Virally stimulated plasmacytoid dendritic cells produce chemokines and induce migration of T and NK cells

Journal of Leukocyte Biology

Volumn 75, Issue 3, 2004, Pages 504-514

  Megjugorac, Nicholas J ^a   Young, Howard A ^b   Amrute, Sheela B ^a   Olshalsky, Stacey L ^a   Fitzgerald Bocarsly, Patricia ^a  

^a RUTGERS NEW JERSEY MEDICAL SCHOOL   (United States)

^b NATIONAL CANCER INSTITUTE   (United States)

Author keywords

Cell trafficking; Herpes simplex virus; Interferon

Indexed keywords

ALPHA CHEMOKINE; ALPHA INTERFERON; ANTIGEN; CCL4 CHEMOKINE; CD123 ANTIGEN; CHEMOKINE; CXCL CHEMOKINE; CYTOKINE; GLYCOPROTEIN P 15095; HLA DR ANTIGEN; LIN ANTIGEN; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; MONOCYTE CHEMOTACTIC PROTEIN 1; NEUTRALIZING ANTIBODY; RANTES; RIBONUCLEASE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL MIGRATION; CHEMOTAXIS; CYTOKINE PRODUCTION; DENDRITIC CELL; ENDOCYTOSIS; ENZYME LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; GENETIC TRANSCRIPTION; HERPES SIMPLEX VIRUS; INTERFERON PRODUCTION; LYMPHOCYTE ACTIVATION; NATURAL KILLER CELL; NONHUMAN; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; PROTEIN SYNTHESIS; T LYMPHOCYTE; VIRUS GENE;

CHEMOKINES; CHEMOKINES, CXC; CHEMOTAXIS, LEUKOCYTE; DENDRITIC CELLS; HUMANS; INTERFERON-ALPHA; KILLER CELLS, NATURAL; RECEPTORS, CHEMOKINE; RNA, MESSENGER; SIMPLEXVIRUS; T-LYMPHOCYTES; UP-REGULATION;

ANIMALIA; SIMPLEXVIRUS;

EID: 1542313911     PISSN: 07415400     EISSN: None     Source Type: Journal    
DOI: 10.1189/jlb.0603291     Document Type: Article

References (70)

