The neurobiology of stress and development

Annual Review of Psychology

Volumn 58, Issue , 2007, Pages 145-173

  Gunnar, Megan ^a   Quevedo, Karina ^a  

^a UNIVERSITY OF MINNESOTA   (United States)

Author keywords

HPA axis; Psychopathology

Indexed keywords

CORTICOTROPIN; CORTICOTROPIN RELEASING FACTOR;

ADULT; AMYGDALOID NUCLEUS; ANIMAL; AROUSAL; ARTICLE; BLOOD; BRAIN; CHILD; FAMILY; HUMAN; HYPOPHYSIS ADRENAL SYSTEM; HYPOTHALAMUS HYPOPHYSIS SYSTEM; INFANT; LIMBIC SYSTEM; MENTAL DISEASE; MENTAL STRESS; PATHOPHYSIOLOGY; PHYSIOLOGY; POSTTRAUMATIC STRESS DISORDER; PRESCHOOL CHILD; PSYCHOLOGICAL ASPECT; RISK FACTOR; SOCIAL ENVIRONMENT; SURVIVOR; TEMPERAMENT;

ADRENOCORTICOTROPIC HORMONE; ADULT; AMYGDALA; ANIMALS; AROUSAL; BRAIN; CHILD; CHILD, PRESCHOOL; CORTICOTROPIN-RELEASING HORMONE; FAMILY; HUMANS; HYPOTHALAMO-HYPOPHYSEAL SYSTEM; INFANT; LIMBIC SYSTEM; MENTAL DISORDERS; PITUITARY-ADRENAL SYSTEM; RISK FACTORS; SOCIAL ENVIRONMENT; STRESS DISORDERS, POST-TRAUMATIC; STRESS, PSYCHOLOGICAL; SURVIVORS; TEMPERAMENT;

EID: 33847021246     PISSN: 00664308     EISSN: None     Source Type: Book Series    
DOI: 10.1146/annurev.psych.58.110405.085605     Document Type: Article

References (163)

1. Adam EK. 2006. Transactions among trait and state emotion and adolescent diurnal and momentary cortisol activity in naturalistic settings. Psychoneuroendocrinology 31:664-79
2. Ahnert L, Gunnar MR, Lamb ME, Barthel M. 2004. Transition to child care: associations with infant-mother attachment, infant negative emotion, and cortisol elevations. Child Dev. 75:639-50
3. Ainsworth MD, Blehar MC, Waters E, Wall S. 1978. Patterns of Attachment: A Psychological Study of the Strange Situation, Hillsdale NJ: Erlbaum
4. Akil H, Morano M. 1995. Stress. In Psycbopharmacology: The Fourth Generation of Progress, ed. F Bloom, D Kupfer, pp. 773-85. New York: Raven
5. Bale TL, Vale WW. 2004. CRF and CRF receptors: role in stress responsivity and other behaviors. Annu. Rev. Pharmacol. Toxicol. 44:525-57
6. Barbas H. 1995. Anatomic basis of cognitive-emotional interactions in the primate prefrontal cortex. Neurosci. Biobehav. Rev. 19:499-510
7. Barr CS, Newman TK, Shannon C, Parker C, Dvoskin RL, et al. 2004. Rearing condition and rh5-HTTLPR interact to influence limbic-hypothalamic-pituitary- adrenal axis response to stress in infant macaques. Biol. Psychol. 55:733-38
8. Bayart F, Hayashi KT, Faull KF, Barchas JD, Levine S. 1990. Influence of maternal proximity on behavioral and physiological responses to separation in infant rhesus monkeys (Macaca mulatta). Behav. Neurosci. 104:98-107
9. Bohus B, de Kloet ER, Veldhuis HD. 1982. Adrenal steroids and behavioral adaptation: relationship to brain corticoid receptors. In Current Topics in Neuroendocrinology, ed. D Granten, DWPfaff, pp. 107-48. Berlin: Springer-Verlag
10. Bowlby J. 1969. Attachment and Loss: Attachment. New York: Basic Books
11. Bremner JD, Licino J, Darnell A, Krystal JH, Owens MJ, et al. 1997. Elevated CSF corticotropin-releasing factor concentrations in posttraumatic stress disorder. Am. J. Psychiatry 154:624-29
12. Bremner JD, Vermetten E. 2001. Stress and development: behavioral and biological consequences. Dm. Psychopath. 13:473-90
13. Butler PD, Weiss JM, Stout JC, Nemeroff CB. 1990. Corticotropin-releasing factor produces fear-enhancing and behavioral activating effects following infusion into the locus coeruleus. J. Neurosci. 10:176-83
14. Caldji C, Tannenbaum B, Sharma S, Francis D, Plotsky PM, Meaney MJ. 1998. Maternal care during infancy regulates the development of neural systems mediating the expression of fearfulness in the rat. Proc. Natl. Acad. Sci. USA 95:5335-40
15. Cannon WB. 1929. Bodily Changes in Pain, Hunger, Fear, and Rage. Boston: Branford
