Charged Residues in the β2 Subunit Involved in GABAA Receptor Activation

Journal of Biological Chemistry

Volumn 279, Issue 6, 2004, Pages 4887-4893

  Kash, Thomas L ^a   Dizon, Maria Johanna F ^b   Trudell, James R ^c   Harrison, Neil L ^b  

^a Weill Cornell Graduate School of Biomedical Sciences   (United States)

^b WEILL CORNELL MEDICAL COLLEGE   (United States)

^c STANFORD UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; CHEMICAL ACTIVATION; MUTAGENESIS; NEUROLOGY;

CHANNEL GATING; MUTANTS;

BIOCHEMISTRY;

4 AMINOBUTYRIC ACID A RECEPTOR; ASPARTIC ACID; LYSINE; PROTEIN SUBUNIT; RECOMBINANT PROTEIN;

ANIMAL CELL; ARTICLE; BETA CHAIN; BINDING SITE; CENTRAL NERVOUS SYSTEM; CHANNEL GATING; CONFORMATIONAL TRANSITION; DISULFIDE BOND; DRUG RECEPTOR BINDING; NONHUMAN; PHASE TRANSITION; PRIORITY JOURNAL; PROTEIN FAMILY; RESIDUE ANALYSIS; SITE DIRECTED MUTAGENESIS; SYNAPTIC INHIBITION; AMINO ACID SEQUENCE; ANIMAL; CHEMICAL STRUCTURE; CHEMISTRY; DRUG POTENTIATION; ELECTROPHYSIOLOGY; GENETICS; HUMAN; IN VITRO STUDY; METABOLISM; MOLECULAR GENETICS; PROTEIN CONFORMATION; RAT; SEQUENCE HOMOLOGY;

ANIMALIA; MAMMALIA;

AMINO ACID SEQUENCE; ANIMALS; ASPARTIC ACID; ELECTROPHYSIOLOGY; HUMANS; LYSINE; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; PROTEIN CONFORMATION; PROTEIN SUBUNITS; RATS; RECEPTORS, GABA-A; RECOMBINANT PROTEINS; SEQUENCE HOMOLOGY, AMINO ACID;

EID: 1042301377     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M311441200     Document Type: Article

References (34)

1. Klausberger, T., Magill, P. J., Marton, L. F., Roberts, J. D., Cobden, P. M., Buzsaki, G., and Somogyi, P. (2003) Nature 421, 844-848
2. MacDonald, R. L., and Olsen, R. W. (1994)Annu. Rev. Neurosci. 17, 569-602
3. Sieghart, W. (2000) Trends Pharmacol. Sci. 21, 411-413
4. Baumann, S. W., Baur, R., and Sigel, E. (2002) J. Biol. Chem. 277, 46020-46025
5. Boileau, A. J., Newell, J. G., and Czajkowski, C. (2002) J. Biol. Chem. 277, 2931-2937
6. Newell, J. G., and Czajkowski, C. (2003) J. Biol. Chem. 278, 13166-13172
7. Wagner, D. A., and Czajkowski, C. (2001) J. Neurosci. 21, 67-74
8. Smith, G. B., and Olsen, R. W. (1994) J. Biol. Chem. 269, 20380-20387
9. Karlin, A. L. (2002) Nat. Rev. Neurosci. 3, 102-114
10. Jensen, M. L., Timmermann, D. B., Johansen, T. H., Schousboe, A., Varming, T., and Ahring, P. K. (2002) J. Biol. Chem. 277, 41438-41447
11. Corringer, P. J., Le Novere, N., and Changeux, J. P. (2000) Annu. Rev. Pharmacol. Toxicol. 40, 431-458
12. Kash, T. L., Jenkins, A., Kelley, J. C., Trudell, J. R., and Harrison, N. L. (2003) Nature 421, 272-275
13. Hu, X.-Q., Zhang, L., Stewart, R. R., and Weight, F. F. (2003) J. Biol. Chem. 275, 46583-46589
14. Sigel, E., Buhr, A., and Baur, R. (1999) J. Neurochem. 73, 1758-1764
15. Krasowski, M. D., Nishikawa, K., Nikolaeva, N., Lin, A., and Harrison, N. L. (2001) Neuropharmacology 41, 952-964
16. Horenstein, J., Wagner, D. A., Czajkowski, C., and Akabas, M. H. (2001) Nat. Neurosci. 4, 477-485
17. Bertaccini, E., and Trudell, J. R. (2001) Int. Rev. Neurobiol. 48, 141-166
18. O'Shea, S. M., and Harrison, N. L. (2000) J. Biol. Chem. 275, 22764-22768
19. del Castillo, J., and Katz, B. (1957) Proc. R. Soc. Lond. B Biol. Sci. 146, 369-381
20. Colquhoun, D. (1998) Br. J. Pharmacol. 125, 924-947
21. Yu, H., Kono, M., McKee, T. D., and Oprian, D. D. (1995) Biochemistry 34, 14963-14969
22. Wu, J., and Kaback, H. R (1996) Proc. Natl. Acad. Sci. U.S.A. 93, 14498-14502
23. Rajendra, S., Lynch, J. W., Pierce, K. D., French, C. R., Barry, P. H., and Schofield, P. R. (1994) J. Biol. Chem. 269, 18739-18742
24. Gomez, C. M., Maselli, R., Gammack, J., Lasalde, J., Tamamizu, S., Cornblath, D. R., Lehar, M., McNamee, M., and Kuncl, R. W. (1996) Ann. Neurol. 39, 712-723
25. Fisher, J. L. (2002) Mol. Cell. Neurosci. 20, 683-694
26. Topf, N., Jenkins, A., Baron, N., and Harrison, N. L. (2003) Anesthesiology 98, 306-311
27. Brejc, K., van Dijk, W. J., Klaassen, R. V., Schuurmans, M., van Der Oost, J., Smit, A. B., and Sixma, T. K. (2001) Nature 411, 269-276
28. Amin, J., Dickerson, I. M., and Weiss, D. S. (1994) Mol. Pharmacol. 45, 317-323
29. Schofield, C. M., Jenkins, A., and Harrison, N. L. (2003) J. Biol. Chem. 278, 34079-34083
30. Donahue, P. J., Sainz, E., Akeson, M., Kroog, G. S., Mantey, S. A., Battey, J. F., Jensen, R. T., and Northup, J. K. (1999) Biochemistry 28, 9366-9372
31. Makhatadze, G. I., Loladze, V. V., Ermolenko, D. N., Chen, X., and Thomas, S. T. (2003) J. Mol. Biol. 327, 1135-1148
32. Leite, J. F., Blanton, M. P., Shagholi, M., Dougherty, D. A., and Lester, H. A. (2003) Proc. Natl. Acad. Sci. U. S. A. 100, 13054-13059
33. Miyazawa, A., Fujiyoshi, Y., and Unwin, N. (2003) Nature 424, 949-955
34. Unwin, N., Miyazawa, A., Li, J., and Fujiyoshi, Y. (2002) J. Mol. Biol. 319, 1165-1176