-
1
-
-
0036480194
-
Emerging structure of the nicotinic acetylcholine receptors
-
Karlin A. Emerging structure of the nicotinic acetylcholine receptors. Nat. Rev. Neurosci. 3 (2002) 102-114
-
(2002)
Nat. Rev. Neurosci.
, vol.3
, pp. 102-114
-
-
Karlin, A.1
-
3
-
-
13244259427
-
Charge selectivity of the Cys-loop family of ligand-gated ion channels
-
Jensen M.L., Schousboe A., and Ahring P.K. Charge selectivity of the Cys-loop family of ligand-gated ion channels. J. Neurochem. 92 (2005) 217-225
-
(2005)
J. Neurochem.
, vol.92
, pp. 217-225
-
-
Jensen, M.L.1
Schousboe, A.2
Ahring, P.K.3
-
4
-
-
0023162271
-
Mechanism of anion permeation through channels gated by glycine and γ-aminobutyric acid in mouse cultured spinal neurones
-
Bormann J., Hamill O.P., and Sakmann B. Mechanism of anion permeation through channels gated by glycine and γ-aminobutyric acid in mouse cultured spinal neurones. J. Physiol. (Lond.) 385 (1987) 243-286
-
(1987)
J. Physiol. (Lond.)
, vol.385
, pp. 243-286
-
-
Bormann, J.1
Hamill, O.P.2
Sakmann, B.3
-
5
-
-
0038112088
-
Structure and gating mechanism of the acetylcholine receptor pore
-
Miyazawa A., Fujiyoshi Y., and Unwin N. Structure and gating mechanism of the acetylcholine receptor pore. Nature 423 6943 (2003) 949-955
-
(2003)
Nature
, vol.423
, Issue.6943
, pp. 949-955
-
-
Miyazawa, A.1
Fujiyoshi, Y.2
Unwin, N.3
-
6
-
-
13444271681
-
Refined structure of the nicotinic acetylcholine receptor at 4 Å resolution
-
Unwin N. Refined structure of the nicotinic acetylcholine receptor at 4 Å resolution. J. Mol. Biol. 346 (2005) 967-989
-
(2005)
J. Mol. Biol.
, vol.346
, pp. 967-989
-
-
Unwin, N.1
-
8
-
-
0034692175
-
GABA-activated ligand gated ion channels: medicinal chemistry and molecular biology
-
Chebib M., and Johnston G.A.R. GABA-activated ligand gated ion channels: medicinal chemistry and molecular biology. J. Med. Chem. 43 8 (2000) 1427-1447
-
(2000)
J. Med. Chem.
, vol.43
, Issue.8
, pp. 1427-1447
-
-
Chebib, M.1
Johnston, G.A.R.2
-
10
-
-
0030959309
-
A receptors drastically alter the affinity for ligands of the benzodiazepine binding site
-
A receptors drastically alter the affinity for ligands of the benzodiazepine binding site. J. Biol. Chem. 272 18 (1997) 11799-11804
-
(1997)
J. Biol. Chem.
, vol.272
, Issue.18
, pp. 11799-11804
-
-
Buhr, A.1
Baur, R.2
Sigel, E.3
-
11
-
-
0030611649
-
A point mutation in the γ2 subunit of γ-aminobutyric acid type A receptors results in altered benzodiazepine binding site specificity
-
Buhr A., and Sigel E. A point mutation in the γ2 subunit of γ-aminobutyric acid type A receptors results in altered benzodiazepine binding site specificity. Proc. Natl. Acad. Sci. U.S.A. 94 16 (1997) 8824-8829
-
(1997)
Proc. Natl. Acad. Sci. U.S.A.
, vol.94
, Issue.16
, pp. 8824-8829
-
-
Buhr, A.1
Sigel, E.2
-
12
-
-
0031820285
-
A receptors with flunitrazepam identifies a subset of ligands that interact directly with His102 of the α subunit and predicts orientation of these within the benzodiazepine pharmacophore
-
A receptors with flunitrazepam identifies a subset of ligands that interact directly with His102 of the α subunit and predicts orientation of these within the benzodiazepine pharmacophore. Mol. Pharmacol. 54 (1998) 33-43
-
(1998)
Mol. Pharmacol.
, vol.54
, pp. 33-43
-
-
McKernan, R.M.1
Farrar, S.2
Collins, I.3
Emms, F.4
Asuni, A.5
Quirk, K.6
Broughton, H.7
-
13
-
-
12344260655
-
A receptor subtypes: any clue to the mechanism of benzodiazepine dependence?
-
A receptor subtypes: any clue to the mechanism of benzodiazepine dependence?. Curr. Opin. Pharmacol. 5 (2005) 47-52
-
(2005)
Curr. Opin. Pharmacol.