16. Carlson M, Earls F. 1997. Psychological and neuroendocrinological sequelae of early social deprivation in institutionalized children in Romania. Ann. NY Acad. Sci. 807:419-28
17. Carrion VG, Weems CF, Ray RD, Glaser B, Hessl D, Reiss AL. 2002. Diurnal salivary cortisol in pediatric posttraumatic stress disorder. Biol. Psychol. 51:575-82
18. Caspi A, Sugden K, Moffit T, Taylor A, Craig IW, et al. 2003. Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene. Science 301:386-89
19. Cicchetti D. 1996. Child maltreatment: implications for developmental theory and research. Hum. Dev. 39:18-39
20. Cicchetti D, Rogosch FA. 2001a. The impact of child maltreatment and psychopathology on neuroendocrine functioning. Dev. Psycbopathol. 13:783-804
21. Cicchetti D, Rogosch FA. 2001b. Diverse patterns of neuroendocrine activity in maltreated children. Dev. Psychopathol. 13:677-93
22. Cicchetti D, Toth SL. 1995. A developmental psychopathology perspective on child abuse and neglect. J. Am. Acad. Child Adolesc. Psychol. 34:541-65
23. Cicchetti D, Tucker D. 1994. Development and self-regulatory structures of the mind. Dev. Psychopathol. 6:533-49
24. Cirulli F, Alleva BE. 2003. Early disruption of the mother-infant relationship: effects on brain plasticity and implications for psychopathology. Neurosci. Biobehav. Rev. 27:73-82
25. Coie JD, Dodge KA, Kupersmidt JB. 1990. Peer group behavior and social status. In Peer Rejection in Childhood, ed. SR Asher, JD Coie, pp. 17-59. New York: Cambridge Univ. Press
26. Coplan JD, Andrews MW, Rosenblum LA, Owens MJ, Friedman S, et al. 1996. Persistent elevations of cerebrospinal fluid concentrations of corticotropin-releasing factor in adult nonhuman primates exposed to early-life Stressors: implications for the pathophysiology of mood and anxiety disorders. Proc. Natl. Acad. Sci. USA 93:1619-23
27. Dantzer R. 1991. Stress and disease: a psychobiological perspective. Ann. Behav. Med. 13:20510
28. Davis M, Walker DL, Lee Y. 1997. Roles of the amygdala and bed nucleus of the stria terminalis in fear and anxiety measured with the acoustic startle reflex. Ann. NY Acad. Sci. 821:305-31
29. De Bellis MD. 2001. Developmental traumatology: the psychobiological development of maltreated children and its implications for research, treatment, and policy. Dev. Psychopathol. 13(3):539-64
30. De Bellis MD. 2005. The psychobiology of neglect. Child Maltreat. 10:150-72
31. De Bellis MD, Baum AS, Birmaher B, Keshavan MS, Eccard CH, et al. 1999. Developmental traumatology, part 1: biological stress systems. Biol. Psychol. 9:1259-70
32. De Bellis MD, Chrousos GP, Dorn LD, Burke L, Helmers K, et al. 1994. Hypothalamic-pituitary-adrenal axis deregulation in sexually abused girls. J. Clin. Endocrinol. Metab. 78:249-55
33. de Haan M, Nelson CA, Gunnar MR, Tout K. 1998. Hemispheric differences in brain activity related to the recognition of emotional expressions by 5-year-old children. Dev. Neuropsychol. 14:495-518
34. de Kloet ER. 1991. Brain corticosteroid receptor balance and homeostatic control. Front. Neuroendocrinol. 12:95-164
35. de Kloet ER, Rosenfeld P, van Eekelen JA, Sutanto W, Levine S. 1988. Stress, glucocorticoids and development. Prog. Brain Res. 73:101-20
36. de Kloet ER, Rots NY, Cools AR. 1996. Brain-corticosteroid hormone dialogue: slow and persistent. Cell. Mol. Neurobiol. 16:345-56
37. Dettling AC, Gunnar MR, Donzella B. 1999. Cortisol levels of young children in full-day childcare centers: relations with age and temperament. Psychoneuroendocrinology 24:50518
38. Dettling AC, Parker SW, Lane S, Sebanc A, Gunnar MR. 2000. Quality of care and temperament determine whether cortisol levels rise over the day for children in full-day childcare. Psychoneuroendocrinology 25:819-36
