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Volumn 20, Issue 13, 2006, Pages

Mast cells are required for normal healing of skin wounds in mice

Author keywords

Inflammation; Neutrophil

Indexed keywords

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD VESSEL PERMEABILITY; CONTROLLED STUDY; DEGRANULATION; EXTRAVASATION; MAST CELL; MORPHOMETRICS; MOUSE; NEUTROPHIL; NONHUMAN; PRIORITY JOURNAL; SKIN INJURY; UPREGULATION; WOUND CLOSURE; WOUND HEALING; ANIMAL; C57BL MOUSE; CELL DIVISION; CROSS BREEDING; CYTOLOGY; DISEASE MODEL; GENETICS; HISTAMINE RELEASE; INJURY; KERATINOCYTE; MOUSE MUTANT; PHYSIOLOGY; SKIN;

EID: 33845613484     PISSN: 08926638     EISSN: None     Source Type: Journal    
DOI: 10.1096/fj.06-5837fje     Document Type: Article
Times cited : (243)

References (55)
  • 2
    • 0029892080 scopus 로고    scopus 로고
    • Critical protective role of mast cells in a model of acute septic peritonitis
    • Echtenacher B., Mannel, D. N., and Hultner, L. (1996) Critical protective role of mast cells in a model of acute septic peritonitis. Nature 381, 75-77
    • (1996) Nature , vol.381 , pp. 75-77
    • Echtenacher, B.1    Mannel, D.N.2    Hultner, L.3
  • 3
    • 0029981928 scopus 로고    scopus 로고
    • Mast cell modulation of neutrophil influx and bacterial clearance at sites of infection through TNF-alpha
    • Malaviya, R., Ikeda, T., Ross, E., and Abraham, S. N. (1996) Mast cell modulation of neutrophil influx and bacterial clearance at sites of infection through TNF-alpha. Nature 381, 77-80
    • (1996) Nature , vol.381 , pp. 77-80
    • Malaviya, R.1    Ikeda, T.2    Ross, E.3    Abraham, S.N.4
  • 4
    • 0030718543 scopus 로고    scopus 로고
    • Impaired mast cell-dependent natural immunity in complement C3-deficient mice
    • Prodeus, A. P., Zhou, X., Maurer, M., Galli, S. J., and Carroll, M. C. (1997) Impaired mast cell-dependent natural immunity in complement C3-deficient mice. Nature 390, 172-175
    • (1997) Nature , vol.390 , pp. 172-175
    • Prodeus, A.P.1    Zhou, X.2    Maurer, M.3    Galli, S.J.4    Carroll, M.C.5
  • 5
  • 7
    • 0037325835 scopus 로고    scopus 로고
    • Pattern analysis of human cutaneous mast cell populations by total body surface mapping
    • Weber, A., Knop, J., Maurer, M. (2003) Pattern analysis of human cutaneous mast cell populations by total body surface mapping. Br. J. Dermatol. 148, 625-631
    • (2003) Br. J. Dermatol. , vol.148 , pp. 625-631
    • Weber, A.1    Knop, J.2    Maurer, M.3
  • 8
    • 0027925168 scopus 로고
    • New concepts about the mast cell
    • Galli, S. J. (1993) New concepts about the mast cell. N. Engl. J. Med. 328, 257-265
    • (1993) N. Engl. J. Med. , vol.328 , pp. 257-265
    • Galli, S.J.1
  • 9
    • 0019794485 scopus 로고
    • Mediation of local homeostasis and inflammation by leukotrienes and other mast cell-dependent compounds
    • Lewis, R. A., and Austen, K. F. (1981) Mediation of local homeostasis and inflammation by leukotrienes and other mast cell-dependent compounds. Nature 293, 103-108
    • (1981) Nature , vol.293 , pp. 103-108
    • Lewis, R.A.1    Austen, K.F.2
  • 12
    • 0037220342 scopus 로고    scopus 로고
    • Early macrophage influx to sites of cutaneous granuloma formation is dependent on MIP-1alpha /beta released from neutrophils recruited by mast cell-derived TNF-alpha
    • Von Stebut, E., Metz, M., Milon, G., Knop, J., and Maurer, M. (2003) Early macrophage influx to sites of cutaneous granuloma formation is dependent on MIP-1alpha /beta released from neutrophils recruited by mast cell-derived TNF-alpha. Blood 101, 210-215
