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Volumn 109, Issue 3, 2007, Pages 1043-1050

Human plasmacytoid dendritic cells regulate immune responses to Epstein-Barr virus (EBV) infection and delay EBV-related mortality in humanized NOD-SCID mice

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA INTERFERON; CHLOROQUINE; CPG OLIGODEOXYNUCLEOTIDE; TOLL LIKE RECEPTOR 9;

EID: 33846878526     PISSN: 00064971     EISSN: 00064971     Source Type: Journal    
DOI: 10.1182/blood-2005-12-024802     Document Type: Article
Times cited : (76)

References (55)
  • 1
    • 0018397164 scopus 로고
    • Primary infection with Epstein-Barr virus in infants in the United States: Clinical and serologic observations
    • Fleisher G, Henle W, Henle G, Lennette E, Biggar R. Primary infection with Epstein-Barr virus in infants in the United States: clinical and serologic observations. J Infect Dis. 1979;139:553-558.
    • (1979) J Infect Dis , vol.139 , pp. 553-558
    • Fleisher, G.1    Henle, W.2    Henle, G.3    Lennette, E.4    Biggar, R.5
  • 2
    • 0034680005 scopus 로고    scopus 로고
    • Epstein-Barr virus infection
    • Cohen JI. Epstein-Barr virus infection. N Engl J Med. 2000;343:481-492.
    • (2000) N Engl J Med , vol.343 , pp. 481-492
    • Cohen, J.I.1
  • 3
    • 0024389731 scopus 로고
    • Epstein-Barr virus associated lymphoproliferative diseases (B cell lymphoma) after transplantation
    • Garnier J, Berger F, Betual H. Epstein-Barr virus associated lymphoproliferative diseases (B cell lymphoma) after transplantation. Nephrol Dial Transplant. 1989;4:818-823.
    • (1989) Nephrol Dial Transplant , vol.4 , pp. 818-823
    • Garnier, J.1    Berger, F.2    Betual, H.3
  • 4
    • 0028877392 scopus 로고
    • Risk factors and pathogenesis of posttransplant lymphoproliferative disorders
    • Ho M. Risk factors and pathogenesis of posttransplant lymphoproliferative disorders. Transplant Proc. 1995;27:38-40.
    • (1995) Transplant Proc , vol.27 , pp. 38-40
    • Ho, M.1
  • 6
    • 0032546352 scopus 로고    scopus 로고
    • Dendritic cells and the control of immunity
    • Banchereau J, Steinman RM. Dendritic cells and the control of immunity. Nature. 1998;392:245-251.
    • (1998) Nature , vol.392 , pp. 245-251
    • Banchereau, J.1    Steinman, R.M.2
  • 7
    • 0036556202 scopus 로고    scopus 로고
    • Dendritic cells, tolerance induction and transplant outcome
    • Coates PTH, Thomson AW. Dendritic cells, tolerance induction and transplant outcome. Am J Transplant. 2002;2:299-307.
    • (2002) Am J Transplant , vol.2 , pp. 299-307
    • Coates, P.T.H.1    Thomson, A.W.2
  • 9
    • 0034919938 scopus 로고    scopus 로고
    • Dendritic cell lineage, plasticity and cross-regulation
    • Liu Y, Kanzler H, Soumelis V, Gilliet M. Dendritic cell lineage, plasticity and cross-regulation. Nat Immunol. 2001;2:585-589.
    • (2001) Nat Immunol , vol.2 , pp. 585-589
    • Liu, Y.1    Kanzler, H.2    Soumelis, V.3    Gilliet, M.4
  • 10
    • 17644372733 scopus 로고    scopus 로고
    • IPC: Professional type I interferon-producing cells and plasmacytoid dendritic cell precursors
    • Liu YJ. IPC: professional type I interferon-producing cells and plasmacytoid dendritic cell precursors. Annu Rev Immunol. 2005;23:275-306.
    • (2005) Annu Rev Immunol , vol.23 , pp. 275-306
    • Liu, Y.J.1
  • 11
    • 0034547923 scopus 로고    scopus 로고
    • BDCA-2, BDCA-3, and BDCA-4: Three markers for distinct subsets of dendritic cells in human peripheral blood
    • Dzionek A, Fuchs A, Schmidt P, et al. BDCA-2, BDCA-3, and BDCA-4: three markers for distinct subsets of dendritic cells in human peripheral blood. J Immunol. 2000;165:6037-6046.