39. Diorio D, Viau V, Meaney MJ. 1993. The role of the medial prefrontal cortex (cingulate gyrus) in the regulation of hypothalamic-pituitaiy-adrenal responses to stress. J. Neurosci. 13:3839-47
40. Dobbing J. 1981. The later development of the brain and its vulnerability. In Scientific Foundations of Pediatrics, ed. JA Davis, J Dobbing, pp. 744-59. London: Heinemann Med. Books
41. Dozier M, Peloso E, Gordon MK, Manni M, Gunnar MR, et al. 2006. Foster children's diurnal production of cortisol: an exploratory study. Child Maltreat. 11:189-97
42. Elmlinger MW, Kuhnel W, Ranke MB. 2002. Reference ranges for serum concentrations of lutropin (LH), follitropin (FSH), estradiol (E2), prolactin, progesterone, sex hormone binding globulin (SHBG), dehydroepiandrosterone (DHEAS), cortisol, and ferritin in neonates, children, and young adults. Clin. Chem. Lab. Med. 40:1151-60
43. Essex MJ, Klein M, Cho E, Kaiin NH. 2002. Maternal stress beginning in infancy may sensitize children to later stress exposure: effects on cortisol and behavior. Biol. Psychiatry 52:776-84
44. Fisher PA, Gunnar R, Chamberlain P, Reid JB. 2000. Preventive intervention for maltreated preschool children: impact on children's behavior, neuroendocrine activity, and foster parent functioning. J. Am. Acad. ChildAdolesc. Psychol. 39:1356-64
45. Flinn MV, England BG. 1995. Childhood stress and family environment. Curr. Anthropol. 36:854-66
46. Fox NA, Henderson HA, Rubin KH, Calkins SD, Schmidt LA. 2001. Continuity and discontinuity of behavioral inhibition and exuberance: psychophysiological and behavioral influences across the first four years of life. Child Dev. 72:1-21
47. Fox NA, Nichols K, Henderson H, Rubin K, Schmidt L, et al. 2005. Evidence for a geneenvironment interaction in predicting behavioral inhibition in middle childhood. Psychol. Sci. 16:921-26
48. Francis D, Diorio J, Plotsky PM, Meaney MJ. 2002. Environmental enrichment reverses the effects of maternal separation on stress reactivity. J. Neurosci. 22:7840-43
49. Frankenhaeuser M. 1986. A psychobiological framework for research on human stress and coping. In Dynamics of Stress: Physiological, Psychological, and Social Perspectives, ed. MH Appley, R Trumbull, pp. 101-16. New York: Plenum
50. Girdler SS, Sherwood A, Hinderliter A, LesermanJ, Costello N, et al. 2003. Biologic correlates of abuse in women with premenstrual dysphoric disorder and healthy controls. Psychol. Med. 65:849-56
51. Glaser D. 2000. Child abuse and neglect and the brain - a review. J. Child Psychol. Psychiatry 41:97-116
52. Granger DA, Weisz JR, McCracken JT. 1996. Reciprocal influences among adrenocortical activation, psychosocial processes, and the behavioral adjustment of clinic-referred children. Child Dev. 67:3259-60
53. Gray TS, Bingaman EW. 1996. The amygdala: corticotropin-releasing factor, steroids, and stress. Crit. Rev. Neurobiol. 10:155-68
54. Gunnar M. 1992. Reactivity of the hypothalamic-pituitary-adrenocortical system to Stressors in normal infants and children. Pediatrics 90:491-97
55. Gunnar M. 2000. Early adversity and the development of stress reactivity and regulation, In The Effects of Adversity on Neurobehavioral Development. The Minnesota Symposia on Child Psychology, ed. CA Nelson, pp. 163-200. Mahwah, NJ: Erlbaum
56. Gunnar M. 2001. The role of glucocorticoids in anxiety disorders: a critical analysis. In The Developmental Psychopathology of Anxiety, ed. MW Vasey, M Dadds, pp. 143-59. New York: Oxford Univ. Press
57. Gunnar M. 2003. Integrating neuroscience and psychosocial approaches in the study of early experiences. In Roots of Mental Illness in Children, ed. JA King, CF Ferris, II Lederhendler, pp. 238-47. New York: NY Acad. Sci.
