Evidence for a gene-environment interaction in predicting behavioral inhibition in middle childhood

Psychological Science

Volumn 16, Issue 12, 2005, Pages 921-926

  Fox, Nathan A ^a   Nichols, Kate E ^a   Henderson, Heather A ^b   Rubin, Kenneth ^a   Schmidt, Louis ^c   Hamer, Dean ^d   Ernst, Monique ^d,e   Pine, Daniel S ^d,e  

^a UNIVERSITY OF MARYLAND   (United States)

^b Department of Biology   (United States)

^c MCMASTER UNIVERSITY   (Canada)

^d NATIONAL CANCER INSTITUTE   (United States)

^e NATIONAL INSTITUTE OF MENTAL HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

SEROTONIN TRANSPORTER;

ARTICLE; CHILD; CHILD BEHAVIOR; FEMALE; GENETIC POLYMORPHISM; GENETICS; HUMAN; INFANT; INHIBITION (PSYCHOLOGY); MALE; MOTHER CHILD RELATION; PHYSIOLOGY; QUESTIONNAIRE; SOCIAL ENVIRONMENT; SOCIAL SUPPORT;

CHILD; CHILD BEHAVIOR; FEMALE; HUMANS; INFANT; INHIBITION (PSYCHOLOGY); MALE; MOTHER-CHILD RELATIONS; POLYMORPHISM, GENETIC; QUESTIONNAIRES; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS; SOCIAL ENVIRONMENT; SOCIAL SUPPORT;

EID: 30344484828     PISSN: 09567976     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1467-9280.2005.01637.x     Document Type: Article

References (27)

1. Adamakos, H., Ryan, K., Ullman, D.G., & Pascoe, J. (1986). Maternal social support as a predictor of mother-child stress and stimulation. Child Abuse and Neglect, 10, 463-470.
2. Aiken, L.S., & West, S.G. (1991). Multiple regression: Testing and interpreting interactions. Newbury Park, CA: Sage Publications.
3. Arbelle, S., Benjamin, J., Golin, M., Kremer, I., Belmaker, R.H., & Ebstein, R.P. (2003). Relation of shyness in grade school children to the genotype for the long form of the serotonin transporter promoter region polymorphism. American Journal of Psychiatry, 160, 671-676.
4. Battaglia, M., Ogliari, A., Zanoni, A., Citterio, A., Pozzoli, U., Giorda, R., Maffei, C., & Marino, C. (2005). Influence of the serotonin transporter promoter gene and shyness on children's cerebral responses to facial expressions. Archives of General Psychiatry, 62, 85-94.
5. Beck, A.T., Ward, C.H., Mendelson, M., Mock, J., & Erbaugh, J. (1961). An inventory for measuring depression. Archives of General Psychiatry, 4, 561-571.
6. Brandt, P.A., & Weinert, C. (1981). The PRQ: A social support measure. Nursing Research, 30, 277-280.
7. Caspi, A., Snugden, K., Moffitt, T.E., Taylor, A., Craig, I.W., Harrington, H., McClay, J., Mill, J., Martin, J., Braithwaite, A., & Poulton, R. (2003). Influence of life stress on depression: Moderation by a polymorphism in the 5-HTT gene. Science, 301, 386-389.
8. Dealer-Deckard, K. (1998). Parenting stress and child adjustment: Some old hypotheses and new questions. Clinical Psychology: Science and Practice, 5, 314-332.
9. Fox, N.A., Henderson, H.H., Rubin, K., Calkins, S.D., & Schmidt, L.A. (2001). Continuity and discontinuity of behavioral inhibition and exuberance: Psychophysiological and behavioral influences across the first four years of life. Child Development, 72, 1-21.
10. Gelfand, D.M., & Teti, D.M. (1990). The effects of maternal depression on children. Clinical Psychology Review, 10, 329-353.
11. Gross, C., & Hen, R. (2004). The developmental origins of anxiety. Nature Reviews Neuroscience, 5, 545-552.
12. Hariri, A.R., Mattay, V.S., Tessitore, A., Kolachana, B., Fera, F., Goldman, D., Egan, M.F., & Weinberger, D.R. (2002). Serotonin transporter genetic variation and the response of the human amygdala. Science, 297, 400-403.
13. Heinz, A., Braus, D., Smolka, M.N., Wrase, J., Puls, I., Hermann, D., Klein, S., Grusser, S.M., Flor, H., Schumann, G., Mann, K., & Buchel, C. (2005). Amygdala-prefrontal coupling depends on a genetic variation of the serotonin transporter. Nature Neuroscience, 8, 20-21.
14. Kagan, J., Reznick, J.S., & Snidman, N. (1987). The physiology and psychology of behavioral inhibition in children. Child Development, 58, 1459-1473.
15. Kaufman, J., Yang, B.Z., Douglas-Palumberi, H., Houshyar, S., Lipschitz, D., Krystal, J.H., & Gelernter, J. (2004). Social supports and serotonin transporter gene moderate depression in maltreated children. Proceedings of the National Academy of Sciences, USA, 101, 17316-17421.
16. Lesch, K.P., Bengel, D., Heilis, A., Sabol, S.Z., Greenberg, B.D., Petri, S., Benjamin, J., Muller, C.R., Hamer, D.H., & Murphy, D.L. (1996). Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region. Science, 274, 1527-1531.
17. Meaney, M.J. (2001). Maternal care, gene expression, and the transmission of individual differences in stress reactivity across generations. Annual Review of Neuroscience, 24, 1161-1192.
18. Merikangas, K.R., & Risch, N. (2003). Genomic priorities in public health. Science, 302, 599-601.
19. Munafo, M.R., Clark, T.G., Moore, L.R., Payne, E., Walton, R., & Flint, J. (2003). Genelic polymorphisms and personality in healthy adulls: A systematic review and mela-analysis. Molecular Psychiatry, 8, 471-484.
20. Osofsky, J.D., & Thompson, M.D. (2000). Adaptive and maladaptive parenting: Perspeetives on risk and protective factors. In S.J. Meisels & J.P. Shonkoff (Eds.), Handbook of early Intervention (2nd ed., pp. 54-75). Cambridge, England: Cambridge University Press.
21. Risch, N., & Merikangas, K.R. (1996). The future of genetic studies of complex human diseases. Science, 273, 1516-1517.
22. Rowe, D.C., & Plomin, R.J. (1977). Temperament in early childhood. Journal of Personality Assessment, 41, 150-156.
23. Rubin, K.H. (2001). The Play Observation Scale (PUS). College Park: University of Maryland. (Available from K.H. Rubin. 3304 Benjamin Bldg., College Park, MD 20740)
24. Schmidt, L.A., Fox, N.A., Rubin, K.H., Hu, S., & Hamer, D.H. (2002). Molecular genetics of shyness and aggression in preschoolers. Personality and Individual Differences, 33, 227-238.
25. Schwartz, C.E., Wright, G.I., Shin, L.M., Kagan, J., & Rauch, S.L. (2003). Inhibited and uninhibited infants "grown up": Adult amygdalar response to novelty. Science, 300, 1952-1953.
26. Silberg, J., Rutter, M., Neale, M., & Eaves, L. (2001). Genetic moderation of environmental risk for depression and anxiety in adolescent girls. British Journal of Psychiatry, 179, 116-121.
27. Suomi, S.J. (2004). How gene-environment interactions shape biobehavioral development: Lessons from studies with rhesus monkeys. Research in Human Development, 3, 205-222.