, vol.5
, pp. 47-52
-
-
Wafford, K.A.1
-
14
-
-
0030895793
-
Subunit-dependent interaction of the general anaesthetic etomidate with the γ-aminobutyric acid type A receptor
-
Hill-Venning C., Belelli D., Peters J.A., and Lambert J.J. Subunit-dependent interaction of the general anaesthetic etomidate with the γ-aminobutyric acid type A receptor. Br. J. Pharmacol. 120 (1997) 749-756
-
(1997)
Br. J. Pharmacol.
, vol.120
, pp. 749-756
-
-
Hill-Venning, C.1
Belelli, D.2
Peters, J.A.3
Lambert, J.J.4
-
15
-
-
0030922807
-
The interaction of the general anesthetic etomidate with the γ-aminobutyric acid type A receptor is influenced by a single amino acid
-
Belelli D., Lambert J.J., Peters J.A., Wafford K.A., and Whiting P.J. The interaction of the general anesthetic etomidate with the γ-aminobutyric acid type A receptor is influenced by a single amino acid. Proc. Natl. Acad. Sci. U.S.A. 94 (1997) 11031-11036
-
(1997)
Proc. Natl. Acad. Sci. U.S.A.
, vol.94
, pp. 11031-11036
-
-
Belelli, D.1
Lambert, J.J.2
Peters, J.A.3
Wafford, K.A.4
Whiting, P.J.5
-
16
-
-
0035902009
-
Crystal structure of an ACh-binding protein reveals the ligand-binding domain of nicotinic receptors
-
Brejc K., van Dijk W.J., Klaassen R.V., Schuurmans M., van der Oost J., Smit A.B., and Sixma T.K. Crystal structure of an ACh-binding protein reveals the ligand-binding domain of nicotinic receptors. Nature 411 6835 (2001) 269-276
-
(2001)
Nature
, vol.411
, Issue.6835
, pp. 269-276
-
-
Brejc, K.1
van Dijk, W.J.2
Klaassen, R.V.3
Schuurmans, M.4
van der Oost, J.5
Smit, A.B.6
Sixma, T.K.7
-
17
-
-
0030801002
-
Gapped BLAST and PSI-BLAST: a new generation of protein database search programs
-
Altschul S.F., Madden T.L., Schäffer A.A., Zhang J., Zhang Z., Miller W., and Lipman D.J. Gapped BLAST and PSI-BLAST: a new generation of protein database search programs. Nucleic Acids Res. 25 (1997) 3389-3402
-
(1997)
Nucleic Acids Res.
, vol.25
, pp. 3389-3402
-
-
Altschul, S.F.1
Madden, T.L.2
Schäffer, A.A.3
Zhang, J.4
Zhang, Z.5
Miller, W.6
Lipman, D.J.7
-
18
-
-
33846569660
-
-
MOE Program, Chemical Computing Group Inc., Montréal, Québec, Canada, 2003.
-
-
-
-
19
-
-
33846578004
-
-
SYBYL, version 7.1, Tripos Inc., 1699 South Hanley Road, St. Louis, MI 63144, USA, 2005.
-
-
-
-
20
-
-
0020475449
-
A simple method for displaying the hydropathic character of a protein
-
Kyte J., and Doolittle R. A simple method for displaying the hydropathic character of a protein. J. Mol. Biol. 157 (1982) 105-132
-
(1982)
J. Mol. Biol.
, vol.157
, pp. 105-132
-
-
Kyte, J.1
Doolittle, R.2
-
21
-
-
0242488935
-
Structure and action of the nicotinic acetylcholine receptor explored by electron microscopy
-
Unwin N. Structure and action of the nicotinic acetylcholine receptor explored by electron microscopy. FEBS Lett. 555 (2003) 91-95
-
(2003)
FEBS Lett.
, vol.555
, pp. 91-95
-
-
Unwin, N.1
-
22
-
-
0036304564
-
Activation of the nicotinic acetylcholine receptor involves a switch in conformation of the α subunits
-
Unwin N., Miyazawa A., Li J., and Fujiyoshi Y. Activation of the nicotinic acetylcholine receptor involves a switch in conformation of the α subunits. J. Mol. Biol. 319 (2002) 1165-1176
-
(2002)