1. Engering, A., Cella, M., Fluitsma, D., Brockhaus, M., Hoefsmit, E., Lanzavecchia, A. (1997) The mannose receptor functions as a high capacity and broad specificity antigen receptor on human dendritic cells. Eur. J. Immunol. 27, 2417-2425.
2. Sallusto, F., Cella, M., Danieli, C., Lanzavecchia, A. (1995) Dendritic cells use macropinocytosis and the mannose receptor to concentrate macromolecules in the major histocompatibility complex class II compartment: downregulation by cytokines and bacterial products. J. Exp. Med. 182, 389-400.
3. Jiang, W., Swiggard, W. J., Heufler, C., Peng, M., Mirza, A., Steinman, R. M., Nussenzweig, M. C. (1995) The receptor DEC-205 expressed by dendritic cells and thymic epithelial cells is involved in antigen processing. Nature 375, 151-155.
4. Tan, M., Mommaas, A., Drijfhout, J., Jordens, R., Onderwater, J., Verwoerd, D., Mulder, A., van der Heiden, A., Scheidegger, D., Oomen, L., Ottenhoff, T., Tulp, A., Neefjes, J., Koning, F. (1997) Mannose receptor-mediated uptake of antigens strongly enhances HLA class II-restricted antigen presentation by cultured dendritic cells. Eur. J. Immunol. 27, 2426-2435.
5. Reis e Sousa, C., Stahl, P., Austyn, J. M. (1993) Phagocytosis of antigens by Langerhans cells in vitro. J. Exp. Med. 178, 509-519.
6. Bevan, M. J. (1976) Cross-priming for a secondary cytotoxic response to minor H antigens with H-2 congenic cells which do not cross react in a cytotoxic assay. J. Exp. Med. 143, 1283-1288.
7. Bevan, M. J. (1977) Priming for a cytotoxic response to minor histocompatibility antigens: antigen specificity and failure to demonstrate a carrier effect. J. Immunol. 118, 1370-1374.
8. Norbury, C., Chambers, B., Prescott, A., Ljunggren, H., Watts, C. (1997) Constitutive macropinocytosis allows TAP-dependent major histocompatibility complex class I presentation of exogenous soluble antigen by bone marrow derived dendritic cells. Eur. J. Immunol. 27, 280-288.
9. Banchereau, J., Steinman, R. M. (1998) Dendritic cells and the control of immunity. Nature 392, 245-252.
10. Bell, D., Young, J. W., Banchereau, J. (1999) Dendritic cells. Adv. Immunol. 72, 255-324.
11. Hart, D. (1997) Dendritic cells: unique leukocyte populations, which control the primary immune response. Blood 90, 3245-3287.
12. Steinman, R. M. (1991) The dendritic cell system and its role in immunogenicity. Annu. Rev. Immunol. 9, 271-296.
13. + blood dendritic cells are potent producers of IFN-α in response to in vitro HIV-1 infection. J. Immunol. 152, 4649-4662.
14. Svensson, H., Johannisson, A., Nikkila, T., Alm, G. V., Cederblad, B. (1996) The cell surface phenotype of human natural interferon-α producing cells as determined by flow cytometry. Scand. J. Immunol. 44, 164-172.
15. Siegal, F., Kadowaki, N., Shodell, M., Fitzgerald-Bocarsly, P., Shah, K., Ho, S., Antonenko, A., Liu, Y. J. (1999) The nature of the principal type 1 interferon-producing cells in human blood. Science 284, 1835-1837.
16. Galy, A., Christopherson, I., Ferlazzo, G., Liu, G., Spits, H., Georgopolous, K. (2000) Distinct signals control the hematopoiesis of lymphoid-related dendritic cells. Blood 95, 128-137.
17. Spits, H., Couwenberg, F., Bakker, A., Weijer, K., Uittenbogaart, C. (2000) Id2 and Id3 inhibit development of CD34+ stem cells into predendritic cell (pre-DC)2 but not into pre-DC1: evidence for a lymphoid origin of pre-DC2. J. Exp. Med. 192, 1775-1783.
18. Nilsson, H., Johansson, C., Sandberg, K., Funa, K., Alm, G. V., Scheynius, A. (1989) Induction of mRNA for HLA-DR β in human keratinocytes cocultured with interferon-γ. Arch. Dermatol. Res. 281, 260-266.
19. Sandberg, K., Matsson, P., Alm, G. V. (1990) A distinct population of non-phagocytic and CD4+ null lymphocytes produce interferon-α after stimulation by Herpes simplex virus infected cells. J. Immunol. 145, 1015-1020.
