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Subtyping schizophrenia: implications for genetic research
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Jablensky A. Subtyping schizophrenia: implications for genetic research. Mol Psychiatry 11 (2006) 815-836
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Grey matter changes over time in high risk subjects developing schizophrenia
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Job D.E., Whalley H.C., Johnstone E.C., and Lawrie S.M. Grey matter changes over time in high risk subjects developing schizophrenia. NeuroImage 25 (2005) 1023-1030
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Job, D.E.1
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0035949688
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Mapping adolescent brain change reveals dynamic wave of accelerated gray matter loss in very early-onset schizophrenia
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Thompson P.M., Vidal C., Giedd J.N., Gochman P., Blumenthal J., Nicolson R., Toga A.W., and Rapoport J.L. Mapping adolescent brain change reveals dynamic wave of accelerated gray matter loss in very early-onset schizophrenia. Proc Natl Acad Sci USA 98 (2001) 11650-11655
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Thompson, P.M.1
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Blumenthal, J.5
Nicolson, R.6
Toga, A.W.7
Rapoport, J.L.8
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Schizophrenia genes, gene expression, and neuropathology: on the matter of their convergence
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Harrison P.J., and Weinberger D.R. Schizophrenia genes, gene expression, and neuropathology: on the matter of their convergence. Mol Psychiatry 10 (2005) 40-68
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Harrison, P.J.1
Weinberger, D.R.2
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33745606684
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Genes and schizophrenia: beyond schizophrenia: the role of DISC1 in major mental illness
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Hennah W., Thomson P., Peltonen L., and Porteous D. Genes and schizophrenia: beyond schizophrenia: the role of DISC1 in major mental illness. Schizophr Bull 32 (2006) 409-416
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Hennah, W.1
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Disrupted in schizophrenia 1: building brains and memories
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Porteous D.J., and Millar J.K. Disrupted in schizophrenia 1: building brains and memories. Trends Mol Med 12 (2006) 255-261
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Trends Mol Med
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Porteous, D.J.1
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33747193538
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Schizophrenia susceptibility genes converge on interlinked pathways related to glutamatergic transmission and long-term potentiation, oxidative stress and oligodendrocyte viability
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Carter C.J. Schizophrenia susceptibility genes converge on interlinked pathways related to glutamatergic transmission and long-term potentiation, oxidative stress and oligodendrocyte viability. Schizophr Res 86 (2006) 1-14
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Disruption of two novel genes by a translocation co-segregating with schizophrenia
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Millar J.K., Wilson-Annan J.C., Anderson S., Christie S., Taylor M.S., Semple C.A., Devon R.S., Clair D.M., Muir W.J., Blackwood D.H., et al. Disruption of two novel genes by a translocation co-segregating with schizophrenia. Hum Mol Genet 9 (2000) 1415-1423
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Millar, J.K.1
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Semple, C.A.6
Devon, R.S.7
Clair, D.M.8
Muir, W.J.9
Blackwood, D.H.10
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11
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0034927864
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Schizophrenia and affective disorders - cosegregation with a translocation at chromosome 1q42 that directly disrupts brain-expressed genes: clinical and P300 findings in a family
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Blackwood D.H., Fordyce A., Walker M.T., St Clair D.M., Porteous D.J., and Muir W.J. Schizophrenia and affective disorders - cosegregation with a translocation at chromosome 1q42 that directly disrupts brain-expressed genes: clinical and P300 findings in a family. Am J Hum Genet 69 (2001) 428-433
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Blackwood, D.H.1
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St Clair, D.M.4
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Muir, W.J.6
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12
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27744554247
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Association of DISC1/TRAX haplotypes with schizophrenia, reduced prefrontal gray matter, and impaired short- and long-term memory
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The first twin study model that persuasively links DISC1 haplotypes to quantitative measures of cognition and neuroanatomical changes in the prefrontal cortex.
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Cannon T.D., Hennah W., van Erp T.G., Thompson P.M., Lonnqvist J., Huttunen M., Gasperoni T., Tuulio-Henriksson A., Pirkola T., Toga A.W., et al. Association of DISC1/TRAX haplotypes with schizophrenia, reduced prefrontal gray matter, and impaired short- and long-term memory. Arch Gen Psychiatry 62 (2005) 1205-1213. The first twin study model that persuasively links DISC1 haplotypes to quantitative measures of cognition and neuroanatomical changes in the prefrontal cortex.
