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Bioorganic and Medicinal Chemistry Letters

Volumn 16, Issue 4, 2006, Pages 938-942

Synthesis and structure-activity relationships of novel poly(ADP-ribose) polymerase-1 inhibitors

(7) Tao, Ming a Park, Chung Ho a Bihovsky, Ron a,b Wells, Gregory J a Husten, Jean a Ator, Mark A a Hudkins, Robert L a

a CEPHALON INC (United States)

b Key Synthesis LLC (United States)

Author keywords

PARP 1 inhibitors; Pyrrolocarbazoles

Indexed keywords

CARBAZOLE DERIVATIVE; IMIDE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE 1; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE INHIBITOR; PYRROLOCARBAZOLE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CRYSTAL STRUCTURE; DIELS ALDER REACTION; DRUG ACTIVITY; DRUG IDENTIFICATION; DRUG SYNTHESIS; IC 50; STRUCTURE ACTIVITY RELATION; X RAY CRYSTALLOGRAPHY;

CARBAZOLES; CRYSTALLOGRAPHY, X-RAY; ENZYME INHIBITORS; HUMANS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; POLY(ADP-RIBOSE) POLYMERASES; STRUCTURE-ACTIVITY RELATIONSHIP;

BETULACEAE;

EID: 30344446655 PISSN: 0960894X EISSN: None Source Type: Journal
DOI: 10.1016/j.bmcl.2005.10.099 Document Type: Article

Times cited : (47)

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