mast cell activation by pedicellarial toxin of sea urchin, Toxopneustes pileolus. FEBS Lett 1993 328 : 59 62.
255. Cormier SM. Physalia venom mediates histamine release from mast cells. J Exp Zool 1981 218 : 117 120.
256. Soter NA, Wasserman SI. Physical urticaria/angioedema: an experimental model of mast cell activation in humans. J Allergy Clin Immunol 1980 66 : 358 365.
257. Stokes AJ, Shimoda LM, Koblan-Huberson M, Adra CN, Turner H. A TRPV2-PKA signaling module for transduction of physical stimuli in mast cells. J Exp Med 2004 200 : 137 147.