A haplotype within the DISC1 gene is associated with visual memory functions in families with a high density of schizophrenia

Molecular Psychiatry

Volumn 10, Issue 12, 2005, Pages 1097-1103

  Hennah, W ^a   Tuulio Henriksson, A ^a   Paunio, T ^a,b   Ekelund, J ^a   Varilo, T ^a,c   Partonen, T ^a   Cannon, T D ^d   Lonnqvist J ^a,b   Peltonen, L ^a,c,e  

^a NATIONAL PUBLIC HEALTH INSTITUTE   (Finland)

^b HELSINKI UNIVERSITY CENTRAL HOSPITAL   (Finland)

^c UNIVERSITY OF HELSINKI   (Finland)

^d UNIVERSITY OF CALIFORNIA   (United States)

^e UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

DISC1; Finland; QTL; Schizophrenia

Indexed keywords

ADULT; ALLELE; ARTICLE; ATTENTION; DISC1 GENE; DISEASE ASSOCIATION; FAMILY; FEMALE; HAPLOTYPE; HUMAN; MAJOR CLINICAL STUDY; MALE; MEMORY DISORDER; PRIORITY JOURNAL; PROGENY; SCHIZOPHRENIA; TASK PERFORMANCE; VISUAL MEMORY; WORKING MEMORY;

AGED; ATTENTION; CHROMOSOMES, HUMAN, PAIR 1; DNA-BINDING PROTEINS; FEMALE; GENETIC PREDISPOSITION TO DISEASE; HAPLOTYPES; HUMANS; LINKAGE DISEQUILIBRIUM; LOD SCORE; MALE; MEMORY; MEMORY DISORDERS; MIDDLE AGED; NERVE TISSUE PROTEINS; PATTERN RECOGNITION, VISUAL; QUANTITATIVE TRAIT LOCI; REFERENCE VALUES; SCHIZOPHRENIA; VERBAL LEARNING;

EID: 32844455739     PISSN: 13594184     EISSN: 14765578     Source Type: Journal    
DOI: 10.1038/sj.mp.4001731     Document Type: Article

References (41)

