Lack of lymphatic vascular specificity of vascular endothelial growth factor receptor 3 in 185 vascular tumors

Cancer

Volumn 86, Issue 11, 1999, Pages 2406-2412

  Partanen, Taina A ^a   Alitalo, Kari ^a   Miettinen, Markku ^b  

^a UNIVERSITY OF HELSINKI   (Finland)

^b ARMED FORCES INSTITUTE OF PATHOLOGY   (United States)

Author keywords

Angiosarcoma; Hemangioendothelioma; Hemangioma; Lymphangioma; Vascular endothelial growth factor receptor 3 (VEGFR 3)

Indexed keywords

AVIDIN; BIOTIN; MONOCLONAL ANTIBODY; PEROXIDASE; VASCULOTROPIN RECEPTOR;

ADULT; AGED; ANGIOSARCOMA; ARTICLE; CAPILLARY HEMANGIOMA; CONTROLLED STUDY; ENDOTHELIUM CELL; FEMALE; HEMANGIOENDOTHELIOMA; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; KAPOSI SARCOMA; LYMPH VESSEL; LYMPHANGIOMA; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; SCHOOL CHILD; TISSUE DISTRIBUTION; TISSUE SPECIFICITY; TUMOR DIFFERENTIATION; TUMOR VASCULARIZATION; VASCULAR TUMOR;

EPITOPES; HEMANGIOMA; HEMANGIOSARCOMA; HUMANS; IMMUNOHISTOCHEMISTRY; LYMPHANGIOMA; NEOPLASMS, VASCULAR TISSUE; NEOVASCULARIZATION, PATHOLOGIC; RECEPTOR PROTEIN-TYROSINE KINASES; RECEPTORS, CELL SURFACE; SENSITIVITY AND SPECIFICITY; TISSUE DISTRIBUTION; TUMOR MARKERS, BIOLOGICAL; VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-3;

EID: 0033451902     PISSN: 0008543X     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-0142(19991201)86:11<2406::AID-CNCR31>3.0.CO;2-E     Document Type: Article

References (28)

