Epstein-barr virus (EBV) load and interleukin-10 in EBV-positive and EBV-negative post-transplant lymphoproliferative disorders

British Journal of Haematology

Volumn 122, Issue 6, 2003, Pages 927-933

  Muti, Giuliana ^a   Klersy, Catherine ^b   Baldanti, Fausto ^b   Granata, Simonetta ^a   Oreste, Pierluigi ^a   Pezzetti, Laura ^a   Gatti, Marta ^b   Gargantini, Livio ^a   Caramella, Marianna ^a   Mancini, Valentina ^a   Gerna, Giuseppe ^b   Morra, Enrica ^a  

^a OSPEDALE NIGUARDA CA GRANDA   (Italy)

^b FONDAZIONE IRCCS POLICLINICO SAN MATTEO   (Italy)

Author keywords

Diagnosis; Epstein Barr virus; Interleukin 10; Post transplant lymphoproliferative disorders

Indexed keywords

INTERLEUKIN 10; VIRUS DNA;

ARTICLE; CELL ASSAY; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE ASSOCIATION; EPSTEIN BARR VIRUS; FOLLOW UP; HUMAN; HUMAN CELL; HUMAN TISSUE; LYMPHOPROLIFERATIVE DISEASE; MICROBIOLOGICAL EXAMINATION; MONONUCLEAR CELL; POSTOPERATIVE COMPLICATION; POSTOPERATIVE PERIOD; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROTEIN FUNCTION; QUANTITATIVE ANALYSIS; RISK ASSESSMENT; VIRUS DETECTION; VIRUS IDENTIFICATION; VIRUS INFECTION; VIRUS LOAD;

ADULT; BIOLOGICAL MARKERS; DNA, VIRAL; EPSTEIN-BARR VIRUS INFECTIONS; FOLLOW-UP STUDIES; HERPESVIRUS 4, HUMAN; HUMANS; INTERLEUKIN-10; LYMPHOPROLIFERATIVE DISORDERS; ORGAN TRANSPLANTATION; SENSITIVITY AND SPECIFICITY; VIRAL LOAD;

EID: 0141428884     PISSN: 00071048     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2141.2003.04540.x     Document Type: Article

References (29)

