Structural-functional organization of the adenylyl cyclases in unicellular eukaryotes and molecular mechanisms of its regulation

Tsitologiya

Volumn 49, Issue 2, 2007, Pages 91-106

  Shpakov, A O ^a  

^a SECHENOV INSTITUTE OF EVOLUTIONARY PHYSIOLOGY AND BIOCHEMISTRY   (Russian Federation)

Author keywords

[No Author keywords available]

Indexed keywords

ADENYLATE CYCLASE; CYCLIC AMP; FUNGAL PROTEIN; PROTOZOAL PROTEIN;

ANIMAL; ARTICLE; CELL MEMBRANE; CHEMISTRY; CLASSIFICATION; ENZYMOLOGY; EUKARYOTIC CELL; EVOLUTION; FUNGUS; METABOLISM; PHYSIOLOGY; PROTOZOON; SPECIES DIFFERENCE;

ADENYLATE CYCLASE; ANIMALS; CELL MEMBRANE; CYCLIC AMP; EUKARYOTIC CELLS; EVOLUTION; FUNGAL PROTEINS; FUNGI; PROTOZOA; PROTOZOAN PROTEINS; SPECIES SPECIFICITY;

EID: 34247393294     PISSN: 00413771     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (129)

1. Russian source
2. Russian source
3. Russian source
4. Russian source
5. Russian source
6. Russian source
7. Russian source
8. Alexandre S., Paindavoine P., Hanocq-Quertier J., Paturiaux-Hanocq F., Tebabi P., Pays E. 1996. Families of adenylate cyclase genes in Trypanosoma brucei. Mol. Biochem. Parasitai. 77 : 173-182.
9. Alspaugh J. A., Pukkila-Worley R., Harashima T., Cavallo L. M., Funnell D., Cox G. M., Perfect J. R., Kronstad J. W., Heitman J. 2002. Adenylyl cyclase functions downstream of the Ga protein Opal and controls mating and pathogenicity of Cryptococcus neoformans. Eukaryot. Cell. 1 : 75-84.
10. Anjard C., Soderbom F., Loomis W. F. 2001. Requirements for the adenylyl cyclases in the development of Dictyostelium. Development. 128 : 3649-3654.
11. Bahn Y. S., Hicks J. K., Giles S. S., Cox G. M., Heitman J. 2004. Adenylyl cyclase-associated protein Acal regulates virulence and differentiation of Cryptococcus neoformans via the cyclic AMP-protein kinase A cascade. Eukaryot. Cell. 3 : 1476-1491.
12. Baker D. A. 2004. Adenylyl and guanylyl cyclases from the malaria parasite Plasmodium falciparum. IUBMB Life. 56 : 535-540.
13. Baker D. A., Kelly J. M., 2004a. Structure, function, and evolution of microbial adenylyl and guanylyl cyclases. Mol. Microbiol. 52 : 1229-1242.
14. Baker D. A., Kelly J. M., 2004b. Purine nucleotide cyclases in the malaria parasite. Trends in Parasitol. 20 : 227-232.
15. Banno S., Ochiai N., Noguchi R., Kimura M., Yamaguchi I., Kanzaki S. I., Murayama T., Fujimura M. 2005. A catalytic subunit of cyclic AMP-dependent protein kinase, PKAC-1, regulates asexual differentiation in Neurospora crassa. Genes Genet. Syst. 80 : 25-34.
16. Barsanti L., Passarelli V., Walne P. L., Gualtieri P. 2000. The photoreceptor protein of Euglena gracilis. FEBS Lett. 482 : 247-251.
17. Bieger B., Essen L. O. 2001. Structural analysis of adenylate cyclases form Trypanosoma brucei in their monomeric state. EMBO J. 20 : 433-145.
18. Billker O., Dechamps S., Tewari R., Wenig G., Franke-Fayard B., Brinkmann V. 2004. Calcium and a calcium-dependent protein kinase regulate gamete formation and mosquito transmission in a malaria parasite. Cell. 117 : 503-514.
