Hepatitis B virus (HBV)-transgenic mice as an investigative tool to study immunopathology during HBV infection

International Journal of Experimental Pathology

Volumn 79, Issue 5, 1998, Pages 279-291

  Fazle Akbar, Sk Md ^a   Onji, Morikazu ^a  

^a EHIME UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Dendritic cells; Hepatitis B virus; Immunobiology; Transgenic mice

Indexed keywords

GENE PRODUCT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIGEN PRESENTING CELL; CONTROLLED STUDY; DENDRITIC CELL; GENE EXPRESSION REGULATION; HEPATITIS B VIRUS; IMMUNE RESPONSE; IMMUNOMODULATION; IMMUNOPATHOLOGY; INFECTION CONTROL; MOUSE; NONHUMAN; PRIORITY JOURNAL; REVIEW; TRANSGENIC MOUSE; VIRUS CARRIER; VIRUS GENOME; VIRUS INFECTION; VIRUS REPLICATION;

ANIMALS; CARRIER STATE; DENDRITIC CELLS; DISEASE MODELS, ANIMAL; HEPATITIS B; HEPATITIS B ANTIBODIES; HEPATITIS B SURFACE ANTIGENS; HEPATITIS B VIRUS; HUMANS; IMMUNITY, CELLULAR; MICE; MICE, TRANSGENIC;

EID: 15144349954     PISSN: 09599673     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2613.1998.740406.x     Document Type: Review

References (49)

