Oxidative stress, histone deacetylase and corticosteroid resistance in severe asthma and COPD

Current Respiratory Medicine Reviews

Volumn 3, Issue 1, 2007, Pages 57-68

  Adenuga, David ^a   Rahman, Irfan ^a  

^a UNIVERSITY OF ROCHESTER MEDICAL CENTER   (United States)

Author keywords

Cigarette smoke; COPD; Glucocorticoids; Histone acetylation; Histone deacetylase; NF B; Polyphenols

Indexed keywords

ALDEHYDE; CIGARETTE SMOKE; CORTICOSTEROID; CURCUMIN; GLUCOCORTICOID; GLUCOCORTICOID RECEPTOR; HISTONE; HISTONE DEACETYLASE; HISTONE DEACETYLASE 2; HORMONE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; MITOGEN ACTIVATED PROTEIN KINASE P38 INHIBITOR; NITRIC OXIDE; OXIDIZING AGENT; POLYPHENOL; STRESS ACTIVATED PROTEIN KINASE; THEOPHYLLINE; TRANSCRIPTION FACTOR AP 1;

ACETYLATION; ASTHMA; CHROMATIN ASSEMBLY AND DISASSEMBLY; CHRONIC OBSTRUCTIVE LUNG DISEASE; DEACETYLATION; DISEASE SEVERITY; DRUG EFFICACY; ENZYME ACTIVATION; ENZYME INHIBITION; GENE ACTIVITY; GENE EXPRESSION; GENE SWITCHING; HUMAN; INFLAMMATION; MEDIATOR; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN PROCESSING; REVIEW; STEROID THERAPY;

EID: 33847674059     PISSN: 1573398X     EISSN: None     Source Type: Journal    
DOI: 10.2174/157339807779941857     Document Type: Review

References (64)

