메뉴 건너뛰기




Volumn 14, Issue 1, 2000, Pages 2-8

A hypothesis for the pathogenesis of myelodysplastic syndromes: Implications for new therapies

Author keywords

Acute nonlymphocytic leukemia; Myelodysplastic syndrome; Preleukemia; Refractory anemia

Indexed keywords

FAS LIGAND; TUMOR NECROSIS FACTOR ALPHA;

EID: 0033967640     PISSN: 08876924     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.leu.2401618     Document Type: Review
Times cited : (116)

References (113)
  • 1
    • 0015209133 scopus 로고
    • Granulopoiesis in acute myeloid leukemia and preleukemia
    • Greenberg PL, Nichols WC, Schrier SL. Granulopoiesis in acute myeloid leukemia and preleukemia. New Engl J Med 1971; 22: 1225-1232.
    • (1971) New Engl J Med , vol.22 , pp. 1225-1232
    • Greenberg, P.L.1    Nichols, W.C.2    Schrier, S.L.3
  • 2
    • 0029964026 scopus 로고    scopus 로고
    • Recurring diagnostic problems in the pathology of the myelodysplastic syndromes
    • Rosati S, Anastasi J, Vardiman J. Recurring diagnostic problems in the pathology of the myelodysplastic syndromes. Semin Hematol 1996; 33: 111-126.
    • (1996) Semin Hematol , vol.33 , pp. 111-126
    • Rosati, S.1    Anastasi, J.2    Vardiman, J.3
  • 3
    • 0028337826 scopus 로고
    • Evidence for nonclonal hematopoietic progenitor cell populations in bone marrow of patients with myelodysplastic syndromes
    • Asano H, Ohashi H, Ichihara M, Kinoshita T, Murate T, Kobayashi M, Saito H, Hotta T. Evidence for nonclonal hematopoietic progenitor cell populations in bone marrow of patients with myelodysplastic syndromes. Blood 1994; 84: 588-594.
    • (1994) Blood , vol.84 , pp. 588-594
    • Asano, H.1    Ohashi, H.2    Ichihara, M.3    Kinoshita, T.4    Murate, T.5    Kobayashi, M.6    Saito, H.7    Hotta, T.8
  • 4
    • 0028805708 scopus 로고
    • Polyclonal primitive hematopoietic progenitors can be detected in mobilized peripheral blood from patients with high-risk myelodysplastic syndromes
    • Delforge M, Demuynck H, Vandenberghe P, Verhoef G, Zachée P, Van Duppen V, Marijnen P, Van den Berghe H, Boogaerts M. Polyclonal primitive hematopoietic progenitors can be detected in mobilized peripheral blood from patients with high-risk myelodysplastic syndromes. Blood 1995; 86: 3660-3667.
    • (1995) Blood , vol.86 , pp. 3660-3667
    • Delforge, M.1    Demuynck, H.2    Vandenberghe, P.3    Verhoef, G.4    Zachée, P.5    Van Duppen, V.6    Marijnen, P.7    Van Den Berghe, H.8    Boogaerts, M.9
  • 6
    • 0026554983 scopus 로고
    • Pathogenesis and biology of myelodysplasia
    • List AF, Jacobs A. Pathogenesis and biology of myelodysplasia. Semin Oncol 1992; 29: 14-24.
    • (1992) Semin Oncol , vol.29 , pp. 14-24
    • List, A.F.1    Jacobs, A.2
  • 7
    • 0031456965 scopus 로고    scopus 로고
    • Etiopathogeny, prognosis and therapy of myelodysplastic syndromes
    • Sanz GF, Sanz MA, Vallespi T. Etiopathogeny, prognosis and therapy of myelodysplastic syndromes. Hematol Cell Ther 1997; 39: 277-294.
    • (1997) Hematol Cell Ther , vol.39 , pp. 277-294
    • Sanz, G.F.1    Sanz, M.A.2    Vallespi, T.3
  • 8
    • 0031438734 scopus 로고    scopus 로고
    • The molecular basis of myelodysplastic syndromes
    • Gallagher A, Darley RL, Padua R. The molecular basis of myelodysplastic syndromes. Haematologica 1997; 82: 191-204.
    • (1997) Haematologica , vol.82 , pp. 191-204
    • Gallagher, A.1    Darley, R.L.2    Padua, R.3
  • 9
    • 0031906395 scopus 로고    scopus 로고
    • Pathogenesis, etiology and epidemiology of myelodysplastic syndromes
    • Aul C, Bowen DT, Yoshida Y. Pathogenesis, etiology and epidemiology of myelodysplastic syndromes. Haematologica 1998; 83: 71-86.