    • (2003) Blood , vol.101 , pp. 210-215
    • Von Stebut, E.1    Metz, M.2    Milon, G.3    Knop, J.4    Maurer, M.5
  • 13
    • 0025242472 scopus 로고
    • Mast cells as a source of multifunctional cytokines
    • Gordon, J. R., Burd, P.R., and Galli, S. J. (1990) Mast cells as a source of multifunctional cytokines. Immunol. Today 11, 458-464
    • (1990) Immunol. Today , vol.11 , pp. 458-464
    • Gordon, J.R.1    Burd, P.R.2    Galli, S.J.3
  • 14
    • 0034693950 scopus 로고    scopus 로고
    • Mast cells control neutrophil recruitment during T cell-mediated delayed-type hypersensitivity reactions through tumor necrosis factor and macrophage inflammatory protein 2
    • Biedermann, T., Kneilling, M., Mailhammer, R., Maier, K., Sander, C.A., Kollias, G., Kunkel, S.L., Hultner, L., and Rocken, M. (2000) Mast cells control neutrophil recruitment during T cell-mediated delayed-type hypersensitivity reactions through tumor necrosis factor and macrophage inflammatory protein 2. J. Exp. Med. 192, 1441-1452
    • (2000) J. Exp. Med. , vol.192 , pp. 1441-1452
    • Biedermann, T.1    Kneilling, M.2    Mailhammer, R.3    Maier, K.4    Sander, C.A.5    Kollias, G.6    Kunkel, S.L.7    Hultner, L.8    Rocken, M.9
  • 16
    • 0027437297 scopus 로고
    • Mast cell and myofibroblast in wound healing
    • Hebda, P.A., Collins, M.A., and Tharp, M. D. (1993) Mast cell and myofibroblast in wound healing. Dermatol. Clin. 11, 685-696
    • (1993) Dermatol. Clin. , vol.11 , pp. 685-696
    • Hebda, P.A.1    Collins, M.A.2    Tharp, M.D.3
  • 17
    • 0032938967 scopus 로고    scopus 로고
    • Mast cells and their mediators in cutaneous wound healing - Active participants or innocent bystanders?
    • Artuc, M., Hermes, B., Steckelings, U. M., Grutzkau, A., and Henz, B. M. (1999) Mast cells and their mediators in cutaneous wound healing - active participants or innocent bystanders? Exp. Dermatol. 8, 1-16
    • (1999) Exp. Dermatol. , vol.8 , pp. 1-16
    • Artuc, M.1    Hermes, B.2    Steckelings, U.M.3    Grutzkau, A.4    Henz, B.M.5
  • 18
    • 0033967262 scopus 로고    scopus 로고
    • Mast cell involvement in normal human skin wound healing: Expression of monocyte chemoattractant protein-1 is correlated with recruitment of mast cells which synthesize interleukin-4 in vivo
    • Trautmann, A., Toksoy, A., Engelhardt, E., Brocker, E. B., and Gillitzer, R. (2000) Mast cell involvement in normal human skin wound healing: expression of monocyte chemoattractant protein-1 is correlated with recruitment of mast cells which synthesize interleukin-4 in vivo. J. Pathol. 190, 100-106
    • (2000) J. Pathol. , vol.190 , pp. 100-106
    • Trautmann, A.1    Toksoy, A.2    Engelhardt, E.3    Brocker, E.B.4    Gillitzer, R.5
  • 19
    • 0035749441 scopus 로고    scopus 로고
    • The mast cell in wound healing
    • Noli, C., and Miolo, A. (2001) The mast cell in wound healing. Vet. Dermatol. 12, 303-313
    • (2001) Vet. Dermatol. , vol.12 , pp. 303-313
    • Noli, C.1    Miolo, A.2
  • 20
    • 0035723861 scopus 로고    scopus 로고
    • The differentiation and function of myofibroblasts is regulated by mast cell mediators
    • Gailit, J., Marchese, M. J., Kew, R. R., and Gruber, B. L. (2001) The differentiation and function of myofibroblasts is regulated by mast cell mediators. J. Invest. Dermatol. 117, 1113-1119
    • (2001) J. Invest. Dermatol. , vol.117 , pp. 1113-1119
    • Gailit, J.1    Marchese, M.J.2    Kew, R.R.3    Gruber, B.L.4