1. Halliwell B. Reactive oxygen species in living systems: source, biochemistry, and role in human disease. Am J Med 1991; 91: 14S-22S.
2. Halliwell B and Gutteridge JMC. Free radicals in biology and medicine. Clarendon Press Oxford, Second Ed 1989; 1-20.
3. Kinnula VL, Crapo JD and Raivio KO. Biology of disease: generation and disposal of reactive oxygen metabolites in the lung. Lab Invest 1995; 73: 3-19.
4. Winterbourn CC, and Kettle AJ. Biomarkers of myeloperoxidase-derived hypochlorous acid. Free Radic Biol Med 2000; 29: 403-409.
5. Van Dalen CJ. and Kettle AJ. Substrates and products of eosinophil peroxidase. Biochem J 2001; 358: 233-239.
6. Kinnula VL, Chang L, Everitt JI and Crapo JD. Oxidants and antioxidants in alveolar epithelial type II cells: in situ, freshly isolated, and cultured cells. Am J Physiol 1992; 262: L69-77.
7. Rahman I and MacNee W. Role of oxidants/antioxidants in smoking-induced airways diseases. Free Rad Biol Med 1996; 21: 669-81.
8. Rahman I and MacNee W. Lung glutathione and oxidative stress: Implications in cigarette smoke-induced airways disease. Am J Physiol 1999; 277: L1067-L1088.
9. Church T and Pryor WA. Free radical chemistry of cigarette smoke and its toxicological implications. Environ Health Perspect 1985; 64: 111-26.
10. Pryor WA and Stone K. Oxidants in cigarette smoke: radicals, hydrogen peroxides, peroxynitrate, and peroxynitrite. Annals N Y Acad Sci 1993; 686: 12-28.
11. Morrison D, Rahman I, Lannan S and MacNee W. Epithelial permeability, inflammation and oxidant stress in the airspaces of smokers. Am J Respir Crit Care Med 1999; 159: 473-79.
12. Uchida K, Shiraishi M, Naito Y, Torii N, Nakamura Y, Osawa T. Activation of stress signaling pathways by the end product of lipid peroxidation. J Biol Chem 1999; 274: 2234-42.
13. Rahman I, Morrison D, Donaldson K, MacNee W. Systemic oxidative stress in asthma, COPD, and smokers. Am. J Respir Crit Care Med 1996; 154: 1055-1060.
14. Rahman I, Van Schadewijk AA, Crowther AJ, et al. 4-Hydroxy-2-nonenal, a specific lipid peroxidation product, is elevated in lungs of patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2002; 166: 490-95.
15. Baldwin AS, Jr. The NF-kappa B and I kappa B proteins: new discoveries and insights. Annu Rev Immunol 1996; 14: 649-683.
16. Gloire G, Legrand-Poels S, Piette J. NF-kappaB activation by reactive oxygen species: Fifteen years later. Biochem Pharmacol 2006; 72: 1493-1505.
17. Rahman I and Adcock IM. Oxidative stress and redox regulation of lung inflammation in COPD. Eur Respir J 2006; 28: 219-242.
18. Di Stefano A, Caramori G, Oates T, et al. Increased expression of nuclear factor-be in bronchial biopsies from smokers and patients with COPD. Eur Respir J 2002; 20: 556-63.
19. Caramori G, Romagnoli M, Casolari P, et al. Nuclear localization of p65 in sputum macrophages but not in sputum neutrophils during COPD exacerbations. Thorax 2003; 58: 348-51.
20. Rahman I, Marwick J and Kirkham P. Redox modulation of chromatin remodeling: impact on histone acetylation and deacetylation, NF-κB and pro-inflammatory gene expression. Biochem Pharmacol 2004; 68: 1255-67.
21. De Ruijter AJ, Van Gennip AH, Caron HN, Kemp S, Van Kuilenburg AB. Histone deacetylases (HDACs): characterization of the classical HDAC family. Biochem J 2003; 370: 737-49.
22. Yudt MR, and Cidlowski JA. The glucocorticoid receptor: coding a diversity of proteins and responses through a single gene. Mol Endocrinol 2002; 16: 1719-1726.
23. Ito K, Chung KF and Adcock IM. Update on glucocorticoid action and resistance. J Allergy Clin Immunol 2006a; 117: 522-43
24. Aghai ZH, Kumar S, Farhath S, et al. Dexamethasone suppresses expression of Nuclear Factor-kappaB in the cells of tracheobronchial lavage fluid in premature neonates with respiratory distress. Pediatr Res 2006; 59: 811-15.
25. Reichardt HM, Kaestner KH, Tuckermarm J, et al. DNA binding of the glucocorticoid receptor is not essential for survival. Cell 1998; 93: 531-41.
26. Ito K, Ito M, Elliott WM, et al. Decreased Histone Deacetylase Activity in Chronic Obstructive Pulmonary Disease. N Engl J Med 2005; 352: 1967-76.
27. Stellato C. Post-transcriptional and nongenomic effects of glucocorticoids. Proc Am Thorac Soc 2004; 1: 255-263.
28. Zhou J, Kang ZM, Xie QM, et al. Rapid nongenomic effects of glucocorticoids on allergic asthma reaction in the guinea pig. J Endocrinol 2003; 177: R1-4.
29. Rhen T and Cidlowski JA. Anti-inflammatory action of glucocorticoids-new mechanisms for old drugs. N Engl J Med 2005; 353: 1711-23.
30. Glozak MA, Sengupta N, Zhang X and Seto E. Acetylation and deacetylation of non-histone proteins. Gene 2005; 363: 15-23.
31. Fu M, Wang C, Zhang X, Pestell RG. Acetylation of nuclear receptors in cellular growth and apoptosis. Biochem Pharmacol 2004; 68: 1199-1208.
32. Ito K, Yamamura S, Essilfie-Quaye S, et al. Histone deacetylase 2-mediated deacetylation of the glucocorticoid receptor enables NF-κB suppression. J Exp Med 2006; 203: 7-13.
33. Barnes PJ. Inhaled corticosteroids are not helpful in chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2000; 161: 342-44.
34. Barnes PJ, Adcock IM, Ito K. Histone acetylation and deacetylation: importance in inflammatory lung diseases. Eur Respir J 2005; 25: 552-63.
35. Ito K, Barnes PJ, Adcock IM. Glucocorticoid receptor recruitment of histone deacetylase 2 inhibits IL-1β induced histone H4 acetylation on lysines 8 and 12. Mol Cell Biol 2000; 20: 6891-6903.
