The diverse pathology of post-transplant lymphoproliferative disorders: The importance of a standardized approach

Transplant Infectious Disease

Volumn 3, Issue 2, 2001, Pages 88-96

  Nalesnik, M A ^a  

^a UNIVERSITY OF PITTSBURGH MEDICAL CENTER   (United States)

Author keywords

Epstein Barr virus; Lymphoma; Lymphoproliferation; Organ transplantation; Post transplant lymphoproliferative disorders

Indexed keywords

CD20 ANTIGEN;

B LYMPHOCYTE; CELL STRUCTURE; CYTODIAGNOSIS; DISEASE MARKER; EPSTEIN BARR VIRUS; HIGH RISK PATIENT; HISTOPATHOLOGY; HUMAN; LEIOMYOSARCOMA; LYMPHOPROLIFERATIVE DISEASE; NATURAL KILLER CELL; ONCOGENE; OPPORTUNISTIC INFECTION; ORGAN TRANSPLANTATION; PATHOLOGIST; PHENOTYPE; PRIORITY JOURNAL; PROGNOSIS; RECURRENT DISEASE; REVIEW; STANDARDIZATION; VIRUS LOAD;

HUMANS; LYMPHOPROLIFERATIVE DISORDERS; ORGAN TRANSPLANTATION; POSTOPERATIVE COMPLICATIONS;

EID: 0035017112     PISSN: 13982273     EISSN: None     Source Type: Journal    
DOI: 10.1034/j.1399-3062.2001.003002088.x     Document Type: Review

References (59)

