Antibiotics and azathioprine for the treatment of perianal fistulas in Crohn's disease

Alimentary Pharmacology and Therapeutics

Volumn 18, Issue 11-12, 2003, Pages 1113-1120

  Dejaco, C ^a   Harrer, M ^a   Waldhoer, T ^a   Miehsler, W ^a   Vogelsang, H ^a   Reinisch, W ^a,b  

^a UNIVERSITY HOSPITAL INNSBRUCK   (Austria)

^b MEDICAL UNIVERSITY OF VIENNA   (Austria)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTIC AGENT; AZATHIOPRINE; CIPROFLOXACIN; METRONIDAZOLE;

ADULT; ANTIBIOTIC THERAPY; ANUS FISTULA; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROHN DISEASE; DRUG EFFICACY; FEMALE; HUMAN; IMMUNOSUPPRESSIVE TREATMENT; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; TREATMENT OUTCOME;

ADJUVANTS, IMMUNOLOGIC; ADOLESCENT; ADULT; AGED; ANTI-BACTERIAL AGENTS; ANUS DISEASES; AZATHIOPRINE; CIPROFLOXACIN; CROHN DISEASE; DRUG THERAPY, COMBINATION; FEMALE; FOLLOW-UP STUDIES; HUMANS; MALE; METRONIDAZOLE; MIDDLE AGED; PROSPECTIVE STUDIES; RECTAL FISTULA; RECURRENCE; TREATMENT OUTCOME;

EID: 0345802756     PISSN: 02692813     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2036.2003.01793.x     Document Type: Article

References (32)

1. Gasche C, Scholmerich J, Brynskov J, et al. A simple classification of Crohn's disease: report of the Working Party for the World Congresses of Gastroenterology, Vienna 1998. Inflamm Bowel Dis 2000; 6: 8-15.
2. Steinberg DM, Cooke WT, Alexander-Williams J. Abscess and fistulas in Crohn's disease. Gut 1973; 14: 865-9.
3. Farmer RG, Hawk WA, Turnbull RB Jr. Clinical patterns in Crohn's disease: a statistical study of 615 cases. Gastroenterology 1975; 68: 627-35.
4. Rankin GB, Watts HD, Melnyk CS, et al. National Cooperative Crohn's Disease Study: extraintestinal manifestations and perianal complications. Gastroenterology 1979; 77: 914-20.
5. Williams DR, Coller JA, Corman ML, et al. Anal complications in Crohn's disease. Dis Colon Rectum 1981; 24: 22-4.
6. Hellers G, Bergstrand O, Ewerth S, et al. Occurrence and outcome after primary treatment of anal fistulae in Crohn's disease. Gut 1980; 21: 525-7.
7. Schwartz DA, Loftus EV Jr, Tremaine WJ, et al. The natural history of fistulizing Crohn's disease in Olmsted County, Minnesota. Gastroenterology 2002; 122: 875-80.
8. Present DH. Crohn's fistula: current concepts in management. Gastroenterology 2003; 124: 1629-35.
9. Bernstein LH, Frank MS, Brandt LJ, et al. Healing of perineal Crohn's disease with metronidazole. Gastroenterology 1980; 79: 357-65.
10. Brandt LJ, Bernstein LH, Boley SJ, et al. Metronidazole therapy for perineal Crohn's disease: a follow-up study. Gastroenterology 1982; 83: 383-7.
11. Jakobovits J, Schuster MM. Metronidazole therapy for Crohn's disease and associated fistulas. Am J Gastroenterol 1984; 79: 533-40.
12. Turunen U, Farkkila M, Valtonen V. Long-term outcome of ciprofloxacin treatment in severe perianal or fistulous Crohn's disease. Gastroenterology 1993; 104: A793(Abstract).
13. Solomon MJ, McLeod RS, Connor BI, et al. Combination ciprofloxacin and metronidazole in severe perianal Crohn's disease. Can J Gastroenterol 1993; 7: 571-3.
14. Present DH, Korelitz BI, Wisch N, et al. Treatment of Crohn's disease with 6-mercaptopurine. A long-term, randomized, double-blind study. N Engl J Med 1980; 302: 981-7.
15. Korelitz BI, Present DH. Favorable effect of 6-mercaptopurine on fistulas of Crohn's disease. Dig Dis Sci 1985; 30: 58-64.
16. Hanauer SB, Smith MB. Rapid closure of Crohn's disease fistulas with continuous intravenous cyclosporine A. Am J Gastroenterol 1993; 88: 646-9.
17. Present DH, Lichtiger S. Efficacy of cyclosporine in treatment of fistula of Crohn's disease. Dig Dis Sci 1994; 39: 374-80.
18. Sandborn WJ. Preliminary report on the use of oral tacrolimus (FK506) in the treatment of complicated proximal small bowel and fistulizing Crohn's disease. Am J Gastroenterol 1997; 92: 876-9.
19. Sandborn WJ, Present DH, Isaacs KL, et al. Tacrolimus for the treatment of fistulas in patients with Crohn's disease: a randomized, placebo-controlled trial. Gastroenterology 2003; 125: 380-8.
20. Present DH, Rutgeerts P, Targan S, et al. Infliximab for the treatment of fistulas in patients with Crohn's disease. N Engl J Med 1999; 340: 1398-405.
21. Schwartz DA, Pemberton JH, Sandborn WJ. Diagnosis and treatment of perianal fistulas in Crohn's disease. Ann Intern Med 2001; 135: 906-18.
22. Hanauer SB, Sandborn W, and The Practice Parameters Committee of the American College of Gastroenterology. Management of Crohn's disease in adults. Am J Gastroenterol 2001; 96: 625-43.
23. Lennard-Jones JE. Classification of inflammatory bowel disease. Scand J Gastroenterol Suppl 1989; 24: 2-6.
24. Irvine EJ. Usual therapy improves perianal Crohn's disease as measured by a new disease activity index. McMaster IBD Study Group. J Clin Gastroenterol 1995; 20: 27-32.
25. Parks AG, Gordon PH, Hardcastle JD. A classification of fistula-in-ano. Br J Surg 1976; 63: 1-12.
26. Lichtenstein GR. Treatment of fistulizing Crohn's disease. Gastroenterology 2000; 119: 1132-17.
27. Makowiec F, Jehle EC, Starlinger M. Clinical course of perianal fistulas in Crohn's disease. Gut 1995; 37: 696-701.
28. Arnold GL, Beaves MR, Pryjdun VO, et al. Preliminary study of ciprofloxacin in active Crohn's disease. Inflamm Bowel Dis 2002; 8: 10-5.
29. Pearson DC, May GR, Pick GH, et al. AZA and 6-mercaptopurine in Crohn's disease. A meta-analysis. Ann Intern Med 1995; 123: 132-42.
30. Garrett JW, Drossman DA. Health status in IBD: biological and behavioural considerations. Gastroenterology 1990; 99: 90-6.
31. Sandborn WJ, Feagan BG, Hanauer SB, et al. A review of activity indices and efficacy endpoints for clinical trials of medical therapy in adults with Crohn's disease. Gastroenterology 2002; 122: 512-30.
32. Arseneau KO, Cohn SM, Cominelli F, et al. Cost-utility of initial management for Crohn's disease perianal fistulas. Gastroenterology 2001; 120: 1640-56.