Psychological and neuroendocrinological sequelae of early social deprivation in institutionalized children in Romania

Annals of the New York Academy of Sciences

Volumn 807, Issue , 1997, Pages 419-428

  Carlson, Mary ^a   Earls, Felton ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HYDROCORTISONE;

BRAIN DEVELOPMENT; BRAIN INJURY; COGNITIVE DEVELOPMENT; CONFERENCE PAPER; CONTROLLED STUDY; HUMAN; HYDROCORTISONE BLOOD LEVEL; INFANT; NEUROENDOCRINOLOGY; PHYSICAL DEVELOPMENT; PRESCHOOL CHILD; ROMANIA; SENSORY DEPRIVATION; SOCIAL ISOLATION; STRESS;

EID: 0030973724     PISSN: 00778923     EISSN: None     Source Type: Book Series    
DOI: 10.1111/j.1749-6632.1997.tb51936.x     Document Type: Conference Paper

References (34)

1. THE SITUATION OF CHILD AND FAMILY IN ROMANIA. 1995. The National Committee for Child Protection, Romanian Government and United Nations Children's Fund (UNICEF).
2. MUNIR, K & F. EARLS. 1992. Ethical principles governing research in child and adolescent psychiatry. J. Am. Acad. Child Adolesc. Psychiatry 31: 408-414.
3. THIS DOCUMENT WAS ADOPTED BY THE U.N. GENERAL ASSEMBLY IN 1989. As of March 1996, 180 member countries have signed or become State Parties to the CRC while the United States is among the 6 countries that have neither signed nor become State Parties to this document.
4. HAMMERBERG, T. 1992. Making Reality of the Rights of the Child, Save the Children. Sweden.
5. HARLOW, H. F. AND M. K. HARLOW. 1973. Social deprivation in monkeys. In Readings from the Scientific American: The Nature and Nurture of Behavior.: 108-116. W. H. Freeman Co. San Francisco.
6. MASON, W. A. 1970. Early deprivation in the biological perspective. In Education of the Infant and Young Child. V. H. Denenberg, Ed.: 25-50. Academic Press. New York.
7. RANDOLPH, M. C. & W. A. MASON. 1969. Effects of rearing conditions on distress vocalization in chimpanzees. Folia Primatol. 10: 103-112.
8. CARLSON, M. 1990. Role of somatic sensory cortex in tactile discrimination in primates. In Cerebral Cortex. E. G. Jones & A. Peters, Eds. Vol. 8B: 451-486. Plenum. New York.
9. CARLSON, M. & H. BURTON. 1988. Recovery of tactile function after damage to primary or secondary somatic sensory cortex in infant Macaca mulatta. J. Neurosci. 8: 833-859.
10. CARLSON, M., D. D. M. O'LEARY & H. BURTON. 1987. Potential role of thalamocortical connections in recovery of tactile function following somatic sensory cortex lesions in infant primates. Soc. Neurosci. Abstr. 13: 25.2.
11. MEANEY, M. J., R. M. SAPOLSKY & B. S. MCEWEN. 1985. The development of the glucocorticoid receptor system in the rat limbic brain: II. An autoradiographic study. Dev. Brain Res. 18: 159-164.
12. MEANEY, M. J., S. BHATNAGAR, J. DIORO, S. LAROCQUE, D. FRANCIS, D. O'DONNELL, N. SHANKS, S. SHARMA, J. SMYTHE & V. VIAU. 1993. Molecular basis for the development of individual differences in the hypothalamic-pituitary-adrenal stress response. Cell. Mol. Neurobiol. 13: 321-347.
13. MEANEY, M. J., D. H. AITKEN, S. SHARMA, S. VIAU & A. SARRIEAU. 1989. Postnatal handling increases hippocampal type II, glucocorticoid receptors and enhances adreno-cortical negative-feedback efficacy in the rat. Neuroendocrinology 50: 597-604.
14. MEANEY, M. J. & D. H. AITKEN. 1985. The effects of early postnatal handling on the development of hippocampal glucocorticoid receptors: Temporal parameters. Dev. Brain Res. 22: 301-304.
15. SAPOLSKY, R. M., H. UNO, C. S. REBERT & C. E. FINCH. 1990. Hippocampal damage associated with prolonged glucocorticoid exposure in primates. J. Neurosci. 10: 2897-2902.
