Molecular mechanisms of angiotensin II-induced vascular injury

Current Hypertension Reports

Volumn 5, Issue 1, 2003, Pages 73-79

  Ruiz Ortega, Marta ^a   Ruperez, Monica ^a   Esteban, Vanesa ^a   Egido, Jesús ^a  

^a Hospital UniversitarioFundación Jiménez Díaz   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

ALDOSTERONE; ANGIOTENSIN; ANGIOTENSIN 1 RECEPTOR; ANGIOTENSIN 1 RECEPTOR ANTAGONIST; ANGIOTENSIN 2 RECEPTOR; ANGIOTENSIN RECEPTOR ANTAGONIST; CYTOKINE; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; GROWTH FACTOR; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; PLATELET DERIVED GROWTH FACTOR; PROTEIN KINASE; PROTEIN KINASE C; RENIN; TRANSCRIPTION FACTOR; TRANSFORMING GROWTH FACTOR BETA; ANGIOTENSIN II; AUTACOID; GROWTH PROMOTOR; MITOGEN ACTIVATED PROTEIN KINASE KINASE;

ATHEROSCLEROSIS; BLOOD VESSEL INJURY; CARDIOVASCULAR DISEASE; CELL GROWTH; CELL PROLIFERATION; CYTOKINE PRODUCTION; ENZYME ACTIVATION; GROWTH REGULATION; HEART FAILURE; HUMAN; HYPERTENSION; INFLAMMATION; MOLECULAR MECHANICS; NONHUMAN; OXIDATION REDUCTION REACTION; PATHOGENESIS; PATHOPHYSIOLOGY; PROTEIN SYNTHESIS; RECEPTOR UPREGULATION; RENIN ANGIOTENSIN ALDOSTERONE SYSTEM; RENOVASCULAR DISEASE; REVIEW; SIGNAL TRANSDUCTION; VASCULAR FIBROSIS; VASODILATATION; ANIMAL; ARTERY; CELL DIVISION; CYTOLOGY; EXTRACELLULAR MATRIX; FIBROSIS; METABOLISM; PATHOLOGY; PHYSIOLOGY; VASCULAR SMOOTH MUSCLE;

ANGIOTENSIN II; ANIMALS; ARTERIES; CELL DIVISION; EXTRACELLULAR MATRIX; FIBROSIS; GROWTH SUBSTANCES; HUMANS; INFLAMMATION MEDIATORS; MITOGEN-ACTIVATED PROTEIN KINASE KINASES; MUSCLE, SMOOTH, VASCULAR; NF-KAPPA B; SIGNAL TRANSDUCTION;

EID: 0038689470     PISSN: 15226417     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11906-003-0014-0     Document Type: Review

References (54)

