메뉴 건너뛰기




Volumn 17, Issue 1, 2006, Pages 357-366

Phosphoinositide 3-kinase activity controls the chemoattractant-mediated activation and adaptation of adenylyl cyclase

Author keywords

[No Author keywords available]

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; ADENYLATE CYCLASE; CHEMOATTRACTANT; CYCLIC AMP; G PROTEIN COUPLED RECEPTOR; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHOINOSITIDE 3 KINASE 1; PHOSPHOINOSITIDE 3 KINASE 2; UNCLASSIFIED DRUG;

EID: 30044443294     PISSN: 10591524     EISSN: None     Source Type: Journal    
DOI: 10.1091/mbc.E05-08-0781     Document Type: Article
Times cited : (43)

References (61)
  • 1
    • 0029831167 scopus 로고    scopus 로고
    • Direct inhibition of the signaling functions of the mammalian target of rapamycin by the phosphoinositide 3-kinase inhibitors, wortmannin and LY294002
    • Brunn, G. J., Williams, J., Sabers, C., Wiederrecht, G., Lawrence, J. C., Jr., and Abraham, R. T. (1996). Direct inhibition of the signaling functions of the mammalian target of rapamycin by the phosphoinositide 3-kinase inhibitors, wortmannin and LY294002. EMBO J. 15, 5256-5267.
    • (1996) EMBO J. , vol.15 , pp. 5256-5267
    • Brunn, G.J.1    Williams, J.2    Sabers, C.3    Wiederrecht, G.4    Lawrence Jr., J.C.5    Abraham, R.T.6
  • 2
    • 1842783708 scopus 로고    scopus 로고
    • A Gα-dependent pathway that antagonizes multiple chemoattractant responses that regulate directional cell movement
    • Brzostowski, J. A., Parent, C. A., and Kimmel, A. R. (2004). A Gα-dependent pathway that antagonizes multiple chemoattractant responses that regulate directional cell movement. Genes Dev. 18, 805-815.
    • (2004) Genes Dev. , vol.18 , pp. 805-815
    • Brzostowski, J.A.1    Parent, C.A.2    Kimmel, A.R.3
  • 3
    • 0030764770 scopus 로고    scopus 로고
    • Inactivation of two Dictyostelium discoideum genes, DdPIK1 and DdPIK2, encoding proteins related to mammalian phosphatidylinositide 3-kinases, results in defects in endocytosis, lysosome to postlysosome transport, and actin cytoskeleton organization
    • Buczynski, G., Grove, B., Nomura, A., Kleve, M., Bush, J., Firtel, R. A., and Cardelli, J. (1997). Inactivation of two Dictyostelium discoideum genes, DdPIK1 and DdPIK2, encoding proteins related to mammalian phosphatidylinositide 3-kinases, results in defects in endocytosis, lysosome to postlysosome transport, and actin cytoskeleton organization. J. Cell Biol. 136, 1271-1286.
    • (1997) J. Cell Biol. , vol.136 , pp. 1271-1286
    • Buczynski, G.1    Grove, B.2    Nomura, A.3    Kleve, M.4    Bush, J.5    Firtel, R.A.6    Cardelli, J.7
  • 4
    • 0027450410 scopus 로고
    • A tightly associated serine/threonine protein kinase regulates phosphoinositide 3-kinase activity
    • Carpenter, C. L., Auger, K. R., Duckworth, B. C., Hou, W. M., Schaffhausen, B., and Cantley, L. C. (1993). A tightly associated serine/threonine protein kinase regulates phosphoinositide 3-kinase activity. Mol. Cell. Biol. 13, 1657-1665.