16. MCEWEN, B. S., J. ANGULO, H. CAMERON, H. M. CHAO, D. DANIELS, M. N. GANNON, E. GOULD, S. MENDELSON, R. SAKAI, R. SPENCER & C. WOOLLEY. 1992. Paradoxical effects of adrenal steroids on the brain: Protection vs degeneration. Biol. Psychiatry 11: 177-199.
17. WATANABE, Y., E. GOULD & B. S. MCEWEN. 1992. Stress induces atrophy of apical dendrites of hippocampal CA3 pyramidal neurons. Brain Res. 588: 341-345.
18. BODNOFF, S. R., A. G. HUMPHREYS, J. C. LEHMAN, D. M. DIAMOND, G. M. ROSE & M. J. MEANEY. 1995. Enduring effects of chronic corticosterone treatment on spatial learning, synaptic plasticity, and hippocampal neuropathology in young and mid-aged rats. J. Neurosci. 15: 61-69.
19. SAPOLSKY, R. M. 1994. The physiological relevance of glucocorticoid endangerment of the hippocampus. In Brain Corticosteroid Receptors: Studies on the Mechanism, Function and Neurotoxicity of Corticosteroid Action. E. R deKloet, E. C. Azmitia, & P. W. Landfield, Eds. Ann. N.Y. Acad. Sci. 746: 294-307.
20. SPARLING, J., B. BASCOM, M. CIONGRADI, C. DRAGOMIR & A. BODEA. 1992. Programul Screening-Interventie. Paper Presented at the Sixth Annual Conference of Children at Risk. University of Colorado and Pan American Health Organization.
21. MEANEY, M. J., D. H. AITKEN, S. R. BONDNOFF, L. J. INY & R. M. SAPOLSKY. 1985. The effects of postnatal handling on the development of the glucocorticoid receptor systems and stress recovery in the rat. Prog. Neuropsychopharmacol. Biol. Psychol. 9: 731-734.
22. KIRSCHBAUM, C. & D. H. HELLHAMMER. 1994. Salivary cortisol in psychoneuroendocrine research: Recent developments and applications. Psychoneuroendocrinology. 19: 313-333.
23. PRICE, D. A., G. C. CLOSE & B. A. FIELDING. 1983. Age of appearance of circadian rhythm in salivary cortisol values in infancy. Arch. Dis. Child. 58: 454-456.
24. GUNNAR, M., L. HERTSGAARD, M. LARSON & J. RIGATUSO. 1991. Cortisol and behavioral responses to repeated stressor in the human newborn. Dev. Psychobiol. 24: 487-506.
25. YEHUDA, R., B. KAHANA, K. BINDER-BRYNES, S. SOUTHWICK, S. ZEMELMAN, J. W. MASON & E. L. GILLER. 1995. Low urinary cortisol excretion in holocaust survivors with posttraumatic stress disorder. Am. J. Psychiatry 152: 1815-1818.
26. BREMNER, J. D., P. RANDALL, T. M. SCOTT, R. A. BRONEN, J. P. SEIBYL, S. M. SOUTHWICK, R. C. DELANEY, G. MCCARTHY, D. S. CHARNEY & R. B. INNIS. 1995. MRI-based measurement of hippocampal volume in patients with combat-related posttraumatic stress disorder. Am. J. Psychiatry 152: 973-981.
27. STARKMAN, M. N., S. S. GEBARSKI, S. BERENT & D. E. SCHTEINGART. 1992. Hippocampal formation volume, memory dysfunction and cortisol levels in patients with Cushing's syndrome. Biol. Psychiatry 32: 756-765.
28. DAHL, R., N. RYAN, J. PUIG-ANTICH, N. NGUYEN, M. AL-SHABBOUT, V. MEYER & J. PEREL. 1991. 24-hour cortisol measures in adolescents with major depression: A controlled study. Biol. Psychiatry 30: 25-36.
29. BENDER, B. G., J. A. LERNER & E. KOLLASCH. 1988. Mood and memory changes in asthmatic children receiving corticosteroids. J. Am. Acad. Child Adol. Psychiatry 27: 720-725.
30. RUBINOW, D. R., R. M. POST, R. SAVARD & P. W. GOLD. 1984. Cortisol hypersecretion and cognitive impairment in depression. Arch. Gen. Psychiatry 41: 279-283.
31. CARTER, K. M., E. AMES & S. MORISON. 1995. Attachment security and indiscriminately friendly behavior in children adopted from Romanian orphanages. Dev. and Psychopathol. 7: 283-294.
32. EARLS, F. & M. CARLSON. 1996. Recovery from profound social deprivation. In preparation.
33. NATIONAL CENTER ON POVERTY IN CHILDREN. ANNUAL REPORT. 1995. Columbia University School of Public Health. New York, NY.
34. FRANK, D. A., P. E. KLASS, F. EARLS & L. EISENBERG. 1996. Infants and orphanages? A view from the Pediatrics and Child Psychiatry. Pediatrics. 97: 569-578.