    • (2000) J Immunol , vol.165 , pp. 6037-6046
    • Dzionek, A.1    Fuchs, A.2    Schmidt, P.3
  • 12
    • 0035179882 scopus 로고    scopus 로고
    • Specialization and complementarity in microbial molecule recognition by human myeloid and plasmacytoid dendritic cells
    • Jarrossay D, Napolitani G, Colonna M, Sallusto F, Lanzavecchia A. Specialization and complementarity in microbial molecule recognition by human myeloid and plasmacytoid dendritic cells. Eur J Immunol. 2001;31:3388-3393.
    • (2001) Eur J Immunol , vol.31 , pp. 3388-3393
    • Jarrossay, D.1    Napolitani, G.2    Colonna, M.3    Sallusto, F.4    Lanzavecchia, A.5
  • 13
    • 0042123694 scopus 로고    scopus 로고
    • Toll-like receptor 9-mediated recognition of herpes simplex virus-2 by plasmacytoid dendritic cells
    • Lund J, Sato A, Akira S, Medzhitov R, Iwasaki A. Toll-like receptor 9-mediated recognition of herpes simplex virus-2 by plasmacytoid dendritic cells. J Exp Med. 2003;198:513-520.
    • (2003) J Exp Med , vol.198 , pp. 513-520
    • Lund, J.1    Sato, A.2    Akira, S.3    Medzhitov, R.4    Iwasaki, A.5
  • 15
    • 0034304003 scopus 로고    scopus 로고
    • Plasmacytoid dendritic cells activated by influenza virus and CD40L drive a potent Th1 polarization
    • Cella M, Facchetti F, Lanzavecchia A, Colonna M. Plasmacytoid dendritic cells activated by influenza virus and CD40L drive a potent Th1 polarization. Nat Immunol. 2000;1:305-310.
    • (2000) Nat Immunol , vol.1 , pp. 305-310
    • Cella, M.1    Facchetti, F.2    Lanzavecchia, A.3    Colonna, M.4
  • 16
    • 0343647206 scopus 로고    scopus 로고
    • The huPBL-SCID mouse as a means to examine human immune function in vivo
    • Murphy WJ, Taub D, Longo D. The huPBL-SCID mouse as a means to examine human immune function in vivo. Semin Immunol. 1996;8:233-241.
    • (1996) Semin Immunol , vol.8 , pp. 233-241
    • Murphy, W.J.1    Taub, D.2    Longo, D.3
  • 17
    • 0028869986 scopus 로고
    • Multiple defects in innate and adaptive immunologic function in NOD/LtSz-Sicd mice
    • Shultz L, Schweitzer PA, Christianson SW, et al. Multiple defects in innate and adaptive immunologic function in NOD/LtSz-Sicd mice. J Immunol. 1995;154:180-191.
    • (1995) J Immunol , vol.154 , pp. 180-191
    • Shultz, L.1    Schweitzer, P.A.2    Christianson, S.W.3
  • 18
    • 33644867468 scopus 로고    scopus 로고
    • Renal transplantation reverses functional deficiencies in circulating dendritic cell subsets in chronic renal failure patients
    • Lim WH, Kireta S, Russ GR, Coates PTH. Renal transplantation reverses functional deficiencies in circulating dendritic cell subsets in chronic renal failure patients. Transplantation. 2006;81:160-168.
    • (2006) Transplantation , vol.81 , pp. 160-168
    • Lim, W.H.1    Kireta, S.2    Russ, G.R.3    Coates, P.T.H.4
  • 19
    • 0242410962 scopus 로고    scopus 로고
    • Autocrine/paracrine IL-15 that is required for type I IFN-mediated dendritic cell expression of MHC class I-related chain A and B is impaired in hepatitis C virus infection
    • Jinushi M. Autocrine/paracrine IL-15 that is required for type I IFN-mediated dendritic cell expression of MHC class I-related chain A and B is impaired in hepatitis C virus infection. J Immunol. 2003;171:5423-5429.
