Interaction of Smad3 with a proximal smad-binding element of the human α2(I) procollagen gene promoter required for transcriptional activation by TGF-β

Journal of Cellular Physiology

Volumn 183, Issue 3, 2000, Pages 381-392

  Chen, Shu Jen ^a   Yuan, Weihua ^a   Lo, Sientay ^b   Trojanowska, Maria ^b   Varga, John ^a  

^a UNIVERSITY OF ILLINOIS   (United States)

^b MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTISENSE OLIGONUCLEOTIDE; PROCOLLAGEN; SMAD PROTEIN; TRANSFORMING GROWTH FACTOR BETA;

ARTICLE; CELL STRAIN HEPG2; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN PROTEIN INTERACTION; SKIN FIBROBLAST; TANDEM REPEAT; TRANSACTIVATION;

ADENOCARCINOMA; BINDING SITES; BREAST NEOPLASMS; CARCINOMA, HEPATOCELLULAR; DNA-BINDING PROTEINS; FEMALE; FIBROBLASTS; GENE DELETION; HUMANS; LIVER NEOPLASMS; PROCOLLAGEN; PROMOTER REGIONS (GENETICS); SKIN; SMAD3 PROTEIN; SMAD4 PROTEIN; TRANS-ACTIVATION (GENETICS); TRANS-ACTIVATORS; TRANSCRIPTION, GENETIC; TRANSFORMING GROWTH FACTOR BETA; TUMOR CELLS, CULTURED;

EID: 0034011221     PISSN: 00219541     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-4652(200006)183:3<381::AID-JCP11>3.0.CO;2-O     Document Type: Article

References (43)

