Effect of resection margins on the recurrence of Crohn's disease in the small bowel: A randomized controlled trial

Annals of Surgery

Volumn 224, Issue 4, 1996, Pages 563-573

  Fazio, Victor W ^a   Marchetti, Floriano ^a   Church, James M ^a   Goldblum, John R ^a   Lavery, Lan C ^a   Hull, Tracy L ^a   Milsom, Jeffrey W ^a   Strong, Scott A ^a   Oakley, John R ^a   Secic, Michelle ^a  

^a LERNER RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIINFLAMMATORY AGENT; AZATHIOPRINE; CYCLOSPORIN; IMMUNOSUPPRESSIVE AGENT; MERCAPTOPURINE; MESALAZINE; METRONIDAZOLE; SALAZOSULFAPYRIDINE; STEROID;

ADULT; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROHN DISEASE; FEMALE; FOLLOW UP; HUMAN; INTESTINE ANASTOMOSIS; INTESTINE OBSTRUCTION; INTESTINE RESECTION; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; TREATMENT INDICATION;

ADULT; COLON; CROHN DISEASE; HUMANS; ILEUM; INTESTINE, SMALL; JEJUNUM; METHODS; POSTOPERATIVE COMPLICATIONS; RECURRENCE;

EID: 10144252422     PISSN: 00034932     EISSN: None     Source Type: Journal    
DOI: 10.1097/00000658-199610000-00014     Document Type: Article

References (51)