1. de Gasparo M, Catt KJ, Inagami T, et al.: International union of pharmacology. XXIII. The angiotensin II receptors. Pharmacol Rev 2000, 52:415-472.
2. Ruiz-Ortega M, Lorenzo O, Suzuki Y, et al.: Proinflammatory actions of angiotensins. Curr Opin Nephrol Hypertens 2001, 10:321-329.
3. Itoh H, Mukoyama M, Pratt RE, et al.: Multiple autocrine growth factors modulate vascular smooth muscle cell growth response to angiotensin II. J Clin Invest 1993, 91:2268-2274.
4. Diep QN, Li JS, Schiffrin EL: In vivo study of AT1 and AT2 angiotensin receptors in apoptosis of rat blood vessels. Hypertension 1999, 34:617-624.
5. Tea BS, Der Sarkissian S, Touyz RM, et al.: Proapoptotic and growth-inhibitory role of angiotensin II type 2 receptor in vascular smooth muscle cells of spontaneously hypertensive rats in vivo. Hypertension 2000, 35:1069-1073.
6. Mezzano S, Ruiz-Ortega M, Egido J: Angiotensin II and renal fibrosis. Hypertension 2001, 38:635-638.
7. Brede M, Hein L: Transgenic mouse models of angiotensin receptor subtype function in the cardiovascular system. Regul Pept 2001, 96:125-132.
8. Lombardi DM, Viswanathan M, Vio CP, et al.: Renal and vascular injury induced by exogenous angiotensin II is AT1 receptor-dependent. Nephron 2001, 87:66-74.
9. Ford CM, Li S, Pickering JG: Angiotensin II stimulates collagen synthesis in human vascular smooth muscle cells. Involvement of the AT1 receptor, transforming growth factor-β, and tyrosine phosphorylation. Arterioscler Thromb Vasc Biol 1999, 19:1843-1851.
10. Ruiz-Ortega M, Egido J: Angiotensin II modulates cell growth related events and synthesis of matrix proteins in renal interstitial fibroblasts. Kidney Int 1997, 52:1497-1510.
11. Mifune M, Sasamura H, Shimizu-Hirota R, et al.: Angiotensin II type 2 receptors stimulate collagen synthesis in cultured vascular smooth muscle cells. Hypertension 2000, 36:845-850.
12. Li JS, Touyz RM, Schiffrin EL: Effects of AT1 and AT2 angiotensin receptor antagonists in angiotensin II-infused rats. Hypertension 1998, 31:487-492.
13. Levy BI, Bennessiano J, Henrion D, et al.: Chronic blockade of AT2-subtype receptors prevents the effect of angiotensin II on the rat vascular structure. J Clin Invest 1996, 98:418-425.
14. Laviades C, Varo N, Fernandez J, et al.: Abnormalities of the extracellular degradation of collagen type I in essential hypertension. Circulation 1998, 98:535-540.
15. Nakamura S, Nakamura I, Ma L, et al.: Plasminogen activator inhibitor-1 expression is regulated by the angiotensin type 1 receptor in vivo. Kidney Int 2000, 58:251-259.
16. Border WA, Noble NA: Interactions of transforming growth factor-b and angiotensin II in renal fibrosis. Hypertension 1998, 31:181-188.
17. Lau LF, Lam SCT: The CCN family of angiogenic regulators: The integrin connection. Exp Cell Res 1999, 248:44-57.
18. Rupérez M, Lorenzo O, Blanco-Colio L, et al.: Intracelular signals invoved in angiotensin II-induced fibrosis in vascular damage. Description of a new mediator: the connective tissue growth factor. Circulation 2001, 104:179.
19. Rupérez M, Lorenzo O, Egido J, Ruiz-Ortega M: Angiotensin II increases connective tissue growth factor in the kidney. J Am Soc Nephrol 2001, 12:471A.
20. Massfelder T, Taesch N, Endlich N, et al.: Paradoxical actions of exogenous and endogenous parathyroid hormone-related protein on renal vascular smooth muscle cell proliferation: reversion in the SHR model of genetic hypertension. FASEB J 2001, 15:707-718.
21. Lorenzo O, Ruiz-Ortega M, Esbrit P, et al.: Modulation of parathyroid hormone (PTH)-related protein (PTHRP) and the PTH/PHJRP receptor-1 by angiotensin ii in the rat kidney. J Am Soc Nephrol 2002, 13:1595-1607.
22. Ruiz-Ortega M, Ruperez M, Lorenzo O, et al.: Angiotensin II regulates the synthesis of proinflammatory cytokines and chemokines in the kidney. Kidney Int 2002, In press.
23. Levine B, Kalman J, Mayer L, et al.: Elevated circulating levels of tumor necrosis factor in severe chronic heart failure. N Engl J Med 1990, 323:236-241.
24. Yokoyama T, Sekiguchi K, Tanaka T, et al.: Angiotensin II and mechanical stretch induce production of tumor necrosis factor in cardiac fibroblasts Am J Physiol 1999, 276:H1968-H1976.
25. Barath P, Fishbein MC, Cao J, et al.: Detection and localization of tumor necrosis factor in human atheroma. Am J Cardiol 1990, 65:297-302.
26. Tharaux PL, Chatzaiantoniou C, Fakhouri F, Dussaule JC: Angiotensin II activates collagen I gene through a mechanism involving the MAP/ER kinase pathway. Hypertension 2000, 36:330-336.
27. Verrecchia F, Mauviel A: Control of connective tissue gene expression by TGF beta: role of Smad proteins in fibrosis. Curr Rheumatol Rep 2002, 4:143-149.
28. Hao J, Wang B, Jones SC, et al.: Interaction between angiotensin II and Smad proteins in fibroblasts in failing heart and in vitro. Am J Physiol Heart Circ Physiol 2000, 279:H3020-3030.
29. Hayashida T, Poncelet AC, Hubchak SC, Schnapper HW: TGF-β1 activates MAP kinase in human mesangial cells: a possible role in collagen expression. Kidney Int 1999, 56:1710-1720.
