Modulation of the activity of pro-inflammatory enzymes, COX-2 and iNOS, by chrysin derivatives

Pharmacological Research

Volumn 49, Issue 1, 2004, Pages 37-43

  Cho, Heeyeong ^a   Yun, Cheol Won ^b   Park, Woo Kyu ^a   Kong, Jae Yang ^a   Kim, Kyoung Soon ^c   Park, Youmie ^c   Lee, Sanghyun ^c   Kim, Bak Kwang ^c  

^a Korea Research Institute of Chemical Technology   (South Korea)

^b Pukyong National University   (South Korea)

^c Seoul National University   (South Korea)

Author keywords

5,7 Diacetylflavone (Ch 4); Chrysin; COX 2; iNOS; Selectivity

Indexed keywords

5 HYDROXY 7 DODECOXYFLAVONE; 5,7 DIACETYLFLAVONE; ANTIINFLAMMATORY AGENT; CHRYSIN; CHRYSIN 7 O 4 METHOXYCINNAMATE; CHRYSIN DERIVATIVE; CYCLOOXYGENASE 1; CYCLOOXYGENASE 1 INHIBITOR; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITOR; LIPOPOLYSACCHARIDE; NITRATE; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE INHIBITOR; TECTOCHRYSIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; DRUG MECHANISM; DRUG SELECTIVITY; ENZYME ACTIVITY; ENZYME INHIBITION; HYDROGEN BOND; IC 50; MACROPHAGE; MOLECULAR MODEL; MONOCYTE; MOUSE; MUTANT; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS;

EID: 0142215549     PISSN: 10436618     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1043-6618(03)00248-2     Document Type: Article

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