20. Fitzgerald-Bocarsly, P. (1993) Human natural interferon-α producing cells. Pharmacol. Ther. 60, 39-62.
21. Feldman, S. B., Ferraro, M., Zheng, H. M., Patel, N., Gould-Fogerite, S., Fitzgerald-Bocarsly, P. (1994) Viral induction of low frequency interferon-α producing cells. Virology 204, 1-7.
22. Dzionek, A., Fuchs, A., Schmidt, P., Cremer, S., Zysk, M., Miltenvi, S., Buck, D. W., Schmitz, J. (2000) BDCA-2, BDCA-3, and BDCA-4: three markers for distinct subsets of dendritic cells in human peripheral blood. J. Immunol. 165, 6037-6046.
23. Cederblad, B., Alm, G. (1990) Infrequent but efficient interferon-α-producing human mononuclear leukocytes induced by herpes simplex virus in vitro studies by immunoplaque and limiting dilution assays. J. Interferon Res. 10, 65-73.
24. Howell, D. M., Fitzgerald-Bocarsly, P. (1991) Natural killer-mediated lysis of some but not all HSV-1 or VSV infected targets requires the participation of HLA-DR positive accessory cells. Immunology 72, 443-447.
25. Grouard, G., Rissoan, M., Filguiera, L., Durand, I., Banchereau, J., Liu, J. (1997) The enigmatic plasmacytoid T cells develop into dendritic cells with interleukin-3 and CD40 ligand. J. Exp. Med. 185, 1101-1111.
26. Sellati, T. J., Waldrop, S. L., Salazar, J. C., Bergstresser, P. R., Picker, L., Radolf, J. D. (2001) The cutaneous response in humans to Treponema pallidum lipoprotein analogues involves cellular elements of both innate and adaptive immunity. J. Immunol. 166, 4131-4140.
27. Jahnsen, F., Lund-Johansen, F., Dunne, J., Farkas, L., Haye, R., Brandtzaeg, P. (2000) Experimentally induced recruitment of plasmacytoid (CD123high) dendritic cells in human nasal allergy. J. Immunol. 165, 4062-4068.
28. Rissoan, M-C., Soumelis, V., Kadowaki, N., Grouard, G., Briere, F., de Waal Malefyt, R., Liu, Y-J. (1999) Reciprocal control of T helper cell and dendritic cell differentiation. Science 283, 1183-1186.
29. Olweris, J., BitMansour, A., Warnke, R., Thompson, P., Carballido, J., Picker, L., Lund-Johansen, F. (1997) Dendritic cell ontogeny: a human dendritie cell lineage of myeloid origin. Proc. Natl. Acad. Sci. USA. 94, 12551-12556.
30. Sallusto, F., Lanzavecchia, A. (1994) Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/ macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor. J. Exp. Med. 179, 1109-1118.
31. Blom, B., Ho, S., Antonenko, S., Liu, Y. J. (2000) Generation of interferon α-producing predendritic cell (Pre-DC)2 from human CD34(+) hematopoietic stem cells. J. Exp. Med. 192, 1785-1796.
32. Caux, C., Massacrier, C., Vanbervliet, B., Dubois, B., Durand, I., Cella, M., Lanzavecchia, A., Banchereau, J. (1997) CD34+ hematopoietic progenitors from human cord blood differentiate along two independent dendritic cell pathways in response to granulocyte-macrophagecolony-stimulating factor plus tumor necrosis factor α: II. Functional analysis. Blood 90, 1458-1470.
33. Peters, J., Xu, H., Ruppert, J., Ostermeier, D., Friedrichs, D., Gieseler, R. (1993) Signals required for differentiating dendritic cells from human monocytes in vitro. Adv. Exp. Med. Biol. 329, 275-280.
34. Romani, N., Gruner, S., Brang, D., Kampgen, E., Lenz, A., Trockenbacher, B., Konwalinka, G., Fritsch, P. O., Steinmann, R. M., Schuler, G. (1994) Proliferating dendritic cell progenitors in human blood. J. Exp. Med. 180, 83-93.
35. Ridge, J. P., Di Rosa, P., Matzinger, P. (1998) A conditioned dendritic cell can be a temporal bridge between a CD4+ T-helper and a T-killer cell. Nature 393, 474-478.
36. Bennett, S. R., Carbone, F., Karamalis, F., Flavell, R. A., Miller, J. F., Heath, W. R. (1998) Help for cytotoxic T-cell responses is mediated by CD40 signalling. Nature 393, 478-480.