19. Brzostowski J., Johnson C., Kimmel A. 2002. Ga-mediated inhibition of developmental signal response. Curr. Biol. 12 : 1199-1208.
20. Brzostowski J. A., Parent C. A., Kimmel A. R. 2004. A Gα-dependent pathway that antagonizes multiple chemoattractant responses that regulate directional cell movement. Genes Develop. 18 : 805-815.
21. Cann M. J., Hammer A., Zhou J., Kanacher T. 2003. A defined subset of adenylyl cyclases is regulated by bicarbonate ion. J. Biol. Chem. 278 : 35 033-35 038.
22. Carucci D. J., Witney A. A., Muhia D. K., Warhurst D. C., Schaap P., Meima M., Li J.L, Taylor M. C., Kelly J. M., Baker D. A. 2000. Guanylyl cyclase activity associated with putative bifunctional integral membrane proteins in Plasmodium falciparum. J. Biol. Chem. 275 : 22 147-22 156.
23. Chen M. Y., Long Y., Devreotes P. N. 1997. A novel cytosolic regulator, pianissimo, is required for chemoattractant receptor and G protein-mediated activation of the 12 transmembrane domain adenylyl cyclases in Dictyostelium. Genes Develop. 11 : 3218-3231.
24. Choi W., Dean R. A. 1997. The adenylyl cyclases gene MAC1 of Magnaporthe grisea controls appressorium formation and other aspects of growth and development. Plant Cell. 9 : 1973-1983.
25. Christensen S. T., Guerra C. F., Awan A., Wheatley D. N., Saur P. 2003. Insulin receptor-like proteins in Tetrahymena thermophila ciliary membranes. Curr. Biol. 13 : 50-52.
26. Colombo S., Ronchetti D., Thevelein J. M., Winderickx J., Martegani E. 2004. Activation state of the Ras2 protein and glucose-induced signaling in Saccharomyces cerevisiae. J. Biol. Chem. 279:46 715-46 722.
27. Comer F. I., Lippincott C. K., Masbad J. J., Parent C. A. 2005. The PI3K-mediated activation of CRAC independently regulates adenylyl cyclases activation and chemotaxis. Curr. Biol. 15 : 134-139.
28. Comer F. I., Parent C. A. 2006. Phosphoinositide 3-kinase activity controls the chemoattractant-mediated activation and adaptation of adenylyl cyclase. Mol. Biol. Cell. 17 : 357-366.
29. Coppi A., Merali S., Eichinger D. 2002. The enteric parasite Entamoeba uses an autocrine catecholamine system during differentiation into the infectious cyst stage. J. Biol. Chem. 277 : 8083-8090.
30. Cotter D. A., Dunbar A. J., Buconjic S. D., Wheldrake J. F. 1999. Ammonium phosphate in sori of Dictyostelium discoideum promotes spore dormancy through stimulation of the osmosensor ACG. Microbiology. 145 : 1891-1901.
31. Cruz A. K., Terenzi H.F., Jorge J. A. 1988. Cyclic AMP-dependent, sonstitutive thermotolerance in the adenylyl cyclase-deficient cr-1 (crisp) mutant of Neurospora crassa. Curr. Genet. 13 : 451-454.
32. Csaba G., Kovacs P., Pallinger E. 2005. Hormonal interactions in Tetrahymena: effect of hormones on levels of epidermal growth factor (EGF). Cell Biol. Int. 29 : 301-305.
33. Csaba G., Nagy S. U. 1976. Effect of vertebrate hormones on the cyclic AMP level in Tetrahymena. Acta Biol. Med. Ger. 35 : 1399-1401.
34. Csaba G., Nagy S. U., Lantos T. 1976. Are biogenic amines acting on Tetrahymena through a cyclic AMP mechanism? Acta Biol. Med. Ger. 35:259-261.
35. Dornmann D., Kim J.-Y., Devreotes P. N., Weijer C. J. 2001. cAMP receptor affinity controls wave dynamics, geometry and morphogenesis in Dictyostelium. J. Cell Sci. 114 : 2513-2523.