  • 21
    • 0038676258 scopus 로고    scopus 로고
    • Regulation of wound healing by growth factors and cytokines
    • Werner, S., and Grose, R. (2003) Regulation of wound healing by growth factors and cytokines. Physiol. Rev. 83, 835-870
    • (2003) Physiol. Rev. , vol.83 , pp. 835-870
    • Werner, S.1    Grose, R.2
  • 22
    • 10344239869 scopus 로고    scopus 로고
    • The macrophage-activating lipopeptide-2 accelerates wound healing in diabetic mice
    • Deiters, U., Barsig, J., Tawil, B., and Mühlradt, F. (2004) The macrophage-activating lipopeptide-2 accelerates wound healing in diabetic mice. Exp. Dermatol. 13, 731-739
    • (2004) Exp. Dermatol. , vol.13 , pp. 731-739
    • Deiters, U.1    Barsig, J.2    Tawil, B.3    Mühlradt, F.4
  • 24
    • 0030930693 scopus 로고    scopus 로고
    • Mast cells in infection and immunity
    • Abraham, S. N., and Malaviya, R. (1997) Mast cells in infection and immunity. Infect. Immun. 65, 3501-3508
    • (1997) Infect. Immun. , vol.65 , pp. 3501-3508
    • Abraham, S.N.1    Malaviya, R.2
  • 25
    • 0031965909 scopus 로고    scopus 로고
    • Effects of skin mast cells on bleeding time and coagulation activation at the site of platelet plug formation
    • Kauhanen, P., Kovanen, P .T., Reunala, T., and Lassila, R. (1998) Effects of skin mast cells on bleeding time and coagulation activation at the site of platelet plug formation. Thromb. Haemost. 79, 843-847
    • (1998) Thromb. Haemost. , vol.79 , pp. 843-847
    • Kauhanen, P.1    Kovanen, P.T.2    Reunala, T.3    Lassila, R.4
  • 26
    • 0026722686 scopus 로고
    • Mast cell mediators regulate vascular permeability changes in Arthus reaction
    • Ramos, B. F., Zhang, Y., Angkachatchai, V., and Jakschik, B. A. (1992) Mast cell mediators regulate vascular permeability changes in Arthus reaction. J. Pharmacol. Exp. Ther. 262, 559-565
    • (1992) J. Pharmacol. Exp. Ther. , vol.262 , pp. 559-565
    • Ramos, B.F.1    Zhang, Y.2    Angkachatchai, V.3    Jakschik, B.A.4
  • 27
    • 0026065788 scopus 로고
    • Recruitment of neutrophils during IgE-dependent cutaneous late phase reactions in the mouse is mast cell-dependent. Partial inhibition of the reaction with antiserum against tumor necrosis factor-alpha
    • Wershil, B. K., Wang, Z. S., Gordon, J. R., and Galli, S. J. (1991) Recruitment of neutrophils during IgE-dependent cutaneous late phase reactions in the mouse is mast cell-dependent. Partial inhibition of the reaction with antiserum against tumor necrosis factor-alpha. J. Clin. Invest. 87, 446-453
    • (1991) J. Clin. Invest. , vol.87 , pp. 446-453
    • Wershil, B.K.1    Wang, Z.S.2    Gordon, J.R.3    Galli, S.J.4
  • 28
    • 0031451984 scopus 로고    scopus 로고
    • The mast cell products histamine and serotonin stimulate and TNF-alpha inhibits the proliferation of murine epidermal keratinocytes in situ
    • Maurer, M., Opitz, M., Henz, B. M., and Paus, R. (1997) The mast cell products histamine and serotonin stimulate and TNF-alpha inhibits the proliferation of murine epidermal keratinocytes in situ. J. Dermatol. Sci. 16, 79-84
    • (1997) J. Dermatol. Sci. , vol.16 , pp. 79-84
    • Maurer, M.1    Opitz, M.2    Henz, B.M.3    Paus, R.4
  • 29
    • 0026442638 scopus 로고
    • Mast-cell-derived mediators induce epidermal cell proliferation: Clue for lichenified skin lesion formation in atopic dermatitis
    • Katayama, I., Yokozeki, H., and Nishioka, K. (1992) Mast-cell-derived mediators induce epidermal cell proliferation: clue for lichenified skin lesion formation in atopic dermatitis. Int. Arch. Allergy Immunol. 98, 410-414