    • (1993) Mol. Cell. Biol. , vol.13 , pp. 1657-1665
    • Carpenter, C.L.1    Auger, K.R.2    Duckworth, B.C.3    Hou, W.M.4    Schaffhausen, B.5    Cantley, L.C.6
  • 5
    • 0028964405 scopus 로고
    • Occupancy of the Dictyostelium cAMP receptor, cAR1, induces a reduction in affinity which depends upon COOH-terminal serine residues
    • Caterina, M. J., Hereld, D., and Devreotes, P. N. (1995). Occupancy of the Dictyostelium cAMP receptor, cAR1, induces a reduction in affinity which depends upon COOH-terminal serine residues. J. Biol. Chem. 270, 4418-4423.
    • (1995) J. Biol. Chem. , vol.270 , pp. 4418-4423
    • Caterina, M.J.1    Hereld, D.2    Devreotes, P.N.3
  • 6
    • 0030722988 scopus 로고    scopus 로고
    • A novel cytosolic regulator, Pianissimo, is required for chemoattractant receptor and G protein-mediated activation of the 12 transmembrane domain adenylyl cyclase in Dictyostelium
    • Chen, M. Y., Long, Y., and Devreotes, P. N. (1997). A novel cytosolic regulator, Pianissimo, is required for chemoattractant receptor and G protein-mediated activation of the 12 transmembrane domain adenylyl cyclase in Dictyostelium. Genes Dev. 11, 3218-3231.
    • (1997) Genes Dev. , vol.11 , pp. 3218-3231
    • Chen, M.Y.1    Long, Y.2    Devreotes, P.N.3
  • 7
    • 0035449609 scopus 로고    scopus 로고
    • Signaling pathways controlling cell polarity and chemotaxis
    • Chung, C. Y., Funamoto, S., and Firtel, R. A. (2001). Signaling pathways controlling cell polarity and chemotaxis. Trends Biochem. Sci. 26, 557-566.
    • (2001) Trends Biochem. Sci. , vol.26 , pp. 557-566
    • Chung, C.Y.1    Funamoto, S.2    Firtel, R.A.3
  • 8
    • 12544249887 scopus 로고    scopus 로고
    • The PI3K-mediated activation of CRAC independently regulates adenylyl cyclase activation and chemotaxis
    • Comer, F. I., Lippincott, C. K., Masbad, J. J., and Parent, C. A. (2005). The PI3K-mediated activation of CRAC independently regulates adenylyl cyclase activation and chemotaxis. Curr. Biol. 15, 134-139.
    • (2005) Curr. Biol. , vol.15 , pp. 134-139
    • Comer, F.I.1    Lippincott, C.K.2    Masbad, J.J.3    Parent, C.A.4
  • 9
    • 0028575634 scopus 로고
    • Modulation of the chemotactic responsiveness of guinea pig neutrophils to hrIL-8 and fMLP
    • Dai, Y., Holgate, S. T., Church, M. K., and Shute, J. K. (1994). Modulation of the chemotactic responsiveness of guinea pig neutrophils to hrIL-8 and fMLP. J. Leukoc. Biol. 56, 776-783.
    • (1994) J. Leukoc. Biol. , vol.56 , pp. 776-783
    • Dai, Y.1    Holgate, S.T.2    Church, M.K.3    Shute, J.K.4
  • 11
    • 0037743735 scopus 로고    scopus 로고
    • Eukaryotic chemotaxis: Distinctions between directional sensing and polarization
    • Devreotes, P., and Janetopoulos, C. (2003). Eukaryotic chemotaxis: distinctions between directional sensing and polarization. J. Biol. Chem. 278, 20445-20448.
    • (2003) J. Biol. Chem. , vol.278 , pp. 20445-20448
    • Devreotes, P.1    Janetopoulos, C.2
  • 12
    • 0018379637 scopus 로고
    • Cyclic 3′,5′ AMP relay in Dictyostelium discoideum. II. Requirements for the initiation and termination of the response
    • Devreotes, P. N., and Steck, T. L. (1979). Cyclic 3′,5′ AMP relay in Dictyostelium discoideum. II. Requirements for the initiation and termination of the response. J. Cell Biol. 80, 300-309.