1. Cannon TD, Kaprio J, Lönnqvist J, Huttunen M, Koskenvuo M. The genetic epidemiology of schizophrenia in a Finnish twin cohort. Arch Gen Psychiatry 1998; 55: 67-74.
2. Kendler KS, McGuire M, Gruenberg AM, O'Hare A, Spellman M, Walsh D. The Roscommon family study. I. Methods, diagnosis of probands, and risk of schizophrenia in relatives. Arch Gen Psychiatry 1993; 50: 527-540.
3. Tienari P, Wynne LC, Moring J, Lahti I, Naarala M, Sorri A et al. The Finnish adoptive family study of schizophrenia. Implications for family research. Br J Psychiatry Suppl 1994; 23: 20-26.
4. Harrison PJ, Weinberger DR. Schizophrenia genes, gene expression, and neuropathology: on the matter of their convergence. Mol Psychiatry 2005; 10: 40-68.
5. Hennah W, Varilo T, Paunio T, Peltonen L. Haplotype analysis and identification of genes for a complex trait: examples from schizophrenia. Ann Med 2004; 36: 322-331.
6. Hennah W, Varilo T, Kestila M, Paunio T, Arajarvi R, Haukka J et al. Haplotype transmission analysis provides evidence of association for DISC1 to schizophrenia and suggests sex-dependent effects. Hum Mol Genet 2003; 12: 3151-3159.
7. Hodgkinson CA, Goldman D, Jaeger J, Persaud S, Kane JM, Lipsky RH et al. Disrupted in schizophrenia 1 (DISC1): association with schizophrenia, schizoaffective disorder, and bipolar disorder. Am J Hum Genet 2004; 75: 862-872.
8. Kockelkorn TT, Arai M, Matsumoto H, Fukuda N, Yamada K, Minabe Y et al. Association study of polymorphisms in the 5′ upstream region of human DISC1 gene with schizophrenia. Neurosci Lett 2004; 368: 41-45.
9. Millar JK, Wilson-Annan JC, Anderson S, Christie S, Taylor MS, Semple CAM et al. Disruption of two novel genes by a translocation co-segregating with schizophrenia. Hum Mol Genet 2000; 9: 1415-1423.
10. St Clair D, Blackwood D, Muir W, Carothers A, Walker M, Spowart G et al. Association within a family of a balanced autosomal translocation with major mental illness. Lancet 1990; 336: 13-16.
11. Ekelund J, Hovatta I, Parker A, Paunio T, Varilo T, Martin R et al. Chromosome 1 loci in Finnish schizophrenia families. Hum Mol Genet 2001; 10: 1611-1617.
12. Ekelund J, Hennah W, Hiekkalinna T, Parker A, Meyer J, Lonnqvist J et al. Replication of 1q42 linkage in Finnish schizophrenia pedigrees. Mol Psychiatry 2004; 9: 1037-1041.
13. Hwu HG, Liu CM, Fann CS, Ou-Yang WC, Lee SF. Linkage of schizophrenia with chromosome 1q loci in Taiwanese families. Mol Psychiatry 2003; 8: 445-452.
14. Curtis D, Kalsi G, Brynjolfsson J, McInnis M, O'Neill J, Smyth C et al. Genome scan of pedigrees multiply affected with bipolar disorder provides further support for the presence of a susceptibility locus on chromosome 12q23-q24, and suggests the presence of additional loci on 1p and 1q. Psychiatr Genet 2003; 13: 77-84.
15. Miyoshi K, Honda A, Baba K, Taniguchi M, Oono K, Fujita T et al. Disrupted-In-Schizophrenia 1, a candidate gene for schizophrenia, participates in neurite outgrowth. Mol Psychiatry 2003; 8: 685-694.
16. Ozeki Y, Tomoda T, Kleiderlein J, Kamiya A, Bord L, Fujii K et al. Disrupted-in-Schizophrenia-1 (DISC-1): mutant truncation prevents binding to NudE-like (NUDEL) and inhibits neurite outgrowth. Proc Natl Acad Sci USA 2003; 100: 289-294.
17. Austin CP, Ma L, Ky B, Morris JA, Shughrue PJ. DISC1 (Disrupted in Schizophrenia-1) is expressed in limbic regions of the primate brain. Neuroreport 2003; 14: 951-954.
18. Millar JK, Christie S, Porteous DJ. Yeast two-hybrid screens implicate DISC1 in brain development and function. Biochem Biophys Res Commun 2003; 311: 1019-1025.
19. Morris JA, Kandpal G, Ma L, Austin CP. DISC1 (Disrupted-In-Schizophrenia 1) is a centrosome-associated protein that interacts with MAP1A, MIPT3, ATF4/5 and NUDEL: regulation and loss of interaction with mutation. Hum Mol Genet 2003; 12: 1591-1608.
20. Brandon NJ, Handford EJ, Schurov I, Rain JC, Pelling M, Duran-Jimeniz B et al. Disrupted in Schizophrenia 1 and Nudel form a neurodevelopmentally regulated protein complex: implications for schizophrenia and other major neurological disorders. Mol Cell Neurosci 2004; 25: 42-55.
