CTGF expression is induced by TGF-β in cardiac fibroblasts and cardiac myocytes: A potential role in heart fibrosis

Journal of Molecular and Cellular Cardiology

Volumn 32, Issue 10, 2000, Pages 1805-1819

  Chen, Michelle M ^a   Lam, Andrew ^a   Abraham, Judith A ^a   Schreiner, George F ^a   Joly, Alison H ^a  

^a SCIOS INC   (United States)

Author keywords

CTGF; Extracellular matrix; Ischemic heart disease; Myocardial infarction; Quantitative real time PCR; Signal transduction pathway

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; COLLAGEN TYPE 1; COLLAGEN TYPE 3; CONNECTIVE TISSUE GROWTH FACTOR; FIBRONECTIN; FORSKOLIN; PLASMINOGEN ACTIVATOR INHIBITOR 1; TRANSFORMING GROWTH FACTOR BETA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONNECTIVE TISSUE; CONTROLLED STUDY; DISEASE MARKER; EXTRACELLULAR MATRIX; GENE EXPRESSION; HEART INFARCTION; HEART INJURY; HEART MUSCLE CELL; HEART MUSCLE FIBROSIS; HEART MUSCLE ISCHEMIA; HUMAN; HUMAN CELL; ISCHEMIC HEART DISEASE; MALE; NEWBORN; NONHUMAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; RAT; SIGNAL TRANSDUCTION;

ANIMALIA;

EID: 0033745462     PISSN: 00222828     EISSN: None     Source Type: Journal    
DOI: 10.1006/jmcc.2000.1215     Document Type: Article

References (36)

1. The cell biology of the cardiac interstitium
2. Connective tissue growth factor: A cysteine-rich mitogen secreted by human vascular endothelial cells is related to the SRC-induced immediate early gene product CEF-10
3. The connective tissue growth factor/cysteine-rich 61/nephroblastoma overexpressed (CCN) family
4. Identification of a family of low-affinity insulin-like growth factor binding proteins (IGFBPs): Characterization of connective tissue growth factor as a member of the IGFBP superfamily
5. Stimulation of fibroblast cell growth, matrix production, and granulation tissue formation by connective tissue growth factor
6. Regulation of connective tissue growth factor gene expression in human skin fibroblasts and during wound repair
7. Connective tissue growth factor is a regulator for fibrosis in human chronic pancreatitis
8. Connective tissue growth factor gene expression in tissue sections from localized scleroderma, keloid, and other fibrotic skin disorders
9. Expression of connective tissue growth factor in human renal fibrosis
10. Connective tissue growth factor mRNA expression is upregulated in bleomycin-induced lung fibrosis
11. Expression of connective tissue growth factor in experimental rat and human liver fibrosis
12. Connective tissue growth factor: A mediator of TGF-beta action on fibroblasts
13. Role and interaction of connective tissue growth factor with transforming growth factor-beta in persistent fibrosis: A mouse fibrosis model
14. A novel transforming growth factor beta response element controls the expression of the connective tissue growth factor gene
15. TGF-beta signal transduction
16. Connective tissue growth factor mediates transforming growth factor beta-induced collagen synthesis: Down-regulation by cAMP
17. Increased expression of connective tissue growth factor in the infarct zone of experimentally induced myocardial infarction in rats
18. Serum response factor mediates AP-1-dependent induction of the skeletal alpha-actin promoter in ventricular myocytes
19. Myocardial infarct size and ventricular function in rats
20. Altered patterns of gene expression in response to myocardial infarction
21. Involvement of cardiotrophin-1 in cardiac myocyte-nonmyocyte interactions during hypertrophy of rat cardiac myocytes in vitro
22. Endothelin-1 stimulates cardiac fibroblast proliferation through activation of protein kinase C
23. Angiotensin II, adhesion, and cardiac fibrosis
24. Vascular endothelial growth factor (VEGF) activates Raf-1. Mitogen-activated protein (MAP) kinases, and S6 kinase (p90rsk) in cultured rat cardiac myocytes
25. CTGF modulates cell cycle progression in cAMP-arrested NRK fibroblasts
26. Inhibition of TGF-beta-stimulated CTGF gene expression and anchorage-independent growth by cAMP identifies a CTGF-dependent restriction point in the cell cycle
27. Opposing BMP and EGF signalling pathways converge on the TGF-beta family mediator Smad1
28. A mechanism of repression of TGFbeta/Smad signaling by oncogenic Ras
29. Expression of connective tissue growth factor mRNA in the fibrous stroma of mammary tumors
30. TGF-beta receptor signaling
31. The TGF-beta family mediator Smad1 is phosphorylated directly and activated functionally by the BMP receptor kinase
32. Connective tissue growth factor: A potential stimulus for glomerulosclerosis and tubulointerstitial fibrosis in progressive renal disease
33. Regulation of connective tissue growth factor activity in cultured rat mesangial cells and its expression in experimental diabetic glomerulosclerosis
34. Enhanced insulin-like growth factor binding protein-related protein 2 (Connective tissue growth factor) expression in patients with idiopathic pulmonary fibrosis and pulmonary sarcoidosis
35. Serum levels of connective tissue growth factor are elevated in patients with systemic sclerosis: Association with extent of skin sclerosis and severity of pulmonary fibrosis
36. Hepatic expression of mature transforming growth factor beta 1 in transgenic mice results in multiple tissue lesions