37. Schoenberger, S. P., Toes, R. E., van der Voort, E. I., Offringa, R., Melief, C. J. (1998) T-cell help for cytotoxic T lymphocytes is mediated by CD40-CD40L interactions. Nature 393, 480-483.
38. Caux, C., Massacrier, C., Vanbervliet, B., Dubois, B., Van Kooten, C., Durand, I., Banchereau, J. (1994) Activation of human dendritic cells through CD40 cross-linking. J. Exp. Med. 180, 1263-1272.
39. Ito, T., Inaba, M., Inaba, K., Toki, J., Sogo, S., Iguchi, T., Adachi, Y., Yamaguchi, K., Amakawa, R., Valladeau, J., Saeland, S., Fukuhara, S., Ikehara, S. (1999) A CD1a+/CD11c+ subset of human blood dendritic cells is a direct precursor of Langerhans cells. J. Immunol. 163, 1409-1419.
40. Macatonia, S. E., Hosken, N. A., Litton, M., Vieira, P., Hsieh, C. S., Culpepper, J., Wysocka, M., Trinchieri, G. (1995) Dendritic cells produce IL-12 and direct the development of Th1 cells from naive CD4+ T cells. J. Immunol. 154, 5071-5079.
41. Dieu, M. C., Vanbervliet, B., Vicari, A., Bridon, J. M., Oldham, E., Ait-Yahia, S., Briere, F., Zlotnik, A., Lebecque, S., Caux, C. (1998) Selective recruitment of immature and mature dendritic cells by distinct chemokines expressed in different anatomic sites. J. Exp. Med. 188, 373-386.
42. Greaves, D. R., Wang, W., Dairaghi, D. J., Dieu, M. C., Saint-Vis, B., Franz-Bacon, K., Rossi, D., Caux, C., McClanahan, T., Gordon, S., Zlotnik, A., Schall, T. (1997) CCR6, a CC chemokine receptor that interacts with macrophage inflammatory protein 3α and is highly expressed on human dendritic cells. J. Exp. Med. 186, 837-844.
43. Sallusto, F., Lenig, D., Mackay, C. R., Lanzavecchia, A. (1998) Flexible programs of chemokine receptor expression on human polarized T helper 1 and 2 lymphocytes. J. Exp. Med. 187, 875-883.
44. Cella, M., Jarrossay, D., Facchetti, F., Alebardi, O., Nakajima, H., Lanzavecchia, A., Colonna, M. (1999) Plasmacytoid monocytes migrate to inflamed lymph nodes and produce large amounts of type I interferon. Nat. Med. 5, 419-923.
45. Kadowaki, N., Antonenko, S., Lau, J. Y., Liu, Y. J. (2000) Natural interferon α/β-producing cells link innate and adaptive immunity. J. Exp. Med. 192, 219-226.
46. Penna, G., Vulcano, M., Roncari, A., Facchetti, F., Sozzani, S., Adorini, L. (2002) Cutting edge: differential chemokine production by myeloid and plasmacytoid dendritic cells. J. Immunol. 169, 6673-6676.
47. Krug, A., Towarowski, A., Britsch, S., Rothenfusser, S., Homung, V., Bals, R., Giese, T., Engelmann, H., Endres, S., Krieg, A. M., Hartmann, G. (2001) Toll-like receptor expression reveals CpG DNA as a unique microbial stimulus for plasmacytoid dendritic cells which synergizes with CD40 ligand to induce high amounts of IL-12. Eur. J. Immunol. 31, 3026-3037.
48. Gibson, S. J., Lindh, J. M., Riter, T. R., Gleason, R. M., Rogers, L. M., Fuller, A. E., Oesterich, J. L., Gorden, K. B., Qiu, X., McKane, S. W., Noelle, R. J., Miller, R. L., Kedl, R. M., Fitzgerald-Bocarsly, P., Tomai, M. A., Vasilakos, J. P. (2002) Plasmacytoid dendritic cells produce cytokines and mature in response to TLR7 agonists, imiquimod and resiquimod. Cell. Immunol. 218, 74-86.
49. Feldman, M., Howell, D., Fitzgerald-Bocarsly, P. (1992) Interferon-dependent and -independent participation of accessory cells in natural killer cell-mediated lysis of HSV-1-infected fibroblasts. J. Leukoc. Biol. 52, 473-482.
50. Feldman, S. B., Milone, M. C., Kloser, P., Fitzgerald-Bocarsly, P. (1995) Functional deficiencies in two distinct IFN-α producing cell populations in PBMC from human immunodeficiency virus seropositive patients. J. Leukoc. Biol. 57, 214-220.
51. Howell, D., Feldman, S., Kloser, P., Fitzgerald-Bocarsly, P. (1994) Decreased frequency of natural interferon-producing cells in peripheral blood of patients with the acquired immune deficiency syndrome. Clin. Immunol. Immunopathol. 1, 223-230.