    • (1979) J. Cell Biol. , vol.80 , pp. 300-309
    • Devreotes, P.N.1    Steck, T.L.2
  • 13
    • 0027953284 scopus 로고
    • PI 3-kinase is a dual specificity enzyme: Autoregulation by an intrinsic protein-serine kinase activity
    • Dhand, R., et al. (1994). PI 3-kinase is a dual specificity enzyme: autoregulation by an intrinsic protein-serine kinase activity. EMBO J 13, 522-533.
    • (1994) EMBO J , vol.13 , pp. 522-533
    • Dhand, R.1
  • 14
    • 0018946114 scopus 로고
    • Cyclic 3′,5′-AMP relay in Dictyostelium discoideum IV. Recovery of the cAMP signaling response after adaptation to cAMP
    • Dinauer, M. C., Steck, T. L., and Devreotes, P. N. (1980a). Cyclic 3′,5′-AMP relay in Dictyostelium discoideum IV. Recovery of the cAMP signaling response after adaptation to cAMP. J. Cell Biol. 86, 545-553.
    • (1980) J. Cell Biol. , vol.86 , pp. 545-553
    • Dinauer, M.C.1    Steck, T.L.2    Devreotes, P.N.3
  • 15
    • 0018972037 scopus 로고
    • Cyclic 3′,5′-AMP relay in Dictyostelium discoideum V. Adaptation of the cAMP signaling response during cAMP stimulation
    • Dinauer, M. C., Steck, T. L., and Devreotes, P. N. (1980b). Cyclic 3′,5′-AMP relay in Dictyostelium discoideum V. Adaptation of the cAMP signaling response during cAMP stimulation. J. Cell Biol. 86, 554-561.
    • (1980) J. Cell Biol. , vol.86 , pp. 554-561
    • Dinauer, M.C.1    Steck, T.L.2    Devreotes, P.N.3
  • 16
    • 0033230408 scopus 로고    scopus 로고
    • Integrating conflicting chemotactic signals. The role of memory in leukocyte navigation
    • Foxman, E. F., Kunkel, E. J., and Butcher, E. C. (1999). Integrating conflicting chemotactic signals. The role of memory in leukocyte navigation. J. Cell Biol. 147, 577-588.
    • (1999) J. Cell Biol. , vol.147 , pp. 577-588
    • Foxman, E.F.1    Kunkel, E.J.2    Butcher, E.C.3
  • 17
    • 0037205265 scopus 로고    scopus 로고
    • Spatial and temporal regulation of 3-phosphoinositides by PI 3-kinase and PTEN mediates chemotaxis
    • Funamoto, S., Meili, R., Lee, S., Parry, L., and Firtel, R. A. (2002). Spatial and temporal regulation of 3-phosphoinositides by PI 3-kinase and PTEN mediates chemotaxis. Cell 109, 611-623.
    • (2002) Cell , vol.109 , pp. 611-623
    • Funamoto, S.1    Meili, R.2    Lee, S.3    Parry, L.4    Firtel, R.A.5
  • 18
    • 0035858886 scopus 로고    scopus 로고
    • Role of phosphatidylinositol 3′ kinase and a downstream pleckstrin homology domain-containing protein in controlling chemotaxis in Dictyostelium
    • Funamoto, S., Milan, K., Meili, R., and Firtel, R. A.(2001). Role of phosphatidylinositol 3′ kinase and a downstream pleckstrin homology domain-containing protein in controlling chemotaxis in Dictyostelium. J. Cell Biol. 153, 795-810.
    • (2001) J. Cell Biol. , vol.153 , pp. 795-810
    • Funamoto, S.1    Milan, K.2    Meili, R.3    Firtel, R.A.4
  • 19
    • 0025977903 scopus 로고
    • CAMP and human neutrophil chemotaxis. Elevation of cAMP differentially affects chemotactic responsiveness
    • Harvath, L., Robbins, J. D., Russell, A. A., and Seamon, K. B. (1991). cAMP and human neutrophil chemotaxis. Elevation of cAMP differentially affects chemotactic responsiveness. J. Immunol. 146, 224-232.