36. Dubacq C., Guerois R., Courbeyrette R., Kitagawa K., Mann C. 2002. Sgt1p contributes to cyclic AMP pathway activity and physically interacts with the adenylyl cyclases Cyr1p/Cdc35 in budding yeast. Eukaryot. Cell. 1 : 568-582.
37. Dumortier F., Vanhalewyn M., Debast G., Colombo S., Ma P., Winderickx J., Van Dijck P., Thevelein J. M. 2000. A specific mutation in Saccharomyces cerevisiae adenylate cyclase, CyrK176M, eliminates glucose- and acidification-induced cAMP signalling and delays glucose-induced loss of stress resistance. Int. J. Food Microbiol. 10 : 103
38. Dyer M., Day K. 2000. Expression of Plasmodium falciparum trimeric G proteins and their involvement in switching to sexual development. Mol. Biochem. Parasitol. 110 : 437-448.
39. Feng Q., Summers E., Guo B., Fink G. R. 1999. Ras signaling is required for serum-induced hyphal differentiation in Candida albicans. J. Bacteriol. 181 : 6339-6346.
40. Firtel R. A. 1996. Interacting signaling pathways controlling multicellular development in Dictyostelium. Curr. Opin. Genet. Develop. 6 : 545-554.
41. Flawia M. M., Torres H. N. 1972. Activation of membrane-bound adenylyl cyclase by glucagon in Neurospora crassa. Proc. Nat. Acad. Sci. USA. 69 : 2870-2873.
42. Flawia M. M., Torres H. N. 1973. Adenylyl cyclase activity in Neurospora crassa: modulation by glucagon and insulin. J. Biol. Chem. 248:4517-4520.
43. Fraidenraich D., Pena C., Isola E. L., Lammel E. M., Coso O., Anel A. D., Pongor S., Baralle F., Torres H. N., Flawia M. M. 1993. Stimulation of Trypanosoma cruzi adenylate cyclase by an alpha D-globin fragment from Triatoma hindgut: effect of differentiation of epimastigote to trypomastigote forms. Proc. Nat. Acad. Sci. USA. 90 : 10 140-10 144.
44. Frederick J., Eichinger D. 2004. Entamoeba invandens contains the components of a classical adrenergic signaling system. Mol. Biochem. Parasitol. 137 : 339-343.
45. Funamoto S., Meili R., Lee S., Parry L., Firtel R. A. 2002. Spatial and temporal regulation of 3-phospoinositides by PI3-kinase and PTEN mediates chemotaxis. Cell. 109 : 611-623.
46. Harrison T., Samuel B. U., Akompong T., Hamm H., Mohandas N., Lomasney J. W., Haldar K. 2003. Erythrocyte G protein-coupled receptor signaling in malarial infection. Science. 301 : 1734-1736.
47. Hatanaka M., Shimoda C. 2001. The cyclic AMP/PKA signal pathway is required for initiation of spore germination in Schizosaccharomyces pombe. Yeast. 18 : 207-217.
48. Huffman C. S. 2005a. Except in every detail: comparing and contrasting G-protein signaling in Saccharomyces cerevisiae and Schizosaccharomyces pombe. Eukaryot. Cell. 4 : 495-503.
49. Huffman C. S. 2005b. Glucose sensing via the protein kinase A pathway in Schizosaccharomyces pombe. Biochem. Soc. Trans. 33 : 257-260.
50. Insall R. H., Borlies J., Devreotes P. N. 1996. The aimless RasGEF is required for processing of chemotactic signal through G-protein-coupled receptors in Dictyostelium. Curr. Biol. 6: 719-729.
51. Inselburg J. 1983. Stage-specific inhibitory effect of cyclic AMP on asexual maturation and gametocyte formation pf Plasmodium falciparum. J. Parasitol. 69 : 592-597.