1. AKBAR S.M.F., ONJI M., INABA K., YAMAMURA K. & OHTA Y. (1993) Low responsiveness of hepatitis B virus transgenic mice in antibody response to T-cell-dependent antigen: defect in antigen-presenting activity of dendritic cells. Immunology 78, 468-475.
2. AKBAR S.M.F., INABA K. & ONJI M. (1996) Upregulation of MHC class II antigen on dendritic cells from hepatitis B virus transgenic mice:abrogation of immune response defect to a T-cell-dependent antigen. Immunology 87, 519-527.
3. AKBAR S.M.F., KAJINO K., TANIMOTO T., KUROSE K., MASUMOTO T., MICHITAKA K., HORIIKE N. & ONJI M. (1997) Placebo-controlled trial of vaccination with hepatitis B virus surface antigen in hepatitis B virus transgenic mice. J. Hepatol. 26, 131-137.
4. ANDO K., MORIYAMA T., GUIDOTTI L.G., WIRTH S., SCHREIBER R.D., SCHLICHT H.J., HUANG S.N. & CHISARI F.V. (1993) Mechanism of class I restricted immunopathology: a transgenic mice model of fulminant hepatitis. J. Exp. Med. 178, 1541-1554.
5. ANDO K., GUIDOTTI L.G., WIRTH S., ISHIKAWA T., MISSALE G., MORIYAMA T., SCHREIBER R.D., SCHLICHT H.J., HUANG S. & CHISARI F.V. (1994a) Class I restricted cytotoxic T lymphocytes are directly cytopathic for their target cells in vivo. J. Immunol. 152, 3245-3253.
6. ANDO K., GUIDOTTI L.G., CERNI A., ISHIKAWA T. & CHISARI F.V. (1994b) CTL access to tissue antigen is restricted in vivo. J. Immunol. 153, 482-488.
7. ARAKI K., MIYAZAKI J., HINO O., TOMITA N., CHISAKA O., MATSUBARA K. & YAMAMURA K. (1989) Expression and replication of hepatitis B virus genome in transgenic mice. Proc. Natl. Aca. Sci. USA. 86, 207-211.
8. BILLINGHAM R.E., BRENT L. & MEDAWAR P.B. (1953) Actively acquired tolerance of foreign cells. Nature 172, 603-606.
9. BRATING N.M. & BERG P.A. (1983) Immunosuppressive serum factors in viral hepatitis. 1. Characterization of serum inhibitory factor (s) as lymphocyte antiactivator. Hepatology 3, 638-646.
10. BURK R.D., DELOIA J.A., AWADY M.K. & GEARHART J.D. (1988) Tissue preferential expression of hepatitis B virus (HBV) surface antigen gene in two lines of HBV transgenic mice. J. Virol. 62, 649-654.
11. BURNET F.M., STONE J.D. & EDNEY M. (1950) The failure of antibody production in the chick embryo. Aust. J. Exp. Med. 28, 291-297.
12. CHISARI F.V., FILLIPI P., MCLACHLAN A., MILICH D.R., LEE S., PALMITER R.D., PINKERT C.A. & BRINSTER R.L. (1986) Expression of hepatitis B large envelope polypeptide inhibits hepatitis B surface antigen secretion in transgenic mice. J. Virol. 60, 880-887.
13. CHISARI F.V., FILLIPI P., BURAS J., MCLACHLAN A., POPPER H., PINKERT C.A., PALMITER R.D. & BRINSTER R.L. (1987) Structural and pathological effects of synthesis of hepatitis B virus large envelope peptide in transgenic mice. Proc. Natl. Aca. Sci. USA. 84, 6909-6913.
14. CHISARI F.V., KLOPCHIN K., MORIYAMA T., PASQUINELLI C., DUNSFORD H.A., SELL S., PINKERT C.A., BRINSTER R.L. & PALMITER R.D. (1989) Molecular pathogenesis of hepatocellular carcinoma in hepatitis B virus transgenic mice. Cell 59, 1145-1156.
15. CHISARI F.V. (1995) Hepatitis B virus transgenic mice: Insights into the virus and the disease. Hepatology 22, 1316-1325.
16. DELOIA J.A., BURK R.D. & GEARHART J.D. (1989) Developmental regulation of hepatitis B surface antigen expression in two lines of hepatitis B virus transgenic mice. J. Virol. 63, 4069-4073.
17. DUNSFOLD H.A., SELL S. & CHISARI F.V. (1990) Hepatocarcinogenesis due to chronic liver cell injury in hepatitis B virus transgenic mice. Can. Res. 50, 3400-3407.
18. DUSHEIKO G.M., HOOFNAGLE J.H., COOKSLEY W.G., JAMES S.P. & JONES E.A. (1983) Synthesis of antibodies to hepatitis B virus by cultured lymphocytes from chronic hepatitis B virus carriers. J. Clin. Invest. 71, 1104-1111.
19. FARZA H., SALMON A.M., HADCHOUEL M., MOREAU J.L., BABINET C., TIOLLAIS P. & POURCEL C. (1987) Hepatitis B surface antigen gene expression is regulated by sex steroids and glucocorticoids in transgenic mice. Proc. Natl. Aca. Sci. Usa. 84, 1187-1191.
20. FARZA H., HADCHOUEL M., SCOTTO J., TIOLLAIS P. & POURCEL C. (1988) Replication and gene expression of hepatitis B virus in a transgenic mice that contains the complete viral genome. J. Virol. 86, 4144-4152.
21. FERMAN A., CAYZER C.J.R. & COOKSLEY W.G.E. (1989) HBsAg-induced antigen-specific T and B lymphocytes responses in chronic hepatitis B virus carriers and immune individuals. Clin. Exp. Immunol. 76, 222-226.
22. FILIPPI P., BURAS J., MCLACHLAN A., POPPER H., PINKERT C.A., PALMITER R.D., BRINSTER R.L. & CHISARI F.V. (1992) Over-production of hepatitis B virus large envelope polypeptide causes filament storage, ground glass cell formation, hepatocellular injury and nodular hyperplasia in transgenic mice. In viral hepatitis and liver disease. Ed. A.J. Zuckerman. New York: Liss. pp. 632-640.