58. Gunnar M, Brodersen L, Nachmias M, Buss KA, Rugatuso J. 1996. Stress reactivity and attachment security. Dev. Psychobiol. 29:191-204
59. Gunnar M, Davis EP. 2003. The developmental psychobiology of stress and emotion in early childhood. In Comprehensive Handbook of Psychology: Volume 6. Developmental Psychology, ed IB Weiner, RM Lerner, MA Easterbrooks, J Mistry, pp. 113-43. New York: Wiley
60. Gunnar M, Donzella B. 2002. Social regulation of the cortisol levels in early human development. Psychoneuroendocrinology 27:199-220
61. Gunnar M, Fisher PA. 2006. Bringing basic research on early experience and stress neurobiology to bear on preventive interventions for neglected and maltreated children. Dev. Psychopathol. In press
62. Gunnar M, Larson M, Hertsgaard L, Harris M, Brodersen L. 1992. The stressfulness of separation among 9-month-old infants: effects of social context variables and infant temperament. Child Dev. 63:290-303
63. Gunnar M, Sebanc AM, Tout K, Donzella B, van Dulmen MMH. 2003. Temperament, peer relationships, and cortisol activity in preschoolers. Dev. Psychobiol. 43:346-58
64. Gunnar M, Talge NM. 2006. Neuroendocrine measures in developmental research. In Developmental Psychophysiology, ed. LA Schmidt, S Segalowitz. New York: Cambridge Univ. Press. In press
65. Gunnar M, Tout K, de Haan M, Pierce S, Stansbury K. 1997. Temperament, social competence, and adrenocortical activity in preschoolers. Dev. Psychobiol. 31:65-85
66. Gunnar M, Vazquez D. 2006. Stress neurobiology and developmental psychopathology. In Developmental Psycbopatbology: Developmental Neuroscience, ed. D Cicchetti, D Cohen, pp. 533-77. New Yorks Wiley
67. Hadjian AJ, Chedin M, Cochet C, Chambaz EM. 1975. Cortisol binding to proteins in plasma in the human neonate and infant. Pediatr. Res. 9:40-45
68. Halligan SL, Herbert J, Goodyer IM, Murray L. 2004. Exposure to postnatal depression predicts elevated cortisol in adolescent offspring. Biol. Psychol. 55:376-81
69. Hane AA, Fox NA. 2006. Natural variations in maternal caregiving of human infants influence stress reactivity. Psychol. Sci. 17:550-56
70. Hart J, Gunnar M, Cicchetti D. 1995. Salivary cortisol in maltreated children: evidence of relations between neuroendocrine activity and social competence. Dev. Psychopathol. 7:1126
71. Heim C, Nemeroff CB. 2001. The role of childhood trauma in the neurobiology of mood and anxiety disorders: preclinical and clinical studies. Biol. Psycbol. 49:1023-39
72. Heim C, Newport DJ, Bonsall R, Miller AH, Nemeroff CB. 2001. Altered pituitary-adrenal axis responses to provocative challenge tests in adult survivors of childhood abuse. Am. J. Psychiatry 158:575-81
73. Heim C, Newport DJ, Heit S, Graham YP, Wilcox MBR, et al. 2000. Pituitary-adrenal and autonomie responses to stress in women after sexual and physical abuse in childhood. J. Am. Med. Assoc. 284:592-97
74. Heim C, Newport J, Wagner D, Wilcox MM, Miller AH, Nemeroff CB. 2002. The role of early adverse experience and adulthood stress in the prediction of neuroendocrine stress reactivity in women: a multiple regression analysis. Depress. Anxiety 15:117-25
75. Heim C, Plotsky P, Nemeroff CB. 2004. The importance of studying the contributions of early adverse experiences to the neurobiological findings in depression. Neuropsychopharmacology 29:641-48
76. Heinrichs SC, Menzaghi F, Pich EM, Britton KT, Koob GF. 1995. The role of CRF in behavioral aspects of stress. Ann. NYAcad. Sci. 771:92-104
77. Herman JP, Cullinan WE. 1997. Neurocircuitry of stress: central control of the hypothalamo-pituitary-adrenocortical axis. Trends Neurosci. 20:78-84
78. Herman JP, Tasker JG, Ziegler DR, Cullinan WE. 2002. Local circuit regulation of par-aventricular nucleus stress integration glutamate-GABA connections. Pharmacol. Biochem. Behav. 71:457-68
79. Hertsgaard L, Gunnar MR, Erickson M, Nachmias M, 1995. Adrenocortical responses to the strange situation in infants with disorganized/disoriented attachment relationships. Child Dev. 66:1100-6