    • (1998) Haematologica , vol.83 , pp. 71-86
    • Aul, C.1    Bowen, D.T.2    Yoshida, Y.3
  • 10
    • 0028968897 scopus 로고
    • Occupational and environmental exposures and myelodysplasia: A case-control study
    • West RR, Stafford DA, Farrow A, Jacobs A. Occupational and environmental exposures and myelodysplasia: a case-control study. Leukemia Res 1995; 19: 127-139.
    • (1995) Leukemia Res , vol.19 , pp. 127-139
    • West, R.R.1    Stafford, D.A.2    Farrow, A.3    Jacobs, A.4
  • 11
    • 2542553783 scopus 로고    scopus 로고
    • Myelodysplastic syndromes (MDS) and exposure to occupational or environmental hazards: A case-control study
    • Abstr.
    • Nisse C, Grandbastien B, Brizard A, Hebbar M, Haguenoer JM, Fenaux P. Myelodysplastic syndromes (MDS) and exposure to occupational or environmental hazards: a case-control study. Blood 1997; 90 (Suppl. 1): 518a (Abstr.).
    • (1997) Blood , vol.90 , Issue.SUPPL. 1
    • Nisse, C.1    Grandbastien, B.2    Brizard, A.3    Hebbar, M.4    Haguenoer, J.M.5    Fenaux, P.6
  • 13
    • 0033564977 scopus 로고    scopus 로고
    • 609C->T polymorphism in the NAD(P)H: Quinone oxidoreductase (NQO1) gene in patients with primary and therapy-related myeloid leukemia
    • 609C->T polymorphism in the NAD(P)H: quinone oxidoreductase (NQO1) gene in patients with primary and therapy-related myeloid leukemia. Blood 1999; 94: 803-807.
    • (1999) Blood , vol.94 , pp. 803-807
    • Larson, L.A.1    Wang, Y.2    Banerjee, M.3    Wiemels, J.4    Hartford, C.5    Le Beau, M.M.6    Smith, M.T.7
  • 14
    • 0019886073 scopus 로고
    • Natural killer cell activity and preleukaemia
    • Takaku S, Takaku F. Natural killer cell activity and preleukaemia. Lancet 1981; 2: 1178.
    • (1981) Lancet , vol.2 , pp. 1178
    • Takaku, S.1    Takaku, F.2
  • 15
    • 0344840021 scopus 로고
    • In vitro and in vivo response to cyclosporin-A in myelodysplastic syndromes (MDS): Identification of a hypocellular subset responsive to immune suppression
    • Abstr.
    • List AF, Glinsmann-Gibson B, Spier C, Taetle R. In vitro and in vivo response to cyclosporin-A in myelodysplastic syndromes (MDS): identification of a hypocellular subset responsive to immune suppression. Blood 1992; 80 (Suppl. 1): 28a (Abstr.).
    • (1992) Blood , vol.80 , Issue.SUPPL. 1
    • List, A.F.1    Glinsmann-Gibson, B.2    Spier, C.3    Taetle, R.4
  • 16
    • 7344223859 scopus 로고    scopus 로고
    • Hematological response of patients with myelodysplastic syndrome to antithymocyte globulin is associated with a loss of lymphocyte-mediated inhibition of CFU-GM and alterations in T-cell receptor Vβ profiles
    • Molldrem JJ, Jiang YZ, Stetler-Stevenson M, Mavroudis D, Hensel N, Barrett AJ. Hematological response of patients with myelodysplastic syndrome to antithymocyte globulin is associated with a loss of lymphocyte-mediated inhibition of CFU-GM and alterations in T-cell receptor Vβ profiles. Br J Haematol 1998; 102: 1314-1322.
    • (1998) Br J Haematol , vol.102 , pp. 1314-1322
    • Molldrem, J.J.1    Jiang, Y.Z.2    Stetler-Stevenson, M.3    Mavroudis, D.4    Hensel, N.5    Barrett, A.J.6
  • 17
    • 0026781966 scopus 로고
    • Clonal involvement of granulocytes and monocytes, but not of T and B lymphocytes and natural killer cells in patients with myelodysplasia: Analysis by X-linked restriction fragment length polymorphisms and polymerase chain reaction of the phosphoglycerate kinase gene
    • Van Kamp H, Fibbe WE, Jansen RPM, van der Keur M, de Graaff E, Willemze R, Landegent JE. Clonal involvement of granulocytes and monocytes, but not of T and B lymphocytes and natural killer cells in patients with myelodysplasia: analysis by X-linked restriction fragment length polymorphisms and polymerase chain reaction of the phosphoglycerate kinase gene. Blood 1992; 80: 1774-1780.