    • (1991) J. Immunol. , vol.146 , pp. 224-232
    • Harvath, L.1    Robbins, J.D.2    Russell, A.A.3    Seamon, K.B.4
  • 21
    • 0038247883 scopus 로고    scopus 로고
    • Receptor-mediated Regulation of PI3Ks Confines PI(3,4,5)P3 to the Leading Edge of Chemotaxing cells
    • Huang, Y. E., Iijima, M., Parent, C. A., Funamoto, S., Firtel, R. A., and Devreotes, P. (2003). Receptor-mediated Regulation of PI3Ks Confines PI(3,4,5)P3 to the Leading Edge of Chemotaxing cells. Mol. Biol. Cell 14, 1913-1922.
    • (2003) Mol. Biol. Cell , vol.14 , pp. 1913-1922
    • Huang, Y.E.1    Iijima, M.2    Parent, C.A.3    Funamoto, S.4    Firtel, R.A.5    Devreotes, P.6
  • 22
    • 0037205230 scopus 로고    scopus 로고
    • Tumor suppressor PTEN mediates sensing of chemoattractant gradients
    • Iijima, M., and Devreotes, P. (2002). Tumor suppressor PTEN mediates sensing of chemoattractant gradients. Cell 109, 599-610.
    • (2002) Cell , vol.109 , pp. 599-610
    • Iijima, M.1    Devreotes, P.2
  • 23
    • 0036773899 scopus 로고    scopus 로고
    • Temporal and spatial regulation of chemotaxis
    • Iijima, M., Huang, Y. E., and Devreotes, P. (2002). Temporal and spatial regulation of chemotaxis. Dev. Cell 3, 469-478.
    • (2002) Dev. Cell , vol.3 , pp. 469-478
    • Iijima, M.1    Huang, Y.E.2    Devreotes, P.3
  • 24
    • 0028093610 scopus 로고
    • CRAC, a cytosolic protein containing a pleckstrin homology domain, is required for receptor and G protein-mediated activation of adenylyl cyclase in Dictyostelium
    • Insall, R., Kuspa, A., Lilly, P. J., Shaulsky, G., Levin, L. R., Loomis, W. F., and Devreotes, P. (1994). CRAC, a cytosolic protein containing a pleckstrin homology domain, is required for receptor and G protein-mediated activation of adenylyl cyclase in Dictyostelium. J. Cell Biol. 126, 1537-1545.
    • (1994) J. Cell Biol. , vol.126 , pp. 1537-1545
    • Insall, R.1    Kuspa, A.2    Lilly, P.J.3    Shaulsky, G.4    Levin, L.R.5    Loomis, W.F.6    Devreotes, P.7
  • 25
    • 16244377763 scopus 로고    scopus 로고
    • Temporal and spatial regulation of phosphoinositide signaling mediates cytokinesis
    • Janetopoulos, C., Borleis, J., Vazquez, F., Iijima, M., and Devreotes, P. (2005). Temporal and spatial regulation of phosphoinositide signaling mediates cytokinesis. Dev. Cell 8, 467-477.
    • (2005) Dev. Cell , vol.8 , pp. 467-477
    • Janetopoulos, C.1    Borleis, J.2    Vazquez, F.3    Iijima, M.4    Devreotes, P.5
  • 26
    • 4344571626 scopus 로고    scopus 로고
    • Chemoattractant-induced Ras activation during Dictyostelium aggregation
    • Kae, H., Lim, C. J., Spiegelman, G. B., and Weeks, G. (2004). Chemoattractant-induced Ras activation during Dictyostelium aggregation. EMBO Rep. 5, 602-606.
    • (2004) EMBO Rep. , vol.5 , pp. 602-606
    • Kae, H.1    Lim, C.J.2    Spiegelman, G.B.3    Weeks, G.4
  • 27
    • 0037459060 scopus 로고    scopus 로고
    • Adenylyl cyclase localization regulates streaming during chemotaxis
    • Kriebel, P. W., Barr, V. A., and Parent, C. A. (2003). Adenylyl cyclase localization regulates streaming during chemotaxis. Cell 112, 549-560.