80. Izard CE, Forges SW, Simons RF, Haynes OM, Parisi M, Cohen B. 1991. Infant cardiac activity: developmental changes and relations with attachment. Dev. Psycbol. 27:432-39
81. Jonetz-Mentzel L, Wiedenmann G. 1993. Establishment of reference ranges for cortisol in neonates, infants, children and adolescents. Eur. J. Clin. Chem. Clin. Biochem. 31:525-29
82. Kagan J, Reznick JS, Snidman N. 1987. The physiology and psychology of behavioral inhibition in children. Child Dev. 58:1459-73
83. Kagan J, Reznick JS, Snidman N. 1988. Biological bases of childhood shyness. Science 240: 167-71
84. Kalin NH, Larson C, Shelton SE, Davidson RJ. 1998. Asymmetric frontal brain activity, cortisol, and behavior associated with fearful temperament in rhesus monkeys. Behav. Neurosci. 112:286-92
85. Kalin NH, Shelton SE, Barksdale CM. 1988. Opiate modulation of separation-induced distress in nonhuman primates. Brain Res. 440:856-62
86. Kalin NH, Shelton SE, Barksdale CM. 1989. Behavioral and physiologic effects of CRH administered to infant primates undergoing maternal separation. Neuropsychopharmacology 2:97-104
87. Kaufman J, Birmaher B, Perel J, Dahl RE, Moreci P, et al. 1997. The corticotropin-releasing hormone challenge in depressed abused, depressed nonabused, and normal control children. Biol. Psychiatry 42:669-79
88. Kaufman J, Yang BZ, Douglas-Palumberi H, Houshyar S, Lipschitz DKJH, Gelernter J. 2004. Social supports and serotonin transporter gene moderate depression in maltreated children. Proc. Natl. Acad. Sci. USA 101:17316-21
89. Kiess W, Meidert RA, Dressensorfer K, Schriever U, Kessler A, et al. 1995. Salivary cortisol levels throughout childhood and adolescence: relation with age, pubertal stage, and weight. Pediatr. Res. 37:502-6
90. Klimes-Dougan B, Hastings PD, Granger DA, Usher BA, Zahn-Waxler C. 2001. Adrenocortical activity in at-risk and normally developing adolescents: individual differences in salivary cortisol basal levels, diurnal variation, and responses to social challenges. Dev. Psycbol. 13:695-719
91. Klug I, Dressendorfer RA, Strasburger C, Kuhl GP, Reiter A, et al. 2000. Cortisol and 17hydroxyprogesterone in saliva of healthy neonates: normative data and relation to body mass index, arterial cord blood pH and time of sampling after birth. Biol. Neonat. 78:22-26
92. Kroupina M, Gunnar M, Johnson D. 1997. Report on salivary cortisol levels in a Russian baby home. Minneapolis, MN: Inst. Child Dev., Univ. Minn., Minneapolis
93. Ladd CO, Huot RL, Thrivikraman KV, Nemeroff CB, Meaney MJ, Plotsky PM. 2000. Long-term behavioral and neuroendocrine adaptations to adverse early experience. Prog. Brain Res. 122:81-103
94. Larson M, White BP, Cochran A, Donzella B, Gunnar MR. 1998. Dampening of the cortisol response to handling at 3 months in human infants and its relation to sleep, circadian cortisol activity, and behavioral distress. Dev. Psycbobiol. 33:327-37
95. Lashansky G, Saenger P, Kishman K, Gautier T, Mayes D, et al. 1991. Normative data for adrenal steroidogenesis in a healthy pediatric population: age- and sex-related changes after adrenocorticotropin stimulation. J. Clin. Endocrin. Metab. 76:674-86
96. Legro RS, Lin HM, Deniers LM, Lloyd T. 2003. Urinary free cortisol increases in adolescent Caucasian females during perimenarche. J. Clin. Endocrin. Metab. 88:215-19
97. Lesch KP. 2001. Variation of serotonergic gene expression: neurodevelopment and the complexity of response to psychopharmacologic drugs. Eur. Neuropsychopharmacol. 11:457-74
98. Levine S, Wiener SG. 1988. Psychoendocrine aspects of mother-infant relationships in nonhuman primates. Psychoneuroendocrinology 13:143-54
99. Lupien SJ, King S, Meaney MJ, McEwen BS. 2000. Child's stress hormone levels correlate with mother's socioeconomic status and depressive state. Biol. Psychiatry 48:976-80
100. Lyons-Ruth K, Easterbrooks MA, Cibelli CD. 1995. Disorganized attachment strategies and mental lag in infancy: prediction of externalizing problems at age seven. Presented at Soc. Res. Child Dev., Indianapolis, Ind.