    • (2003) J Immunol , vol.171 , pp. 5423-5429
    • Jinushi, M.1
  • 20
    • 0035017112 scopus 로고    scopus 로고
    • The diverse pathology of posttransplant lymphoproliferative disorders: The importance of a standardized approach
    • Nalesnik MA. The diverse pathology of posttransplant lymphoproliferative disorders: the importance of a standardized approach. Transpl Infect Dis. 2001;3:88-96.
    • (2001) Transpl Infect Dis , vol.3 , pp. 88-96
    • Nalesnik, M.A.1
  • 21
    • 0042931206 scopus 로고    scopus 로고
    • Dendritic cells mediate NK cell help for Th1 and CTL responses: Two-signal requirement for the induction of NK cell helper function
    • Mailliard R, Son Y, Redlinger R, et al. Dendritic cells mediate NK cell help for Th1 and CTL responses: two-signal requirement for the induction of NK cell helper function. J Immunol. 2003;171:2366-2373.
    • (2003) J Immunol , vol.171 , pp. 2366-2373
    • Mailliard, R.1    Son, Y.2    Redlinger, R.3
  • 22
    • 33644823775 scopus 로고    scopus 로고
    • Dendritic cell deficiency in the blood of kidney transplant patients on long-term immunosuppression: Results of a prospective matched-cohort study
    • Hackstein H, Renner F, Bohnert A, et al. Dendritic cell deficiency in the blood of kidney transplant patients on long-term immunosuppression: results of a prospective matched-cohort study. Am J Transplant. 2005;5:2945-2953.
    • (2005) Am J Transplant , vol.5 , pp. 2945-2953
    • Hackstein, H.1    Renner, F.2    Bohnert, A.3
  • 23
    • 1642407765 scopus 로고    scopus 로고
    • Peripheral blood dendritic cells in human end-stage heart failure and the early post-transplant period: Evidence for systemic Th1 immune responses
    • Athanassopoulos P, Vaessen L, Maat A, Balk A, Weimar W, Bogers A. Peripheral blood dendritic cells in human end-stage heart failure and the early post-transplant period: evidence for systemic Th1 immune responses. Eur J Cardiothorac Surg. 2004;25:619-626.
    • (2004) Eur J Cardiothorac Surg , vol.25 , pp. 619-626
    • Athanassopoulos, P.1    Vaessen, L.2    Maat, A.3    Balk, A.4    Weimar, W.5    Bogers, A.6
  • 25
    • 17644373015 scopus 로고    scopus 로고
    • The immune response to primary EBV infection: A role for natural killer cells
    • Williams H, McAulay K, Macsween K, et al. The immune response to primary EBV infection: a role for natural killer cells. Br J Haematol. 2005;129:266-274.
    • (2005) Br J Haematol , vol.129 , pp. 266-274
    • Williams, H.1    McAulay, K.2    Macsween, K.3
  • 26
    • 0034767753 scopus 로고    scopus 로고
    • Antiviral actions of interferons
    • Samuel CE. Antiviral actions of interferons. Clin Microbiol Rev. 2001;14:778-809.
    • (2001) Clin Microbiol Rev , vol.14 , pp. 778-809
    • Samuel, C.E.1
  • 27
    • 0035030376 scopus 로고    scopus 로고
    • Type I interferons potently enhance humoral immunity and can promote isotype switching by stimulating dendritic cells in vivo
    • Le Bon A, Schiavoni G, D'Agostinio G, Gresser I, Belardelli F, Tough D. Type I interferons potently enhance humoral immunity and can promote isotype switching by stimulating dendritic cells in vivo. Immunity. 2001;14:461-470.
    • (2001) Immunity , vol.14 , pp. 461-470
    • Le Bon, A.1    Schiavoni, G.2    D'Agostinio, G.3    Gresser, I.4    Belardelli, F.5    Tough, D.6
  • 28
    • 0030265672 scopus 로고    scopus 로고
    • NK cell trafficking and cytokine expression in splenic compartments after IFN induction and viral infection
    • Salazar-Mather T, Ishikawa R, Biron C. NK cell trafficking and cytokine expression in splenic compartments after IFN induction and viral infection. J Immunol. 1996;157:3054-3064.
    • (1996) J Immunol , vol.157 , pp. 3054-3064
    • Salazar-Mather, T.1    Ishikawa, R.2    Biron, C.3
  • 29
    • 0034531435 scopus 로고    scopus 로고
    • Update on the role of adjuvant interferon for high risk melanoma
    • Agarwala S, Kirkwood J. Update on the role of adjuvant interferon for high risk melanoma. Forum (Genova). 2000;10:230.