J. Mol. Biol.
, vol.319
, pp. 1165-1176
-
-
Unwin, N.1
Miyazawa, A.2
Li, J.3
Fujiyoshi, Y.4
-
23
-
-
4344616080
-
Coupling of agonist binding to channel gating in an ACh-binding protein linked to an ion channel
-
Bouzat C., Gumilar F., Spitzmaul G., Wang H.-L., Rayes D., Hansen S.B., Taylor P., and Sine S.M. Coupling of agonist binding to channel gating in an ACh-binding protein linked to an ion channel. Nature 430 (2004) 896-900
-
(2004)
Nature
, vol.430
, pp. 896-900
-
-
Bouzat, C.1
Gumilar, F.2
Spitzmaul, G.3
Wang, H.-L.4
Rayes, D.5
Hansen, S.B.6
Taylor, P.7
Sine, S.M.8
-
25
-
-
0000790849
-
From secondary structure to three-dimensional structure: improved dihedral angle probability distribution function for use with energy searches for native structures of polypeptides and proteins
-
Cheng B., Nayeem A., and Scheraga H.A. From secondary structure to three-dimensional structure: improved dihedral angle probability distribution function for use with energy searches for native structures of polypeptides and proteins. J. Comput. Chem. 17 12 (1996) 1453-1480
-
(1996)
J. Comput. Chem.
, vol.17
, Issue.12
, pp. 1453-1480
-
-
Cheng, B.1
Nayeem, A.2
Scheraga, H.A.3
-
26
-
-
33846645765
-
-
MATLAB, version 6.0.0.88 Release 12, The MathWorks Inc., Massachusetts, USA, 2000.
-
-
-
-
28
-
-
0029011701
-
A second generation force field for the simulation of proteins, nucleic acids and organic molecules
-
Cornell W.D., Cieplak P., Bayly C.I., Gould I.R., Merz K.M.J., Ferguson D.M., Spellmeyer D.C., Fox T., Caldwell J.W., and Kollman P.A. A second generation force field for the simulation of proteins, nucleic acids and organic molecules. J. Am. Chem. Soc. 117 (1995) 5179-5197
-
(1995)
J. Am. Chem. Soc.
, vol.117
, pp. 5179-5197
-
-
Cornell, W.D.1
Cieplak, P.2
Bayly, C.I.3
Gould, I.R.4
Merz, K.M.J.5
Ferguson, D.M.6
Spellmeyer, D.C.7
Fox, T.8
Caldwell, J.W.9
Kollman, P.A.10
-
29
-
-
33846639835
-
-
ArgusLab, version 4.0.1, Mark Thompson and Planaria Software LLC, Seattle, USA, 2004.
-
-
-
-
30
-
-
27544460357
-
A receptor extracellular and transmembrane domains: important insights in pharmacology and function
-
A receptor extracellular and transmembrane domains: important insights in pharmacology and function. Mol. Pharmacol. 68 5 (2005) 1291-1300
-
(2005)
Mol. Pharmacol.
, vol.68
, Issue.5
, pp. 1291-1300
-
-
Ernst, M.1
Bruckner, S.2
Boresch, S.3
Sieghart, W.4
-
31
-
-
13844315498
-
Homology modeling of a human glycine alpha 1 receptor reveals a plausible anesthetic binding Site
-
Bertaccini E.J., Shapiro J., Brutlag D.L., and Trudell J.R. Homology modeling of a human glycine alpha 1 receptor reveals a plausible anesthetic binding Site. J. Chem. Inf. Model. 45 1 (2005) 128-135
-
(2005)
J. Chem. Inf. Model.
, vol.45
, Issue.1
, pp. 128-135
-
-
Bertaccini, E.J.1
Shapiro, J.2
Brutlag, D.L.3
Trudell, J.R.4
-
32
-
-
0033567181
-
General anaesthetic actions on ligand-gated ion channels
-
Krasowski M.D., and Harrison N.L. General anaesthetic actions on ligand-gated ion channels. Cell. Mol. Life Sci. 55 (1999) 1278-1303
-
(1999)
Cell. Mol. Life Sci.
, vol.55
, pp. 1278-1303
-
-
Krasowski, M.D.1
Harrison, N.L.2
-
33
-
-
4143088670
-
Comparative modeling of a GABAA alpha1 receptor using three crystal structures as templates
-
Trudell J.R., and Bertaccini E. Comparative modeling of a GABAA alpha1 receptor using three crystal structures as templates. J. Mol. Graphics Modell. 23 (2004) 39-49
-
(2004)
J. Mol. Graphics Modell.
, vol.23
, pp. 39-49
-
-
Trudell, J.R.1
Bertaccini, E.2
-
34
-
-
0033778416
-
A receptor α subunit: effects on channel gating and regulation by ethanol
-
A receptor α subunit: effects on channel gating and regulation by ethanol. Br. J. Pharmacol. 131 2 (2000) 296-302
-
(2000)
Br. J. Pharmacol.
