NOD/SCID mice transplanted with marrow from patients with myelodysplastic syndrome (MDS) show long-term propagation of normal but not clonal human precursors

Leukemia Research

Volumn 27, Issue 5, 2003, Pages 425-436

  Benito, Ana I ^a   Bryant, Eileen ^a,b   Loken, Michael R ^c   Sale, George E ^a,b   Nash, Richard A ^a,b   Gass, M John ^a   Deeg, H Joachim ^a,b  

^a Fred Hutchinson Cancer Research Center   (United States)

^b UNIVERSITY OF WASHINGTON   (United States)

^c HEMATOLOGICS INC   (United States)

Author keywords

Hematopoiesis; MDS; NOD SCID; Xenotransplantation

Indexed keywords

ANIMAL EXPERIMENT; ARTICLE; BONE MARROW CELL; BONE MARROW TRANSPLANTATION; CHIMERA; CONTROLLED STUDY; FLOW CYTOMETRY; FLUORESCENCE IN SITU HYBRIDIZATION; HEMATOPOIESIS; HEMATOPOIETIC STEM CELL; HUMAN; HUMAN CELL; MOUSE; MYELODYSPLASTIC SYNDROME; NONHUMAN; PRIORITY JOURNAL; SPLEEN; T LYMPHOCYTE; XENOTRANSPLANTATION;

ADULT; ANEMIA, REFRACTORY; ANEMIA, REFRACTORY, WITH EXCESS OF BLASTS; ANIMALS; ANTIGENS, CD; BONE MARROW TRANSPLANTATION; CHILD; CLONE CELLS; GRAFT SURVIVAL; HEMATOPOIETIC STEM CELLS; HUMANS; IMMUNOPHENOTYPING; INFANT; KARYOTYPING; MICE; MICE, INBRED NOD; MICE, SCID; MIDDLE AGED; MYELODYSPLASTIC SYNDROMES; RADIATION CHIMERA; RECEPTORS, ANDROGEN; SPECIFIC PATHOGEN-FREE ORGANISMS; TRANSPLANTATION, HETEROLOGOUS;

EID: 0037400551     PISSN: 01452126     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0145-2126(02)00221-7     Document Type: Article

References (54)

