Lowering effects of onion intake on oxidative stress biomarkers in streptozotocin-induced diabetic rats

Journal of Clinical Biochemistry and Nutrition

Volumn 40, Issue 2, 2007, Pages 131-140

  Azuma, Keiko ^a   Minami, Yuko ^b   Ippoushi, Katsunari ^a   Terao, Junji ^b  

^a NATIONAL INSTITUTE OF VEGETABLE AND TEA SCIENCE   (Japan)

^b UNIVERSITY OF TOKUSHIMA   (Japan)

Author keywords

Antioxidant; Diabetes; Onion; Oxidative stress; Quercetin

Indexed keywords

8 HYDROXYDEOXYGUANOSINE; BIOLOGICAL MARKER; CHOLESTEROL ESTERASE; COPPER ION; GLUCOSE; ISOQUERCITRIN; ONION EXTRACT; QUERCETIN AGLYCONE; QUERCETIN DERIVATIVE; STREPTOZOCIN; THIOBARBITURIC ACID REACTIVE SUBSTANCE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; CREATININE URINE LEVEL; DRUG BLOOD LEVEL; DRUG EFFECT; DRUG METABOLISM; FOOD INTAKE; GLUCOSE BLOOD LEVEL; LIPID PEROXIDATION; MALE; NONHUMAN; ONION; ORGAN WEIGHT; OXIDATIVE STRESS; RAT; STREPTOZOCIN DIABETES; TRIACYLGLYCEROL BLOOD LEVEL; WEIGHT GAIN;

ALLIUM CEPA; RATTUS;

EID: 34247260351     PISSN: 09120009     EISSN: None     Source Type: Journal    
DOI: 10.3164/jcbn.40.131     Document Type: Article

References (44)

