The Cullin3 ubiquitin ligase functions as a Nedd8-bound heterodimer

Molecular Biology of the Cell

Volumn 18, Issue 3, 2007, Pages 899-909

  Wimuttisuk, Wananit ^a   Singer, Jeffrey D ^a  

^a BROWN UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CULLIN; HETERODIMER; MUTANT PROTEIN; NEDD8 PROTEIN; PROTEIN BTB; PROTEIN CUL3; PROTEIN RBX1; PROTEIN SUBUNIT; UBIQUITIN CONJUGATING ENZYME; UBIQUITIN PROTEIN LIGASE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CARBOXY TERMINAL SEQUENCE; COMPLEX FORMATION; CONTROLLED STUDY; DIMERIZATION; ENZYME ACTIVATION; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME SPECIFICITY; ENZYME SUBSTRATE COMPLEX; ENZYME SUBUNIT; HUMAN; HUMAN CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; REGULATORY MECHANISM;

AMINO ACID SEQUENCE; ANIMALS; CHO CELLS; CRICETINAE; CRICETULUS; CULLIN PROTEINS; CYCLIN E; DIMERIZATION; HUMANS; HYDROPHOBICITY; MODELS, BIOLOGICAL; MOLECULAR SEQUENCE DATA; MUTANT PROTEINS; PROTEIN BINDING; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; SACCHAROMYCES CEREVISIAE; UBIQUITINS;

EID: 33947107495     PISSN: 10591524     EISSN: None     Source Type: Journal    
DOI: 10.1091/mbc.E06-06-0542     Document Type: Article

References (53)

