Optimization of a privileged structure leading to potent and selective human melanocortin subtype-4 receptor ligands

Bioorganic and Medicinal Chemistry Letters

Volumn 16, Issue 5, 2006, Pages 1130-1133

  Bakshi, Raman K ^a   Hong, Qingmei ^a   Tang, Rui ^a   Kalyani, Rubana N ^a   MacNeil, Tanya ^a   Weinberg, David H ^a   Van Der Ploeg, Lex H T ^a   Patchett, Arthur A ^a   Nargund, Ravi P ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Melanocortin 4; Privileged structure

Indexed keywords

HORMONE RECEPTOR STIMULATING AGENT; LIGAND; MELANOCORTIN 4 RECEPTOR; OXAZOLIDINONE DERIVATIVE; PIPERIDINE DERIVATIVE; SULFONAMIDE; UREA;

ARTICLE; BINDING AFFINITY; DRUG ACTIVITY; DRUG DESIGN; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; IC 50;

DRUG DESIGN; HUMANS; LIGANDS; MOLECULAR STRUCTURE; RECEPTOR, MELANOCORTIN, TYPE 4; SENSITIVITY AND SPECIFICITY; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY;

EID: 31344465505     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2005.11.095     Document Type: Article

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