101. Mason WA. 2000. Early developmental influences of experience on behavior, temperament, and stress. In Biology of Animal Stress: Basic Principles and Implications for Animal Welfare, ed. GP Moberg, JAMench, pp. 269-90. Wallingford, UK: CAB Int.
102. Matagos S, Moustogiannis A, Vagenakis AG. 1998. Diurnal variation in plasma cortisol levels in infancy. J. Pediatr. Endocrin. Metab. 11:549-53
103. McBurnett K, Lahey BB. 1994. Psychophysiological and neuroendocrine correlates of conduct disorder and antisocial behavior in children and adolescents. Prog. Exp. Pers. Psychopathol. Res. 1994:199-213
104. McBurnett K, Lahey BB, Rathouz PJ, Loeber R. 2000. Low salivary cortisol and persistent aggression in boys referred for disruptive behavior. Arch. Gen. Psychiatry 57:38-43
105. McEwen BS, Seeman T. 1999. Protective and damaging effects of mediators of stress: elaborating and testing the concepts of allostasis and allostatic load. Ann. NYAcad. Sci. 896:30-47
106. Meaney M, Szyf M. 2005. Environmental programming of stress responses through DNA methylation: life at the interface between a dynamic environment and a fixed genome. Dialogues Clin. Neurosci. 7:103-23
107. Morilak DA, Barrera G, Echevarria J, Garcia AS, Hernandez A, et al. 2005. Role of brain norepinephrine in the behavioral response to stress. Prog. Neuropsychopharmacol. Biol. Psychiatry 29:1214-24
108. Nachmias M, Gunnar MR, Mangelsdorf S, Parritz R, Buss KA. 1996. Behavioral inhibition and stress reactivity: moderating role of attachment security. Child Dev. 67:508-22
109. Nemeroff CB. 1996. The corticotropin-releasing factor (CRF) hypothesis of depression: new findings and new directions. Mol. Psychiatry 1:336-42
110. Netherton C, Goodyer I, Tamplin A, Herbert J. 2004. Salivary cortisol and dehydroepiandrosterone in relation to puberty and gender. Psychoneuroendocrinology 29:125-40
111. Newport DJ, Heim C, Bonsall R, Miller AH, Nemeroff CB. 2004. Pituitary-adrenal responses to standard and low-dose dexamethasone suppression tests in adult survivors of child abuse. Biol. Psychiatry 55:10-20
112. Newport DJ, Heim C, Owen MJ, Ritchie JC, Ramsey CH, et al. 2003. Cerebral spinal fluid corticotropin-releasing factor (CRF) and vasopressin concentrations predict pituitary responses to the CRF stimulation test: a multiple regression analysis. Neuropsychopharmacology 28:569-76
113. Palkovits M. 1987. Organization of the stress response at the anatomical level. In Progress in Brain Research, ed. ER de Kloet, VM Wiegant, D de Wied, pp. 47-55. Amsterdam: Elsevier Sci.