52. Iseki M., Matsunaga S., Murakami A., Ohno K., Shiga K., Yoshida K., Sigai M., Takahashi T., Hori T., Watanabe M. 2002. A blue-light-activated adenylyl cyclase mediates photo avoidance in Euglena gracilis. Nature. 415 : 1047-1051.
53. Ivey F. D., Huffman C. S. 2005. Direct activation of fission yeast adenylyl cyclase by the Gpa2 Gα of the glucose signaling pathway. Proc. Nat. Acad. Sci. USA. 102 : 6108-6113.
54. i protein and adenylyl cyclase in regulating development and stress responses in Neurospora crassa. Eukaryot. Cell. 1 : 634-642.
55. i homologue in Neurospora crassa. Fungal Genet. Biol. 26 : 48-61.
56. + channel. Nature. 423 : 33-41.
57. Kanacher T., Schultz A., Linder J. U., Schultz J.E. 2002. A GAF-domain-regulated adenylyl cyclase from Anabaena is a self-activating cAMP switch. EMBO J. 21 : 3672-3680.
58. Kataoka T., Broek D., Wigler M. 1985. DNA sequence and characterization of the Saccharomyces cerevisiae gene encoding adenylyl cyclase. Cell. 43 : 493-505.
59. Kaushal D. C., Carter R., Miller L. H., Krishna G. 1980. Gametocytogenesis by malaria parasites in continuous culture. Nature. 286 : 490-492.
60. Kays A. M., Rowley P. S., Baasiri R. A., Borkovich K. A. 2000. Regulation of conidiation and adenylyl cyclase levels by the Gα protein GNA-2 in Neurospora crassa. Mol. Cell. Biol. 20 : 7693-7705.
61. Kido M., Shima F., Satan T., Asato T., Kariya-Ki K., Kataoka T. 2002. Critical function of the Ras-associated domain as a primary Ras-binding site for regulation of Saccharomyces cerevisiae adenylyl cyclase. J. Biol. Chem. 277 : 3117-3123.
62. Kim H. J., Chang W. T., Meima M., Gross K. D., Schaap P. 1998. A novel adenylyl cyclase detected in rapidly developing mutants of Dictyostelium. J. Biol. Chem. 273 : 30 859-30 862.
63. Kitagawa K., Skowyra D., Elledge S. J., Harper J. W., Hieter P. 1999. SGT1 encodes an essential components of the year kinetochore assembly pathway and a novel subunit of the SCF ubiquitin ligase complex. Mol. Cell. Biol. 4 : 21-33.
64. Kohidai L., Katona J., Csaba G. 2003. Effects of steroid hormones on five functional parameters of Tetrahymena: evolutionary conclusions. Cell Biochem. Funct. 21 : 19-26.
65. Kore-eda S., Murayama T., Uno I. 1991. Isolation and characterization of the adenylate cyclase structure gene of Neurospora crassa. Jap. J. Genet. 66 : 317-334.
66. Kothe G. O., Free S. J. 1998. The isolation and characterization of nrc-1 and nrc-2, two genes encoding protein kinases that con trol growth and development in Neurospora crassa. Genetics. 149 : 117-130.
67. Kriebel P. W., Parent C. A. 2004. Adenylyl cyclase expression and regulation during the differentiation of Dietyostelium discoideum. IUBMB Life. 56 : 541-546.
68. Ksiazek D., Brandstetter H., Israel L., Bourenkov G. P., Katchalova G., Janssen K. P., Bartunik H. D., Noegel A. A., Schleicher M., Holak T. A. 2003. Structure of the N-terminal domain of the adenylyl cyclase-associated protein (CAP) from Dictyostelium discoideum. Structure. 11 : 1171-1178.
69. Kuble E., Mosch H. U., Rupp S., Lisanti M. P. 1997. Gpa2, a G-protein α subunit, regulates growth and pseudohyphal development in Saccharomyces cerevisiae via a cAMP-dependent mechanism. J. Biol. Chem. 272 : 20 321-20 323.