    • (2000) Forum (Genova) , vol.10 , pp. 230
    • Agarwala, S.1    Kirkwood, J.2
  • 30
    • 0032573751 scopus 로고    scopus 로고
    • Interferon-alpha treatment of posttransplant lymphoproliferative disorder in recipients of solid organ transplant
    • Davis C, Wood B, Sabath D, Joseph J, Stehman-Breen C, Broudy V. Interferon-alpha treatment of posttransplant lymphoproliferative disorder in recipients of solid organ transplant. Transplantation. 1998;66:1770-1779.
    • (1998) Transplantation , vol.66 , pp. 1770-1779
    • Davis, C.1    Wood, B.2    Sabath, D.3    Joseph, J.4    Stehman-Breen, C.5    Broudy, V.6
  • 31
    • 3843103508 scopus 로고    scopus 로고
    • Herpes-simplex virus type-1 induces IFN-alpha production via Toll-like receptor 9-dependent and independent pathways
    • Hochrein H, Schlatter B, O'Keeffe M, et al. Herpes-simplex virus type-1 induces IFN-alpha production via Toll-like receptor 9-dependent and independent pathways. Proc Natl Acad Sci U S A. 2004;101:11416-11421.
    • (2004) Proc Natl Acad Sci U S A , vol.101 , pp. 11416-11421
    • Hochrein, H.1    Schlatter, B.2    O'Keeffe, M.3
  • 32
    • 0036376644 scopus 로고    scopus 로고
    • Type I interferon production by plasmacytoid dendritic cells and monocytes is triggered by viruses, but the level of production is controlled by distinct cytokines
    • Gary-Gouy H, Lebon P, Dalloul A. Type I interferon production by plasmacytoid dendritic cells and monocytes is triggered by viruses, but the level of production is controlled by distinct cytokines. J Interferon Cytokine Res. 2002;22:653-659.
    • (2002) J Interferon Cytokine Res , vol.22 , pp. 653-659
    • Gary-Gouy, H.1    Lebon, P.2    Dalloul, A.3
  • 33
    • 0025335354 scopus 로고
    • Homology of cytokine synthesis inhibitory factor (IL-10) to the Epstein-Barr virus gene BCRF1
    • Moore K, Vieira P, Fiorentino D, Trounstine M, Khan T, Mosmann T. Homology of cytokine synthesis inhibitory factor (IL-10) to the Epstein-Barr virus gene BCRF1. Science. 1990;248:1230-1234.
    • (1990) Science , vol.248 , pp. 1230-1234
    • Moore, K.1    Vieira, P.2    Fiorentino, D.3    Trounstine, M.4    Khan, T.5    Mosmann, T.6
  • 34
    • 17844379775 scopus 로고    scopus 로고
    • Epstein-Barr viral load, interleukin-6 and interleukin-10 levels in post-transplant lymphoproliferative disease: A nested case-control study in a renal transplant cohort
    • Baiocchi O, Colleoni G, Caballero O, et al. Epstein-Barr viral load, interleukin-6 and interleukin-10 levels in post-transplant lymphoproliferative disease: a nested case-control study in a renal transplant cohort. Leuk Lymphoma. 2005;46:533-539.
    • (2005) Leuk Lymphoma , vol.46 , pp. 533-539
    • Baiocchi, O.1    Colleoni, G.2    Caballero, O.3
  • 35
    • 0141428884 scopus 로고    scopus 로고
    • Cooperative Study Group on PTLDs. Epstein-Barr virus (EBV) load and interleukin-10 in EBV-positive and EBV-negative post-transplant lymphoproliferative disorders
    • Muti G, Klersy C, Baldanti F, et al, Cooperative Study Group on PTLDs. Epstein-Barr virus (EBV) load and interleukin-10 in EBV-positive and EBV-negative post-transplant lymphoproliferative disorders. Br J Haematol. 2003;122:927-933.
    • (2003) Br J Haematol , vol.122 , pp. 927-933
    • Muti, G.1    Klersy, C.2    Baldanti, F.3
  • 36
    • 24944509220 scopus 로고    scopus 로고
    • T cells and viral persistence: Lessons from diverse infections
    • Klenerman P, Hill A. T cells and viral persistence: lessons from diverse infections. Nat Immunol. 2005;6:873-879.