    • (1992) Int. Arch. Allergy Immunol. , vol.98 , pp. 410-414
    • Katayama, I.1    Yokozeki, H.2    Nishioka, K.3
  • 30
    • 0025216059 scopus 로고
    • Mast cells enhance migration and proliferation of fibroblasts into an in vitro wound
    • Levi-Schaffer, F., and Kupietzky, A. (1990) Mast cells enhance migration and proliferation of fibroblasts into an in vitro wound. Exp. Cell Res. 188, 42-49
    • (1990) Exp. Cell Res. , vol.188 , pp. 42-49
    • Levi-Schaffer, F.1    Kupietzky, A.2
  • 31
    • 0029166407 scopus 로고
    • Angiogenic factors stimulate mast-cell migration
    • Gruber, B. L., Marchese, M. J., and Kew, R. (1995) Angiogenic factors stimulate mast-cell migration. Blood 86, 2488-2493
    • (1995) Blood , vol.86 , pp. 2488-2493
    • Gruber, B.L.1    Marchese, M.J.2    Kew, R.3
  • 32
    • 0034659880 scopus 로고    scopus 로고
    • Mast cell density is associated with angiogenesis and poor prognosis in pulmonary adenocarcinoma
    • Takanami, I., Takeuchi, K., and Naruke, M. (2000) Mast cell density is associated with angiogenesis and poor prognosis in pulmonary adenocarcinoma. Cancer 88, 2686-2692
    • (2000) Cancer , vol.88 , pp. 2686-2692
    • Takanami, I.1    Takeuchi, K.2    Naruke, M.3
  • 33
  • 36
    • 8644230030 scopus 로고    scopus 로고
    • Possible involvement of mast cells in collagen remodelling in the late phase of cutaneous wound healing in mice
    • Iba, Y., Shibata, A., Kato, M., and Masukawa, T. (2004) Possible involvement of mast cells in collagen remodelling in the late phase of cutaneous wound healing in mice. Int. Immunopharmacol. 4, 1873-1880
    • (2004) Int. Immunopharmacol. , vol.4 , pp. 1873-1880
    • Iba, Y.1    Shibata, A.2    Kato, M.3    Masukawa, T.4
  • 37
    • 0037282778 scopus 로고    scopus 로고
    • Mast cells modulate the inflammatory but not the proliferative response in healing wounds
    • Egozi, E.I., Ferreira, A.M., Burns, A.L., Gamelli, R.L., and Dipietro, L. A. (2003) Mast cells modulate the inflammatory but not the proliferative response in healing wounds. Wound Repair Regen. 11, 46-54
    • (2003) Wound Repair Regen. , vol.11 , pp. 46-54
    • Egozi, E.I.1    Ferreira, A.M.2    Burns, A.L.3    Gamelli, R.L.4    Dipietro, L.A.5
  • 38
    • 0029989339 scopus 로고    scopus 로고
    • Immune and inflammatory responses in TNF-alpha-deficient mice: A critical requirement for TNF- alpha in the formation of primary B cell follicles, follicular dendritic cell networks and germinal centers, and in the maturation of the humoral immune response
    • Pasparakis, M., Alexopoulou, L., Episkopou, V., and Kollias, G. (1996) Immune and inflammatory responses in TNF-alpha-deficient mice: a critical requirement for TNF- alpha in the formation of primary B cell follicles, follicular dendritic cell networks and germinal centers, and in the maturation of the humoral immune response. J. Exp. Med. 184, 1397-1411
    • (1996) J. Exp. Med. , vol.184 , pp. 1397-1411
    • Pasparakis, M.1    Alexopoulou, L.2    Episkopou, V.3    Kollias, G.4
  • 39
    • 0022386455 scopus 로고
    • Fate of bone marrow-derived cultured mast cells after intracutaneous, intraperitoneal, and intravenous transfer into genetically mast cell- deficient W/Wv mice. Evidence that cultured mast cells can give rise to both connective tissue type and mucosal mast cells