1. Angers, S., Thorpe, C. J., Biechele, T. L., Goldenberg, S. J., Zheng, N., MacCoss, M. J., and Moon, R. T. (2006). The KLHL12-Cullin-3 ubiquitin ligase negatively regulates the Wnt-beta-catenin pathway by targeting Dishevelled for degradation. Nat. Cell Biol. 8, 348-357.
2. Ciechanover, A., Heller, H., Elias, S., Haas, A. L., and Hershko, A. (1980). ATP-dependent conjugation of reticulocyte proteins with the polypeptide required for protein degradation. Proc. Natl. Acad. Sci. USA. 77, 1365-1368.
3. Clurman, B. E., Sheaff, R. J., Thress, K., Groudine, M., and Roberts, J. M. (1996). Turnover of cyclin E by the ubiquitin-proteasome pathway is regulated by cdk2 binding and cyclin phosphorylation. Genes Dev. 10, 1979-1990.
4. Cope, G. A., Suh, G. S., Aravind, L., Schwarz, S. E., Zipursky, S. L., Koonin, E. V., and Deshaies, R. J. (2002). Role of predicted metalloprotease motif of Jab1/Csn5 in cleavage of Nedd8 from Cul1. Science 298, 608-611.
5. Geyer, R., Wee, S., Anderson, S., Yates, J., and Wolf, D. A. (2003). BTB/POZ domain proteins are putative substrate adaptors for Cullin 3 ubiquitin ligases. Mol. Cell 12, 783-790.
6. Glickman, M. H., and Cienchanover, A. (2002). The ubiquitin-proteasome proteolytic pathway: destruction for the sake of construction. Physiol. Rev. 82, 373-428.
7. Handeli, S., and Weintraub, H. (1992). The ts41 mutation in Chinese hamster cells leads to successive S phases in the absence of intervening G2, M, and G1. Cell 71, 599-611.
8. Hernandez-Munoz, I., Lund, A. H., van der Stoop, P., Boutsma, E., Muijrers, I., Verhoeven, E., Nusinow, D. A., Panning, B., Marahrens, Y., and van Lohuizen, M. (2005). Stable X chromosome inactivation involves the PRC1 Polycomb complex and requires histone MACROH2A1 and the CULLIN3/ SPOP ubiquitin E3 ligase. Proc. Natl. Acad Sci. USA 102, 7635-7640.
9. Hershko, A., and Ciechanover, A. (1998). The ubiquitin system. Annu. Rev. Biochem. 67, 425-479.
10. Hori, T., Osaka, F., Chiba, T., Miyamoto, C., Okabayashi, K., Shimbara, N., Kato, S., and Tanaka, K. (1999). Covalent modification of all members of human cullin family proteins by NEDD8. Oncogene 18, 6829-6834.
11. Kamitani, T., Nguyen, H. P., Kito, K., Fukuda-Kamitani, T., and Yeh, E. T. (1998). Covalent modification of PML by the sentrin family of ubiquitin-like proteins. J. Biol. Chem. 273, 3117-3120.
12. Kang, R. S., Daniels, C. M., Francis, S. A., Shih, S. C., Salerno, W. J., Hicke, L., and Radhakrishnan, I. (2003). Solution structure of a CUE-ubiquitin complex reveals a conserved mode of ubiquitin binding. Cell 113, 621-630.
13. Kawakami, T. et al. (2001). NEDD8 recruits E2-ubiquitin to SCF E3 ligase. EMBO J. 20, 4003-4012.
14. Kurz, T., Pintard, L., Willis, J. H., Hamill, D. R., Gonczy, P., Peter, M., and Bowerman, B. (2002). Cytoskeletal regulation by the Nedd8 ubiquitin-like protein modification pathway. Science 295, 1294-1298.
15. Kwon, J. E. et al. (2006). BTB domain-containing speckle-type POZ protein (SPOP) serves as an adaptor of Daxx for ubiquitination by Cul3-based ubiquitin ligase. J. Biol. Chem. 281, 12664-12672.
16. Lammer, D., Mathias, N., Laplaza, J. M., Jiang, W., Liu, Y., Callis, J., Goebl, M., and Estelle, M. (1998). Modification of yeast Cdc53p by the ubiquitin-related protein rub1p affects function of the SCFCdc4 complex. Genes Dev. 12, 914-926.
17. Lyapina, S., Cope, G., Shevchenko, A., Serino, G., Tsuge, T., Zhou, C., Wolf, D. A., Wei, N., and Deshaies, R. J. (2001). Promotion of NEDD-CUL1 conjugate cleavage by COP9 signalosome. Science 292, 1382-1385.
18. Lykke-Andersen, K., Schaefer, L., Menon, S., Deng, X. W., Miller, J. B., and Wei N. (2003). Disruption of the COP9 signalosome Csn2 subunit in mice causes deficient cell proliferation, accumulation of p53 and cyclin E., and early embryonic death. Mol. Cell Biol. 23, 6790-6797.
19. Mueller, T. D., and Feigon, J. (2002). Solution structures of UBA domains reveal a conserved hydrophobic surface for protein-protein interactions. J. Mol. Biol. 319, 1243-1255.
20. Ohh, M., Kim, W. Y., Moslehi, J. J., Chen, Y., Chau, V., Read, M. A., and Kaelin, W. G., Jr. (2002). An intact NEDD8 pathway is required for Cullin-dependent ubiquitylation in mammalian cells. EMBO Rep. 3, 177-182.
21. Ohta, T., Michel, J. J., and Xiong, Y. (1999). Association with cullin partners protects ROC proteins from proteasome-dependent degradation. Oncogene 18, 6758-6766.
22. Osaka, F., Kawasaki, H., Aida, N., Saeki, M., Chiba, T., Kawashima, S., Tanaka, K., and Kato, S. (1998). A new NEDD8-ligating system for cullin-4A. Genes Dev. 12, 2263-2268.
23. Ou, C.-Y., Lin, Y.-F., Chen, Y.-J., and Chien, C.-T. (2002). Distinct protein degradation mechanisms mediated by Cul1 and Cul3 controlling Ci stability in Drosophila eye development. Genes Dev. 16, 2401-2414.
24. Pan, Z. Q., Kentsis, A., Dias, D. C., Yamoah, K., and Wu, K. (2004). Nedd 8 on cullin: building an expressway to protein destruction. Oncogene 23, 1985-1997.
25. Parry, G., and Estelle, M. (2004). Regulation of cullin-based ubiquitin ligases by the Nedd8/RUB ubiquitin-like proteins. Semin. Cell Dev. Biol. 15, 221-229.