1. Mufti G.J. Chromosomal deletions in the myelodysplastic syndrome. Leuk. Res. 16:1992;35. [review].
2. Raskind W.H., Tirumali N., Singer J., Fialkow P.J. Evidence for a multistep pathogenesis of a myelodysplastic syndrome. Blood. 63:1984;1318.
3. Nowell P.C. Chromosome abnormalities in myelodysplastic syndromes. Semin. Oncol. 19:1992;25. [review].
4. Parlier V., van Melle G., Beris P., Schmidt P.M., Tobler A., Haller E.et al. Hematologic, clinical, and cytogenetic analysis in 109 patients with primary myelodysplastic syndrome. Prognostic significance of morphology and chromosome findings. Cancer Genet. Cytogenet. 78:1994;219.
5. Greenberg P., Cox C., LeBeau M.M., Fenaux P., Morel P., Sanz G.et al. International scoring system for evaluating prognosis in myelodysplastic syndromes [published erratum appears in Blood 1998;91:1100]. Blood. 89:1997;2079.
6. Suciu S., Kuse R., Weh H.J., Hossfeld D.K. Results of chromosome studies and their relation to morphology, course, and prognosis in 120 patients with de novo myelodysplastic syndrome. Cancer Genet. Cytogenet. 44:1990;15.
7. Gersuk G.M., Beckham C., Loken M.R., Kiener P., Anderson J.E., Farrand A.et al. A role for tumor necrosis factor-α, Fas and Fas-ligand in marrow failure associated with myelodysplastic syndrome. Br. J. Haematol. 103:1998;176.
8. Bernell P., Jacobsson B., Nordgren A., Hast R. Clonal cell lineage involvement in myelodysplastic syndromes studied by fluorescence in situ hybridization and morphology. Leukemia. 10:1996;662.
9. Weimar I.S., Bourhis J.H., de Gast G.C., Gerritsen W.R. Clonality in myelodysplastic syndromes. Leuk. Lymphoma. 13:1994;215. [review].
10. Asano H., Ohashi H., Ichihara M., Kinoshita T., Murate T., Kobayashi M.et al. Evidence for nonclonal hematopoietic progenitor cell populations in bone marrow of patients with myelodysplastic syndromes. Blood. 84:1994;588.
11. Janssen J.W.G., Buschle M., Layton M., Drexler H.G., Lyons J., Van Den Berghe H.et al. Clonal analysis of myelodysplastic syndromes: evidence of multipotent stem cell origin. Blood. 73:1989;248.
12. Bennett J.M., Catovsky D., Daniel M.T., Flandrin G., Galton D.A.G., Gralnick H.R.et al. The French-American-British (FAB) co-operative group. Proposals for the classification of the myelodysplastic syndromes. Br. J. Haematol. 51:1982;189.
13. Noel P., Solberg L.A. Jr. Myelodysplastic syndromes. Pathogenesis, diagnosis and treatment. Crit. Rev. Oncol. Haematol. 12:1992;193.
14. Lowenthal R.M., Marsden K.A. Myelodysplastic syndromes. Int. J. Haematol. 65:1997;319. [review].
15. Shetty V., Mundle S., Alvi S., Showel M., Broady-Robinson L., Dar S.et al. Measurement of apoptosis, proliferation and three cytokines in 46 patients with myelodysplastic syndromes. Leuk. Res. 20:1996;891.
16. Shetty V., Hussaini S., Broady-Robinson L., Allampallam K., Mundle S., Borok R.et al. Intramedullary apoptosis of hematopoietic cells in myelodysplastic syndrome patients can be massive: apoptotic cells recovered from high-density fraction of bone marrow aspirates. Blood. 96:2000;1388.
17. Yoshida Y., Mufti G.J. Apoptosis and its significance in MDS: controversies revisited. Leuk. Res. 23:1999;777. [review].
18. Parker J.E., Mufti G.J., Rasool F., Mijovic A., Devereux S., Pagliuca A. The role of apoptosis, proliferation, and the Bcl-2-related proteins in the myelodysplastic syndromes and acute myeloid leukemia secondary to MDS. Blood. 96:2000;3932.
19. Oyake T, Ishida Y, Ito S, Utsugisawa T, Murai K, Kuriya S-I. Leukemic progression in myelodysplastic syndrome is associated with the decreased frequency of excessive apoptosis in blast cells. Blood 2000;96(Suppl 1):359a, 1548 [abstract].
20. Jacobs A. Genetic abnormalities in myelodysplastic syndrome. Cancer Genet. Cytogenet. 56:1991;1. [review].
21. McCune J.M., Namikawa R., Kaneshima H., Shultz L.D., Lieberman M., Weissman I.L. The SCID-hu mouse: murine model for the analysis of human hematolymphoid differentiation and function. Science. 241:1988;1632.
22. Shultz L.D., Schweitzer P.A., Christianson S.W., Gott B., Schweitzer I.B., Tennent B.et al. Multiple defects in innate and adaptive immunologic function in NOD/LtSz-scid mice. J. Immunol. 154:1995;180.
23. Pflumio F., Izac B., Katz A., Shultz L.D., Vainchenker W., Coulombel L. Phenotype and function of human hematopoietic cells engrafting immune-deficient CB17-severe combined immunodeficiency mice and nonobese diabetic-severe combined immunodeficiency mice after transplantation of human cord blood mononuclear cells. Blood. 88:1996;3731.
24. Cashman J.D., Lapidot T., Wang J.C.Y., Doedens M., Shultz L.D., Lansdorp P.et al. Kinetic evidence of the regeneration of multilineage hematopoiesis from primitive cells in normal human bone marrow transplanted into immunodeficient mice. Blood. 89:1997;4307.
25. Lapidot T., Fajerman Y., Kollet O. Immune-deficient SCID and NOD/SCID mice models as functional assays for studying normal and malignant human hematopoiesis. J. Mol. Med. 75:1997;664. [review].
26. Ailles L.E., Gerhard B., Kawagoe H., Hogge D.E. Growth characteristics of acute myelogenous leukemia progenitors that initiate malignant hematopoiesis in nonobese diabetic/severe combined immunodeficient mice. Blood. 94:1999;1761.
