Novel piperazines: Potent melanocortin-4 receptor antagonists with anxiolytic-like activity

Bioorganic and Medicinal Chemistry

Volumn 15, Issue 6, 2007, Pages 2375-2385

  Nozawa, Dai ^a   Okubo, Taketoshi ^a   Ishii, Takaaki ^a   Takamori, Kazuaki ^a   Chaki, Shigeyuki ^a   Okuyama, Shigeru ^a   Nakazato, Atsuro ^a  

^a TAISHO PHARMACEUTICAL CO LTD   (Japan)

Author keywords

Anxiety; Depression; Melanocortin 4 receptor antagonist; Piperazine

Indexed keywords

1 (3 BIPHENYL 2 YLPROPYL) 4 [2 (4 FLUOROPHENYL) 2 (1 ISOPROPYLPIPERIDIN 4 YL)ETHYL]PIPERAZINE; 1 [2 (4 FLUOROPHENYL) 2 (1 ISOPROPYLPIPERIDIN 4 YL)ETHYL] 4 [4 (2 METHOXY 1 NAPHTHYL)BUTYL]PIPERAZINE; 1 [2 (4 FLUOROPHENYL) 2 (1 METHYLPIPERIDIN 4 YL)ETHYL] 4 [4 (1 NAPHTHYL)BUTYL]PIPERAZINE; 1 [3 (2' FLUOROBIPHENYL 2 YL)PROPYL] 4 [2 (4 FLUOROPHENYL) 2 (ISOPROPYLPIPERADIN 4 YL)ETHYL]PIPERAZINE; 1 [3 (3 FLUOROBIPHENYL 2 YL)PROPYL] 4 [2 (4 FLUOROPHENYL) 2 (1 ISOPROPYLPIPERIDIN 4 YL)ETHYL]PIPERAZINE; 1 [3 (3' FLUOROBIPHENYL 2 YL)PROPYL] 4 [2 (4 FLUOROPHENYL) 2 (1 ISOPROPYLPIPERIDIN 4 YL)ETHYL]PIPERAZINE; 1 [3 (4 FLUOROBIPHENYL 2 YL)PROPYL] 4 [2 (4 FLUOROPHENYL) 2 (1 ISOPROPYLPIPERIDIN 4 YL)ETHYL]PIPERAZINE; 1 [3 (4' FLUOROBIPHENYL 2 YL)PROPYL] 4 [2 (4 FLUOROPHENYL) 2 (ISOPROPYLPIPERIDIN 4 YL)ETHYL]PIPERAZINE; 1 [3 (5 FLUOROBIPHENYL 2 YL)PROPYL] 4 [2 (4 FLUOROPHENYL) 2 (1 ISOPROPYLPIPERIDIN 4 YL)ETHYL]PIPERAZINE; 1 [3 (6 FLUORODIPHENYL 2 YL)PROPYL] 4 [2 (4 FLUOROPHENYL) 2 (1 ISOPROPYLPIPERIDIN 4 YL)ETHYL)PIPERAZINE; HORMONE RECEPTOR BLOCKING AGENT; MCL 0129; MELANOCORTIN 4 RECEPTOR ANTAGONIST; PIPERAZINE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL BEHAVIOR; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANXIETY DISORDER; ARTICLE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG SYNTHESIS; MALE; NONHUMAN; PHARMACODYNAMICS; RAT; STRESS; STRUCTURE ACTIVITY RELATION; TRANQUILIZING ACTIVITY;

ANIMALS; ANTI-ANXIETY AGENTS; BEHAVIOR, ANIMAL; CERCOPITHECUS AETHIOPS; COS CELLS; ESCAPE REACTION; MALE; MOTOR ACTIVITY; PIPERAZINES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTOR, MELANOCORTIN, TYPE 4; STRUCTURE-ACTIVITY RELATIONSHIP;

RATTUS;

EID: 33846906969     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2007.01.019     Document Type: Article

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