A general method for C3 reductive alkylation of indoles

Tetrahedron Letters

Volumn 44, Issue 24, 2003, Pages 4589-4591

  Mahadevan, Anu ^a   Sard, Howard ^a   Gonzalez, Mario ^a   McKew, John C ^b  

^a ORGANIX INC   (United States)

^b PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INDOLE DERIVATIVE;

ALKYLATION; ARTICLE; CHEMICAL REACTION; PROTON NUCLEAR MAGNETIC RESONANCE; REDUCTION; THIN LAYER CHROMATOGRAPHY;

EID: 0038741975     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0040-4039(03)01010-4     Document Type: Article

References (14)

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11. 19BrClN: C, 60.58; H, 5.08; N, 3.72. Found: C, 60.71; H, 5.08; N, 3.62.
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14. 3 dialkylated indole was formed. The desired product was difficult to separate from the dialkylated product and the resulting mixture was used in the reductive alkylation reaction. The yield on these reactions is thus based upon the amount of aldehyde used.