Ornidazole for prophylaxis of postoperative Crohn's disease recurrence: A randomized, double-blind, placebo-controlled trial

Gastroenterology

Volumn 128, Issue 4, 2005, Pages 856-861

  Rutgeerts, Paul ^a   Van Assche, Gert ^a   Vermeire, Séverine ^a   D'Haens, Geert ^a   Baert, Filip ^b   Noman, Maja ^a   Aerden, Isolde ^a   De Hertogh, Gert ^a   Geboes, Karel ^a   Hiele, Martin ^a   D'Hoore, Andre ^a   Penninckx, Freddy ^a  

^a UNIVERSITY HOSPITALS LEUVEN   (Belgium)

^b Heilig Hart Ziekenhuis   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

ORNIDAZOLE;

ADULT; ALCOHOL INTOLERANCE; ARTHRALGIA; ARTHRITIS; ARTICLE; CLINICAL ARTICLE; CLINICAL FEATURE; CLINICAL TRIAL; CONFIDENCE INTERVAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROHN DISEASE; DRUG EFFICACY; DRUG MEGADOSE; DRUG SAFETY; FATIGUE; FEMALE; FISHER EXACT TEST; FLUSHING; GASTROINTESTINAL TOXICITY; HEADACHE; HUMAN; LIVER TOXICITY; MALE; MYOPATHY; PARESTHESIA; POLYNEUROPATHY; PRIORITY JOURNAL; PRURITUS; PSYCHOSIS; RANDOMIZED CONTROLLED TRIAL; RECURRENT DISEASE; SIDE EFFECT; TUMOR RECURRENCE;

EID: 20244388832     PISSN: 00165085     EISSN: None     Source Type: Journal    
DOI: 10.1053/j.gastro.2005.01.010     Document Type: Article

References (18)

1. J.M. Becker Surgical therapy for ulcerative colitis and Crohn's disease Gastroenterol Clin North Am 28 1999 371 390
2. G.R. D'Haens, K. Geboes, M. Peeters, F. Baert, F. Penninckx, P. Rutgeerts Early lesions of recurrent Crohn's disease caused by infusion of intestinal excluded ileum Gastroenterology 114 1998 262 267
3. P. Rutgeerts, K. Geboes, G. Vantrappen, J. Beyls, R. Kerremans, M. Hiele Predictability of the postoperative course of Crohn's disease Gastroenterology 99 1990 956 963
4. P. Rutgeerts, M. Hiele, K. Geboes, M. Peeters, F. Penninckx, R. Aerts, R. Kerremans Controlled trial of metronidazole treatment for prevention of Crohn's recurrence after ileal resection Gastroenterology 108 1995 1617 1621
5. R.S. McLeod, B.G. Wolff, A.H. Steinhart, P.W. Carryer, K. O'Rourke, D.F. Andrews, J.E. Blair, J.R. Cangemi, Z. Cohen, J.B. Cullen, R.G. Chaytor, G.R. Greenberg, N.M. Jaffer, K.N. Jeejeebhoy, R.L. MacCarty, R.L. Ready, L.H. Weiland Prophylactic mesalamine treatment decreases postoperative recurrence of Crohn's disease Gastroenterology 109 1995 404 413
6. C. Brignola, M. Cottone, A. Pera, S. Ardizzone, M.L. Scribano, R. De Franchis, A. D'Arienzo, G. D'Albasio, D. Pennestri Mesalamine in the prevention of endoscopic recurrence after intestinal resection for Crohn's disease Gastroenterology 108 1995 345 349
7. H. Lochs, M. Mayer, W. Fleig, P.B. Mortensen, P. Bauer, D. Genser, W. Petritsch, M. Raithel, R. Hoffmann, V. Gross, M. Plauth, M. Staun, L.B. Nesje Prophylaxis of postoperative relapse in Crohn's disease with mesalamine European Cooperative Crohn's Disease Study VI Gastroenterology 118 2000 264 273
8. S.B. Hanauer, B.I. Korelitz, P. Rutgeerts, M.A. Peppercorn, R.A. Thisted, R.D. Cohen, D.H. Present Post-operative maintenance of Crohn's disease remission with 6-mercaptopurine, mesalamine or placebo a 2-year trial Gastroenterology 127 2004 723 729
9. L. Bergman Krause U Postoperative treatment with corticosteroids and salazosulphapyridine (Salazopyrin) Scand J Gastroenterol 11 1976 651 656
10. A. Wenckert, M. Kristensen, A.E. Eklund, F. Barany, S. Jarnum, H. Worning, O. Folkenborg, A. Holtz, O. Bonnevie, P. Rijs The long term prophylactic effect of salazosulphapyridine (Salazopyrin) in primary resected patients with Crohn's disease Scand J Gastroenterol 13 1978 161 167
11. K. Ewe, H.C. Herfarth, W.H. Malchow, H.J. Jesdinsky Postoperative recurrence of Crohn's disease in relation to radicality of operation and sulfasalazine prophylaxis a multicenter trial Digestion 42 1989 224 232
12. L.R. Sutherland, F. Martin, R.J. Bailey, R.N. Fedorak, M. Poleski, C. Dallaire, R. Rossman, F. Saibil, L. Lariviere A randomized, placebo-controlled, double-blind trial of mesalamine in the maintenance of remission of Crohn's Disease The Canadian Mesalamine for Remission of Crohn's Disease Study Group Gastroenterology 112 1997 1069 1077
13. G. Hellers, A. Cortot, D. Jewell, C.E. Leijonmarck, R. Lofberg, H. Malchow, L.G. Nilsson, F. Pallone, S. Pena, T. Persson, C. Prantera, P. Rutgeerts Oral budesonide for prevention of postsurgical recurrence in Crohn's disease Gastroenterology 116 1999 294 300
14. S. Ardizzone, G. Maconi, G.M. Sampietro, A. Russo, E. Radice, E. Colombo, V. Imbesi, M. Molteni, P.G. Danelli, A.M. Taschieri, G. Bianchi Porro Azathioprine and mesalamine for prevention of relapse after conservative surgery for Crohn's disease Gastroenterology 127 2004 730 740
15. R.S. McLeod, B.G. Wolff, A.H. Steinhart, P.W. Carryer, K. O'Rourke, D.F. Andrews, J.E. Blair, J.R. Cangemi, Z. Cohen, J.B. Cullen, R.G. Chaytor, G.R. Greenberg, N.M. Jaffer, K.N. Jeejeebhoy, R.L. MacCarty, R.L. Ready, L.H. Weiland Risk and significance of endoscopic/radiological evidence of recurrent Crohn's disease Gastroenterology 113 1997 1823 1827
16. J.K. Triantafillidis, D. Nicolakis, A. Emmanoullidis, A. Antoniou, K. Papatheodorou, P. Cheracakis Ornidazole in the treatment of active Crohn's disease short-term results Ital J Gastroenterol 28 1996 10 14
17. J.K. Triantafillidis, A. Antoniou, A. Emmanoulidis, D. Nicolakis, C. Barbatzas, P. Cheracakis Ornidazole in the prevention of recurrence of Crohn's disease Ital J Gastroenterol Hepatol 30 1998 446 447
18. J.K. Triantafillidis, D. Nicolakis, A. Antoniou, I. Hereti Absence of toxicity of ornidazole after a 10-yr continuous daily use for Crohn's disease Am J Gastroenterol 96 2001 254 255