1. Afrakhte M, Morén A, Jossan S, Itoh S, Sampath K, Westermark B, Heldin C-H, Heldin N-E, ten Dijke P. 1998. Induction of inhibitory Smad6 and Smad7 mRNA by TGF-β family members. Biochem Biophys Res Commun 249:505-511.
2. Border W, Noble N. 1994. Transforming growth factor-β in tissue fibrosis. N Engl J Med 331:1286-1292.
3. Chen S-J, Yuan W, Mori Y, Levenson A, Trojanowska M, Varga J. 1999. Stimulation of type I collagen transcription in human skin fibroblasts by transforming growth factor-β: involvement of Smad 3. J Invest Dermatol 112:49-57.
4. Chen X, Weisberg E, Fridmacher V, Watanabe M, Naco G, Whitman M. 1997. Smad4 and FAST-1 in the assembly of activin-responsive factor. Nature 389:85-88.
5. Chung K-Y, Agarwal A, Uitto J, Mauviel A. 1996. An AP-1 binding sequence is essential for regulation of the human α2(I) collagen (COL1A2) promoter activity by transforming growth factor-β. J Biol Chem 271:3272-3278.
6. Dennler S, Itoh S, Vivien D, ten Dijke P, Huet S, Gauthier J-M. 1998. Direct binding of Smad3 and Smad4 to critical TGFβ-inducible elements in the promoter region of human plasminogen activator inhibitor-type 1 gene. EMBO J 17:3091-3100.
7. Derynck R, Zhang Y, Feng X-H. 1998. Smads: transcriptional activators of TGF-β responses. Cell 95:737-740.
8. de Winter JP, Roelen BAJ, ten Dijke P, van der Burg N, van den Eijnden-van Raaij AJM. 1997. DPC4 (SMAD4) mediates transforming growth factor-β1 (TGF-β1) induced growth inhibition and transcriptional response in breast tumour cells. Oncogene 14:1891-1899.
9. Hao J, Ju H, Zhao S, Junaid A, Scammel-LeFleur T, Dixon IMC. 1999. Elevation of expression of Smads 2, 3, and 4, decorin and TGF-β in the chronic phase of myocardial infarct scar healing. J Mol Cell Cardiol 31:667-678.
10. Hata A, Lagna G, Massagué J, Hemmati-Brivanlou A. 1998. Smad6 inhibits BMP/Smad1 signaling by specifically competing with the Smad4 tumor suppressor. Genes Dev 12:186-197.
11. Hayashi H, Abdollah S, Qiu Y, Cai J, Xu Y-Y, Grinnell BW, Richardson MA, Topper JN, Gimbrone Jr MA, Wrana JL, Falb D. 1997. The MAD-related protein Smad7 associates with the TGFβ receptor and functions as an antagonist of TGFβ signaling. Cell 89:1165-1173.
12. Heldin C-H, Miyazano K, ten Dijke P. 1997. TGF-β signalling from cell membrane to nucleus through SMAD proteins. Nature 390: 465-469.
13. Higashi K, Kouba DJ, Song Y-J, Uitto J, Mauviel A. 1998. A proximal element within the human α2(I) collagen (COL1A2) promoter, distinct from the tumor necrosis factor-α response element, mediates transcriptional repression by interferon-γ. Matrix Biol 16:447-456.
14. Hocevar BA, Brown TL, Howe PH. 1999. TGF-β induces fibronectin synthesis through a c-Jun N-terminal kinase-dependent, Smad4-independent pathway. EMBO J 18:1345-1356.
15. Hoodless PA, Wrana JL. 1998. Mechanism and function of signaling by the TGF-β superfamily. Curr Top Microbiol Immunol 228:235-272.
16. Hua X, Liu X, Ansari D, Lodish HF. 1998. Synergistic cooperation of TFE3 and Smad proteins in TGF-β-induced transcription of the plasminogen activator inhibitor-1 gene. Genes Dev 12:3084-3095.
17. Imamura T, Takase M, Nishihara A, Oeda E, Hanai J-I, Kawabata M, Miyazano K. 1997. Smad6 inhibits signalling by the TGF-β superfamily. Nature 389:622-626.
18. Inagaki Y, Truter S, Ramirez F. 1994. Transforming growth factor-β stimulates α2(I) collagen gene expression through a cis-acting element that contains an Sp-1 binding site. J Biol Chem 269:14828-14832.
19. Jonk LJC, Itoh S, Heldin C-H, ten Dijke P, Kruijer W. 1996. Identification and functional characterization of a Smad binding element (SBE) in the JunB promoter that acts as a transforming growth factor-β, activin, and bone morphogenetic protein-inducible enhancer. J Biol Chem 278:21145-21152.
20. Kingsley DM. 1994. The TGF-β superfamily: new members, new receptors, and new genetic tests of function in different organisms. Genes Dev 8:133-146.
21. Labbé E, Silvestri C, Hoodless PA, Wrana JL, Attisano L. 1998. Smad2 and Smad3 positively and negatively regulate TGFβ-dependent transcription through the forkhead DNA-binding protein FAST2. Mol Cell 2:109-120.
22. Liberati NT, Datto MB, Frederick JP, Shen X, Wong C, Rougier-Chapman E, Wang X-F. 1999. Smads bind directly to the Jun form of the AP-1 transcription factor. Proc Natl Acad Sci USA 96:4844-4849.