    • (2003) Cell , vol.112 , pp. 549-560
    • Kriebel, P.W.1    Barr, V.A.2    Parent, C.A.3
  • 28
    • 10344252820 scopus 로고    scopus 로고
    • Adenylyl cyclase expression and regulation during the differentiation of Dictyostelium discoideum
    • Kriebel, P. W., and Parent, C. A. (2004). Adenylyl cyclase expression and regulation during the differentiation of Dictyostelium discoideum. IUBMB Life 56, 541-546.
    • (2004) IUBMB Life , vol.56 , pp. 541-546
    • Kriebel, P.W.1    Parent, C.A.2
  • 30
    • 0032849043 scopus 로고    scopus 로고
    • A novel Ras-interacting protein required for chemotaxis and cyclic adenosine monophosphate signal relay in Dictyostelium
    • Lee, S., Parent, C. A., Insall, R., and Firtel, R. A. (1999). A novel Ras-interacting protein required for chemotaxis and cyclic adenosine monophosphate signal relay in Dictyostelium. Mol. Biol. Cell 10, 2829-2845.
    • (1999) Mol. Biol. Cell , vol.10 , pp. 2829-2845
    • Lee, S.1    Parent, C.A.2    Insall, R.3    Firtel, R.A.4
  • 31
    • 20244379418 scopus 로고    scopus 로고
    • Regulation of PTEN by Rho small GTPases
    • Li, Z., et al. (2005). Regulation of PTEN by Rho small GTPases. Nat. Cell Biol. 7, 399-404.
    • (2005) Nat. Cell Biol. , vol.7 , pp. 399-404
    • Li, Z.1
  • 32
    • 0034635221 scopus 로고    scopus 로고
    • Roles of PLC-β2 and -β3 and PI3Kγ in chemoattractant- mediated signal transduction
    • Li, Z., Jiang, H., Xie, W., Zhang, Z., Smrcka, A. V., and Wu, D. (2000). Roles of PLC-β2 and -β3 and PI3Kγ in chemoattractant-mediated signal transduction. Science 287, 1046-1049.
    • (2000) Science , vol.287 , pp. 1046-1049
    • Li, Z.1    Jiang, H.2    Xie, W.3    Zhang, Z.4    Smrcka, A.V.5    Wu, D.6
  • 33
    • 0028978605 scopus 로고
    • Chemoattractant and GTP gamma S-mediated stimulation of adenylyl cyclase in Dictyostelium requires translocation of CRAC to membranes
    • Lilly, P. J., and Devreotes, P. N. (1995). Chemoattractant and GTP gamma S-mediated stimulation of adenylyl cyclase in Dictyostelium requires translocation of CRAC to membranes. J. Cell Biol. 129, 1659-1665.
    • (1995) J. Cell Biol. , vol.129 , pp. 1659-1665
    • Lilly, P.J.1    Devreotes, P.N.2
  • 34
    • 0016789730 scopus 로고
    • Chemotaxis and binding of cyclic AMP in cellular slime molds
    • Mato, J. M., and Konijn, T. M. (1975). Chemotaxis and binding of cyclic AMP in cellular slime molds. Biochim. Biophys. Acta 385, 173-179.
    • (1975) Biochim. Biophys. Acta , vol.385 , pp. 173-179
    • Mato, J.M.1    Konijn, T.M.2
  • 35
    • 0010503979 scopus 로고
    • Signal input for a chemotactic response in the cellular slime mold Dictyostelium discoideum. Proc
    • Mato, J. M., Losada, A., Nanjundiah, V., and Konijn, T. M. (1975). Signal input for a chemotactic response in the cellular slime mold Dictyostelium discoideum. Proc. Natl. Acad. Sci. USA 72, 4991-4993.