    • Nakano, T., Sonoda, T., Hayashi, C., Yamatodani, A., Kanayama, Y., Yamamura, T., Asai, H., Yonezawa, T., Kitamura, Y., and Galli, S. J. (1985) Fate of bone marrow-derived cultured mast cells after intracutaneous, intraperitoneal, and intravenous transfer into genetically mast cell- deficient W/Wv mice. Evidence that cultured mast cells can give rise to both connective tissue type and mucosal mast cells. J. Exp. Med. 162, 1025-1043
    • (1985) J. Exp. Med. , vol.162 , pp. 1025-1043
    • Nakano, T.1    Sonoda, T.2    Hayashi, C.3    Yamatodani, A.4    Kanayama, Y.5    Yamamura, T.6    Asai, H.7    Yonezawa, T.8    Kitamura, Y.9    Galli, S.J.10
  • 41
    • 0023940250 scopus 로고    scopus 로고
    • Mast cell-dependent amplification of an immunologically nonspecific inflammatory response. Mast cells are required for the full expression of cutaneous acute inflammation induced by phorbol 12-myristate 13-acetate
    • Wershil, B. K., Murakami, T.,and Galli, S. J. (1998) Mast cell-dependent amplification of an immunologically nonspecific inflammatory response. Mast cells are required for the full expression of cutaneous acute inflammation induced by phorbol 12-myristate 13-acetate. J. Immunol. 140, 2356-2360
    • (1998) J. Immunol. , vol.140 , pp. 2356-2360
    • Wershil, B.K.1    Murakami, T.2    Galli, S.J.3
  • 42
    • 0028029793 scopus 로고
    • IL-10 inhibits cytokine production, vascular leakage, and swelling during T helper 1 cell-induced delayed-type hypersensitivity
    • Li, L., Elliott, J. F., and Mosmann, T. R. (1994) IL-10 inhibits cytokine production, vascular leakage, and swelling during T helper 1 cell-induced delayed-type hypersensitivity. J. Immunol. 153, 3967-3978
    • (1994) J. Immunol. , vol.153 , pp. 3967-3978
    • Li, L.1    Elliott, J.F.2    Mosmann, T.R.3
  • 43
    • 0032982971 scopus 로고    scopus 로고
    • Potent mast cell degranulation and vascular permeability triggered by urocortin through activation of corticotropin-releasing hormone receptors
    • Singh, L. K., Boucher, W., Pang, X., Letourneau, R., Seretakis, D., Green, M., and Theoharides, T. C. (1999) Potent mast cell degranulation and vascular permeability triggered by urocortin through activation of corticotropin-releasing hormone receptors. J. Pharmacol. Exp. Ther. 288, 1349-1356
    • (1999) J. Pharmacol. Exp. Ther. , vol.288 , pp. 1349-1356
    • Singh, L.K.1    Boucher, W.2    Pang, X.3    Letourneau, R.4    Seretakis, D.5    Green, M.6    Theoharides, T.C.7
  • 44
    • 0020051148 scopus 로고
    • Measurement of cutaneous inflammation: Estimation of neutrophil content with an enzyme marker
    • Bradley, P. P., Priebat, D. A., Christensen, R. D., and Rothstein, G. (1982) Measurement of cutaneous inflammation: estimation of neutrophil content with an enzyme marker. J. Invest. Dermatol. 78, 206-209
    • (1982) J. Invest. Dermatol. , vol.78 , pp. 206-209
    • Bradley, P.P.1    Priebat, D.A.2    Christensen, R.D.3    Rothstein, G.4
  • 45
    • 0033150593 scopus 로고    scopus 로고
    • Neutrophil myeloperoxidase is a potent and selective inhibitor of mast cell tryptase
    • Cregar, L., Elrod, K. C., Putnam, D., and Moore, W. R. (1999) Neutrophil myeloperoxidase is a potent and selective inhibitor of mast cell tryptase. Arch. Biochem. Biophys. 366, 125-130
    • (1999) Arch. Biochem. Biophys. , vol.366 , pp. 125-130
    • Cregar, L.1    Elrod, K.C.2    Putnam, D.3    Moore, W.R.4
  • 46
    • 0030038691 scopus 로고    scopus 로고
    • The role of H1- and H2-receptros in the effect of compound 48/80 in the asphyxation and body temperature of mice