1. PENN I. The problem of cancer in organ transplant recipients: An overview. Transpl Sci 1994: 4: 23-32.
2. HOWARD TK, KLINTMALM GBG, STONE MJ, et al. Lymphoproliferative disorder masquerading as rejection in liver transplant recipients - an early aggressive tumor with atypical presentation. Transplantation 1992: 53: 1145-1147.
3. TRPKOV K, MARCUSSEN N, RAYNER D, LAM G, SOLEZ K. Kidney allograft with a lymphocytic infiltrate: acute rejection, post-transplantation lymphoproliferative disorder, neither, or both entities? Am J Kidney Dis 1997: 30: 449-454.
4. DRACHENBERG CB, ABRUZZO LV, KLASSEN DK, et al. Epstein-Barr virus-related post-transplantation lymphoproliferative disorder involving pancreas allografts: histological differential diagnosis from acute allograft rejection. Human Pathol 1998: 29: 569-577.
5. FINN L, REYES J, BUENO J, YUNIS E. Epstein-Barr virus infections in children after transplantation of the small intestine. Am J Surg Pathol 1998: 22: 299-309.
6. WU TT, SWERDLOW SH, LOCKER J, et al. Recurrent Epstein-Barr virus-associated lesions in organ transplant recipients. Human Pathol 1996: 27: 157-164.
7. MANDELL JW, GULLEY ML, WILLIAMS ME, STOLER MR Recurrent Epstein-Barr virus-associated post-transplant lymphoproliferative disorder: report of a patient with histologically similar but clonally distinct metachronous abdominal and brain lesions. Human Pathol 1999: 30: 1262-1265.
8. HARRIS NL, FERRY JA, SWERDLOW SH. Post-transplant lymphoproliferative disorders (PTLD): Summary of Society for Hematopathology Workshop. Semin Diagnostic Pathol 1997: 14: 8-14.
9. STARZL TE. Discussion of Murray JE, Wilson RE, Tilney NL, et al. Five years' experience in renal transplantation with immunosuppressive drugs: survival, function, complications and the role of lymphocyte depletion by thoracic duct fistula. Ann Surg 1968: 168: 416.
10. FRIZZERA G, HANTO DW, GAJL-PECZALSKA KJ, et al. Polymorphic diffuse B-cell hyperplasias and lymphomas in renal transplant recipients. Cancer Res 1981: 41: 4262-4279.
11. CLEARY ML, WARNKE R, SKLAR J. Monoclonality of lymphoproliferative lesions in cardiac-transplant recipients. N Engl J Med 1984: 310: 477-482.
12. STARZL TE, PENN I, HALGRIMSON CG. Immunosuppression and malignant neoplasms. N Engl J Med 1970: 283: 934-935.
13. STARZL TE, NALESNIK MA, PORTER KA, et al. Reversibility of lymphomas and lymphoproliferative lesions developing under cyclosporine-steroid therapy. Lancet 1984: i: 583-587.
14. NALESNIK MA, JAFFE R, STARZL TE, et al. The pathology of post-transplant lymphoproliferative disorders occurring in the setting of cyclosporine A-prednisone immunosuppression. Am J Pathol 1988: 133: 173-192.
15. SWERDLOW SH. Post-transplant lymphoproliferative disorders: A morphologic, phenotypic and genotypic spectrum of disease. Histopathol 1992: 20: 373-385.
16. WEISS LM, MOVAHED LA. In situ demonstration of Epstein-Barr viral genomes in viral-associated B cell lymphoproliferations. Am J Pathol 1989: 134: 651.
17. LOCKER J, NALESNIK M. Molecular genetic analysis of lymphoid tumors arising after organ transplantation. Am J Pathol 1989: 135: 977-987.
18. KNOWLES DM, CESARMAN E, CHADBURN A, et al. Correlative morphologic and molecular genetic analysis demonstrates three distinct categories of post-transplantation lymphoproliferative disorders. Blood 1995: 85: 552-565.
19. GARNIER J-L, LEBRANCHU Y, DANTAL J, et al. Hodgkin's disease after transplantation. Transplantation 1996: 61: 71-76.
20. DOCKRELL DH, STRICKLER JG, PAYA CV. Epstein-Barr virus-induced T cell lymphoma in solid organ transplant recipients. Clin Infect Dis 1998: 26: 180-182.
21. HARRIS NL, JAFFE ES, STEIN H, et al. A revised European-American classification of lymphoid neoplasms: A proposal from the International Lymphoma Study Group. Blood 1994: 84: 1361-11392.
22. LEBLOND V, DAVI F, CHARLOTTE F, et al. Post-transplant lymphoproliferative disorders not associated with Epstein-Barr virus: a distinct entity? J Clin Oncol 1998: 16: 2052-2059.
23. DOTTI G, FIOCCHI R, MOTTA T, et al. Epstein-Barr virus-negative lymphoproliferate disorders in long-term survivors after heart, kidney, and liver transplant Transplantation 2000: 69: 827-833.
24. NELSON BP, NALESNIK MA, BAHLER DW, LOCKER J, FUNG JJ, SWERDLOW SH. Epstein-Barr virus-negative post-transplant lymphoproliferative disorders: a distinct entity? Am J Surg Pathol 2000: 24: 375-385.
25. LIPPMAN SM, GROGAN TM, CARRY P, OGDEN DA, MILLER TP. Post-transplantation T cell lymphoblastic lymphoma. Am J Med 1987: 82: 814-816.
26. KIM JY, KIM CW, AHN C, BANG YJ, LEE HS. Rapidly developing T-cell post-transplantation lymphoproliferative disorder. Am J Kidney Dis 1999: 34: e3.
27. KRAUS MD, CRAWFORD DF, KALEEM Z, SHENOY S, MACARTHUR CA, LONGTINE JA. T gamma/delta hepatosplenic lymphoma in a heart transplant patient after an Epstein-Barr virus positive lymphoproliferative disorder: a case report. Cancer 1998: 82: 983-992.
28. WALLER EK, ZIEMIANSKA M, BANGS CD, CLEARY M, WEISSMAN I, KAMEL OW. Characterization of post-transplant lymphomas that express T-cell-associated markers: immunophenotypes, molecular genetics, cytogenetics, and heterotransplantation in severe combined immunodeficient mice. Blood 1993: 82: 247-261.
29. HSI ED, PICKEN MM, ALKAN S. Post-transplantation lymphoproliferative disorder of the NK-cell type: a case report and review of the literature. Mod Pathol 1998: 11: 479-484.
30. KWONG YL, LAM CC, CHAN TM. Post-transplantation lymphoproliferative disease of natural killer cell lineage: a clinicopathological and molecular analysis. Br J Haematol 2000: 110: 197-202.