    • (2005) Nat Immunol , vol.6 , pp. 873-879
    • Klenerman, P.1    Hill, A.2
  • 37
    • 0037432787 scopus 로고    scopus 로고
    • Requirement for CD4 T cell help in generating functional CD8 T cell memory
    • Shedlock D, Shen H. Requirement for CD4 T cell help in generating functional CD8 T cell memory. Science. 2003;300:337-339.
    • (2003) Science , vol.300 , pp. 337-339
    • Shedlock, D.1    Shen, H.2
  • 39
    • 0033009888 scopus 로고    scopus 로고
    • Natural killer cells in antiviral defense: Function and regulation by innate cytokines
    • Biron C, Nguyen K, Pien G, Cousens L, Salazar-Mather T. Natural killer cells in antiviral defense: function and regulation by innate cytokines. Annu Rev Immunol. 1999;17:189-220.
    • (1999) Annu Rev Immunol , vol.17 , pp. 189-220
    • Biron, C.1    Nguyen, K.2    Pien, G.3    Cousens, L.4    Salazar-Mather, T.5
  • 41
    • 11844268647 scopus 로고    scopus 로고
    • The reciprocal interaction of NK cells with plasmacytoid or myeloid dendritic cells profoundly affects innate resistance functions
    • Gerosa F, Gobbi A, Zorzi P, et al. The reciprocal interaction of NK cells with plasmacytoid or myeloid dendritic cells profoundly affects innate resistance functions. J Immunol. 2005;174:727-734.
    • (2005) J Immunol , vol.174 , pp. 727-734
    • Gerosa, F.1    Gobbi, A.2    Zorzi, P.3
  • 42
    • 4043142169 scopus 로고    scopus 로고
    • Cytokine and contact-dependent activation of natural killer cells by influenza A or Sendai virus-infected macrophages
    • Siren J, Sareneva T, Pirhonen J, et al. Cytokine and contact-dependent activation of natural killer cells by influenza A or Sendai virus-infected macrophages. J Gen Virol. 2004;85:2357-2364.
    • (2004) J Gen Virol , vol.85 , pp. 2357-2364
    • Siren, J.1    Sareneva, T.2    Pirhonen, J.3
  • 43
    • 0034939227 scopus 로고    scopus 로고
    • IFN-alpha and IL-18 synergistically enhance IFN-gamma production in human NK cells: Differential regulation of Stat4 activation and IFN-gamma gene expression by IFN-alpha and IL-12
    • Matikainen S, Paananen A, Miettinen M, et al. IFN-alpha and IL-18 synergistically enhance IFN-gamma production in human NK cells: differential regulation of Stat4 activation and IFN-gamma gene expression by IFN-alpha and IL-12. Eur J Immunol. 2001;31:2236-2245.
    • (2001) Eur J Immunol , vol.31 , pp. 2236-2245
    • Matikainen, S.1    Paananen, A.2    Miettinen, M.3
  • 45
    • 11044220305 scopus 로고    scopus 로고
    • IL-10 stimulatory effects on human NK cells explored by gene profile analysis
    • Mocellin S, Panelli M, Wang E, et al. IL-10 stimulatory effects on human NK cells explored by gene profile analysis. Genes Immun. 2004;5:621-630.
    • (2004) Genes Immun , vol.5 , pp. 621-630
    • Mocellin, S.1    Panelli, M.2    Wang, E.3
  • 46
    • 33749355639 scopus 로고    scopus 로고
    • TLR agonists promote ERK-mediated preferential IL-10 production of regulatory dendritic cells (diffDCs) leading to NK cell activation
    • Qian C, Jiang X, An H, et al. TLR agonists promote ERK-mediated preferential IL-10 production of regulatory dendritic cells (diffDCs) leading to NK cell activation. Blood. 2006;108:2307-2315.
    • (2006) Blood , vol.108 , pp. 2307-2315
    • Qian, C.1    Jiang, X.2    An, H.3
  • 47
    • 1542313911 scopus 로고    scopus 로고
    • Virally stimulated plasmacytoid dendritic cells produce chemokines and induce migration of T and NK cells
    • Megjugorac N, Young H, Amrute S, Olshalsky S, Fitzgerald-Bocarsly P. Virally stimulated plasmacytoid dendritic cells produce chemokines and induce migration of T and NK cells. J Leuk Biol. 2004;75:504-514.