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Arch Gen Psychiatry
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Cannon, T.D.1
Hennah, W.2
van Erp, T.G.3
Thompson, P.M.4
Lonnqvist, J.5
Huttunen, M.6
Gasperoni, T.7
Tuulio-Henriksson, A.8
Pirkola, T.9
Toga, A.W.10
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13
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32844455739
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A haplotype within the DISC1 gene is associated with visual memory functions in families with a high density of schizophrenia
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Hennah W., Tuulio-Henriksson A., Paunio T., Ekelund J., Varilo T., Partonen T., Cannon T.D., Lonnqvist J., and Peltonen L. A haplotype within the DISC1 gene is associated with visual memory functions in families with a high density of schizophrenia. Mol Psychiatry 10 (2005) 1097-1103
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Mol Psychiatry
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Hennah, W.1
Tuulio-Henriksson, A.2
Paunio, T.3
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Varilo, T.5
Partonen, T.6
Cannon, T.D.7
Lonnqvist, J.8
Peltonen, L.9
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14
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24044449980
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DISC1 and neurocognitive function in schizophrenia
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Burdick K.E., Hodgkinson C.A., Szeszko P.R., Lencz T., Ekholm J.M., Kane J.M., Goldman D., and Malhotra A.K. DISC1 and neurocognitive function in schizophrenia. NeuroReport 16 (2005) 1399-1402
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NeuroReport
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Burdick, K.E.1
Hodgkinson, C.A.2
Szeszko, P.R.3
Lencz, T.4
Ekholm, J.M.5
Kane, J.M.6
Goldman, D.7
Malhotra, A.K.8
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15
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20844463251
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Variation in DISC1 affects hippocampal structure and function and increases risk for schizophrenia
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The first study showing a strong correlation between DISC1 genotype and brain structure and function using functional magnetic resonance imaging.
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Callicott J.H., Straub R.E., Pezawas L., Egan M.F., Mattay V.S., Hariri A.R., Verchinski B.A., Meyer-Lindenberg A., Balkissoon R., Kolachana B., et al. Variation in DISC1 affects hippocampal structure and function and increases risk for schizophrenia. Proc Natl Acad Sci USA 102 (2005) 8627-8632. The first study showing a strong correlation between DISC1 genotype and brain structure and function using functional magnetic resonance imaging.
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(2005)
Proc Natl Acad Sci USA
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Callicott, J.H.1
Straub, R.E.2
Pezawas, L.3
Egan, M.F.4
Mattay, V.S.5
Hariri, A.R.6
Verchinski, B.A.7
Meyer-Lindenberg, A.8
Balkissoon, R.9
Kolachana, B.10
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16
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24044481269
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Association between genotype at an exonic SNP in DISC1 and normal cognitive aging
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Thomson P.A., Harris S.E., Starr J.M., Whalley L.J., Porteous D.J., and Deary I.J. Association between genotype at an exonic SNP in DISC1 and normal cognitive aging. Neurosci Lett 389 (2005) 41-45
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Neurosci Lett
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Thomson, P.A.1
Harris, S.E.2
Starr, J.M.3
Whalley, L.J.4
Porteous, D.J.5
Deary, I.J.6
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17
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33749576292
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Impact of the DISC1 Ser704Cys polymorphism on risk for major depression, brain morphology, and ERK signaling
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Hashimoto R., Numakawa T., Ohnishi T., Kumamaru E., Yagasaki Y., Ishimoto T., Mori T., Nemoto K., Adachi N., Izumi A., et al. Impact of the DISC1 Ser704Cys polymorphism on risk for major depression, brain morphology, and ERK signaling. Hum Mol Genet 15 (2006) 3024-3033
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Hashimoto, R.1
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Kumamaru, E.4
Yagasaki, Y.5
Ishimoto, T.6
Mori, T.7
Nemoto, K.8
Adachi, N.9
Izumi, A.10
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18
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27944502874
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DISC1 and PDE4B are interacting genetic factors in schizophrenia that regulate cAMP signaling
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These authors show that the DISC1 protein modulates cellular cAMP signalling through physical interaction with the phosphodiesterase PDE4B. Because PDE4s have previously been implicated in learning, memory and mood disorders, perturbation of this pathway is implicated in the phenotypic overlap between psychotic and affective disorders. Moreover, expression levels are reduced by 50% in patient cells lines carrying DISC1 or PDE4B chromosomal disruptions, favouring a model of pathophysiology based on a haploinsufficiency mechanism.