23. Liu X, Sun Y, Constantinescu SN, Karam E, Weinberg RA, Lodish HF. 1997. Transforming growth factor β-induced phosphorylation of Smad3 is required for growth inhibition and transcriptional induction in epithelial cell. Proc Natl Acad Sci USA 94:10669-10674.
24. Moustakas A, Kardassis D. 1998. Regulation of the human p21/ WAF1/Cip1 promoter in hepatic cells by functional interactions between Sp1 and Smad family members. Proc Natl Acad Sci USA 95:6733-6738.
25. Nakao A, Afrakhte M, Morén A, Nakayama T, Christian JL, Heuchel R, Itoh S, Kawabata M, Heldin N-E, Heldin C-H, ten Dijke P. 1997. Identification of Smad7, a TGFβ-inducible antagonist of TGF-β signalling. Nature 389:631-634.
26. Shi Y, Wang Y-F, Jayaraman L, Yang H, Massague J, Pavletich N. 1998. Crystal structure of a Smad MH1 domain bound to DNA: insights on DNA binding in TGF-β signaling. Cell 94:585-594.
27. Song C-Z, Siok TE, Gelehrter TD. 1998. Smad4/DPC4 and Smad3 mediate transforming growth factor-β (TGF-β) signaling through direct binding to a novel TGF-β-responsive element in the human plasminogen activator inhibitor-1 promoter. J Biol Chem 273:29287-29290.
28. Tamaki T, Ohnishi K, Hartl C, LeRoy EC, Trojanowska M. 1995. Characterization of a GC-rich region containing Sp1 binding site(s) as a constitutive responsive element of the α2(I) collagen gene in human fibroblasts. J Biol Chem 270:4299-4304.
29. Usui T, Takase M, Kaji Y, Suzuki K, Ishida K, Tsuru T, Miyata K, Kawabata M, Yamashita H. 1998. Extracellular matrix production regulation by TGF-β in corneal endothelial cells. Invest Ophthalmol Vis Sci 39:1981-1988.
30. Varga J, Jimenez SA. 1995. Modulation of collagen gene expression: its relation to fibrosis in systemic sclerosis and other disorders. Ann Intern Med 122:60-64.
31. Varga J, Rosenbloom J, Jimenez SA. 1987. Transforming growth factor β (TGFβ) causes a persistent increase in steady-state amounts of type I and type II collagen and fibronectin mRNAs in normal human dermal fibroblasts. Biochem J 247:597-604.
32. Vindevoghel L, Lechleider RJ, Kon A, De Caestecker MP, Uitto J, Roberts AB, Mauviel A. 1998. SMAD3/4-dependent transcriptional activation of the human type VII collagen gene (COL7A1) promoter by transforming growth factor β. Proc Natl Acad Sci USA 95: 14769-14774.
33. Vuorio E, de Crombrugghe B. 1990. The family of collagen genes. Annu Rev Biochem 59:837-72.
34. Wieser R, Wrana JL, Massagué J. 1995. GS domain mutations that constitutively activate TbR-I, the downstream signaling component in the TGF-β receptor complex. EMBO J 14:2199-2208.
35. Wong C, Rougier-Chapman EM, Frederick JP, Datto MB, Liberati NT, Li J-M, Wang X-F. 1999. Smad3-Smad4 and AP-1 complexes synergize in transcriptional activation of the c-Jun promoter by transforming growth factor β. Mol Cell Biol 19:1821-1830.
36. Yanagisawa J, Yanagi Y, Masuhiro Y, Suzawa M, Watanabe M, Kashiwagi K. 1999. Convergence of transforming growth factor-β and Vitamin D signaling pathways on SMAD transcriptional coactivators. Science 283:1317-1321.
37. Yang X, Letterio JJ, Lechleider RJ, Chen L, Hayman R, Gu H, Roberts AB, Deng C. 1999. Targeted disruption of SMAD3 results in impaired mucosal immunity and diminished T cell responsiveness to TGF-β. EMBO J 18:1280-1291.
38. Yingling JM, Datto MB, Wong C, Frederick JP, Liberati NT, Wang XF. 1997. Tumor suppressor Smad4 is a transforming growth factor beta-inducible DNA binding protein. Mol Cell Biol 17: 7019-7028.
39. Zawel L, Dai JL, Buckhaults P, Zhou S, Kinzler KW, Vogelstein B, Kern SE. 1998. Human Smad3 and Smad4 are sequence-specific transcription activators. Mol Cell 1:611-617.
40. Zhang Y, Feng X-H, Wu R-Y, Derynck R. 1996. Receptor-associated Mad homologues synergize as effectors of the TGF-β response. Nature 383:168-172.
41. Zhang Y, Feng X-H, Wu R-Y, Derynck R. 1998. Smad3 and Smad4 cooperate with c-Jun/c-fos to mediate TGF-β-induced transcription. Nature 394:909-913.
42. Zhao J, Lee M, Smith S, Warburton D. 1998. Abrogation of Smad3 and Smad2 or of Smad4 gene expression positively regulates murine embryonic lung branching morphogenesis in culture. Dev Biol 194: 182-195.
43. Zhou S, Zawel L, Lengauer C, Kinzler KW, Vogelstein B. 1998. Characterization of human FAST-1, a TGF beta and activin signal transducer. Mol Cell 2:121-127.