    • (2004) J Leuk Biol , vol.75 , pp. 504-514
    • Megjugorac, N.1    Young, H.2    Amrute, S.3    Olshalsky, S.4    Fitzgerald-Bocarsly, P.5
  • 48
    • 5444262511 scopus 로고    scopus 로고
    • Toll-like receptor control of the adaptive immune responses
    • Iwasaki A, Medzhitov R. Toll-like receptor control of the adaptive immune responses. Nat Immunol. 2004;5:987-995.
    • (2004) Nat Immunol , vol.5 , pp. 987-995
    • Iwasaki, A.1    Medzhitov, R.2
  • 49
    • 0041331693 scopus 로고    scopus 로고
    • Subcellular localization of toll-like receptor 3 in human dendritic cells
    • Matsumoto M. Subcellular localization of toll-like receptor 3 in human dendritic cells. J Immunol. 2003;171:3154-3162.
    • (2003) J Immunol , vol.171 , pp. 3154-3162
    • Matsumoto, M.1
  • 50
    • 0035903288 scopus 로고    scopus 로고
    • Subsets of human dendritic cell precursors express different Toll-like receptors and respond to different microbial antigens
    • Kadowaki N, Ho S, Antonenko S, et al. Subsets of human dendritic cell precursors express different Toll-like receptors and respond to different microbial antigens. J Exp Med. 2001;194:863-869.
    • (2001) J Exp Med , vol.194 , pp. 863-869
    • Kadowaki, N.1    Ho, S.2    Antonenko, S.3
  • 51
    • 0142027131 scopus 로고    scopus 로고
    • Ex vivo priming of naive T cells into EBV-specific Th1/Tc1 effector cells by mature autologous DC loaded with apoptotic/necrotic LCL
    • Popescu I, Macedo C, Zeevi A, et al. Ex vivo priming of naive T cells into EBV-specific Th1/Tc1 effector cells by mature autologous DC loaded with apoptotic/necrotic LCL. Am J Transplant. 2003;3:1369-1377.
    • (2003) Am J Transplant , vol.3 , pp. 1369-1377
    • Popescu, I.1    Macedo, C.2    Zeevi, A.3
  • 52
    • 0037080198 scopus 로고    scopus 로고
    • + cytotoxic T cells from virus naive individuals
    • + cytotoxic T cells from virus naive individuals. J Immunol. 2002;168:909-918.
    • (2002) J Immunol , vol.168 , pp. 909-918
    • Savoldo, B.1    Cubbage, M.2    Durett, A.3
  • 53
    • 33746140392 scopus 로고    scopus 로고
    • Review of Epstein-Barr virus and post-transplant lymphoproliferative disorder post-solid organ transplantation
    • Lim W, Russ G, Coates PTH. Review of Epstein-Barr virus and post-transplant lymphoproliferative disorder post-solid organ transplantation. Nephrology. 2006;11:355-366.
    • (2006) Nephrology , vol.11 , pp. 355-366
    • Lim, W.1    Russ, G.2    Coates, P.T.H.3
  • 54
    • 0034655607 scopus 로고    scopus 로고
    • Granulocyte-colony stimulating factor mobilizes T helper 2-inducing dendritic cells
    • Arpinati M, Green C, Heimfeld S, Heuser J, Anasetti C. Granulocyte-colony stimulating factor mobilizes T helper 2-inducing dendritic cells. Blood. 2000;95:2484-2490.
    • (2000) Blood , vol.95 , pp. 2484-2490
    • Arpinati, M.1    Green, C.2    Heimfeld, S.3    Heuser, J.4    Anasetti, C.5
  • 55
    • 0034254472 scopus 로고    scopus 로고
    • In vivo generation of human dendritic cell subsets by Flt3 ligand
    • Maraskovsky E, Daro E, Rous E, et al. In vivo generation of human dendritic cell subsets by Flt3 ligand. Blood. 2000;96:878-885.
    • (2000) Blood , vol.96 , pp. 878-885
    • Maraskovsky, E.1    Daro, E.2    Rous, E.3


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