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Millar J.K., Pickard B.S., Mackie S., James R., Christie S., Buchanan S.R., Malloy M.P., Chubb J.E., Huston E., Baillie G.S., et al. DISC1 and PDE4B are interacting genetic factors in schizophrenia that regulate cAMP signaling. Science 310 (2005) 1187-1191. These authors show that the DISC1 protein modulates cellular cAMP signalling through physical interaction with the phosphodiesterase PDE4B. Because PDE4s have previously been implicated in learning, memory and mood disorders, perturbation of this pathway is implicated in the phenotypic overlap between psychotic and affective disorders. Moreover, expression levels are reduced by 50% in patient cells lines carrying DISC1 or PDE4B chromosomal disruptions, favouring a model of pathophysiology based on a haploinsufficiency mechanism.
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(2005)
Science
, vol.310
, pp. 1187-1191
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Millar, J.K.1
Pickard, B.S.2
Mackie, S.3
James, R.4
Christie, S.5
Buchanan, S.R.6
Malloy, M.P.7
Chubb, J.E.8
Huston, E.9
Baillie, G.S.10
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19
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33750058844
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Differential expression of Disrupted-in-Schizophrenia (DISC1) in bipolar disorder
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Maeda K., Nwulia E., Chang J., Balkissoon R., Ishizuka K., Chen H., Zandi P., McInnis M.G., and Sawa A. Differential expression of Disrupted-in-Schizophrenia (DISC1) in bipolar disorder. Biol Psychiatry 60 (2006) 929-935
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Biol Psychiatry
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Maeda, K.1
Nwulia, E.2
Chang, J.3
Balkissoon, R.4
Ishizuka, K.5
Chen, H.6
Zandi, P.7
McInnis, M.G.8
Sawa, A.9
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20
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4544339685
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DISC1 and DISC2: discovering and dissecting molecular mechanisms underlying psychiatric illness
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Millar J.K., James R., Brandon N.J., and Thomson P.A. DISC1 and DISC2: discovering and dissecting molecular mechanisms underlying psychiatric illness. Ann Med 36 (2004) 367-378
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Ann Med
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Millar, J.K.1
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21
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33745221854
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A review of Disrupted-In-Schizophrenia-1 (DISC1): neurodevelopment, cognition, and mental conditions
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Ishizuka K., Paek M., Kamiya A., and Sawa A. A review of Disrupted-In-Schizophrenia-1 (DISC1): neurodevelopment, cognition, and mental conditions. Biol Psychiatry 59 (2006) 1189-1197
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Ishizuka, K.1
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Sawa, A.4
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22
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0442292274
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Expression of Disrupted-In-Schizophrenia-1, a schizophrenia-associated gene, is prominent in the mouse hippocampus throughout brain development
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Austin C.P., Ky B., Ma L., Morris J.A., and Shughrue P.J. Expression of Disrupted-In-Schizophrenia-1, a schizophrenia-associated gene, is prominent in the mouse hippocampus throughout brain development. Neuroscience 124 (2004) 3-10
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Austin, C.P.1
Ky, B.2
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23
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Expression of disrupted in schizophrenia 1 (DISC1) protein in the adult and developing mouse brain indicates its role in neurodevelopment
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Schurov I.L., Handford E.J., Brandon N.J., and Whiting P.J. Expression of disrupted in schizophrenia 1 (DISC1) protein in the adult and developing mouse brain indicates its role in neurodevelopment. Mol Psychiatry 9 (2004) 1100-1110
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Schurov, I.L.1
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Whiting, P.J.4
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24
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The Caenorhabditis elegans gene unc-76 and its human homologs define a new gene family involved in axonal outgrowth and fasciculation
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Bloom L., and Horvitz H.R. The Caenorhabditis elegans gene unc-76 and its human homologs define a new gene family involved in axonal outgrowth and fasciculation. Proc Natl Acad Sci USA 94 (1997) 3414-3419
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Bloom, L.1