    • (1975) Natl. Acad. Sci. USA , vol.72 , pp. 4991-4993
    • Mato, J.M.1    Losada, A.2    Nanjundiah, V.3    Konijn, T.M.4
  • 36
    • 0033560747 scopus 로고    scopus 로고
    • Chemoattractant-mediated transient activation and membrane localization of Akt/PKB is required for efficient chemotaxis to cAMP in Dictyostelium
    • Meili, R., Ellsworth, C., Lee, S., Reddy, T. B., Ma, H., and Firtel, R. A. (1999). Chemoattractant-mediated transient activation and membrane localization of Akt/PKB is required for efficient chemotaxis to cAMP in Dictyostelium. EMBO J. 18, 2092-2105.
    • (1999) EMBO J. , vol.18 , pp. 2092-2105
    • Meili, R.1    Ellsworth, C.2    Lee, S.3    Reddy, T.B.4    Ma, H.5    Firtel, R.A.6
  • 37
    • 23144450820 scopus 로고    scopus 로고
    • Protein kinase activity of phosphoinositide 3-kinase regulates β-adrenergic receptor endocytosis
    • Naga Prasad, S. V., Jayatilleke, A., Madamanchi, A., and Rockman, H. A. (2005). Protein kinase activity of phosphoinositide 3-kinase regulates β-adrenergic receptor endocytosis. Nat. Cell Biol. 7, 785-796.
    • (2005) Nat. Cell Biol. , vol.7 , pp. 785-796
    • Naga Prasad, S.V.1    Jayatilleke, A.2    Madamanchi, A.3    Rockman, H.A.4
  • 38
    • 0016712881 scopus 로고
    • Chemotaxis under agarose: A new and simple method for measuring chemotaxis and spontaneous migration of human polymorphonuclear leukocytes and monocytes
    • Nelson, R., Quie, P., and Simmons, R. (1975). Chemotaxis under agarose: a new and simple method for measuring chemotaxis and spontaneous migration of human polymorphonuclear leukocytes and monocytes. J. Immunol. 115, 1650-1656.
    • (1975) J. Immunol. , vol.115 , pp. 1650-1656
    • Nelson, R.1    Quie, P.2    Simmons, R.3
  • 39
    • 1642328487 scopus 로고    scopus 로고
    • Making all the right moves: Chemotaxis in neutrophils and Dictyostelium
    • Parent, C. A. (2004). Making all the right moves: chemotaxis in neutrophils and Dictyostelium. Curr. Opin. Cell Biol. 16, 4-13.
    • (2004) Curr. Opin. Cell Biol. , vol.16 , pp. 4-13
    • Parent, C.A.1
  • 40
    • 0032475863 scopus 로고    scopus 로고
    • G protein signaling events are activated at the leading edge of chemotactic cells
    • Parent, C. A., Blacklock, B. J., Froehlich, W. M., Murphy, D. B., and Devreotes, P. N. (1998). G protein signaling events are activated at the leading edge of chemotactic cells. Cell 95, 81-91.
    • (1998) Cell , vol.95 , pp. 81-91
    • Parent, C.A.1    Blacklock, B.J.2    Froehlich, W.M.3    Murphy, D.B.4    Devreotes, P.N.5
  • 41
    • 0029088825 scopus 로고
    • Isolation of inactive and G protein-resistant adenylyl cyclase mutants using random mutagenesis
    • Parent, C. A., and Devreotes, P. N. (1995). Isolation of inactive and G protein-resistant adenylyl cyclase mutants using random mutagenesis. J. Biol. Chem. 270, 22693-22696.
    • (1995) J. Biol. Chem. , vol.270 , pp. 22693-22696
    • Parent, C.A.1    Devreotes, P.N.2
  • 42
    • 0029943450 scopus 로고    scopus 로고
    • Molecular genetics of signal transduction in Dictyostelium
    • Parent, C. A., and Devreotes, P. N. (1996). Molecular genetics of signal transduction in Dictyostelium. Annu. Rev. Biochem. 65, 411-440.