1. Baldanti, F., Grossi, P., Furione, M., Simoncini, L., Saracini, A., Comoli, P., Maccario, R., Fiocchi, R. & Gerna, G. (2000) High levels of Epstein-Barr virus DNA in blood of solid-organ transplant recipients and their value in predicting post-transplant lymphoproliferative disorders. Journal of Clinical Microbiology, 38, 613-619.
2. Birkeland, S.A., Bendtzen, K., Moller, B., Hamilton-Dutoit, S. & Andersen, H.K. (1999) Interleukin-10 and post-transplant lymphoproliferative disorder after kidney transplantation. Transplantation, 67, 876-881.
3. Cohen, J. (2000) Epstein-Barr virus infection. New England Journal of Medicine, 343, 481-491.
4. Comoli, P., Labirio, M., Basso, S., Baldanti, F., Grossi, P., Furione, M., Viganò, M., Fiocchi, R., Rossi, G., Ginevri, F., Gridelli, B., Moretta, A., Montagna, D., Locatelli, F., Gerna, G. & Maccario, R. (2002) Infusion of autologous Epstein-Barr virus (EBV)-specific cytotoxic T cells for prevention of EBV-related lymphoproliferative disorder in solid organ transplant recipients with evidence of active virus replication. Blood, 99, 2592-2598.
5. Fickenscher, H., Hor, S., Kupers, H., Knappe, A., Wittmann, S. & Sticht, H. (2002) The interleukin-10 family of cytokines. Trends in Immunology, 23, 89-96.
6. Garnier, J.-L., Blanc-Brunat, N., Vivier, G., Rousset, F. & Touraine, J.-L. (1999) Interleukin-10 in Epstein-Barr virus-associated posttransplant lymphomas. Clinical Transplantation, 13, 305-312.
7. Green, M., Cacciarelli, T.V., Mazariegos, G.V., Sigurdsson, L., Qu, L., Rowe, D.T. & Reyes, J. (1998) Serial measurement of Epstein-Barr viral load in peripheral blood in pediatric liver transplant recipients during treatment for post-transplant lymphoproliferative disease. Transplantation, 66, 1641-1644.
8. Haque, T. & Crawford, D.H. (1999) The role of adoptive immunotherapy in the prevention and treatment of lymphoproliferative disease following transplantation. British Journal of Haematology, 106, 309-316.
9. Holmes, R.D., Orban-Eller, K., Karrer, F.R., Rowe, D.T., Narkewicz, M.R. & Sokol, R.J. (2002) Response of elevated Epstein-Barr virus DNA levels to therapeutic changes in pediatric liver transplant patients: 56-month follow up and outcome. Transplantation, 74, 367-372.
10. Hopwood, P.A., Brooks, L., Parratt, R., Hunt, B.J., Maria, B., Alero, T.J., Magdi, Y. & Crawford, D. (2002) Persistent Epstein-Barr virus infection: unrestricted latent and lyric viral gene expression in healthy immunosuppressed transplant recipients. Transplantation, 74, 191-202.
11. Kenagy, D.N, Schlesinger, Y., Weck, K., Ritter, J.H. Gaudreault-Keener, M.M. & Storch, G.A. (1995) Epstein-Barr virus DNA in peripheral blood leukocytes of patients with Post-transplant lymphoproliferative disease. Transplantation, 60, 547-554.
12. Kimura, H., Makoto, M., Yabuta, Y., Kuzushima, K., Kato, K., Kojima, S., Matsuyama, T. & Morishima, T. (1999) Quantitative analysis of Epstein-Barr virus load using a real-time PCR assay. Journal of Clinical Microbiology, 37, 132-136.
13. Knowles, D.M., Cesarman, E., Chadburn, A., Frizzera, G., Chen, J., Rose, E.A. & Michler, R.E. (1995) Correlative morphologic and molecular genetic analysis demonstrates three distinct categories of post-transplantation lymphoproliferative disorders. Blood, 85, 552-565.
14. Leblond, V., Davi, F., Charlotte, F., Dorent, R., Bitter, M.-O., Sutton, L., Gandjbakhch, I., Binet, J.-L. & Raphael, M. (1998) Posttransplant lymphoproliferative disorders not associated with Epstein-Barr virus: a distinct entity? Journal of Clinical Oncology, 16, 2052-2059.
15. Lucas, K.G., Filo, R., Heilman, D.K., Lee, C.H. & Emanuel, D.J. (1998a) Semiquantitative Epstein-Barr virus polymerase chain reaction analysis of peripheral blood from organ transplant patients and risk for the development of lymphoproliferative disease. Blood, 92, 3977-3978.