    • (1992) Blood , vol.80 , pp. 1774-1780
    • Van Kamp, H.1    Fibbe, W.E.2    Jansen, R.P.M.3    Van Der Keur, M.4    De Graaff, E.5    Willemze, R.6    Landegent, J.E.7
  • 18
    • 0029932589 scopus 로고    scopus 로고
    • Imnumological abnormalities in myelodysplastic syndromes
    • Hamblin TJ. Imnumological abnormalities in myelodysplastic syndromes. Semin Hematol 1996; 33: 150-162.
    • (1996) Semin Hematol , vol.33 , pp. 150-162
    • Hamblin, T.J.1
  • 19
    • 0025319860 scopus 로고
    • Clonal studies in the myelodysplastic syndrome using X-linked restriction fragment length polymorphisms
    • Tefferi A, Thibodeau SN, Solberg LA. Clonal studies in the myelodysplastic syndrome using X-linked restriction fragment length polymorphisms. Blood 1990; 75: 1770-1773.
    • (1990) Blood , vol.75 , pp. 1770-1773
    • Tefferi, A.1    Thibodeau, S.N.2    Solberg, L.A.3
  • 21
    • 0027476532 scopus 로고
    • Cytogenetic clonality in myelodysplastic syndromes studied with fluorescence in situ hybridization: Lineage, response to growth factor therapy, and clone expansion
    • Anastasi J, Feng J, Le Beau M, Larson RA, Rowley JD, Vardiman JW. Cytogenetic clonality in myelodysplastic syndromes studied with fluorescence in situ hybridization: lineage, response to growth factor therapy, and clone expansion. Blood 1993; 81: 1580-1585.
    • (1993) Blood , vol.81 , pp. 1580-1585
    • Anastasi, J.1    Feng, J.2    Le Beau, M.3    Larson, R.A.4    Rowley, J.D.5    Vardiman, J.W.6
  • 22
    • 0027533768 scopus 로고
    • Myeloid but not lymphoid cells carry the 5 q deletion: Polymerase chain reaction analysis of loss of heterozygosity using mini-repeat sequences on highly purified cell fractions
    • Kroef MJPL, Fibbe WE, Mout R, Jansen RPM, Haak HL, Wessels JW, Van Kamp H, Willemze R, Landegent JE. Myeloid but not lymphoid cells carry the 5 q deletion: polymerase chain reaction analysis of loss of heterozygosity using mini-repeat sequences on highly purified cell fractions. Blood 1993; 81: 1849-1854.
    • (1993) Blood , vol.81 , pp. 1849-1854
    • Kroef, M.J.P.L.1    Fibbe, W.E.2    Mout, R.3    Jansen, R.P.M.4    Haak, H.L.5    Wessels, J.W.6    Van Kamp, H.7    Willemze, R.8    Landegent, J.E.9
  • 23
    • 0003356423 scopus 로고
    • Anti-thymocyte globulin for hypoplastic myelodysplastic syndrome
    • Abstr.
    • Sulecki M, Shadduck RK, Zeigler Z. Anti-thymocyte globulin for hypoplastic myelodysplastic syndrome. Blood 1988; 72 (Suppl. 1): 229a (Abstr.).
    • (1988) Blood , vol.72 , Issue.SUPPL. 1
    • Sulecki, M.1    Shadduck, R.K.2    Zeigler, Z.3
  • 24
    • 0030992129 scopus 로고    scopus 로고
    • Immunosuppressive therapy tor hypoplastic myelodysplastic syndrome
    • Biesma DH, van den Tweel JG, Verdonck LF. Immunosuppressive therapy tor hypoplastic myelodysplastic syndrome. Cancer 1997; 79: 1548-1551.
    • (1997) Cancer , vol.79 , pp. 1548-1551
    • Biesma, D.H.1    Van Den Tweel, J.G.2    Verdonck, L.F.3
  • 29
    • 0032532037 scopus 로고    scopus 로고
    • Fluorescence in situ hybridization of progenitor cells obtained by fluorescence-activated cell sorting for the detection of cells affected by chromosome abnormality trisomy 8 in patients with myelodysplastic syndromes
    • Saitoh K, Miura I, Takahashi N, Miura AB. Fluorescence in situ hybridization of progenitor cells obtained by fluorescence-activated cell sorting for the detection of cells affected by chromosome abnormality trisomy 8 in patients with myelodysplastic syndromes. Blood 1998; 92: 2886-2892.
