Overexpression of cyclooxygenase-2 in gastric cancer correlates with the high abundance of vascular endothelial growth factor-C and lymphatic metastasis

Medical Oncology

Volumn 22, Issue 4, 2005, Pages 389-397

  Liu, Jin ^a   Yu, Hong Gang ^a   Yu, Jie Ping ^a   Wang, Xiao Ling ^a   Zhou, Xiao Dong ^a   Luo, He Sheng ^a  

^a RENMIN HOSPITAL OF WUHAN UNIVERSITY   (China)

Author keywords

Cyclooxygenase; Immunohistochemistry; Metastasis; Reverse transcription polymerase chain reaction; Stomach neoplasms; Vascular endothelial growth factor

Indexed keywords

BETA ACTIN; CYCLOOXYGENASE 2; MESSENGER RNA; VASCULOTROPIN C; TUMOR MARKER; VASCULAR ENDOTHELIAL GROWTH FACTOR C, HUMAN;

ADULT; AGED; ARTICLE; CANCER INVASION; CONTROLLED STUDY; CORRELATION ANALYSIS; FEMALE; GENE OVEREXPRESSION; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LYMPH NODE METASTASIS; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DETERMINATION; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA ANALYSIS; SAMPLING; STANDARD; STOMACH CANCER; STOMACH MUCOSA; ADENOCARCINOMA; BIOSYNTHESIS; GENE EXPRESSION; GENETICS; METABOLISM; MIDDLE AGED; PATHOLOGY; STOMACH TUMOR;

ADENOCARCINOMA; ADULT; AGED; AGED, 80 AND OVER; CYCLOOXYGENASE 2; FEMALE; GENE EXPRESSION; HUMANS; IMMUNOHISTOCHEMISTRY; LYMPHATIC METASTASIS; MALE; MIDDLE AGED; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; STOMACH NEOPLASMS; TUMOR MARKERS, BIOLOGICAL; VASCULAR ENDOTHELIAL GROWTH FACTOR C;

EID: 33644834225     PISSN: 13570560     EISSN: None     Source Type: Journal    
DOI: 10.1385/MO:22:4:389     Document Type: Article

References (29)