1. Enzinger FM, Weiss SW. Soft tissue tumors. 3rd edition. St. Louis: C.V. Mosby Co., 1995:579-676.
2. Ramani P, Bradley NJ, Fletcher CD. QBEND/10, a new monoclonal antibody to endothelium: assessment of its diagnostic utility in paraffin sections. Histopathology 1990;17:237-42.
3. Traweek ST, Kandalaft PL, Mehta P, Battifora H. The human hematopoietic progenitor cell antigen (CD34) in vascular neoplasia. Am J Clin Pathol 1991;96:25-31.
4. van de Rijn M, Rouse RV. CD 34. A review. Appl Immunohistochem 1994;2:71-80.
5. Ohsawa M, Naka N, Tomita Y, Kawamori D, Kanno H, Aozasa K. Use of immunohistochemical procedures in diagnosing angiosarcoma. Cancer 1995;75:2867-74.
6. Kuzu I, Bicknell R, Harris AL, Jones M, Gatter KC, Mason DY. Heteogeneity of vascular endothelial cells with relevance to diagnosis of vascular tumours. J Clin Pathol 1992;455:143-8.
7. De Young BR, Wick MR, Fitzgibbon JF. CD31: an immunospecific marker for endothelial differentiation human neoplasms. Appl Immunohistochem 1993;1:97-100.
8. Miettinen M, Lindenmayer AE, Chaubal A. Endothelial cell markers CD31, CD34, and BNH9 antibody to H- and Y-antigens: evaluation of their specificity and sensitivity in the diagnosis of vascular tumors and comparison with von Willebrand's factor. Mod Pathol 1994;7:82-90.
9. Aziza J, Mazerolles C, Seleves J, Voigt J-J, Gorguet B, Szekeres G, et al. Comparison of the reactivities of monoclonal antibodies QBEND10 (CD34) and BNH9 in vascular tumors. Appl Immunohistochem 1993;1:51-5.
10. Risau W. Development and differentiation of endothelium. Kidney Int Suppl 1998;67:S3-6.
11. Dumont DJ, Jussila L, Taipale J, Lymboussaki A, Mustonen T, Pajusola K, et al. Cardiovascular failure in mouse embryos deficient in VEGF receptor 3. Science 1998:282:946-9.
12. Joukov V, Pajusola K, Kaipainen A, Chilov D, Lahtinen I, Kukk E, et al. Novel vascular endothelial growth factor VEGF-C is a ligand for the FLT-4 (VEGFR-3) and KDR (VEGFR-2) receptor receptor tyrosine kinases. EMBO J 1996; 15:290-8.
13. Lee J, Gray A, Yan J, Luoh S-M, Avraham H, Hood WOD. Vascular endothelial growth factor-related protein: ligand and specific activator of the tyrosine kinase receptor FLT4. Proc Natl Acad Sci USA 1996;93:1988-92.
14. Yamada Y, Netsu J, Chimane M, Hirata Y. Molecular cloning of a novel vascular endothelial growth factor, VEGF-D. Genomics 1997;42:483-8.
15. Achen MG, Jeltsch M, Kukk E, Mäkinen T, Vitali A, Wilks AF, et al. Vascular endothelial growth factor D (VEGFD) is a ligand for the tyrosine kinases VEGF receptor 2 (Flk1) and VEGF receptor 3 (Flt4). Proc Natl Acad Sci USA 1998;95:548-53.
16. Kaipainen A, Korhonen J, Mustonen T, Van Hinsberg V, Fang G, Dumont D, et al. Expression of the fms-like tyrosine kinase 4 gene becomes restricted to lymphatic endothelium during development. Proc Natl Acad Sci USA 1995;92:2566-70.
17. Kukk E, Lymboussaki A, Taira S, Kaipainen A, Jeltsch M, Joukov V, et al. VEGF-C receptor binding and pattern of expression with VEGFR-3 suggests a role in lymphatic vascular development. Development 1996;122:3829-37.
18. Lymboussaki A, Partanen TA, Olofsson B, Thomas-Crusells I, Fletcher CDM, de Waal RMW, et al. Expression of the vascular endothelial growth factor C receptor VEGFR-3 in lymphatic endothelium of the skin and in vascular tumors. Am J Pathol 1998;153:395-403.
19. Jussila L, Valtola R, Partanen TA, Salven P, Heikkilä P, Matikainen MT, et al. Lymphatic endothelium and Kaposi's sarcoma spindle cells detected by antibodies against the vascular endothelial growth factor receptor-3. Cancer Res 1998;58:1599-604.
20. Mills SE, Cooper PH, Fechner RE. Lobular capillary hemangioma: the underlying lesion of pyogenic granuloma. Am J Surg Pathol 1980;4:471-5.
21. Perkins P, Weiss SW. Spindle cell hemangioendothelioma. An analysis of 78 cases with reassessment of its pathogenesis and biologic behavior. Am J Surg Pathol 1996;20:1196-204.
22. Zukerberg LR, Nickoloff BJ, Weiss SW. Kaposiform hemangioendothelioma of infancy and childhood. An aggressive neoplasm associated with Kasabach-Merritt syndrome and lymphangiomatosis. Am J Surg Pathol 1993;17:321-8.
23. Weiss SW, Ishak K, Dail DH, Sweet DE, Enzinger FM. Epithelioid hemangioendothelioma and related lesions. Semin Diagn Pathol 1986;3:259-87.
24. Fletcher CDM, Beham A, Bekir S, Clarke AMT, Marley JNE. Epithelioid angiosarcoma of deep soft tissue: a distinctive tumor readily mistaken for an epithelial neoplasm. Am J Surg Pathol 1991;15:915-24.
25. Rosai J, Gold J, Landy R. The histiocytoid hemangiomas. A unifying concept embracing several previously described entities of skin, soft tissue, large vessels, bone and heart. Hum Pathol 1979;10:707-30.
26. Hashimoto H, Ohsawa M, Ohnishi A, Naka N, Hirota S, Kitamura Y, et al. Expression of vascular endothelial growth factor and its receptor mRNA in angiosarcoma. Lab Invest 1995;73:859-63.
27. Brown LF, Tognazzi K, Dvorak H, Harrist TJ. Strong expression of kinase insert domain-containing receptor, a vascular permeability factor/vascular endothelial growth factor receptor in AIDS-associated Kaposi's sarcoma and cutaneous angiosarcoma. Am J Pathol 1996;148:1065-74.
28. Zietz C, Rössle M, Haas C, Sendelhofert A, Hirschmann A, Stürzl M, et al. MDM-2 oncoprotein overexpression, p53 gene mutation and VEGF up-regulation in angiosarcomas. Am J Pathol 1998;153:1425-33.