    • (1998) Blood , vol.92 , pp. 2886-2892
    • Saitoh, K.1    Miura, I.2    Takahashi, N.3    Miura, A.B.4
  • 30
    • 0029416957 scopus 로고
    • Interferon-gamma and tumor necrosis factor-alpha suppress both early and late stages of hematopoiesis and induce programmed cell death
    • Selleri C, Sato T, Anderson S, Young NS, Maciejewski JP. Interferon-gamma and tumor necrosis factor-alpha suppress both early and late stages of hematopoiesis and induce programmed cell death. J Cell Physiol 1995; 165: 538-546.
    • (1995) J Cell Physiol , vol.165 , pp. 538-546
    • Selleri, C.1    Sato, T.2    Anderson, S.3    Young, N.S.4    Maciejewski, J.P.5
  • 32
    • 0029016931 scopus 로고
    • Fas antigen expression on CD344+ human marrow cells is induced by interteron γ and tumor necrosis factor α and potentiates cytokine-mediated hematopoietic suppression in vitro
    • Maciejewski J, Selleri C, Anderson S, Young NS. Fas antigen expression on CD344+ human marrow cells is induced by interteron γ and tumor necrosis factor α and potentiates cytokine-mediated hematopoietic suppression in vitro. Blood 1995; 85: 3183-3190.
    • (1995) Blood , vol.85 , pp. 3183-3190
    • Maciejewski, J.1    Selleri, C.2    Anderson, S.3    Young, N.S.4
  • 33
    • 0026100476 scopus 로고
    • Increased levels of soluble interleukin-2 receptors and tumor necrosis factor in serum of patients with myelodysplastic syndromes
    • Zoumbos N, Symeonidis A, Kourakli A, Katevas P, Matsouka P, Perraki M, Georgoulias V. Increased levels of soluble interleukin-2 receptors and tumor necrosis factor in serum of patients with myelodysplastic syndromes. Blood 1991; 77: 413-414.
    • (1991) Blood , vol.77 , pp. 413-414
    • Zoumbos, N.1    Symeonidis, A.2    Kourakli, A.3    Katevas, P.4    Matsouka, P.5    Perraki, M.6    Georgoulias, V.7
  • 35
    • 0030923572 scopus 로고    scopus 로고
    • Serum levels of tumour necrosis factor-α predict response to recombinant human erythropoietin in patients with myelodysplastic syndrome
    • Stasi R, Brunetti M, Bussa S, Conforti M, Martin LS, Presa ML, Bianchi M, Parma A, Pagano A. Serum levels of tumour necrosis factor-α predict response to recombinant human erythropoietin in patients with myelodysplastic syndrome. Clin Lab Haematol 1997; 19: 197-201.
    • (1997) Clin Lab Haematol , vol.19 , pp. 197-201
    • Stasi, R.1    Brunetti, M.2    Bussa, S.3    Conforti, M.4    Martin, L.S.5    Presa, M.L.6    Bianchi, M.7    Parma, A.8    Pagano, A.9
  • 36
    • 0029154403 scopus 로고
    • Spontaneous cytokine overproduction by peripheral blood mononuclear cells from patients with myelodysplastic syndromes and aplastic anemia
    • Koike M, Ishiyama T, Tomoyasu S, Tsuruoka N. Spontaneous cytokine overproduction by peripheral blood mononuclear cells from patients with myelodysplastic syndromes and aplastic anemia. Leukemia Res 1995; 19: 639-644.
    • (1995) Leukemia Res , vol.19 , pp. 639-644
    • Koike, M.1    Ishiyama, T.2    Tomoyasu, S.3    Tsuruoka, N.4
  • 37
    • 0031464758 scopus 로고    scopus 로고
    • Overexpression of tumor necrosis factor (TNF)-α and Interferon (IFN)-γ by bone marrow cells from patients with myelodysplastic syndromes
    • Kitagawa M, Saito I, Kuwata T, Yoshida S, Yamaguchi S, Takahaski M, Tanizawa T, Kamiyama R, Hirokawa K. Overexpression of tumor necrosis factor (TNF)-α and Interferon (IFN)-γ by bone marrow cells from patients with myelodysplastic syndromes. Leukemia 1997; 11: 2049-2054.