36. Ito K, Lim G, Caramori G, Chung KF, Barnes PJ, Adcock IM. Cigarette smoking reduces histone deacetylase 2 expression, enhances cytokine expression, and inhibits glucocorticoid actions in alveolar macrophages. FASEB J 2001; 15: 1110-12.
37. Yang SR, Chida AS, Bauter M, Shafiq N, et al. Cigarette smoke induces pro-inflammatory cytokine release by activation of NF-κB and post-translational modifications of histone deacetylase in macrophages. Am J Physiol Lung Cell Mol Physiol 2006; 29: L46-L57.
38. Marwick JA, Kirkham PA, Stevenson CS, et al. Cigarette smoke alters chromatin remodeling and induces proinflammatory genes in rat lungs. Am J Respir Cell Mol Biol 2004; 31: 633-42.
39. Szulakowski P, Crowther AJ, Jimenez LA, et al. The effect of smoking on the transcriptional regulation of lung inflammation in patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2006; 174: 41-50.
40. Culpitt SV, Rogers DF, Shah P, et al. Impaired inhibition by dexamethasone of cytokine release by alveolar macrophages from COPD patients. Am J Respir Crit Care Med 2002; 167: 24-31.
41. Cosio BG, Tsaprouni L, Ito K, Jazrawi E, Adcock IM, Barnes PJ. Theophylline restores histone deacetylase activity and steroid responses in COPD macrophages. J Exp Med 2004; 2004: 689-95.
42. Moodie FM, Marwick JA, Anderson CS, et al. Oxidative stress and cigarette smoke alter chromatin remodeling but differentially regulate NF-κB activation and proinflammatory cytokine release in alveolar epithelial cells. FASEB J 2004; 18: 1897-1899.
43. Zhong H, May MJ, Jimi E, Ghosh S. The phosphorylation status of nuclear NF-kappa B determines its association with CBP/p300 or HDAC-1. Mol Cell 2002; 9: 625-36.
44. Ashburner BP, Westerheide SD, Baldwin Jr. AS. The p65 (RelA) subunit of NF-kappaB interacts with the histone deacetylase (HDAC) corepressors HDAC1 and HDAC2 to negatively regulate gene expression. Mol Cell Biol 2001; 21: 7065-77.
45. Qiu Y, Zhao Y, Becker M, et al. HDAC1 acetylation is linked to progressive modulation of steroid receptor-induced gene transcription. Mol Cell 2006; 22: 669-79.
46. Sher ER, Leung DY, Surs W, et al. Steroid-resistant asthma. Cellular mechanisms contributing to inadequate response to glucocorticoid therapy. J Clin Invest 1994; 93: 33-39.
47. Goleva E, Li LB, Eves PT, Strand MJ, Martin RJ, Leung DY. Increased glucocorticoid receptor beta alters steroid response in glucocorticoid-insensitive asthma. Am J Respir Crit Care Med 2006; 173: 607-16.
48. Strickland I, Kisich K, Hauk PJ, et al. High constitutive glucocorticoid receptor beta in human neutrophils enables them to reduce their spontaneous rate of cell death in response to corticosteroids. J Exp Med 2001; 193: 585-93.
49. Chen L, Fischle W, Verdin E, Greene WC. Duration of nuclear NF-kappaB action regulated by reversible acetylation. Science 2001; 293: 1653-57.
50. Irusen E, Matthews JG, Takahashi A, Barnes PJ, Chung KF, Adcock IM. p38 Mitogen-activated protein kinase-induced glucocorticoid receptor phosphorylation reduces its activity: role in steroid-insensitive asthma. J Allergy Clin Immunol 2002; 109: 649-57.
51. Lagrue G, Branellec A, Lebargy F. Toxicology of tobacco. Rev Prat 1993; 43: 1203-1207.
52. Lam CW, Casanova M, Heck HD. Depletion of nasal mucosal glutathione by acrolein and enhancement of formaldehyde-induced DNA-protein cross-linking by simultaneous exposure to acrolein. Arch Toxicol 1985; 58: 67-71.
53. Cassee FR, Groten JP, Feron VJ. Changes in the nasal epithelium of rats exposed by inhalation to mixtures of formaldehyde, acetaldehyde, and acrolein. Fundam Appl Toxicol 1996; 29: 208-218.
54. Kirkham P, Rahman I. Oxidative stress in asthma and COPD: Antioxidants as a therapeutic strategy. Pharm Ther 2006; 111: 476-94.
55. Slevogt H, Schmeck B, Jonatat C, et al. Moraxella catarrhalis induces inflammatory response of bronchial epithelial cells via MAPK and NF-kappaB activation and histone deacetylase activity reduction. Am J Physiol Lung Cell Mol Physiol 2006; 290: L818-826.
56. Ito K, Lim S, Caramori G, Cosio B, et al. A molecular mechanism of action of theophylline: induction of histone deacetylase activity to decrease inflammatory gene expression. Proc Natl Acad Sci USA 2002; 99: 8921-26.
57. Ito K, Lim S, Chung KF, Barnes PJ, Adcock IM. Theophylline enhances histone deacetylase activity and restores glucocorticoid function during oxidative stress. Am J Respir Crit Care Med 2002; 65: A625.
58. Rahman I, Biswas SK, Kirkham PA. Regulation of inflammation and redox signaling by dietary polyphenols. Biochem Pharmacol 2006; [Epub ahead of print].
59. Culpitt SV, Rogers DF, Fenwick PS, et al. Inhibition by red wine extract, resveratrol, of cytokine release by alveolar macrophages in COPD. Thorax 2003; 58: 942-46.
60. Donnelly LE, Newton R, Kennedy GE, et al. Anti-Inflammatory Effects of Resveratrol in Lung Epithelial Cells: Molecular Mechanisms. Am J Physiol Lung Cell Mol Physiol 2004; 287: L774-83.
61. Kang J, Chen J, Shi Y, Jia J, Zhang Y. Curcumin-Induced Histone Hypoacetylation: the Role of Reactive Oxygen Species. Biochem Pharmacol 2005; 69: 1205-13.
62. Knekt P, Kumpulainen J, Jarvinen R, et al. Flavonoid intake and risk of Chronic Diseases. Am J Clin Nutr 2002; 76: 560-568.
63. Tabak C, Arts IC, Smith HA, Heederik D, Kromhout D. Chronic obstructive pulmonary disease and intake of catechins, flavonols, and flavones: the MORGEN Study. Am J Respir Crit Care Med 2001; 164:61-64.
64. Walda IC, Tabak C, Smit HA, et al. Diet and 20-year chronic obstructive pulmonary disease mortality in middle-aged men from three European countries. Eur J Clin Nutr 2002; 56:638-643.