114. Pollak SD. 2005. Early adversity and mechanisms of plasticity: integrating affective neuroscience with developmental approaches to psychopathology. Dev. Psychopathol. 17:735-52
115. Porges SW. 1992. Vagal tone: a physiological marker of stress vulnerability. Pediatrics 90:498504
116. Porges SW, Doussard-Roosevelt JA, Portales AL, Suess PE. 1994. Cardiac vagal tone: stability and relation to difficultness in infants and 3-year-olds. Dev. Psychobiol. 27:289-300
117. Repetti R, Taylor SE, Seeman T. 2002. Risky families: family social environments and the mental and physical health of offspring. Psycbol. Bull. 128:330-66
118. Rinne T, de Kloet ER, Wouters L, Goekoop JG, DeRijk RH, van den Brink W. 2002. Hyperresponsiveness of hypothalamic-pituitary-adrenal axis to combined dexamethasone/corticotropin releasing hormone challenge in female borderline personality disorder subjects with a history of sustained child abuse. Biol. Psychiatry 52:1102-12
119. Rosen JB, Schulkin J. 1998. From normal fear to pathological anxiety. Psychol. Rev. 105:325-50
120. Rosenblum LA, Andrews MW. 1994. Influences of environmental demand on maternal behavior and infant development. Acta Paediat. Suppl. 397:57-63
121. Rosenblum LA, Coplan JD, Friedman S, Bassoff T, Gorman JM, Andrews MW. 1994. Adverse early experiences affect noradrenergic and serotonergic functioning in adult primates. Biol. Psychiatry 35:221-27
122. Rosenfeld P, Suchecki D, Levine S. 1992. Multifactorial regulation of the hypothalamicpituitary-adrenal axis during development. Neurosci. Biobehav. Rev. 16:553-68
123. Rosner W. 1990. The function of corticosteroid-binding globulin and sex hormone-binding globulin: recent advances. Endocr. Rev. 11:80-91
124. Rothbart MK, Evans DE, Ahadi SA. 2000. Temperament and personality: origins and outcomes. J. Personal. Soc. Psychol. 78:122-35
125. Rubin K, Bukowski W, Parker JG. 1998. Peer interactions, relationships, and groups. In Handbook of Child Psychology, Volume 3, ed. W Damon, N Eisenberg, pp. 619-700. New York: Wiley
126. Sanchez MM, Ladd CO, Plotsky PM. 2001. Early adverse experience as a developmental risk factor for later psychopathology: evidence from rodent and primate models. Dev. Psychopathol. 13:419-50
127. Sanchez MM, Young LJ, Plotsky PM, Insel TR. 1999. Different rearing conditions affect the development of corticotropin-releasing hormone (CRF) and arginine vasoprtssin (AVP) systems in the nonhumanprimate. Presented at 29th Annu. Meet. Soc. Neurosci., Miami Beach, FL
128. Sanchez MM, Young LJ, Plotsky PM, Insel TR. 2000. Distribution of corticosteroid receptors in the rhesus brain: relative absence of glucocorticoid receptors in the hippocampal formation. J. Neurosci. 20:4657-68
129. Sapolsky RM. 1997. McEwen-induced modulation of endocrine history: a partial review. Stress 2:1-12
130. Sapolsky RM, Romero LM, Munck AU, 2000. How do glucocorticoids influence stress responses? Integrating permissive, suppressive, stimulatory, and preparative actions. Endocr. Rev. 21:55-89
131. Schmidt LA, Fox NA, Rubin KH, Sternberg EM, Gold PW, et al. 1997. Behavioral and neuroendocrine responses in shy children. Dev. Psychobiol. 30:127-40
132. Schwartz CE, Wright CI, Shin LM, KaganJ, Rauch SL. 2003. Inhibited and uninhibited infants "grown up": adult amygdalar response to novelty. Science 300:1952-53
133. Shekhar A, Truitt W, Rainnie D, Sajdyk T. 2005. Role of stress, corticotrophin-releasing factor (CRF) and amygdala plasticity in chronic anxiety. Stress 8:209-19
134. Shirtcliff E. 2 003. Low salivary cortisol levels and externalizing behavior problems: a latent state trait model in normally developing youth. PhD thesis. Penn. State Univ., Univ. Park
135. Smotherman WP, Hunt LE, McGinnis LM, Levine S. 1979. Mother-infant separation in group-living rhesus macaques: a hormonal analysis. Dev. Psychobiol. 12:211-17
136. Spangler G, Grossmann K. 1997. Individual and physiological correlates of attachment disorganization in infancy, In Attachment Disorganization, ed. J Solomon, C George, pp. 95-126. New York: Guilford
137. Spangler G, Schieche M. 1998. Emotional and adrenocortical responses of infants to the strange situation: the differential function of emotional expression. Int. J. Behav. Dev. 22:681-706
138. Spear LP. 2000. The adolescent brain and age-related behavioral manifestations. Neurosci. Biobehav. Rev. 24:417-63
139. Sroufe LA, Waters E. 1979. Heart rate as a convergent measure in clinical and developmental research. Merrill-Palmer Q. 23:3-27
140. Stansbury K, Gunnar M. 1994. Adrenocortical activity and emotion regulation. Monogr. Soc. Res. Child Dev. 59(2-3): 108-34
141. Stratakis CA, Chrousos GP. 1995. Neuroendocrinology and pathophysiology of the stress system. In Stress: Basic Mechanisms and Clinical Implications, ed. GP Chrousos, RMcCarty, KPacak, G Cizza, E Sternberg, PWGold, RKvetsnansky, pp. 1-18. New York: NY Acad. Sci.