1. de Whalley, C.V., Rankin, S.M., Hoult, J.R., Jessup, W., and Leake, D.: Flavonoids inhibit the oxidative modification of low density lipoproteins by macropharges. Biochem. Pharmacol., 39, 1743-1750, 1990.
2. 2+-mediated oxidative modification of low-density lipoprotein. Biol. Pharm. Bull., 18, 1-4, 1995.
3. da Silva, E.L., Tsushida, T., and Terao, J.: Inhibition of mammalian 15-lipoxygenase-dependent lipid peroxidation in low-density lipoprotein by quercetin and quercetin monoglucosides. Arch. Biochem. Biophys., 349, 313-320, 1998.
4. Hertog, M.G.L., Kromhout, D., Aravanis, C., Blackburn, H., Buzina, R., Fidanza, F., Giampaoli, S., Jansen, A., Menotti, A., Nedelijkovic, S., Pekkarinen, M., Simic, B.S., Toshoma, H., Feskens, E.J.M., Hollman, P.C.H., and Katan, M.: Flavonoid intake and long-term risk of coronary heart disease and cancer in the seven countries study. Arch. Intern. Med., 155, 381-386, 1995.
5. Knekt, P., Jarvinen, R., Reunanen, A., and Maatela, J.: Flavonoid intake and coronary mortality in Finland: a cohort study. Br. Med. J., 312, 478-481, 1996.
6. Yochum, L., Kushi, L., Meyer, K., and Folsom, A.: Dietary flavonoid intake and risk of cardiovascular disease in postmenopausal women. Am. J. Epidemiol., 149, 943-949, 1999.
7. Terao, J.: Dietary flavonoids as antioxidants in vivo: conjugated metabolites of (-)-epicatechin and quercetin participate in antioxidative defense in blood plasma. J. Med. Investigation, 46, 159-168, 1999.
8. Murota, K. and Terao, J.: Antioxidative flavonoid quercetin: implication of its intestinal absorption and metabolism. Arch. Biochem. Biophys., 417, 12-17, 2003.
9. Terao, J.: Quercetin glycosides: their absorption, metabolism and antioxidant activity. Vitamins, 79, 3-11, 2005.
10. Day, A.J., Canada, F.J., Diaz, J.C., Kroon, P.A., Mclauchlan, R., Faulds, C.B., Plumb, G.W., Morgan, M.R., and Williamson, G.: Dietary flavonoid and isoflavone glycosides are hydrolyzed by the lactase site of lactase phlorizin hydrolase. FEBS Lett., 468, 166-170, 2000.
11. Walgren, R.A., Lin, J.T., Kinne, R.K., and Walle, T.: Cellular uptake of dietary flavonoid quercetin 4′-beta-glucoside by sodium-dependent glucose transporter SGLT1. J. Pharmacol. Exp. Ther., 294, 837-843, 2000.
12. Gee, J.M., DuPont, M.S., Day, A.J., Plumb, G.W., Williamson, G., and Johnson, I.T.: Intestinal transport of quercetin glycosides in rats involves both deglycosylation and interaction with the hexose transport pathway. J. Nutr., 130, 2765-2771, 2000.
13. Azuma, K., Nakayama, M., Koshioka, M., Ippoushi, K., Yamaguchi, Y., Kohata, K., Yamauchi, Y., Ito, H., and Higashio, H.: Phenolic antioxidants from the leaves of Corchorus olitorius L. J. Agric. Food Chem., 47, 3963-3966, 1999.
14. Tsushida, T. and Suzuki, M.: Content of flavonol glucosides and some properties of enzymes metabolizing the glucosides in onion. Nippon Shokuhin Kogaku Kogaku Kaishi, 43, 642-649, 1996.
15. Price, K.R., Bacon, J.R., and Rhodes, J.C.: Effect of storage and domestic processing on the content and composition of flavonol glucosides in onion (Allium cepa L.). J. Agric. Food Chem., 45, 938-942, 1997.
16. Azuma, K., Ippoushi, K., Ito, H., Horie, H., and Terao, J.: Enhancing effect of lipids and emulsifiers on the accumulation of quercetin metabolites in blood plasma after the short-term ingestion of onion by rats. Biosci. Biotechnol. Biochem., 67, 2548-2555, 2003.
17. Azuma, K., Ippoushi, K., Ito, H., Higashio, H., and Terao, J.: Combination of lipids and emulsifiers enhances the absorption of orally administered quercetin in rats. J. Agric. Food Chem., 50, 1706-1712, 2002.
18. McAnlis, G.T., McEneny, J., Pearce, J., and Young, I.S.: Absorption and antioxidant effects of quercetin from onions, in man. Eur. J. Clin. Nutr., 53, 92-96, 1999.
19. Moon, J.-H., Nakata, R., Oshima, S., Inafuku, T., and Terao, J.: Accumulation of quercetin conjugates in blood plasma after the short-term ingestion of onion by women. Am. J. Physiol. Regulatory Integrative Comp. Phys., 279, R461-R467, 2000.
20. Lean, M.E.J., Noroozi, M., Kelly, I., Burns, J., Talwar, D., Sattar, N., and Crozier, N.: Dietary flavonols protect diabetic human lymphocytes against oxidative damage to DNA. Diabetes, 48, 176-181, 1999.
21. Boyle, S.P., Dobson, V.L., Duthie, S.J., Kyle, J.A.M., and Collins, A.R.: Absorption and DNA protective effects of flavonoid glycosides from an onion meal. Eur. J. Nutr., 39, 213-223, 2000.