70. Labrecque J., Deschenes J., McNicoll N., De Lean A. 2001. Agonistic induction of a covalent dimer in a mutant of natriuretic peptide receptor-A documents a juxtamembrane interaction that accompanies receptor activation. J. Biol. Chem. 276 : 8064-8072.
71. Leberer E., Harcus D., Dignard D., Johnson L., Ushinsky S., Thomas D. Y., Schroppel K. 2001. Ras links cellular morphogenesis to virulence by regulation of the MAP kinase and cAMP signalling pathways in the pathogenic fungus Candida albicans. Mol. Microbiol. 42 : 674-687.
72. Lee N., D'Souza C. A., Kronstad J. W. 2003. Of smuts, blasts, mildews, and blights: cAMP signaling in phytopathogenic fungi. Annu. Rev. Phytopathol. 41 : 399-427.
73. Lee S., Comer F. I., Sasaki A., McLeod I. X., Duong Y., Okumura K., Yates lii J. R., Parent C. A., Firtel R. A. 2005. TOR complex 2 integrates cell movement during chemotaxis and signal relay in Dictyostelium. Mol. Biol. Cell. 16 : 4572-4583.
74. Lee S., Parent C. A., Insall R., Firtel R. A. 1999. A novel Ras-interacting protein requires for chemotaxis and cyclic adenosine monophosphate signal relay in Dictyostelium. Mol. Biol. Cell. 10: 2829-2845.
75. Lim C. J., Spiegelman G. B., Weeks G. 2001. RasC is required for optimal activation of adenylyl cyclase and Akt/PKB during aggregation. EMBO J. 20 : 4490-4499.
76. Linder J. U., Engel P., Reimer A., Kruger T., Plattner H., Schultz A., Schult: J. E. 1999. Guanylyl cyclases with the topology of mammalian adenylyl cyclases and an N-terminal P-type ATP-ase-like domain in Paramecium, Tetrahymena and Plasmodium. EMBO J. 18 : 4222-4232.
77. Lorenz M. C., Heitman J. 1997. Yeast pseudohyphal growth is regulated by GPA2, a G protein α homolog. EMBO J. 16 : 7008-7018.
78. Maidan M. M., De Rop L., Serneels J., Exler S., Rupp S., Tournu H., Thevelein J. M., Van Dijck P. 2005. The G protein-coupled receptor Gprl and the Ga protein Gpa2 act through the cAMP-protein kinase A pathway to induce morphogenesis in Candida albicans. Mol. Biol. Cell. 16 : 1971-1986.
79. Mallet L., Renault G., Jacquet M. 2000. Functional cloning of the adenylyl cyclase gene of Candida albicans in Saccharomyces cerevisiae within a genomic fragment containing five other genes, including homologues of CHS6 and SAP 185. Yeast. 16: 959-966.
80. Manahan C. L., Iglesias P. A., Long Y., Devreotes P. N. 2004. Chemoattractant signaling in Dictyostelium discoideum. Annu. Rev. Cell. Develop. Biol. 20 : 223-254.
81. Mavoungou C., Israel L., Rehm T., Ksiazek D., Krajewski M., Popowicz G., Noegel A. A., Schleicher M., Holak T. A. 2004. NMR structural characterization of the N-terminal domain of the adenylyl cyclase-associated protein (CAP) from Dictyostelium discoideum. J. Biomol. NMR. 29 : 73-84.
82. Meza I. 2000. Extracellular matrix-induced signaling in Entamoeba histolytica: its role in invasiveness. Parasitai. Today. 16 : 23-28.
83. Miwa T., Takagi Y., Shinozaki M., Yun C.-W., Schell W. A., Perfect J. R., Kumagai H., Tamaki H. 2004. Gprl, a putative G-protein-coupled receptor, regulates morphogenesis and hypha formation in the pathogenic fungus Candida albicans. Eukaryot. Cell. 3 : 919-931.
84. Mougel C., Zhulin I. B. 2001. CHASE: an extracellular sensing domain common to transmembrane receptors from prokaryotes, lower eukaryotes and plants. Trends Biochem. Sci. 26 : 582-584.