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0346433821
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Identification of a tissue-non-specific homologue of axonal fasciculation and elongation protein ζ-1
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Fujita T., Ikuta J., Hamada J., Okajima T., Tatematsu K., Tanizawa K., and Kuroda S. Identification of a tissue-non-specific homologue of axonal fasciculation and elongation protein ζ-1. Biochem Biophys Res Commun 313 (2004) 738-744
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Kuroda, S.7
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26
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Expression of fasciculation and elongation protein ζ-1 (FEZ1) in the developing rat brain
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Honda A., Miyoshi K., Baba K., Taniguchi M., Koyama Y., Kuroda S., Katayama T., and Tohyama M. Expression of fasciculation and elongation protein ζ-1 (FEZ1) in the developing rat brain. Brain Res Mol Brain Res 122 (2004) 89-92
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Tohyama M: Disrupted-In-Schizophrenia 1, a candidate gene for schizophrenia, participates in neurite outgrowth
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Miyoshi K., Honda A., Baba K., Taniguchi M., Oono K., Fujita T., Kuroda S., and Katayama T. Tohyama M: Disrupted-In-Schizophrenia 1, a candidate gene for schizophrenia, participates in neurite outgrowth. Mol Psychiatry 8 (2003) 685-694
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Mol Psychiatry
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Miyoshi, K.1
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Kuroda, S.7
Katayama, T.8
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28
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28544453286
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A schizophrenia-associated mutation of DISC1 perturbs cerebral cortex development
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DISC1 is shown to be associated with a microtubule-associated dynein motor protein complex and is essential for maintaining this complex at the centrosome. Using an in utero gene transfer technique and RNA interference, the authors also demonstrate that inhibiting DISC1 function in mice causes abnormal development of the cerebral cortex through a mechanism that perturbs correct neuronal migration.
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Kamiya A., Kubo K., Tomoda T., Takaki M., Youn R., Ozeki Y., Sawamura N., Park U., Kudo C., Okawa M., et al. A schizophrenia-associated mutation of DISC1 perturbs cerebral cortex development. Nat Cell Biol 7 (2005) 1167-1178. DISC1 is shown to be associated with a microtubule-associated dynein motor protein complex and is essential for maintaining this complex at the centrosome. Using an in utero gene transfer technique and RNA interference, the authors also demonstrate that inhibiting DISC1 function in mice causes abnormal development of the cerebral cortex through a mechanism that perturbs correct neuronal migration.
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(2005)
Nat Cell Biol
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Kamiya, A.1
Kubo, K.2
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Takaki, M.4
Youn, R.5
Ozeki, Y.6
Sawamura, N.7
Park, U.8
Kudo, C.9
Okawa, M.10
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29
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0037422609
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Disrupted-in-Schizophrenia-1 (DISC-1): mutant truncation prevents binding to NudE-like (NUDEL) and inhibits neurite outgrowth
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Ozeki Y., Tomoda T., Kleiderlein J., Kamiya A., Bord L., Fujii K., Okawa M., Yamada N., Hatten M.E., Snyder S.H., et al. Disrupted-in-Schizophrenia-1 (DISC-1): mutant truncation prevents binding to NudE-like (NUDEL) and inhibits neurite outgrowth. Proc Natl Acad Sci USA 100 (2003) 289-294
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Proc Natl Acad Sci USA
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Ozeki, Y.1
Tomoda, T.2
Kleiderlein, J.3
Kamiya, A.4
Bord, L.5
Fujii, K.6
Okawa, M.7
Yamada, N.8
Hatten, M.E.9
Snyder, S.H.10
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30
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DISC1 (Disrupted-In-Schizophrenia 1) is a centrosome-associated protein that interacts with MAP1A, MIPT3, ATF4/5 and NUDEL: regulation and loss of interaction with mutation
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Morris J.A., Kandpal G., Ma L., and Austin C.P. DISC1 (Disrupted-In-Schizophrenia 1) is a centrosome-associated protein that interacts with MAP1A, MIPT3, ATF4/5 and NUDEL: regulation and loss of interaction with mutation. Hum Mol Genet 12 (2003) 1591-1608
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31
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Disrupted in Schizophrenia 1 and Nudel form a neurodevelopmentally regulated protein complex: implications for schizophrenia and other major neurological disorders