26. Petroski, M. D., and Deshaies, R. J. (2005). Function and regulation of cullin-RING ubiquitin ligases. Nat. Rev. Mol. Cell Biol. 6, 9-20.
27. Pines, J., and Lindon, C. (2005). Proteolysis: anytime, any place, anywhere? Nat. Cell Biol. 7, 731-735.
28. Pintard, L., Kurz, T., Glaser, S., Willis, J. H., Peter, M., and Bowerman, B. (2003a). Neddylation and deneddylation of Cul-3 is required to target MEI-1/Katenin for degradation at the meiosis-to-mitosis transition in C. elegans. Curr. Biol. 13, 911-921.
29. Pintard, L., Willems, A., and Peter, M. (2004). Cullin-based ubiquitin ligases: Cul3-BTB complexes join the family. EMBO J. 23, 1681-1687.
30. Pintard, L. et al. (2003b). The BTB protein MEL-26 is a substrate-specific adaptor of the CUL-3 ubiquitin-ligase. Nature 425, 311-316.
31. Prag, G., Misra, S., Jones, E. A., Ghirlando, R., Davies, B. A., Horazdovsky, B. F., and Hurley, J. H. (2003). Mechanism of ubiquitin recognition by the CUE domain of Vps9p. Cell 113, 609-620.
32. Robinson, D. N., and Cooley, L. (1997). Drosophila kelch is an oligomeric ring canal actin organizer. J. Cell Biol. 138, 799-810.
33. Schwechheimer, C., and Deng, X. W. (2000). The COP/DET/FUS proteins-regulators of eukaryotic growth and development. Semin. Cell Dev. Biol. 11, 495-503.
34. Schwechheimer, C., and Deng, X. W. (2001). COP9 signalosome revisited: a novel mediator of protein degradation. Trends Cell Biol. 11, 420-426.
35. Seol, J. H. et al. (1999). Cdc53/cullin and the essential Hrt1 RING-H2 subunit of SCF define a ubiquitin ligase module that activates the E2 enzyme Cdc34. Genes Dev. 13, 1614-1626.
36. Cip1 ubiquitination. Mol. Cell 4, 403-410.
37. Shih, S. C., Prag, G., Francis, S. A., Sutanto, M. A., Hurley, J. H., and Hicke, L. (2003). A ubiquitin-binding motif required for intramolecular monoubiquitylation, the CUE domain. EMBO J. 22, 1273-1281.
38. Singer, J. D., Gurian-West, M., Clurman, B., and Roberts, J. M. (1999). Cullin-3 targets cyclin E for ubiquitination and controls S phase in mammalian cells. Genes Dev. 13, 2375-2387.
39. Stogios, P. J., Downs, G. S., Jauhal, J. J., Nandra, S. K., and Prive, G. G. (2005). Sequence and structural analysis of BTB domain proteins. Genome Biol. 6, R82.
40. Tateishi, K., Omata, M., Tanaka, K., and Chiba, T. (2001). The NEDD8 system is essential for cell cycle progression and morphogenetic pathway in mice. J. Cell Biol. 155, 571-579.
41. Torii, K. U., McNellis, T. W., and Deng, X. W. (1998). Functional dissection of Arabidopsis COP1 reveals specific roles of its three structural modules in light control of seedling development. EMBO J. 17, 5577-5587.
42. Wada, H., Yeh, E. T., and Kamitani, T. (1999). Identification of NEDD8-conjugation site in human cullin-2. Biochem. Biophys. Res. Commun. 257, 100-105.
43. Wilkinson, C. R., Seeger, M., Hartmann-Petersen, R., Stone, M., Wallace, M., Semple, C., and Gordon, C. (2001). Proteins containing the UBA domain are able to bind to multi-ubiquitin chains. Nat. Cell Biol. 3, 939-943.
44. Wu, K., Chen, A., and Pan, Z. Q. (2000). Conjugation of Nedd8 to CUL1 enhances the ability of the ROC1-CUL1 complex to promote ubiquitin polymerization. J. Biol. Chem. 275, 32317-32324.
45. Wu, K., Chen, A., Tan, P., and Pan, Z. Q. (2002). The Nedd8-conjugated ROC1-CUL1 core ubiquitin ligase utilizes Nedd8 charged surface residues for efficient polyubiquitin chain assembly catalyzed by Cdc34. J. Biol. Chem. 277, 516-527.
46. Xu, L., Liu, F., Lechner, E., Genschik, P., Crosby, W. L., Ma, H., Peng, W., Huang, D., and Xie, D. (2002). The SCF(COI1) ubiquitin-ligase complexes are required for jasmonate response in Arabidopsis. Plant Cell 14, 1919-1935.
47. Xu, L., Yue, Y., Reboul, J., Vaglio, P., Shin, T.-H., Vidal, M., Elledge, S. J., and Harper, J. W. (2003). BTB proteins are substrate-specific adaptors in an SCF-like modular ubiquitin ligase containing CUL-3. Nature 425, 316-321.
48. Zhang, D. D., Lo, S. C., Cross, J. V., Templeton, D. J., and Hannink, M. (2004). Keap1 is a redox-regulated substrate adaptor protein for a Cul3-dependent ubiquitin ligase complex. Mol. Cell. Biol. 24, 10941-10953.
49. Zhang, Q., Zhang, L., Wang, B., Ou, C. Y., Chien, C. T., and Jiang, J. (2006). A Hedgehog-induced BTB protein modulates Hedgehog signaling by degrading Ci/Gli transcription factor. Dev. Cell 10, 719-729.
50. Zheng, N. et al. (2002). Structure of the Cul1-Rbx1-Skp1-F boxSkp2 SCF ubiquitin ligase complex. Nature 416, 703-709.
51. Zhou, C., Seibert, V., Geyer, R., Rhee, E., Lyapina, S., Cope, G., Deshaies, R. J., and Wolf, D. A. (2001). The fission yeast COP9/signalosome is involved in cullin modification by ubiquitin-related Ned8p. BMC Biochem. 2, 7.
52. Zhou, C., Wee, S., Rhee, E., Naumann, M., Dubiel, W., and Wolf, D. A. (2003). Fission yeast COP9/signalosome suppresses cullin activity through recruitment of the deubiquitylating enzyme Ubp12p. Mol. Cell 11, 927-938.
53. Zhu, S., Perez, R., Pan, M., and Lee, T. (2005). Requirement of Cul3 for axonal arborization and dendritic elaboration in Drosophila mushroom body neurons. J. Neurosci. 25, 4189-4197.