85. Muhia D. K., Swales C. A., Eckslein-Ludwig U., Saran S., Polley S. D., Kelly J. M., Schaap P., Krishna S., Baker D. A. 2003. Multiple splice variants encode a novel adenylyl cyclase of possible plastid origin expressed in the sexual stage of the malaria parasite Plasmodium falciparum. J. Biol. Chem. 278 : 22 014-22 022.
86. Naula C., Schaub R., Leech V., Melville S., Seebeck T. 2001. Spontaneous dimerization and leucine-zipper induced activation of the recombinant catalytic domain of a new adenylyl cyclase of Trypanosoma brucei, GRESAG4.4B. Mol. Biochem. Parasitol. 112 : 19-28.
87. Nishida Y., Shima F., Sen H., Tanaka Y., Yanagihara C., Yamawaki-Kataoka Y., Kariya K., Kataoka T. 1998. Coiled-coil interaction of N-terminal 36 residues of cyclase-associated protein with adenylyl cyclase is sufficient for its function in Saccharomyces cerevisiae Ras pathway. J. Biol. Chem. 273 : 28 019-28 024.
88. Ntefidou M., Iseki M., Watanabe M., Lebert M., Hader D. P. 2003. Photoactivated adenylyl cyclase controls phototaxis in the flagellate Euglena gracilis. Plant Physiol. 133 : 1517-1521.
89. Ogihara H., Shima F., Naito K., Asato T., Kariya K.-I., Kataoka T. 2004. Direct activation of fission yeast adenylyl cyclase by heterotrimeric G protein gpa2. Kobe J. Med. Sci. 50 : 111-121.
90. Ott A., Oehme F., Keller H., Schuster S. C. 2000. Osmotic stress response in Dictyostelium is mediated by cAMP. EMBO J. 19 : 5782-5792.
91. Parent C. A., Borleis J., Devreotes P. N. 2002. Regulation of adenylyl cyclase by a region outside the minimally functional cytoplasmic domains. J. Biol. Chem. 277 : 1354-1360.
92. Parent C. A., Devreotes P. N. 1995. Isolation in inactive and G-protein resistant adenylyl cyclase mutants using random mutagenesis. J. Biol. Chem. 270 : 22 693-22 696.
93. Parent C. A., Devreotes P. N. 1996. Constitutively active adenylyl cyclase mutant requires neither G proteins nor cytosolic regulators. J. Biol. Chem. 271 : 18 333-18 336.
94. Parent C. A., Devreotes P. N. 1999. A cell's sense of direction. Science. 284 : 765-770.
95. Paveto C., Torres H. N., Flawia M. M., Garcia-Espitia M., Ortega A., Orozco E. 1999. Entamoeba histolytica: signaling through G proteins. Exp. Parasitol. 91 : 170-175.
96. Pitt G. S., Brandt R., Lin K. C., Devreotes P. N., Schaap P. 1993. Extracellular cAMP is sufficient to restore developmental gene expression and morphogenesis in Dictyostelium cells lacking the aggregation adenylyl cyclase (ACA). Genes Develop. 7 : 2172-2180.
97. Read L. K., Mikkelsen R. B. 1991. Comparison of adenylate cyclase and cAMP-dependent protein kinase in gametocytogenesis and nongametocytogenesis clones of Plasmodium falciparum. J. Parasiol. 77 : 346-352.
98. Rocha C. R., Schroppel K., Harcus D., Marcil A., Dignard D., Taylor B. N., Thomas D. Y., Whiteway M., Leberer E. 2001. Signaling through adenylyl cyclase is essential for hyphal growth and virulence in the pathogenic fungus Candida albicans. Mol. Biol. Cell. 12: 3631-3643.
99. Rodriquez E., Lazaro M. I., Renaud F. L., Marino M. 2004. Opioid activity of β-endorphin-like proteins from Tetrahymena. J. Eukaryot. Microbiol. 51 : 60-65.