16. Lucas, K.G., Burton, R.L., Zimmerman, S.E., Wang, J., Cornetta, K.G., Robertson, K.A., Lee, C.H. & Emanuel, D.J. (1998b) Semiquantitative Epstein-Barr virus (EBV) polymerase chain reaction for the determination of patients at risk for EBV-induced lymphoproliferative disease after stem cell transplantation. Blood, 91, 3654-3661.
17. Mamzer-Bruneel, M.F., Bourquelot, P., Hermine, O., Legendre, C. & Kreis, H. (1997) Treatment and prognosis of post-transplant lymphoproliferative disease. Annals of Transplantation, 2, 42-48.
18. Meijer, E., Dekker, A.W., Weersink, A.J.L., Rozenberg-Arska, M. & Verdonk, L.F. (2002) Prevention and treatment of Epstein-Barr virus-associated lymphoproliferative disorders in recipients of bone marrow and solid organ transplants. British Journal of Haematology, 119, 596-607.
19. Muti, G., Cantoni, S., Oreste, P., Klersy, C., Gini, G., Rossi, V., D'Avanzo, G., Comoli, P., Baldanti, F., Montillo, M., Nosari, A. & Morra, E. (2002) Post-transplant lymphoproliferative disorders: improved outcome after clinico-pathologically tailored treatment. Haematologica, 87, 67-77.
20. Nalesnik, M.A., Zeevi, A., Randhawa, P.S., Faro, A., Spichty, K.J., Demetris, A.J., Fung, J.J., Whiteside, T.L. & Starzl, T.E. (1999) Cytokine mRNA profiles in Epstein-Barr virus-associated posttransplant lymphoproliferative disorders. Clinical Transplantation, 13, 39-44.
21. Nelson, B.P., Nalesnik, M.A., Bahler, D.W., Locker, J., Fung, J.J. & Swerdlow, S.H. (2000) Epstein-Barr virus -negative post-transplant lymphoproliferative disorders. A distinct entity? American Journal of Surgical Pathology, 24, 375-385.
22. Paya, C.V., Fung, J.J., Nalesnik, M.A., Kieff, E., Green, M., Gores, G., Habermann, T.M., Wiesner, R.H., Swinnen, L.J., Woodle, E.S. & Bromberg, J.S. for the ASTS/ASTPEBV-PTLD Task Force and the Mayo Clinic Organized International Consensus Development Meeting on Epstein-Barr Virus-induced Post-transplant Lymphoproliferative Disorders (PTLD) (1999) Epstein-Barr virus-induced post-transplant lymphoproliferative disorders. Transplantation, 68, 1517-1525.
23. Riddler, S.A., Breinig, M.C. & McKnight, J.L.C. (1994) Increased levels of circulating Epstein-Barr virus (EBV)-infected lymphocytes and decreased EBV nuclear antigen antibody responses are associated with the development of post-transplant lymphoproliferative disease in solid-organ transplant recipients. Blood, 84, 972-984.
24. Rooney, C.M., Loftin, S.K., Holladay, M.S. Brenner, M.K., Krance, R.A. & Heslop, H.E. (1995) Early identification of Epstein-Barr virus-associated post-transplantation lymphoproliferative disease. British Journal of Haematology, 89, 98-103.
25. Stevens, S.J., Vervoort, M.B., Van Den Brule, A.J., Meenhorst, P.L., Meijer, C.J. & Middeldorp, J.M. (1999) Monitoring of Epstein-Barr virus DNA load in peripheral blood by quantitative competitive PCR. Journal of Clinical Microbiology, 37, 2852-2857.
26. Stevens, S.J., Verschuuren, E.A.M., Pronk, I., van der Bij, W., Harmsen, M.C., The, T.H., Meijer, C.J.L.M., van der Brule, A.J.C. & Middeldorp, J.M. (2001) Frequent monitoring of Epstein-Barr virus DNA load in unfractionated whole blood is essential for early detection of post-transplant lymphoproliferative disease in high-risk patients. Blood, 97, 1165-1171.
27. Swinnen, L.J. (2000) Diagnosis and treatment of transplant-related lymphoma. Annals of Oncology, 11, S45-S48.
28. Voorzanger, N. & Blay, J.-Y. (1996) Interleuidn 10 and non Hodgkin's lymphomas. In: Cancer in Transplantation. Prevention and Treatment (ed. by J.L. Touraine et al.), pp. 229-241. Kluwer Academic Publishers, Dordrecht.
29. Wagner, H.-J., Cheng, Y.C., Zhensheng, L., Savoldo, B., Huls, H.M., Gee, A.P., Heslop, H.E. & Rooney, C.R. (2001) Monitoring of transplanted patients at risk of Epstein-Barr virus (EBV)-induced lymphoproliferative disorder (LPD) by real time PCR quantification of EBV DNA in peripheral blood. Blood, 98, S480a.