23. GERBER M.A., HADZIYANNIS S., VISSOULIS C., SCHAFFNER F., PARONETTO F. & POPPER H. (1974a) Hepatitis B antigen: nature and distribution of cytoplasmic antigen in hepatocytes of carriers. Proc. Soc. Exp. Biol. Med. 145, 863-867.
24. GERBER M.A., HADZIYANNIS S., VISSOULIS C., SCHAFFNER F., PARONETTO F. & POPPER H. (1974b) Electron microscopy and immunoelectronmicroscopy of cytoplasmic hepatitis B antigen in hepatocytes. Am. J. Pathol. 75, 489-502.
25. GILLES P.N., FEY G. & CHISARI F.V. (1992) Tumor necrosis factor-alpha negatively regulates hepatitis B virus gene expression in transgenic mice. J. Virol. 66, 3955-3960.
26. GILLES P.M., GUERRETTE D.L., ULEVITCH R.J., SCHREIBER R.D. & CHISARI F.V. (1994) Hepatitis B surface antigen retention sensitizes the hepatocyte to injury by physiologic concentration of gamma interferon. Hepatology 16, 655-663.
27. GUIDOTTI L.G., MARTINEZ V., LOH Y.T., ROGLER C.E. & CHISARI F.V. (1994a) Hepatitis B virus nucleocapsid particles do not cross the hepatocytes nuclear membrane in trasngeniuc mice. J. Virol. 68, 5469-5475.
28. GUIDOTTI L.G., ANDO K., HOBBS M.V., ISHIKAWA T., RUNKEL L., SCHREIBER B.D. & CHISARI F.V. (1994b) Cytotoxic T lymphocytes inhibit hepatitis B virus gene expression by a noncytolytic mechanism in transgenic mice. Proc. Natl. Aca. Sci. USA. 91, 3764-3768.
29. GUIDOTTI L.G., GUILHOT S. & CHISARI F.V. (1994c) Interleukin 2 and interferon alpha/beta down regulate hepatitis B virus gene expression in vivo by tumor necrosis factor dependent and independent pathways. J. Virol. 68, 1265-1270.
30. GUIDOTTI L.G., MATZKE B. & SCHALLER. & CHISARI F.V. (1995) High-level hepatitis B virus replication in transgenic mice. J. Virol. 69, 6158-6169.
31. GUILHOT S., GUIDOTTI L.G. & CHISARI F.V. (1993) Interleukin-2 downregulates hepatitis B virus gene expression in transgenic mice by a post transcriptional mechanism. J. Virol. 67, 7444-7449.
32. HOOFNAGLE J.H., SHAFRITZ D.A. & POPPER H. (1987) Chronic type B hepatitis and 'healthy' HBsAg asymptomatic carrier state. Hepatology 7, 758-763.
33. KIM C.-M., KOIKE K., SAITO I., MIYAMURA T. & JAY G. (1991) HBX gene of hepatitis B virus induces liver cancer in transgenic mice. Nature 351, 317-320.
34. KOBRA B.E., WELLS F., TENNANT B.C., YOAKUM G.H., PURCELL R.H. & GERIN J.L. (1986) Hepadnavirus infection of peripheral blood lymphocytes in vivo: woodchuck and chimpanzee models of viral hepatitis. J. Virol. 58, 1-8.
35. KUROSE K., AKBAR S.M.F., YAMAMOTO K. & ONJI M. (1997) Production of antibody to hepatitis B surface antigen (anti-HBs) by murine hepatitis B virus carriers; neonatal tolerance versus antigen presentation by dendritic cells. Immunology 92, 494-500.
36. LEE T.-H., FINEGOLD M.J., SHEN R.F., DEMAYO J.L., Woo S.L. & BUTEL J.S. (1990) Hepatitis B virus transactivator X protein is not tumorigenic in transgenic mice. J. Virol. 64, 5939-5947.
37. MARUYAMA T., THORNTON G.B., IINO S., KUROKAWA K. & MILICH D.R. (1992) Use of anti-peptide antibodies for the design of antigen-specific immune complex assays. J. Immunol. Method. 155, 65-75.
38. MARUYAMA T., MCLACHIAN A., IINO S., KOIKE K., KUROKAWA K. & MILICH D.R. (1993) The serology of chronic hepatitis B infection Revisited. J. Clin. Invest. 91, 2586-2595.
39. MATZINGER P. (1994) Tolerance, danger and extended family. Annu. Rev. Immunol. 12, 991-1045.
40. MORIYAMA T., GUILHOT S., KLOPCHIN K., MOSS B., PINKERT C.A., PALMITER R.D., BRINSTER R.L., KANAGAWA O. & CHISARI F.V. (1990) Immunobiology and pathogenesis of hepatocellular injury in hepatitis B virus transgenic mice. Science 248, 361-364.
41. NOWICKI M.J., TONG M.J., NAIR P.V. & STEVENSON D. (1986) Impaired antibody synthesis in patients with chronic hepatitis B infection. Hepatology 6, 180-185.
42. ONJI M., LEVER A.M.L., SAITO I. & THOMAS H.C. (1989) Defective response of interferons in cells transfected with hepatitis B virus genome. Hepatology 9, 92-96.
43. PERIOLLO R.P. (1993) Interferon in the management of chronic hepatitis. Dig. Dis. Sci. 38, 577-593.
44. PETERS M., VIERLING J., GERSHWIN M.E., MILLICH D., CHISARI F.V. & HOOFNAGLE J.H. (1991) Immunology and the liver. Hepatology 13, 977-994.
45. RIDGE J.P., FUCHS E.J. & MATZINGER P. (1996) Neonatal tolerance revisited: turning on newborn T cells with dendritic cells. Science 271, 1723-1726.
46. STEINMAN R.M. (1991) The dendritic cell system and its role in immunogenicity. Annu. Rev. Immunol. 9, 271-296.
47. SYLVAN S.P.E., HELLSTROM U.B. & LUNDBERGH P.R. (1985) Detection of cellular and humoral immunity to hepatitis B surface antigen (HBsAg) in asymptomatic HBsAg carriers. Clin. Exp. Immunol. 62, 288-295.
48. THOMAS H.C., MONTANO L., GOODALL A., DE KONING R., OLADAPO J. & WEIDMAN K.H. (1982) Immunological mechanism in chronic hepatitis B virus infection. Hepatology 2, 116S-121S.
49. YAMAUCHI K., NAKANISHI T., CHIOU S.-S. & OBATA H. (1988) Suppression of hepatitis B antibody synthesis by factor made by T cells from chronic hepatitis B carriers. Lancet i, 324-325.