    • Ulogol, A., Karadag, H., Dokmeci, D., and Dokmeci, I. (1996) The role of H1- and H2-receptros in the effect of compound 48/80 in the asphyxation and body temperature of mice. Yonsei. Med. J. 37, 97-103
    • (1996) Yonsei. Med. J. , vol.37 , pp. 97-103
    • Ulogol, A.1    Karadag, H.2    Dokmeci, D.3    Dokmeci, I.4
  • 49
    • 28444491902 scopus 로고    scopus 로고
    • The status quo and quo vadis of mast cells
    • Maurer, M., and Metz, M. (2005) The status quo and quo vadis of mast cells. Exp. Dermatol. 14, 923-929
    • (2005) Exp. Dermatol. , vol.14 , pp. 923-929
    • Maurer, M.1    Metz, M.2
  • 50
    • 20144386128 scopus 로고    scopus 로고
    • How best to fight that nasty itch - From new insights into the neuroimmunological, neuroendocrine, and neurophysiological bases of pruritus to novel therapeutic approaches
    • Biro, T., Ko, M. C., Bromm, B., Wie, E. T., Bigliardi, P., Siebenhaar, F., Hashizume, H., Misery, L., Bergasa, N. V., Kamei, C., Schouenborg, J., et al. (2005) How best to fight that nasty itch - from new insights into the neuroimmunological, neuroendocrine, and neurophysiological bases of pruritus to novel therapeutic approaches. Exp. Dermatol. 14, 225-240
    • (2005) Exp. Dermatol. , vol.14 , pp. 225-240
    • Biro, T.1    Ko, M.C.2    Bromm, B.3    Wie, E.T.4    Bigliardi, P.5    Siebenhaar, F.6    Hashizume, H.7    Misery, L.8    Bergasa, N.V.9    Kamei, C.10    Schouenborg, J.11
  • 51
    • 0026454166 scopus 로고
    • Role of mast cells in plasma permeation due to immune injury of the skin basement membrane
    • Zhang, Y., Ramos, B. F., and Jakschik, B. A. (1992) Role of mast cells in plasma permeation due to immune injury of the skin basement membrane. Immunology. 77, 422-427
    • (1992) Immunology , vol.77 , pp. 422-427
    • Zhang, Y.1    Ramos, B.F.2    Jakschik, B.A.3
  • 52
    • 0025763220 scopus 로고
    • Release of both preformed and newly synthesized tumor necrosis factor alpha (TNF-alpha)/cachectin by mouse mast cells stimulated via the Fc epsilon RI. A mechanism for the sustained action of mast cell-derived TNF-alpha during IgE-dependent biological responses
    • Gordon, J. R., and Galli, S. J. (1991) Release of both preformed and newly synthesized tumor necrosis factor alpha (TNF-alpha)/cachectin by mouse mast cells stimulated via the Fc epsilon RI. A mechanism for the sustained action of mast cell-derived TNF-alpha during IgE-dependent biological responses. J. Exp. Med. 174, 103-107
    • (1991) J. Exp. Med. , vol.174 , pp. 103-107
    • Gordon, J.R.1    Galli, S.J.2
  • 53
    • 0020062859 scopus 로고
    • Tissue distribution of histamine in a mutant mouse deficient in mast cells: Clear evidence for the presence of non-mast-cell histamine
    • Yamatodani, A., Maeyama, K., Watanabe, T., Wada, H., and Kitamura, Y. (1982) Tissue distribution of histamine in a mutant mouse deficient in mast cells: clear evidence for the presence of non-mast-cell histamine. Biochem. Pharmacol. 31, 305-309
    • (1982) Biochem. Pharmacol. , vol.31 , pp. 305-309
    • Yamatodani, A.1    Maeyama, K.2    Watanabe, T.3    Wada, H.4    Kitamura, Y.5
  • 55
    • 0016803130 scopus 로고
    • The effects of histamine liberators and exogenous histamine on wound healing in rat
    • Dabrowski, R., Maslinski, C., and Gorski, P. (1975) The effects of histamine liberators and exogenous histamine on wound healing in rat. Agents Actions 5, 311-314
    • (1975) Agents Actions , vol.5 , pp. 311-314
    • Dabrowski, R.1    Maslinski, C.2    Gorski, P.3


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