22. Babu, P.S. and Srinivasan, K.: Influence of dietary capsaicin and onion on the metabolic abnormalities associated with streptozotocin induced diabetes mellitus. Mol. Cell. Bio chem., 175, 49-57, 1997.
23. Babu, P.S. and Srinivasan, K.: Renal lesions in streptozotocin-induced diabetic rats maintained on onion and capsaicin containing diets. J. Nutr. Biochem., 10, 477-483, 1999.
24. Sanders, R.A., Rauscher, F.M., and Watkins, J.B.: Effects of quercetin on antioxidant defense in streptozotocin-induced diabetic rats. J. Biochem. Mol. Toxic., 15, 143-149, 2001.
25. Mahesh, T. and Menon, V.P.: Quercetin allievates oxidative stress in streptozotocin-induced diabetic rats. Phytother. Res., 18, 123-127, 2004.
26. Femia, A.P., Caderni, G., Ianni, M., Salvadori, M., Schijlen, E., Collins, G., Bovy, A., and Dolara, P.: Effect of diets fortified with tomatoes and onions with variable quercetin-glycoside content on azoxymethane-induced aberrant crypt foci in the colon of rats. Eur. J. Nutr., 42, 346-352, 2003.
27. Arai, H., Terao, J., Abdalla, D.S.P., Suzuki, T., and Takama, K.: Coulometric detection in high-performance liquid chromatographic analysis of cholesteryl ester hydroperoxides. Free Radic. Biol. Med., 20, 365-371, 1996.
28. Yagi, K.: Assay for blood plasma or serum. Methods Enzymol., 105, 328-331, 1984.
29. Kosugi, H., Kojima, T., and Kikugawa, K.: Characteristics of the thiobarbituric acid reactivity of oxidized fats and oils. J. Am. Oil Chem. Soc., 68, 51-55, 1991.
30. Uchiyama, M. and Mihara, M.: Determination of malonaldehyde precursor in tissues by thiobarbituric acid test. Anal. Biochem., 86, 271-278, 1978.
31. da Silva, E.L., Piskula, M.K., Yamamoto, N., Moon, J.-H., and Terao, J.: Quercetin metabolites inhibit copper ion-induced lipid peroxidation in rat plasma. FEBS Lett., 430, 405-408, 1998.
32. Flohe, L. and Gunzler, W.A.: Assays of glutathione peroxidase, Methods Enzymol., 105, 114-120, 1984.
33. Letan, A.: The relation of structure to antioxidant activity of quercetin and some of its derivatives. I Primary activity. J. Food Sci., 31, 518-523, 1966.
34. Ree, S.J., Choe, W.K., and Ha, T.U.: The effect of vitamin E on the antioxidative defense mechanism in streptozotocin-induced diabetic rats. Nippon Shokuhin Eiyou Gakkaishi, 48, 451-457, 1995.
35. Sugimoto, E., Igarashi, K., Kubo, K., Molyneux, J., and Kubomura, K.: Protective effects of boysenberry anthocyanins on oxidative stress in diabetic rats. Food Sci. Technol. Res., 9, 345-349, 2003.
36. Sun, F., Iwaguchi, K., Shudo, R., Nagaki, Y., Tanaka, K., Ikeda, K., Tokumaru, S., and Kojo, S.: Change in tissue concentrations of lipid hydroperoxides, vitamin C and vitamin E in rats with strepotozotocin-induced diabetes. Clin. Sci., 96, 185-190, 1999.
37. Kakker, R., Kalra, J., Mantha, S.V., and Prasad, K.: Lipid peroxidation and activity of antioxidant enzymes in diabetic rats. Mol. Cell Biochem., 151, 113-119, 1995.
38. Rauscher, F.M., Sanders, R.A., and Watkins, J.B.: Effects of piperine on antioxidant pathways in tissues from normal and streptozotocin-induced diabetic rats. J. Mol. Biochem. Toxicol., 14, 329-334, 2000.
39. Vessal, M., Hemmati, M., and Vasei, M.: Antidiabetic effects of quercetin in streptozocin-induced diabetic rats. Comp. Biochem. Physiol. C. Toxicol. Pharmacol., 135C, 357-364, 2003.
40. Hii, C.S. and Howell, S.L.: Effects of flavonoids on insulin secretion and 45Ca2+ handling in rat islets of Langerhans. J. Endocrinol., 107, 1-8, 1985.
41. Best, L., Trebilcock, R., and Tomlinson, S.: Acute stimulation of pancreatic islets by inhibitors of lactic acid transport. Biochem. Pharmacol., 41, 405-409, 1991.
42. Klanns-Dieter, A.: Sulfur contend free radicals. in Radiopro tectors and anticarcinogens, eds. By Nygaard, O.F. and Simic, M.G. Academic press, New York, pp. 23-42, 1983.
43. Helen, A., Rajasree, C.R., Krishnakumar, K., Augusti, K.T., and Vijayammal, P.L.: Antioxidant role of oils isolated from garlic (Allium sativum Linn) and onion (Allium cepa Linn) on nicotine-induced lipid peroxidation. Vet. Human Toxicol., 41, 316-319, 1999.
44. Helen, A., Krishnakumar, K., Vijayammal, P.L., and Augusti, K.T.: Antioxidant effect of onion (Allium cepa Linn) on the damages induced by nicotine in rats as compared to alpha-tocopherol. Toxicol. Lett., 116, 61-68, 2000.