27. Larochelle A., Vormoor J., Hanenberg H., Wang J.C., Bhatia M., Lapidot T.et al. Identification of primitive human hematopoietic cells capable of repopulating NOD/SCID mouse bone marrow: implications for gene therapy. Nat. Med. 2:1996;1329.
28. Bhatia M., Wang J.C.Y., Kapp U., Bonnet D., Dick J.E. Purification of primitive human hematopoietic cells capable of repopulating immune-deficient mice. Proc. Natl. Acad. Sci. U.S.A. 94:1997;5320.
29. Bonnet D., Dick J.E. Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell. Nat. Med. 3:1997;730.
30. Pinkel D., Straume T., Gray J.W. Cytogenetic analysis using quantitative, high-sensitivity, fluorescence hybridization. Proc. Natl. Acad. Sci. U.S.A. 83:1986;2934.
31. Busque L., Gilliland D.G. The PGK-PCR clonality assay (PPCA). Mol. Biotechnol. 5:1996;275.
32. Allen R.C., Zoghbi H.Y., Moseley A.B., Rosenblatt H.M., Belmont J.W. Methylation of Hpa II and Hha I sites near the polymorphic CAG repeat in the human androgen-receptor gene correlates with X chromosome inactivation. Am. J. Hum. Genet. 51:1992;1229.
33. Thanopoulou E, Cashman J, Zoumbos N, Eaves A, Eaves C. Evidence of early transient engraftment of NOD/SCID-β2 microglobulin null mice with neoplastic cells from myelodysplastic syndrome patients. Blood 2000;96(Suppl 1):835a, 3606 [abstract].
34. Lapidot T., Pflumio F., Doedens M., Murdoch B., Williams D.E., Dick J.E. Cytokine stimulation of multilineage hematopoiesis from immature human cells engrafted in SCID mice. Science. 255:1992;1137.
35. Garcia S., Dadaglio G., Gougeon M.L. Limits of the human-PBL-SCID mice model: severe restriction of the V beta T-cell repertoire of engrafted human T cells. Blood. 89:1997;329.
36. Leung W., Ramirez M., Novelli E.M., Civin C.I. In vivo engraftment potential of clinical hematopoietic grafts. J. Invest. Med. 46:1998;303.
37. White N.J., Nacheva E., Asimakopoulos F.A., Bloxham D., Paul B., Green A.R. Deletion of chromosome 20q in myelodysplasia can occur in a multipotent precursor of both myeloid cells and B cells. Blood. 83:1994;2809.
38. Nilsson L., Astrand-Grundstrom I., Arvidsson I., Jacobsson B., Hellstrom-Lindberg E., Hast R.et al. Isolation and characterization of hematopoietic progenitor/stem cells in 5q-deleted myelodysplastic syndromes: evidence for involvement at the hematopoietic stem cell level. Blood. 96:2000;2012.
39. Gerritsen W.R., Donohue J., Bauman J., Jhanwar S.C., Kernan N.A., Castro-Malaspina H.et al. Clonal analysis of myelodysplastic syndrome: monosomy 7 is expressed in the myeloid lineage, but not in the lymphoid lineage as detected by fluorescent in situ hybridization. Blood. 80:1992;217.
40. Kroef M.J., Bolk M.J., Muus P., Wessels J.W., Beverstock G.C., Willemze R.et al. Mosaicism of the 5q deletion as assessed by interphase FISH is a common phenomenon in MDS and restricted to myeloid cells. Leukemia. 11:1997;519.
41. Nilsson L, Åstrand-Grundström I, Anderson K, Arvidsson I, Hokland P, Kjeldsen L, et al. Involvement and intrinsic deficiencies of hematopoietic stem cells in MDS patients with trisomy 8. Blood 2001;98(1):354a, 1491 [abstract].
42. - cells in lymphohematopoiesis. Leuk. Lymphoma. 31:1998;285. [review].
43. - progenitor cells. Blood. 77:1991;1218.
44. Culligan D.J., Cachia P., Whittaker J., Jacobs A., Padua R.A. Clonal lymphocytes are detectable in only some cases of MDS. Br. J. Haematol. 81:1992;346.
45. Nakamura R, Epperson DE, Saunthararajah Y, Melenhorst JJ, Barrett AJ. Oligoclonal T cell expansion in myelodysplastic syndrome: evidence for an autoimmune process. Blood 2000;96(Suppl 1):355a, 1534 [abstract].
46. Ramirez M., Rottman G.A., Shultz L.D., Civin C.I. Mature human hematopoietic cells in donor bone marrow complicate interpretation of stem/progenitor cell assays in xenogeneic hematopoietic chimeras. Exp. Haematol. 26:1998;332.
47. Fujiki Y., Onodera M., Yamaguchi T., Osawa M., Sudo K., Hamada H.et al. Dominant expansion of human T cells in non-obese diabetic/severe combined immunodeficiency mice implanted with human bone fragments. Exp. Haematol. 28:2000;792.
48. Molldrem J.J., Jiang Y.Z., Stetler-Stevenson M., Mavroudis D., Hensel N., Barrett A.J. Haematological response of patients with myelodysplastic syndrome to antithymocyte globulin is associated with a loss of lymphocyte-mediated inhibition of CFU-GM and alterations in T-cell receptor V beta profiles. Br. J. Haematol. 102:1998;1314.
49. Bogdanovic A.D., Jankovic G.M., Colovic M.D., Trpinac D.P., Bumbasirevic V.Z. Apoptosis in bone marrow of myelodysplastic syndrome patients. Blood. 87:1996;3064. [letter].
50. Deeg H.J. Marrow stroma in MDS: culprit or bystander? Leuk. Res. 26:2002;687.
51. Awaya N, Rupert K, Bryant E, Torok-Storb B. Marrow stromal cells are not derived from the malignant clone in myelodysplastic syndromes (MDS). Blood 2001;98(1):353a, 1487 [abstract].
52. + T cell engraftment in beta 2-microglobulin-deficient NOD-scid mice. J. Immunol. 158:1997;3578.
53. 2 microglobulin-null mice. J. Clin. Invest. 107:2001;199.
54. 2 microglobulin null mice. Blood 2001;98(1):729a, 3042 [abstract].