30. Moriguchi Y, Matsubara H, Mori Y, et al.: Angiotensin II-induced transactivation of epidermal growth factor receptor regulates fibronectin and transforming growth factor-beta synthesis via transcriptional and posttranscriptional mechanisms. Circ Res 1999, 84:1073-1084.
31. Treisman R: Regulation of transcription by MAP kinase cascades. Curr Opin Cell Biol 1996, 8:205-215.
32. Deguchi J, Makuuchi M, Nakaoka T, et al.: Angiotensin II stimulates platelet-derived growth factor-B chain expression in newborn rat vascular smooth muscle cells and neointimal cells through Ras, extracellular signal-regulated protein kinase, and c-Jun N-terminal protein kinase mechanisms. Circ Res 1999, 85:565-574.
33. Tamura K, Nyui N, Tamura N, et al.: Mechanism of angiotensin II-mediated regulation of fibronectin gene in rat vascular smooth muscle cells. Biol Chem 1998, 273:26487-2649.6
34. Nahman NS, Rothe KL, Falkenhain ME, et al.: Angiotensin II induction of fibronectin biosynthesis in cultured human mesangial cells: association with CREB transcription factor activation. J Lab Clin Med 1996, 127:599-611.
35. Aoki H, Izumo S, Sadoshima J: Angiotensin II activates RhoA in cardiac myocytes: a critical role of RhoA in angiotensin II-induced premyofibril formation. Circ Res 1998, 82:666-676.
36. Johns DG, Dorrance AM, Leite R, et al.: Novel signaling pathways contributing to vascular changes in hypertension. J Biomed Sci 2000, 7:431-433.
37. Kataoka C, Egashira K, Inoue S, et al.: important role of Rho-kinase in the pathogenesis of cardiovascular inflammation and remodeling induced by long-term blockade of nitric oxide synthesis in rats. Hypertension 2002, 39:245-250.
38. Rupérez M, Blanco-Colio L, Lorenzo O, et al.: HMG-CoA reductase inhibitors regulate angiotensin II responses via rho proteins: modulation of connective tissue growth factor in vascular smooth muscle cells. Circulation 2002, In press.
39. Griendling KK, Ushio-Fukai M: Reactive oxygen species as mediators of angiotensin II signaling. Regul Pept 2000, 91:21-27.
40. Eguchi S, Inagami T: Signal transduction of angiotensin II type 1 receptor through receptor tyrosine kinase. Regul Pept 2000, 91:13-20.
41. Schneider A, Panzer U, Zahner G, et al.: Monocyte chemoattractant protein-1 mediates collagen deposition in experimental glomerulonephritis by transforming growth factor-b. Kidney Int 1999, 56:135-144.
42. Ortiz LA, Champion HC, Lasky JA, et al.: Enalapril protects mice from pulmonary hypertension by inhibiting TNF-mediated activation of NF-kappaB and AP-1. Am J Physiol Lung Cell Mol Physiol 2002, 282:L1209-L1221.
43. Muller DN, Dechend R, Mervaala EM, et al.: NF-kappaB inhibition ameliorates angiotensin II-induced inflammatory damage in rats. Hypertension 2000, 35:193-201.
44. Lorenzo O, Rupérez M, Esteban V, et al.: The AT2 receptor participates in the inflammatory cell recruitment during kidney damage. Role of NF-kB pathway. J Am Soc Nephrol 2002, 13:346.
45. Ruiz-Ortega M, Lorenzo O, Ruperez M, et al.: Role of AT1 and AT2 receptors in angiotensin II-induced nuclear transcription factor kB activation in vascular smooth muscle cells. Circ Res 2000, 86:1266-1272.
46. Ruiz-Ortega M, Lorenzo O, Ruperez M, et al.: Systemic infusion of angiotensin II into normal rats activates nuclear factor k-b and Ap-1 in the kidney. Role of AT1 and AT2 receptors. Am J Pathol 2001, 158:1743-1756.
47. Wolf G, Hannaken T, Burs K, et al.: Angiotensin II activates the NF-kB pathway through AT2 receptors. J Am Soc Nephrol 2000, 11:430.
48. Ruiz-Ortega M, Lorenzo O, Rupérez M, et al.: Angiotensin II activates nuclear transcription factor -kB in aorta of normal rats and in vascular smooth muscle cells of AT1 knockout mice. Nephrol Dial Transplant 2001, 16(Suppl 6):1-7
49. Ruiz-Ortega M, Lorenzo O, Egido J: Angiotensin III increases MCP-1 and activates NF-kappaB and AP-1 in cultured mesangial and mononuclear cells. Kidney Int 2000, 57:2285-2298.
50. Lorenzo O, Ruiz-Ortega M, Suzuki Y, et al.: Angiotensin III activates nuclear transcription factor-kb in cultured mesangial cells mainly via AT2 receptors: studies with AT1 receptor-knockout mice. J Am Soc Nephrol 2002, 13:1162-1171.
51. Wolf G, Ziyadeh FN, Thaiss F, et al.: Angiontensin II stimulates expression of the chemokine RANTES in rat glomerular endothelial cells. Role of the angiotensin type 2 receptor. J Clin Invest 1997, 100:1047-1058.
52. Akishita M, Horiuchi M, Yamada H, et al.: Inflammation influences vascular remodeling through AT2 receptor expression and signaling. Physiol Genomics 2000, 24:13-20.
53. Li JY, Avallet O, Berthelon MC, et al.: Transcriptional and translational regulation of angiotensin II type 2 receptor by angiotensin II and growth factors. Endocrinology 1999, 140:4988-4994.
54. Senbonmatsu T, Ichihara S, Price E Jr, et al.: Evidence for angiotensin II type 2 receptor-mediated cardiac myocyte enlargement during in vivo pressure overload. J Clin Invest 2000, 106:R25-R29.