1. Rotterdam H, Korelitz BI, Sommers SC. Microgranulomas in grossly normal rectal mucosa in Crohn's disease. Am J Clin Pathol 1977; 67:550-554.
2. Hamilton SR, Bussey HJR, Boitnott JK, Morson BC. Active inflammation and granulomas in grossly uninvolved colonic mucosa of Crohn's disease resection specimens studied with en face histologic technique. Gastroenterology 1981; 80:1167 (abstract).
3. Goodman MJ, Skinner JM, Truelove SC. Abnormalities in the apparently normal bowel mucosa in Crohn's disease. Lancet 1976; i:275-278.
4. Van Spreeuwel JP, Lindeman J, Van Der Wal AM, et al. Morphological and immunohistochemical findings in upper gastrointestinal biopsies of patients with Crohn's disease of the ileum and colon. J Clin Pathol 1982; 35:934-940.
5. Ferguson R, Allan RN,Cooke WT. A study of the cellular infiltrate of the proximal jejunum mucosa in ulcerative colitis and Crohn's disease. Gut 1975; 16:205-208.
6. Dunne WT, Cooke WT, Allan RN. Enzymatic and morphometric evidence for Crohn's disease as a diffuse lesion of the gastrointestinal tract. Gut 1977; 18:290-294.
7. Arvanitakis C. Abnormalities of jejunal mucosal enzymes in ulcerative colitis and Crohn's disease. Digestion 1979; 19:259-266.
8. Nagel E, Bartels M, Pichlmayr R. Scanning electron-microscopic lesions in Crohn's disease: relevance for the interpretation of postoperative recurrence. Gastroenterology 1995; 108:376-382.
9. Dvorak AM, Connell AB, Dickersin GR. Crohn's disease: a scanning electron microscopic study. Human Pathol 1979; 10:165-177.
10. Nyhlin H, Stenling R. The small-intestinal mucosa in patients with Crohn's disease assessed by scanning electron and light microscopy. Scand J Gastroenterol 1984; 19:433-440.
11. deDombal FT, Burton I, Goligher JC. Recurrence of Crohn's disease after primary excisional surgery. Gut 1971; 12:519-527.
12. Greenstein AJ, Sachar DB, Paternack BS, Janowitz HD. Reoperation and recurrence in Crohn's colitis and ileocolitis. N Engl J Med 1975; 293:685-690.
13. Lennard Jones JE, Stalder GA. Prognosis after resection of chronic regional ileitis. Gut 1967; 8:332-336.
14. Rutgeerts P, Geboes K, Vantrappen G, et al. Natural history of recurrent Crohn's disease at the ileocolic anastomosis after curative surgery. Gut 1984; 25:665-672.
15. Rutgeerts P, Geboes K, Peters M, et al. Effect of faecal stream diversion on recurrence of Crohn's disease in the neoterminal ileum. Lancet 1991; 338:771-774.
16. Lock MR, Farmer RG, Fazio VW, et al. Recurrence and reoperation for Crohn's disease: the role of disease location in prognosis. N Engl J Med 1981; 304:1586-1588.
17. Colcock PB, Fortin C. Surgical treatment of regional enteritis: review of 85 cases. Ann Surg 1965; 161:812-817.
18. Fasth S, Hellberg R, Hulten L, Ahren C. Site of recurrence, extent of ileal disease and magnitude of resection in primary and recurrent Crohn's disease. Acta Chir Scand 1981; 147:569-576.
19. Pennington L, Hamilton SR, Bayless TM, Cameron JL. Surgical management of Crohn's disease: influence of disease at margin of resection. Ann Surg 1980; 192:311-317.
20. Cameron JL, Hamilton SR, Coleman J, et al. Patterns of ileal recurrence in Crohn's disease: a prospective randomized study. Ann Surg 1992; 215:546-552.
21. Heimann TM, Greenstein AJ, Lewis B, et al. Prediction of early symptomatic recurrence after intestinal resection in Crohn's disease. Ann Surg 1993; 218:294-299.
22. Gabbert HE, Ewe K, Singe CC, et al. The early recurrence of Crohn's disease after "curative" resection: a prospective endoscopic and histological study. German Dtsch Med Wochenschr 1990; 115:447-451.
23. Bergman L, Krause U. Crohn's disease: a long-term study of the clinical course in 186 patients. Scand J Gastroenterol 1977; 12:937-944.
24. Ihasz M, Mester E, Refi M. Experience in surgical management of Crohn's disease. Am J Proctol 1975; 26:47-62.
25. Nygaard K, Fausa O. Crohn's disease: recurrence after surgical treatment. Scand J Gastroenterol 1977; 12:577-584.
26. Karesen R, Serch-Hanssen A, Thoresen BO, Hertzberg J. Crohn's disease: long term results of surgical treatment. Scand J Gastroenterol 1981; 16:57-64.
27. Lindhagen T, Ekelund G, Leandoer L, et al. Recurrence rate after surgical treatment of Crohn's disease. Scand J Gastroenterol 1983; 18:1037-1044.
28. Wolff BG, Beart RW Jr, Frydenberg HB, et al. The importance of disease-free margins in resection for Crohn's disease. Dis Colon Rectum 1983; 26:239-243.
29. Martin G, Heyen F, Dubé S. Facteurs de récidive dans la maladie de Crohn. Ann Chir 1994; 48:685-690.
30. Fazio V W. Regional enteritis (Crohn's disease): indications for surgery and operative strategy. Surg Clin N Am 1983; 63:27-48.
31. Kotanagi H, Kramer K, Fazio VW, Petras RE. Do microscopic abnormalities at resection margins correlate with increased anastomotic recurrence in Crohn's disease: retrospective analysis of 100 cases. Dis Colon Rectum 1991; 34:909-916.
32. Hellberg R, Húlten L, Rosengren C, Åhrén C. The recurrence rate after primary excisional surgery for Crohn's disease. Acta Chir Scand 1980; 146:435-443.
33. McLeod RS. Resection margins and recurrent Crohn's disease. Hepatogastroenterology 1990; 37:63-66.
34. McLeod RS, Wolff BG, Steinhart AH, et al. Prophylactic mesalamine treatment decreases postoperative recurrence of Crohn's disease. Gastroenterology 1995; 109:404-413.
35. Lee ECG. Papaioannu N. Minimal surgery for chronic obstruction in patients with extensive or universal Crohn's disease. Ann R Coll Surg Engl 1982; 64:229-233.
36. Cuvelier C, Bekaert E, De Potter C, et al. Crohn's disease with adenocarcinoma and dysplasia: macroscopical, histological, and immunohistochemical aspects of two cases. Am J Surg Pathol 1989; 13:187-196.
37. Williams JG, Wong WD, Rothenberger DA, Goldberg SM. Recurrence of Crohn's disease after resection. Br J Surg 1991; 78:10-19.
38. Alexander Williams J. Conservative nonresection operations for Crohn's disease. In: Najarian JS, Delaney JP, eds. Advances in Gastrointestinal Surgery. Chicago. IL: Year Book Medical Publishers; 1984:329-336.
39. Ozuner G, Fazio VW, Lavery IC, et al. The role of strictureplasty in the management of Crohn's disease: how safe is it? Am J Surg 1996; 171:51-61.
40. Tjandra JJ, Fazio VW. Strictureplasty without concomitant resection for small bowel obstruction in Crohn's disease. Br J Surg 1994; 81:561-563.
41. Hertzberg J. Crohn's disease: frozen section studies in surgical treatment. Ann Gastroenterol Hepatol 1985; 21:227-230.
42. Hamilton SR, Reese J, Pennington L, et al. The role of resection margin frozen section in the surgical management of Crohn's disesase. Surg Gynecol Obstet 1985; 160:57-62.
43. Heuman R, Boeryd B, Bolin T, Sjodahl R. The influence of disease at the margin of resection on the outcome of Crohn's disease. Br J Surg 1983; 70:519-521.
44. Cooper JC, Williams NS. The influence of microscopic disease at the margin of resection on the recurrence rates in Crohn's disease. Ann R Coll Surg Engl 1986; 68:23-26.
45. Chardavoynne R, Flint GW, Pollack S, Wise L. Factors affecting recurrence following resection for Crohn's disease. Dis Colon Rectum 1986; 29:495-502.
46. Adloff M, Arnaud J, Ollier J. Does the histologic appearance at the margin of resection affect the postoperative recurrence rate in Crohn's disease? Am Surg 1987; 53:543-546.
47. Wettergren A, Christiansen J. Risk of recurrence and reoperation after resection for ileocolic Crohn's disease. Scand J Gastroenterol 1991; 26:1319-1322.
48. Funayama Y, Sasaki I, Naito H, et al. Surgical results in Crohn's disease: an analysis in view of cumulative risk of recurrence and reoperation. Jpn J Gastroenterol 1991; 88:33-39.
49. Smith RC, Rhodes J, Heatley RV, et al. Low dose steroids and clinical relapse in Crohn's disease: a controlled trial. Gut 1978; 19:606-610.
50. Krause U, Bergamann L, Norlen BJ. Crohn's disease: a clinical study based on 186 patients. Scand J Gastroenterol 1971; 6:97-108.
51. Holmes SJ, Richter HM III, Garberoglio CA, et al. The surgical treatment of Crohn's disease. Br J Clin Pract 1981; 35:5-12.