Characterization of a novel inhibitor of cytosolic phospholipase A2α, pyrrophenone

Biochemical Journal

Volumn 363, Issue 3, 2002, Pages 727-735

  Ono, Takashi ^a   Yamada, Katsutoshi ^a   Chikazawa, Yukiko ^a   Ueno, Masahiko ^a   Nakamoto, Shozo ^a   Okuno, Takayuki ^a   Seno, Kaoru ^a  

^a SHIONOGI AND CO LTD   (Japan)

Author keywords

Arachidonic acid release; CPLA2 ; Cytosolic PLA2 ; Inhibitor

Indexed keywords

BIOASSAY; BIOSYNTHESIS; CELLS; ENZYME INHIBITION;

INHIBITORY POTENCIES;

BIOCHEMISTRY;

ANTIINFLAMMATORY AGENT; ARACHIDONIC ACID; ARACHIDONYL TRIFLUOROMETHYL KETONE; CALCIMYCIN; ESTERASE; INTERLEUKIN 1BETA; LIPOXYGENASE; LYSOPHOSPHOLIPASE; PHOSPHOLIPASE A2; PHOSPHOLIPASE A2 INHIBITOR; PROSTAGLANDIN E2; PROSTAGLANDIN SYNTHASE; PYRROLIDINE DERIVATIVE; PYRROPHENONE; UNCLASSIFIED DRUG;

ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONTROLLED STUDY; CYTOSOL; ENZYME INHIBITION; HUMAN; HUMAN CELL; ICOSANOID METABOLISM; INFLAMMATORY DISEASE; MESANGIUM CELL; MONOCYTE; PRIORITY JOURNAL; PROSTAGLANDIN SYNTHESIS;

ARACHIDONIC ACID; CALCIMYCIN; CELL LINE; CRYSTALLOGRAPHY, X-RAY; CYTOSOL; DINOPROSTONE; ENZYME INHIBITORS; GLOMERULAR MESANGIUM; HUMANS; INTERLEUKIN-1; IONOPHORES; LIPOLYSIS; PHOSPHOLIPASES A; PYRROLIDINES;

EID: 0036566182     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/0264-6021:3630727     Document Type: Article

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