Design, synthesis, and SAR studies on a series of 2-pyridinylpiperazines as potent antagonists of the melanocortin-4 receptor

Bioorganic and Medicinal Chemistry Letters

Volumn 16, Issue 14, 2006, Pages 3693-3696

  Tran, Joe A ^a   Pontillo, Joseph ^a   Fleck, Beth A ^a   Marinkovic, Dragan ^a   Arellano, Melissa ^a   Tucci, Fabio C ^a   Lanier, Marion ^a   Saunders, John ^a   Jiang, Wanlong ^a   Chen, Caroline W ^a   Foster, Alan C ^a   Chen, Chen ^a  

^a NEUROCRINE BIOSCIENCES INC   (United States)

Author keywords

2 Pyridinylpiperazine; Antagonist; Melanocortin; Synthesis

Indexed keywords

BETA ALANINE DEXTRO (2,4 DICHLORO)PHENYLALANINE; DIPEPTIDE DERIVATIVE; MELANOCORTIN 4 RECEPTOR; PIPERAZINE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; DRUG ACTIVITY; DRUG DESIGN; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG SYNTHESIS; STRUCTURE ACTIVITY RELATION;

BETA-ALANINE; DIPEPTIDES; DRUG DESIGN; HUMANS; PIPERAZINES; PYRIDINES; RECEPTOR, MELANOCORTIN, TYPE 4; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 33746502001     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2006.04.069     Document Type: Article

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