, vol.131
, Issue.2
, pp. 296-302
-
-
Ueno, S.1
Lin, A.2
Nikolaeva, N.3
Trudell, J.R.4
Mihic, S.J.5
Harris, R.A.6
Harrison, N.L.7
-
35
-
-
0035869928
-
A receptor
-
A receptor. J. Neurosci. 21 (RC136) (2001) 131-134
-
(2001)
J. Neurosci.
, vol.21 RC136
, pp. 131-134
-
-
Jenkins, A.1
Greenblatt, E.P.2
Faulkner, H.J.3
Bertaccini, E.4
Light, A.5
Lin, A.6
Andreasen, A.7
Viner, A.8
Trudell, J.R.9
Harrison, N.L.10
-
36
-
-
0034255021
-
Specific binding sites for alcohols and anesthetics on ligand-gated ion channels
-
Mascia M.P., Trudell J.R., and Harris R.A. Specific binding sites for alcohols and anesthetics on ligand-gated ion channels. Proc. Natl. Acad. Sci. U.S.A. 97 16 (2000) 9305-9310
-
(2000)
Proc. Natl. Acad. Sci. U.S.A.
, vol.97
, Issue.16
, pp. 9305-9310
-
-
Mascia, M.P.1
Trudell, J.R.2
Harris, R.A.3
-
37
-
-
1842328604
-
Sites of alcohol and volatile anaesthetic action on GABAA and glycine receptors
-
Mihic S.J., Ye Q., Wick M.J., Koltchine V.V., Krasowski M.D., Finn S.E., Mascia M.P., Valenzuela C.F., Hanson K.K., Greenblatt E.P., Harris R.A., and Harrison N.L. Sites of alcohol and volatile anaesthetic action on GABAA and glycine receptors. Nature 389 (1997) 385-389
-
(1997)
Nature
, vol.389
, pp. 385-389
-
-
Mihic, S.J.1
Ye, Q.2
Wick, M.J.3
Koltchine, V.V.4
Krasowski, M.D.5
Finn, S.E.6
Mascia, M.P.7
Valenzuela, C.F.8
Hanson, K.K.9
Greenblatt, E.P.10
Harris, R.A.11
Harrison, N.L.12
-
40
-
-
0035042719
-
Protein mobility and GABA-induced conformational changes in GABAA receptor pore-lining M2 segment
-
Horenstein J., Wagner D.A., Czajkowski C., and Akabas M.H. Protein mobility and GABA-induced conformational changes in GABAA receptor pore-lining M2 segment. Nat. Neurosci. 4 5 (2001) 477-485
-
(2001)
Nat. Neurosci.
, vol.4
, Issue.5
, pp. 477-485
-
-
Horenstein, J.1
Wagner, D.A.2
Czajkowski, C.3
Akabas, M.H.4
-
41
-
-
0030975014
-
1 subunit
-
1 subunit. Eur. J. Pharmacol. 329 (1997) 253-257
-
(1997)
Eur. J. Pharmacol.
, vol.329
, pp. 253-257
-
-
Westh-Hansen, S.E.1
Rasmussen, P.B.2
Hastrup, S.3
Nabekura, J.4
Noguchi, K.5
Akaike, N.6
Witt, M.-R.7
Nielsen, M.8
-
42
-
-
0033516983
-
1, subunit is essential for GABA binding and chloride ion current gating
-
1, subunit is essential for GABA binding and chloride ion current gating. Neuroreport 10 (1999) 2417-2421
-
(1999)
Neuroreport
, vol.10
, pp. 2417-2421
-
-
Westh-Hansen, S.E.1
Witt, M.R.2
Dekermendjian, K.3
Liljefors, T.4
Rasmussen, P.B.5
Nielsen, M.6
-
43
-
-
0037969585
-
191 segment is involved in GABA binding and channel gating
-
191 segment is involved in GABA binding and channel gating. J. Biol. Chem. 278 15 (2003) 13166-13172
-
(2003)
J. Biol. Chem.
, vol.278
, Issue.15
, pp. 13166-13172
-
-
Newell, J.G.1
Czajkowski, C.2
-
47
-
-
0027787023
-
A receptor needs two homologous domains of the β-subunit for activation by GABA but not by pentobarbital
-
A receptor needs two homologous domains of the β-subunit for activation by GABA but not by pentobarbital. Nature 366 (1993) 565-569
-
(1993)
Nature
, vol.366
, pp. 565-569
-
-
Amin, J.1
Weiss, D.S.2
-
48
-
-
0035141668
-
Structure and dynamics of the GABA binding pocket: a narrowing cleft that constricts during activation
-
Wagner D.A., and Czajkowski C. Structure and dynamics of the GABA binding pocket: a narrowing cleft that constricts during activation. J. Neurosci. 21 1 (2001) 67-74
-
(2001)
J. Neurosci.
, vol.21
, Issue.1
, pp. 67-74
-
-
Wagner, D.A.1
Czajkowski, C.2
|