1. Fosslien E. Molecular pathology of cyclooxygenase-2 in neoplasia. Ann Clin Lab Sci 2000; 90(1):3-21.
2. Fujiwaki R, et al. Cyclooxygenase-2 expression in endometrial cancer: correlation with microvessel count and expression of vascular endothelial growth factor and thymidine phosphorylase. Hum Pathol 2002; 33(2):213-219.
3. Tsujii M, et al. Cyclooxygenase regulates angiogenesis induced by colon cancer cells. Cell 1998; 93:705-716.
4. Uefuji K, Ichikura T, Mochizuki H. Cyclooxygenase-2 expression is related to prostaglandin biosynthesis and angiogenesis in human gastric cancer. Clin Cancer Res 2000; 6:135-138.
5. Koga T, et al. Overexpression of cyclooxygenase-2 and tumor angiogenesis in human gastric cancer. Hepatogastroenterology 2004; 51(60):1626-1630.
6. Jaeckel EC, et al. Correlation of expression of cyclooxygenase-2, vascular endothelial growth factor, and peroxisome proliferator-activated receptor delta with head and neck squamous cell carcinoma. Arch Otolaryngol Head Neck Surg 2001; 127(10):1253-1259.
7. Kawabe A, et al. Expression of cyclooxygenase-2 in primary and remnant gastric carcinoma: comparing it with p53 accumulation, Helicobacter pylori infection, and vascular endothelial growth factor expression. J Surg Oncol 2002; 80(2):79-88.
8. Kim MH, et al. Expression of cyclooxygenase-1 and -2 associated with expression of VEGF in primary cervical cancer and at metastatic lymph nodes. Gynecol Oncol 2003; 90(1):83-90.
9. Lim SC. Role of COX-2, VEGF and cyclin D1 in mammary infiltrating duct carcinoma. Oncol Rep 2003; 10(5):1241-1249.
10. Yu H-G, et al. Increased abundance of cyclooxygenase-2 correlates with vascular endothelial growth factor-A abundance and tumor angiogenesis in gastric cancer. Cancer Lett 2003; 195:43-51.
11. Clauss M. Molecular biology of the VEGF and the VEGF receptor family. Semin Thromb Hemost 2000; 26(5):561-569.
12. Li X, Eriksson U. Novel VEGF family members: VEGF-B, VEGF-C and VEGF-D. Intern J Biochem Cell Biol 2001; 33:421-426.
13. Yonemura Y, et al. Role of vascular endothelial growth factor C expression in the development of lymph node metastasis in gastric cancer. Clin Cancer Res 1999; 5:1823-1829.
14. Skobe M, et al. Induction of tumor lymphangiogenesis by VEGF-C promotes breast cancer metastasis. Nat Med 2001; 7:192-198.
15. Morilla-Grasa A, et al. The expression of cyclooxygenase-2 (COX-2) in an animal model of primary and metastatic human uveal melanoma. Invest Ophthalmol Vis Sci 2002; 43:1135.
16. Goulet AC, et al. Analysis of cyclooxygenase 2 (COX-2) expression during malignant melanoma progression. Cancer Biol Ther 2003; 2(6):713-718.
17. Sheeham K, et al. The relationship between cyclooxygenase-2 expression and colorectal cancer. JAMA 1999; 282:1254-1257.
18. Soumaoro T, et al. Cyclooxygenase-2 expression a significant prognostic indicator for patients with colorectal cancer labile. Clin Cancer Res 2004; 10:8465-8471.
19. Shoji T, et al. Orthotopic implantation of a colon cancer xenograft induces high expression of cyclooxygenase-2. Cancer Lett 2003; 195(2):235-241.
20. Esteban Castelao J, et al. Lung cancer and cyclooxygenase-2. Ann Thorac Surg 2003; 76:1327-1335.
21. Soslow RA, et al. COX-2 is expressed in human pulmonary, colonic, and mammary tumors. Cancer (Phila.) 2000; 89:2637-2645.
22. Ristimäki A, Narko K, Enholm B, Joukov V, Alitalo K. Proinflammatory cytokines regulate expression of the lymphatic endothelial mitogen vascular endothelial growth factor-C. J Biol Chem 1998; 273(14):8413-8418.
23. Kishimoto K, et al. Expression of vascular endothelial growth factor-C predicts regional lymph node metastasis in early oral squamous cell carcinoma. Oral Oncol 2003; 39(4):391-396.
24. Kawakami M, et al. Quantification of vascular endothelial growth factor-C and its receptor-3 messenger RNA with real-time quantitative polymerase chain reaction as a predictor of lymph node metastasis in human colorectal cancer. Surgery 2003; 133(3):300-308.
25. Ishikawa M, Kitayama J, Kazama S, Nagawa H. Expression of vascular endothelial growth factor C and D (VEGF-C and -D) is an important risk factor for lymphatic metastasis in undifferentiated early gastric carcinoma. Jpn J Clin Oncol 2003; 33(1):21-27.
26. Tsujii M, Kawano S, DuBois RN. Cyclooxygenase-2 expression in human colon cancer cells increases metastatic potential. Proc Natl Acad Sci USA 1997; 94:3336-3340.
27. Symowicz J, et al. Cyclooxygenase-2 functions as a down-stream mediator of lysophosphatidic acid to promote aggressive behavior in ovarian carcinoma cells. Cancer Res 2005; 15(65):2234-2242.
28. Kyzas PA, Stefanou D, Agnantis NJ. COX-2 expression correlates with VEGF-C and lymph node metastases in patients with head and neck squamous cell carcinoma. Mod Pathol 2005; 18(1):153-160.
29. Su J-L, et al. Cyclooxygenase-2 induces EP1- and HER-2/Neu-dependent vascular endothelial growth factor-C upregulation: a novel mechanism of lymphangiogenesis in lung adenocarcinoma. Cancer Res 2004; 64:554-564.