    • (1996) Annu. Rev. Biochem. , vol.65 , pp. 411-440
    • Parent, C.A.1    Devreotes, P.N.2
  • 43
    • 0033617576 scopus 로고    scopus 로고
    • A cell's sense of direction
    • Parent, C. A., and Devreotes, P. N. (1999). A cell's sense of direction. Science 284, 765-770.
    • (1999) Science , vol.284 , pp. 765-770
    • Parent, C.A.1    Devreotes, P.N.2
  • 44
    • 0026504354 scopus 로고
    • Structurally distinct and stage-specific adenylyl cyclase genes play different roles in Dictyostelium development
    • Pitt, G. S., Milona, N., Borleis, J., Lin, K. C., Reed, R. R., and Devreotes, P. N. (1992). Structurally distinct and stage-specific adenylyl cyclase genes play different roles in Dictyostelium development. Cell 69, 305-315.
    • (1992) Cell , vol.69 , pp. 305-315
    • Pitt, G.S.1    Milona, N.2    Borleis, J.3    Lin, K.C.4    Reed, R.R.5    Devreotes, P.N.6
  • 47
    • 3342895823 scopus 로고    scopus 로고
    • Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton
    • Sarbassov, D. D., Ali, S. M., Kim, D. H., Guertin, D. A., Latek, R. R., Erdjument-Bromage, H., Tempst, P., and Sabatini, D. M. (2004). Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton. Curr. Biol. 14, 1296-1302.
    • (2004) Curr. Biol. , vol.14 , pp. 1296-1302
    • Sarbassov, D.D.1    Ali, S.M.2    Kim, D.H.3    Guertin, D.A.4    Latek, R.R.5    Erdjument-Bromage, H.6    Tempst, P.7    Sabatini, D.M.8
  • 48
    • 8444221934 scopus 로고    scopus 로고
    • Localized Ras signaling at the leading edge regulates PI3K, cell polarity, and directional cell movement
    • Sasaki, A. T., Chun, C., Takeda, K., and Firtel, R. A. (2004). Localized Ras signaling at the leading edge regulates PI3K, cell polarity, and directional cell movement. J. Cell Biol. 167, 505-518.
    • (2004) J. Cell Biol. , vol.167 , pp. 505-518
    • Sasaki, A.T.1    Chun, C.2    Takeda, K.3    Firtel, R.A.4
  • 49
    • 12744280743 scopus 로고    scopus 로고
    • An autoregulatory circuit for long-range self-organization in Dictyostelium cell populations
    • Sawai, S., Thomason, P. A., and Cox, E. C. (2005). An autoregulatory circuit for long-range self-organization in Dictyostelium cell populations. Nature 433, 323-326.
    • (2005) Nature , vol.433 , pp. 323-326
    • Sawai, S.1    Thomason, P.A.2    Cox, E.C.3
  • 50
    • 0034635513 scopus 로고    scopus 로고
    • Polarization of chemoattractant receptor signaling during neutrophil chemotaxis
    • Servant, G., Weiner, O. D., Herzmark, P., Balla, T., Sedat, J. W., and Bourne, H. R. (2000). Polarization of chemoattractant receptor signaling during neutrophil chemotaxis. Science 287, 1037-1040.
    • (2000) Science , vol.287 , pp. 1037-1040
    • Servant, G.1    Weiner, O.D.2    Herzmark, P.3    Balla, T.4    Sedat, J.W.5    Bourne, H.R.6
  • 51
    • 0036532121 scopus 로고    scopus 로고
    • Roles of PI3Ks in leukocyte chemotaxis and phagocytosis
    • Stephens, L., Ellson, C., and Hawkins, P. (2002). Roles of PI3Ks in leukocyte chemotaxis and phagocytosis. Curr. Opin. Cell Biol. 14, 203-213.
    • (2002) Curr. Opin. Cell Biol. , vol.14 , pp. 203-213
    • Stephens, L.1    Ellson, C.2    Hawkins, P.3
  • 52
    • 0020959246 scopus 로고
    • Sensory adaptation of Dictyostelium discoideum cells to chemotactic signals
    • Van Haastert, P. J. (1983). Sensory adaptation of Dictyostelium discoideum cells to chemotactic signals. J. Cell Biol. 96, 1559-1565.