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Brandon N.J., Handford E.J., Schurov I., Rain J.C., Pelling M., Duran-Jimeniz B., Camargo L.M., Oliver K.R., Beher D., Shearman M.S., et al. Disrupted in Schizophrenia 1 and Nudel form a neurodevelopmentally regulated protein complex: implications for schizophrenia and other major neurological disorders. Mol Cell Neurosci 25 (2004) 42-55
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Brandon, N.J.1
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Schurov, I.3
Rain, J.C.4
Pelling, M.5
Duran-Jimeniz, B.6
Camargo, L.M.7
Oliver, K.R.8
Beher, D.9
Shearman, M.S.10
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32
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A LIS1/NUDEL/cytoplasmic dynein heavy chain complex in the developing and adult nervous system
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Sasaki S., Shionoya A., Ishida M., Gambello M.J., Yingling J., Wynshaw-Boris A., and Hirotsune S. A LIS1/NUDEL/cytoplasmic dynein heavy chain complex in the developing and adult nervous system. Neuron 28 (2000) 681-696
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Sasaki, S.1
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Wynshaw-Boris, A.6
Hirotsune, S.7
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33
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0034517593
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LIS1 regulates CNS lamination by interacting with mNudE, a central component of the centrosome
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Feng Y., Olson E.C., Stukenberg P.T., Flanagan L.A., Kirschner M.W., and Walsh C.A. LIS1 regulates CNS lamination by interacting with mNudE, a central component of the centrosome. Neuron 28 (2000) 665-679
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Neuron
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Feng, Y.1
Olson, E.C.2
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Flanagan, L.A.4
Kirschner, M.W.5
Walsh, C.A.6
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34
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5144228139
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Ndel1 operates in a common pathway with LIS1 and cytoplasmic dynein to regulate cortical neuronal positioning
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Shu T., Ayala R., Nguyen M.D., Xie Z., Gleeson J.G., and Tsai L.H. Ndel1 operates in a common pathway with LIS1 and cytoplasmic dynein to regulate cortical neuronal positioning. Neuron 44 (2004) 263-277
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Neuron
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Shu, T.1
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Xie, Z.4
Gleeson, J.G.5
Tsai, L.H.6
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35
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Complete loss of Ndel1 results in neuronal migration defects and early embryonic lethality
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Sasaki S., Mori D., Toyo-oka K., Chen A., Garrett-Beal L., Muramatsu M., Miyagawa S., Hiraiwa N., Yoshiki A., Wynshaw-Boris A., et al. Complete loss of Ndel1 results in neuronal migration defects and early embryonic lethality. Mol Cell Biol 25 (2005) 7812-7827
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Mol Cell Biol
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Sasaki, S.1
Mori, D.2
Toyo-oka, K.3
Chen, A.4
Garrett-Beal, L.5
Muramatsu, M.6
Miyagawa, S.7
Hiraiwa, N.8
Yoshiki, A.9
Wynshaw-Boris, A.10
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36
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20144374692
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Inhibition of NUDEL (nuclear distribution element-like)-oligopeptidase activity by disrupted-in-schizophrenia 1
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This study reminds us that NDEL1 has an enzymatic endo-oligopeptidase activity, which might be distinct from its role in neuronal migration during early development, but is likewise regulated by DISC1.
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Hayashi M.A., Portaro F.C., Bastos M.F., Guerreiro J.R., Oliveira V., Gorrao S.S., Tambourgi D.V., Sant'Anna O.A., Whiting P.J., Camargo L.M., et al. Inhibition of NUDEL (nuclear distribution element-like)-oligopeptidase activity by disrupted-in-schizophrenia 1. Proc Natl Acad Sci USA 102 (2005) 3828-3833. This study reminds us that NDEL1 has an enzymatic endo-oligopeptidase activity, which might be distinct from its role in neuronal migration during early development, but is likewise regulated by DISC1.
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Proc Natl Acad Sci USA
, vol.102
, pp. 3828-3833
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Hayashi, M.A.1
Portaro, F.C.2
Bastos, M.F.3
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Gorrao, S.S.6
Tambourgi, D.V.7
Sant'Anna, O.A.8
Whiting, P.J.9
Camargo, L.M.10
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37
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