142. Suchecki D, Rosenfeld P, Levine S. 1993. Maternal regulation of the hypothalamic-pituitaryadrenal axis in the rat: the roles of feeding and stroking. Dev. Brain Res. 75:185-92
143. Suomi SJ. 1995. Influence of attachment theory on ethological studies of biobehavioral development in nonhuman primates. In Attachment Theory: Social, Developmental, and Clinical Perspectives, ed. S Goldberg, R Muir, J Kerr, pp. 185-201. Hillsdale, NJ: Analytic Press
144. Swiergiel AH, Takahashi LK, Kalin NH. 1993. Attenuation of stress-induced behavior by antagonism ofcorticotropin-releasing factor receptors in the central amygdala in the rat. Brain Res. 623:229-34
145. Tasaptsaris NP, Breslin DJ. 1989. Physiology of the adrenal medulla. Urol. Clin. North Am. 16:439-45
146. Teicher MH, Andersen SL, Polcarri A, Anderson CM, Navalta CP. 2002. Developmental neurobiology of childhood stress and trauma. Psychiatr. Clin. North Am. 25:397-426
147. Tottenham NH, Hare TA, Quinn BT, McCarry TW, Nurse M, et al. 2006. Amygdala volume and sensitivity to emotional information following orphanage rearing. Manuscr. under review
148. Tout K, de Haan M, Campbell EK, Gunnar MR. 1998. Social behavior correlates of cortisol activity in child care: gender differences and time-of-day effects. Child Dev. 69:1247-62
149. van Goozen SH, Matthys W, Cohen-Kettenis PT, Buittelaar JK, van Engeland H. 2000. Hypothalamic-pituitary-adrenal axis and autonomie nervous system activity in disruptive children and matched controls. J. Am. Acad. Child Adolesc. Psychiatry 39:1438-45
150. van Ijzendoorn HW, Schuengel C, Bakersmans-Kranenburg MJ. 1999. Disorganized attachment in early childhood: meta-analysis of precursors, concomitants, and sequelae. Dev. Psychopathol. 11:225-49
151. Vollmer RR. 1996. Selective neural regulation of epinephrine and norepinephrine cells in the adrenal medulla - cardiovascular implications. Clin. Exp. Hypertens. 18:731-51
152. Vythilingam M, Heim C, Newport J, Miller AH, Anderson E, et al. 2002. Childhood trauma associated with smaller hippocampal volume in women with major depression. Am. J. Psychiatry 159:2072-80
153. Walker EF, Walder DJ, Reynolds R. 2001. Developmental changes in cortisol secretion in normal and at-riskyouth. Dev. Psychopathol. 13:721-32
154. Watamura S, Donzella B, Kertes DA, Gunnar MR. 2004. Developmental changes in baseline cortisol activity in early childhood: relations with napping and effortful control. Dev. Psychobiol. 45:125-33
155. Watamura S, Sebanc A, Donzella B, Gunnar M. 2002a. Naptime at childcare: effects on salivary cortisol levels. Dev. Psychobiol. 40:33-42
156. Watamura SE, Donzella B, Alwin J, Gunnar M. 2003. Morning to afternoon increases in cortisol concentrations for infants and toddlers at child care: age differences and behavioral correlates. Child Dev. 74:1006-20
157. Watamura SE, Sebanc AM, Gunnar MR. 2002b. Rising cortisol at childcare: relations with nap, rest, and temperament. Dev. Psychobiol. 40:33-42
158. Weaver IC, Champagne FA, Brown SE, Dymov S, Sharma S, et al. 2005. Reversal of maternal programming of stress responses in adult offspring through methyl supplementation: altering epigenetic marking later in life. J. Neurosci. 25:11045-54
159. Weaver IC, La Plante P, Weaver S, Parent A, Sharma S, et al. 2001. Early environmental regulation of hippocampal glucocorticoid receptor gene expression: characterization of intracellular mediators and potential genomic target sites. Mol. Cell. Endocrinol. 185:20518
160. Wewerka S, Madsen NJ, Wiik K. 2005. Developmental physiologic and neuroendocrine responses to a Stressor in 9-, 11-, and 13-year-old children. Presented at Soc. Res. Child Dev., Atlanta, GA
161. White BP, Gunnar MR, Larson MC, Donzella B, Barr RG. 2000. Behavioral and physiological responsivity, sleep and patterns of daily cortisol in infants with and without colic. Child Dev. 71:862-77
162. Yehuda R. 2 000. Biology of posttraumatic stress disorder. J. Clin. Psychiatry 61 (Suppl. 7) : 15-21
163. Young EA, Haskett RF, Murphy-Weinberg V, Watson SJ, Akil H. 1991. Loss of glucocorticoid fast feedback in depression. Arch. Gen. Psychiatry 48:693-99