31. MUKAI HY, KOJIMA H, SUZUKAWA K, et al. Nasal natural killer cell lymphoma in a post-renal transplant patient. Transplantation 2000: 69: 1501-1503
32. ROWLINGS PA, CURTIS RE, PASSWEG JR, et al. Increased incidence of Hodgkin's disease after allogeneic bone marrow transplantation. J Clin Oncol 1999: 17: 3122-3127.
33. NALESNIK MA, RANDHAWA P, DEMETRIS AJ, CASAVILLA A, FUNG JJ, LOCKER J. Lymphoma resembling Hodgkin disease after post-transplant lymphoproliferative disorder in a liver transplant recipient Cancer 1993: 72: 2568-2573.
34. SMETS F, VAJRO P, CORNU G, REDING R, OTTE JB, SOKAL E. Indications and results of chemotherapy in children with post-transplant lymphoproliferative disease after liver transplantation. Transplantation 2000: 69: 982-984.
35. GROSSO LE, BEE CS. T-cell rich, Ki-I-positive post-transplant lymphoproliferative disorder: a previously undescribed variant following liver transplant. Pathology 1998: 30: 360-363.
36. CHUCRALLAH AE, CROW MK, RICE LE, RAJAGOPALAN S, HUDNALL SD. Multiple myeloma after cardiac transplantation: an unusual form of post-transplant lymphoproliferative disorder. Hum Pathol 1994: 25: 541-545.
37. LEIGH BR, LARKIN EC, DOGGETT RL. Solitary extramedullary plasmacytoma five years after successful cardiac transplantation: case report and review of the literature. Am J Clin Oncol 1997: 20: 467-470.
38. CHAN BK, RANHEIM E, JEFFREY RB Jr. Disseminated peritoneal plasmacytoma following cardiac transplantation. Abdom Imaging 1999: 24: 508-510.
39. NALESNIK MA, RAO AS, FURUKAWA H, et al. Autologous lymphokine-activated killer cell therapy of Epstein-Barr virus-positive and -negative lymphoproliferative disorders arising in organ transplant recipients. Transplantation 1997: 63: 1200-1205.
40. WOTHERSPOON AC, DISS TC, PAN L, SINGH N, WHELAN J, ISAACSON PG. Low grade gastric B-cell lymphoma of mucosa associated lymphoid tissue in immunocompromised patients [see comments]. Histopathology 1996: 28: 129-134.
41. HSI ED, SINGLETON TP, SWINNEN L, DUNPHY CH, ALKAN S. Mucosa-associated lymphoid tissue-type lymphomas occurring in post-transplantation patients. Am J Surg Pathol 2000: 24: 100-106.
42. WEISSMANN DJ, FERRY JA, HARRIS NL, LOUIS DN, DELMONICO F, SPIRO I. Post-transplantation lymphoproliferative disorders in solid organ recipients are predominantly aggressive tumors of host origin. Am J Clin Pathol 1995: 103: 748-755.
43. STRAZZABOSCO M, CORNEO B, IEMMOLO RM, et al. Epstein-Barr virus-associated post-transplant lymphoproliferative disease of donor origin in liver transplant recipients. J Hepatol 1997: 26: 926-934.
44. LONES MA, LOPEZ-TERRADA D, WEISS LM, SHINTAKU IP, SAID JW. Donor origin of post-transplant lymphoproliferative disorder localized to a liver allograft: demonstration by fluorescence in situ hybridization. Arch Pathol Lab Med 1997: 121: 701-706.
45. PENN I. Immunosuppression- A contributing factor in lymphoma formation. Clinical Transplant 1992: 6: 214-219.
46. BENKERROU M, DURANDY A, FISCHER A. Therapy for transplant-related lymphoproliferative diseases. Hematol/ Oncol Clin North Am 1993: 7: 467-475.
47. NALESNIK MA, DEMETRIS AJ, FUNG JJ, STARZL TE. Lymphoproliferative disorders arising under immunosuppression with FK 506: Initial observations in a large transplant population. Transplant Proc 1991: 23: 1108-1110.
48. CESARMAN E, CHADBURN A, LIU YF, MIGLIAZZA A, DALLA-FAVERA R, KNOWLES DM. BCL-6 gene mutations in post-transplantation lymphoproliferative disorders predict response to therapy and clinical outcome. Blood 1998: 92: 2294-2302.
49. CHANG CC, YE BH, CHAGANTI RS, DALLA-FAVERA R. BCL-6, a POZ/zinc-finger protein, is a sequence-specific transcriptional repressor. Proc Natl Acad Sci USA 1996: 93: 6947-6952.
50. BASTARD C, DEWEINDT C, KERCKAERT JP, et al. LAZ3 rearrangements in non-Hodgkin's lymphoma: correlation with histology, immunophenotype, karyotype, and clinical outcome in 217 patients. Blood 1994: 83: 2423-2427.
51. LO COCO F, YE BH, LISTA F, et al. Rearrangements of the BCL6 gene in diffuse large cell non-Hodgkin's lymphoma. Blood 1994: 83: 1757-1759.
52. PASQUALUCCI L, MIGLIAZZA A, FRACCHIOLLA N, et al. BCL-6 mutations in normal germinal center B cells: evidence of somatic hypermutation acting outside Ig loci. Proc Natl Acad Sci USA 1998: 95: 11816-11821.
53. LEE ES, LOCKER J, NALESNIK M, REYES J, et al. The association of Epstein-Barr virus with smooth-muscle tumors occurring after organ transplantation [see comments]. N Engl J Med 1995: 332: 19-25.
54. MCCLAIN KL, LEACH CT, JENSON HB, et al. Association of Epstein-Barr virus with leiomyosarcomas in children with AIDS [see comments]. N Engl J Med 1995: 332: 12-18.
55. JENSON HB, MONTALVO EA, MCCLAIN KL, et al. Characterization of natural Epstein-Barr virus infection and replication in smooth muscle cells from a leiomyosarcoma. J Med Virol 1999: 57: 36-46.
56. KINGMA DW, SHAD A, TSOKOS M, et al. Epstein-Barr virus (EBV)-associated smooth-muscle tumor arising in a post-transplant patient treated successfully for two PT-EBV-associated large-cell lymphomas. Case report Am J Surg Pathol 1996: 20: 1511-1519.
57. LECHAPT-ZALCMAN E, RIEUX C, CORDONNIER C, DESVAUX D. Post-transplantation lymphoproliferative disorder mimicking a nonspecific lymphocytic pleural effusion in a bone marrow transplant recipient. A case report. Acta Cytol 1999: 43: 239-242.
58. SWINNEN LJ. Diagnosis and treatment of transplant-related lymphoma. Ann Oncol 2000: 11 (Suppl 1): 45-48.
59. LISTER TA, ARMITAGE JO. Non-Hodgkin's lymphomas. In: ABELOFF MD, ARMITAGE JO, LICHTER AS, NIEDERHUBER JE, eds. Clinical Oncology. New York: Churchill Livingstone Inc, 1995: 2109-2147.