    • (1983) J. Cell Biol. , vol.96 , pp. 1559-1565
    • Van Haastert, P.J.1
  • 53
    • 0036308458 scopus 로고    scopus 로고
    • Lipid products of PI(3)Ks maintain persistent cell polarity and directed motility in neutrophils
    • Wang, F., Herzmark, P., Weiner, O. D., Srinivasan, S., Servant, G., and Bourne, H. R. (2002). Lipid products of PI(3)Ks maintain persistent cell polarity and directed motility in neutrophils. Nat. Cell Biol. 4, 513-518.
    • (2002) Nat. Cell Biol. , vol.4 , pp. 513-518
    • Wang, F.1    Herzmark, P.2    Weiner, O.D.3    Srinivasan, S.4    Servant, G.5    Bourne, H.R.6
  • 54
    • 0036532115 scopus 로고    scopus 로고
    • Regulation of cell polarity during eukaryotic chemotaxis: The chemotactic compass
    • Weiner, O. D. (2002). Regulation of cell polarity during eukaryotic chemotaxis: the chemotactic compass. Curr. Opin. Cell Biol. 14, 196-202.
    • (2002) Curr. Opin. Cell Biol. , vol.14 , pp. 196-202
    • Weiner, O.D.1
  • 56
    • 0035061264 scopus 로고    scopus 로고
    • Small GTPases in Dictyostelium: Lessons from a social amoeba
    • Wilkins, A., and Insall, R. H. (2001). Small GTPases in Dictyostelium: lessons from a social amoeba. Trends Genet. 17, 41-48.
    • (2001) Trends Genet. , vol.17 , pp. 41-48
    • Wilkins, A.1    Insall, R.H.2
  • 58
    • 0031906278 scopus 로고    scopus 로고
    • 32P]phosphatidylinositol trisphosphate levels, alters F-actin distribution and impairs pinocytosis
    • 32P]phosphatidylinositol trisphosphate levels, alters F-actin distribution and impairs pinocytosis. J. Cell Sci. 111, 283-294.
    • (1998) J. Cell Sci. , vol.111 , pp. 283-294
    • Zhou, K.1    Pandol, S.2    Bokoch, G.3    Traynor-Kaplan, A.E.4
  • 59
    • 0029147402 scopus 로고
    • A phosphatidylinositol (PI) kinase gene family in Dictyostelium discoideum: Biological roles of putative mammalian p110 and yeast Vps34p PI 3-kinase homologs during growth and development
    • Zhou, K., Takegawa, K., Emr, S. D., and Firtel, R. A. (1995). A phosphatidylinositol (PI) kinase gene family in Dictyostelium discoideum: biological roles of putative mammalian p110 and yeast Vps34p PI 3-kinase homologs during growth and development. Mol. Cell. Biol. 15, 5645-5656.
    • (1995) Mol. Cell. Biol. , vol.15 , pp. 5645-5656
    • Zhou, K.1    Takegawa, K.2    Emr, S.D.3    Firtel, R.A.4
  • 60
    • 0017660115 scopus 로고
    • Ability of polymorphonuclear leukocytes to orient in gradients of chemotactic factors
    • Zigmond, S. H. (1977). Ability of polymorphonuclear leukocytes to orient in gradients of chemotactic factors. J. Cell Biol. 75, 606-616.
    • (1977) J. Cell Biol. , vol.75 , pp. 606-616
    • Zigmond, S.H.1
  • 61
    • 0018605361 scopus 로고
    • Sensory adaptation of leukocytes to chemotactic peptides
    • Zigmond, S. H., and Sullivan, S. J. (1979). Sensory adaptation of leukocytes to chemotactic peptides. J. Cell Biol. 82, 517-527.
    • (1979) J. Cell Biol. , vol.82 , pp. 517-527
    • Zigmond, S.H.1    Sullivan, S.J.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.