100. Roelofs J., Loovers H. M., van Hausiert P. J. M. 2001a. GTPγS regulation of a 12-transmembrane guanylyl cyclase is retained after mutation to an adenylate cyclase. J. Biol. Chem. 276 : 40 740-40 745.
101. Roelofs J., Snippe H., Kleineidam R. G., van Haastert P. J. 2001b. Guanylate cyclase in Dictyostelium discoideum with the topology of mammalian adenylate cyclase. Biochem. J. 354 : 697-706.
102. Rolin S., Paindavoine P., Hanocq-Quertier J., Hanocq F., Claes Y., Le Ray D. et al. 1993. Transient adenylate cyclase activation accompanies differentiation of Trypanosoma brucei from bloodstream to procyclic forms. Mol. Biol. Parasitol. 61 : 115-125.
103. Rosner B. M, Bartholomew J. N., Gaines C. D., Riddle M. L., Everett H. A., Rulapaugh K. G., Nickerson L. E., Marshall M. R., Kuruvilla H. G. 2003. Biochemical evidence for a P2Y-like receptor in Tetrahymena thermophila. J. Comp. Physiol. 189 : 781-789.
104. Ross D. T., Raibaud A., Florent I. C., Sather S., Gross M. K., Storm D. R., Eisen H. 1991. The trypanosome VSG expression site encodes adenylate cyclase and a leucine-rich putative regulatory gene. EMBO J. 10 : 2047-2053.
105. Sanchez M. A., Zeoli D., Klamo E. M., Kavanaugh M. P., Landfear S. M. 1995. A family of putative receptor adenylate cyclase from Leishmania donovani. J. Biol. Chem. 270: 17551-17 558.
106. Santiago A., Carbajal M. E., Benitez-King G., Meza I. 1994. Entamoeba histolytica: PKC transduction pathway activation in the trophozoite- fibronectin interaction. Exp. Parasitol. 79 : 436-444.
107. Saran S., Meima M. E., Alvarez-Curto E., Weening K. E., Rozen D.E., Schaap P. 2002. cAMP signaling in Dictyostelium. J. Muscle Res. Cell Motility. 23 : 793-802.
108. Saran S., Schaap P. 2004. Adenylyl cyclase G is activated by an intramolecular osmosensor. Mol. Biol. Cell. 15 : 1479-1486.
109. Schadick K., Fourcade H. M., Boumenot P., Seitz J.J., Morrell J. L., Chang L., Gould K. L., Partridge J. F., Allshire R. C., Kitagawa K., Hieter P., Hofman C. S. 2002. Schizosaccharomyces pombe Git7p, a member of the Saccharomyces cerevisiae Sgtlp family, is required for glucose and cyclic AMP signaling, cell wall integrity, and separation. Eukaryot. Cell. 1 : 558-567.
110. Schultz J. E., Klumpp S. 1993. Cyclic nucleotides and calcium signaling in Paramecium. Adv. Second Messenger Phosphorylation Res. 27 : 25-46.
111. Schultz J. E., Klumpp S., Benz R., Schurhoff-Goeters W. J., Schmid A. 1992. Regulation of adenylyl cyclase from Paramecium by an intrinsic potassium conductance. Science. 255 : 600-603.
112. Seebeck T., Gong K. W., Kunz S., Schaub R., Shalaby T., Zoraghi R. 2001. cAMP signaling in Trypanosoma brucei. Int. J. Parasitai. 31 : 491-498.
113. Segall J. E., Kuspa A., Shulsky G., Ecke M., Maeda M., Gaskins C., Firtel R. A., Loomis W. F. 1995. A MAP kinase necessary for receptor-mediated activation of adenylyl cyclase in Dictyostelium. J. Cell Biol. 128 : 405-413.
114. Shima F., Okada T., Kido M., Sen H., Tanaka Y., Tamada M., Hu C.-D., Yamawaki-Kataoka Y., Kariya K.-I., Kataoka T. 2000. Association of yeast adenylyl cyclase with cyclase-associated protein CAP forms a second Ras-binding site which mediates its Ras-dependent activation. Mol. Cell. Biol. 20 : 26-33.