21. Finkenstadt PM, Kang W-S, Jeon M, Taira E, Tang W, Baraban JM. Somatodendritic localization of translin, a component of the translin/TRAX RNA binding complex. J Neurochem 2000; 75: 1754-1762.
22. Gottesman II, Gould TD. The endophenotype concept in psychiatry: etymology and strategic intentions. Am J Psychiatry 2003; 160: 636-645.
23. Hovatta I, Varilo T, Suvisaari J, Terwilliger JD, Ollikainen V, Arajärvi R et al. A Genomewide screen for schizophrenia genes in an isolated Finnish subpopulation, suggesting multiple susceptibility loci. Am J Hum Genet 1999; 65: 1114-1124.
24. Gasperoni TL, Ekelund J, Huttunen M, Palmer CG, Tuulio-Henriksson A, Lonnqvist J et al. Genetic linkage and association between chromosome 1q and working memory function in schizophrenia. Am J Med Genet 2003; 116B: 8-16.
25. Paunio T, Tuulio-Henriksson A, Hiekkalinna T, Perola M, Varilo T, Partonen T et al. Search for cognitive trait components of schizophrenia reveals a locus for verbal learning and memory on 4q and for visual working memory on 2q. Hum Mol Genet 2004; 13: 1693-1702.
26. American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders, 4th edn (DSM-IV). American Psychiatric Press Inc.: Washington, DC, 1994.
27. Kendler KS, McGuire M, Gruenberg AM, O'Hare A, Spellman M, Walsh D. The Roscommon Family study. III. Schizophrenia-related personality disorders in relatives. Arch Gen Psychiatry 1993; 50: 781-788.
28. Tuulio-Henriksson A, Haukka J, Partonen T, Varilo T, Paunio T, Ekelund J et al. Heritability and number of quantitative trait loci of neurocognitive functions in families with schizophrenia. Am J Med Genet 2002; 114: 483-490.
29. Wechsler D. Wechsler Memory Scale-Revised (WMS-R), Manual. Psychological Corporation, Harcourt Brace Jovanovich Inc.: San Antonio, 1987.
30. Delis DC, Kramer JH, Kaplan E, Ober BA. California Verbal Learning Test: Manual, Research Edition. Psychological Corporation, Harcourt Brace & Company: San Antonio, 1987.
31. Wechsler D. Wechsler Adult Intelligence Scale-Revised (WAIS-R), Manual. Psychological Corporation, Harcourt Brace Jovanovich Inc.: Cleveland, 1981.
32. Tuulio-Henriksson A, Arajarvi R, Partonen T, Haukka J, Varilo T, Schreck M. et al. Familial loading associates with impairment in visual span among healthy siblings of schizophrenia patients. Biol Psychiatry 2003; 54: 623-628.
33. Cannon TD, Huttunen MO, Lonnqvist J, Tuulio-Henriksson A, Pirkola T, Glahn D et al. The inheritance of neuropsychological dysfunction in twins discordant for schizophrenia. Am J Hum Genet 2000; 67: 369-382.
34. Clayton D. A generalization of the transmission/disequilibrium test for uncertain-haplotype transmission. Am J Hum Genet 1999; 65: 1170-1177.
35. Sobel E, Lange K. Descent graphs in pedigree analysis: applications to haplotyping, location scores, and marker-sharing statistics. Am J Hum Genet 1996; 58: 1323-1337.
36. Abecasis GR, Cardon LR, Cookson WO. A general test of association for quantitative traits in nuclear families. Am J Hum Genet 2000; 66: 279-292.
37. Blackwood DHR, Fordyce A, Walker MT, St Clair DM, Porteous DJ, Muir WJ. Schizophrenia and affective disorders-cosegregation with a translocation at chromosome 1q42 that directly disrupts brain-expressed genes: clinical and P300 findings in a family. Am J Hum Genet 2001; 69: 428-433.
38. Jeon YW, Polich J. Meta-analysis of P300 and schizophrenia: patients, paradigms, and practical implications. Psychophysiology 2003; 40: 684-701.
39. Vianin P, Posada A, Hugues E, Franck N, Bovet P, Parnas J et al. Reduced P300 amplitude in a visual recognition task in patients with schizophrenia. Neuroimage 2002; 17: 911-921.
40. Winterer G, Coppola R, Goldberg TE, Egan MF, Jones DW, Sanchez CE et al. Prefrontal broadband noise, working memory, and genetic risk for schizophrenia. Am J Psychiatry 2004; 161: 490-500.
41. Levy R, Goldman-Rakic PS. Segregation of working memory functions within the dorsolateral prefrontal cortex. Exp Brain Res 2000; 133: 23-32.