52. Feldman, S., Stein, D., Amrute, S., Denny, T., Garcia, Z., Kloser, P., Sun, Y., Megjugorac, N., Fitzgerald-Bocarsly, P. (2001) Decreased interferon-α production in HIV-infected patients correlates with numerical and functional deficiencies in circulating type 2 dendritic cell precursors. Clin. Immunol. 101, 201-210.
53. Soumelis, V., Scott, I., Gheyas, F., Bouhour, D., Cozon, G., Cotte, L., Huang, L., Levy, J. A., Liu, Y. J. (2001) Depletion of circulating natural type 1 interferon-producing cells in HIV-infected AIDS patients. Blood 98, 906-912.
54. Fitzgerald, P. A., von Wussow, P., Lopez, C. (1982) Role of interferon in natural kill of HSV-1 infected fibroblasts. J. Immunol. 129, 819-824.
55. Milone, M. C., Fitzgerald-Bocarsly, P. (1998) The mannose receptor mediates induction of IFN-α in peripheral blood dendritic cells by enveloped RNA and DNA viruses. J. Immunol. 161, 2391-2399.
56. Feldman, M., Fitzgerald-Bocarsly, P. (1990) Sequential enrichment and immunocytochemical visualization of human interferon-α-producing cells. J. Interferon Res. 10, 435-446.
57. Penna, G., Sozzani, S., Adorini, L. (2001) Cutting edge: selective usage of chemokine receptors by plasmacytoid dendritic cells. J. Immunol. 167, 1862-1866.
58. Hemmi, H., Kaisho, T., Takeuchi, O., Sato, S., Sanjo, H., Hoshino, K., Horuichi, T., Tomizawa, H., Takeda, A., Akira, S. (2002) Small anti-viral compounds activate immune cells via the TLR7 MyDS8-dependent signaling pathway. Nat. Immunol. 3, 196-200.
59. Hemmi, H., Takeuchi, O., Kawai, T., Kaisho, T., Sato, S., Sanjo, H., Matsumoto, M., Hoshino, K., Wagner, H., Takeda, K. (2000) A Toll-like receptor recognizes bacterial DNA. Nature 408, 740-745.
60. Sallusto, F., Lanzavecchia, A. (1999) Mobilizing dendritic cells for tolerance, priming, and chronic inflammation. J. Exp. Med. 189, 611-614.
61. Padovan, E., Spagnoli, G. C., Ferrantini, M., Heberer, M. (2002) IFN-α2a induces IP-10/CXCL10 and MIG/CXCL9 production in monocyte-derived dendritic cells and enhances their capacity to stimulate CD8+ effector T cells. J. Leukoc. Biol. 71, 669-676.
62. Moser, B., Loetscher, P. (2001) Lymphocyte traffic control by chemokines. Nat. Immunol. 2, 123-128.
63. Krug, A., Uppaluri, R., Facchetti, F., Domer, B., Sheehan, K., Schreiber, R., Cella, M., Colonna, M. (2002) Cutting edge: IFN-producing cells respond to CXCR3 ligands in the presence of CXCL12 and secrete inflammatory chemokines upon activation. J. Immunol. 169, 6079-6083.
64. Lebon, P. (1985) Inhibition of herpes simplex virus type-1 induced interferon synthesis by monoclonal antibodies against viral glycoprotein D and by lysosomotropic drugs. J. Gen. Virol. 66, 2781-2786.
65. Goldman, L. A. (1994) Role of Herpes Simplex Virus Type 1 Immediate Early Genes in Induction of Human Natural Killer Cell Activity. Ph.D. dissertation, UMD NJ, Newark, NJ.
66. Robertson, M. J. (2002) Role of chemokines in the biology of natural killer cells. J. Leukoc. Biol. 71, 173-183.
67. Lande, R., Giacomini, E., Grassi, T., Remoli, M. E., Iona, E., Miettinen, M., Julkunen, I., Coccia, E. M. (2003) IFN-α/β released by Myycobacterium tuberculosis-infected human dendritic cells induces the expression of CXCL10: selective recruitment of NK and activated T cells. J. Immunol. 170, 1174-1182.
68. + accessory cells in natural killing of cytomegalovirus-infected fibroblasts. J. Exp. Med. 164, 180-195.
69. + cells in natural killing of herpes virus-infected fibroblasts. J. Immunol. 139, 2799-2802.
70. Brinkmann, V., Geiger, T., Alkan, S., Heusser, C. H. (1993) Interferon α increases the frequency of intefferon γ-producing human CD4+ T cell. J. Exp. Med. 178, 1655-1663.