115. Shima F., Yamawaki-Kataoka Y., Yanagihara C., Tamada M., Okada T., Kariya K., Kataoka T. 1997. Effect of association with adenylyl cyclase-associated protein on the interaction of yeast adenylyl cyclase with Ras protein. Mol. Cell. Biol. 17 : 1057-1064.
116. Soderbom F., Anjard C., Iranfar N., Fuller D., Loomis W. F. 1999. An adenylyl cyclase that functions during late development of Dictyostelium. Development. 126: 5463-5471.
117. i proteins as possible signal transduction elements in the interaction of trophozoites with fibronectin. Exp. Parasitol. 90 : 262-269.
118. Stiefel J., Wang L., Kelly D. A., Janoo R. T. K., Seitz J., White-hall S. K., Huffman C. S. 2004. Suppressors of an adenylate cyclase deletion in the fission yeast Schizosaccharomyces pombe. Eukaryot. Cell. 3 : 610-619.
119. Suzuki N., Choe H. R., Nishida Y., Yamawaki-Kataoka Y., Ohnishi S., Tamaoki T., Kataoka T. 1990. Leucine-rich repeats and carboxyl terminus are required for interaction of yeast adenylate cyclase with RAS proteins. Proc. Nat. Acad. Sci. USA. 87 : 871-875.
120. Taylor M. C., Muhia D. K., Baker D. A., Mondragon A., Schaap P. B., Kelly J. M. 1999. Trypanosoma cruzi adenylyl cyclase is encoded by a complex multigene family. Mol. Biochem. Parasitol. 104: 205-217.
121. Trager W., Gill G. S. 1989. Plasmodium falciparum gametocyte formation in vitro: its stimulation by phorbol diesters and by 8-bromo cyclic adenosine monophosphate. J. Protozool. 36 : 451-454.
122. Van Es S., Virdy K. J., Pitt G. S., Meima M., Sands T. W., Devreotes P. N., Cotter D. A., Schaap P. 1996. Adenylyl cyclase G, an osmosensor controlling germination of Dictyostelium discoideum. J. Biol. Chem. 271 : 23 623-23 625.
123. Vassella E., Reuner B., Yutzy B., Boshart M. 1997. Differentiation of African trypanosomes is controlled by a density sensing mechanism which signals cell cycle arrest via the cAMP pathway. J. Cell Sei. 110: 2661-2671.
124. Virdy K. J., Sands T. W., Kopko S. H., Van Es S., Meima M., Schaap P., Cotter D. A. 1999. High cAMP in spores of Dictyostelium discoideum: association with spore dormancy and inhibition of germination. Microbiology. 145 : 1883-1890.
125. Weber J. H., Vishnyakov A., Hambach K., Schultz A., SchultzJ. E., Linder J. U. 2004. Adenylyl cyclases from Plasmodium, Paramecium and Tetrahymena are novel ion channel/enzyme fusion proteins. Cell. Signall. 16 : 115-125.
126. Xue C., Bahn Y. S., Cox G. M., Heitman J. 2006. G protein-coupled receptor Gpr4 senses amino acids and activates the cAMP-PKA pathway in Cryptococcus neoformans. Mol. Biol. Cell. 17 : 667-679.
127. i causes uncontrolled proliferation of aerial hyphae and increased sensitivity to heat and oxidative stress in Neurospora crassa. Genetics. 151 : 107-117.
128. Young D., Riggs M., Field J., Vojtek A., Broek D., Wigler M. 1989. The adenylyl cyclase gene from Schaosaccharomyces pombe. Proc. Nat. Acad. Sci. USA. 86 : 7989-7993.
129. Yu S., Avery L., Baude E., Garbers D. L. 1997. Guanylyl cyclase expression in specific sensory neurons: a new family of chemosensory receptors. Proc. Nat. Acad. Sci. USA. 94 : 3384-3387.