    • (1997) Leukemia , vol.11 , pp. 2049-2054
    • Kitagawa, M.1    Saito, I.2    Kuwata, T.3    Yoshida, S.4    Yamaguchi, S.5    Takahaski, M.6    Tanizawa, T.7    Kamiyama, R.8    Hirokawa, K.9
  • 38
    • 0027635984 scopus 로고
    • Increase in number of bone marrow macrophages in patients with myelodysplastic syndromes
    • Kitagawa M, Kamiyama R, Kasuga T. Increase in number of bone marrow macrophages in patients with myelodysplastic syndromes, Eur J Haematol 1993; 51: 56-58.
    • (1993) Eur J Haematol , vol.51 , pp. 56-58
    • Kitagawa, M.1    Kamiyama, R.2    Kasuga, T.3
  • 40
    • 0025727593 scopus 로고
    • Increased circulating colony-stimulating factor-1 in patients with preleukemia, leukemia, and lymphoid malignancies
    • Janowska-Wieczorek A, Belch AR, Jacobs A, Bowen D, Padua RA, Paietta E, Stanley ER. Increased circulating colony-stimulating factor-1 in patients with preleukemia, leukemia, and lymphoid malignancies. Blood 1991; 77: 1796-1803.
    • (1991) Blood , vol.77 , pp. 1796-1803
    • Janowska-Wieczorek, A.1    Belch, A.R.2    Jacobs, A.3    Bowen, D.4    Padua, R.A.5    Paietta, E.6    Stanley, E.R.7
  • 41
    • 0025276780 scopus 로고
    • Mutation of the human FMS gene (M-CSF receptor) in myelodysplastic syndromes and acute myeloid leukemia
    • Tobal K, Pagliuca A, Bhatt B, Bailey N, Layton DM, Mufti GJ. Mutation of the human FMS gene (M-CSF receptor) in myelodysplastic syndromes and acute myeloid leukemia. Leukemia 1990; 4: 486-489.
    • (1990) Leukemia , vol.4 , pp. 486-489
    • Tobal, K.1    Pagliuca, A.2    Bhatt, B.3    Bailey, N.4    Layton, D.M.5    Mufti, G.J.6
  • 45
    • 0030664927 scopus 로고    scopus 로고
    • Oxidative DNA damage in CD34+ myelodysplastic cells is associated with intracellular redox changes and elevated plasma tumour necrosis factor-α concentration
    • Peddie CM, Wolf CR, McLellan LI, Collins AR, Bowen DT. Oxidative DNA damage in CD34+ myelodysplastic cells is associated with intracellular redox changes and elevated plasma tumour necrosis factor-α concentration. Br J Haematol 1997; 99: 625-631.
    • (1997) Br J Haematol , vol.99 , pp. 625-631
    • Peddie, C.M.1    Wolf, C.R.2    McLellan, L.I.3    Collins, A.R.4    Bowen, D.T.5
  • 48
    • 0032100478 scopus 로고    scopus 로고
    • Differential effects of antiFas ligand and anti-tumor necrosis factor α antibodies on acute graft-versus-host disease pathologies
    • Hattori K, Hirano T, Miyajima H, Yamakawa N, Tateno M, Oshimi K, Kayagaki N, Yagita H, Okumura K. Differential effects of antiFas ligand and anti-tumor necrosis factor α antibodies on acute graft-versus-host disease pathologies. Blood 1998; 91: 4051-4055.
    • (1998) Blood , vol.91 , pp. 4051-4055
    • Hattori, K.1    Hirano, T.2    Miyajima, H.3    Yamakawa, N.4    Tateno, M.5    Oshimi, K.6    Kayagaki, N.7    Yagita, H.8    Okumura, K.9
  • 49
    • 0028266001 scopus 로고
    • Gamma-interferon gene expression in the bone marrow of patients with aplastic anemia
    • Nisticò A, Young NS. Gamma-interferon gene expression in the bone marrow of patients with aplastic anemia. Ann Intern Med 1994; 120: 463-469.
    • (1994) Ann Intern Med , vol.120 , pp. 463-469
    • Nisticò, A.1    Young, N.S.2
  • 51
    • 0028852652 scopus 로고
    • Cytokine expression in adherent layers from patients with myelodysplastic syndrome and acute myelogenous leukemia
    • Wetzler M, Kurzrock R, Estrov Z, Esley E, Talpaz M. Cytokine expression in adherent layers from patients with myelodysplastic syndrome and acute myelogenous leukemia. Leukemia Res 1995; 19; 23-34.
    • (1995) Leukemia Res , vol.19 , pp. 23-34
    • Wetzler, M.1    Kurzrock, R.2    Estrov, Z.3    Esley, E.4    Talpaz, M.5
  • 52
    • 0342721155 scopus 로고
    • Cytokine production by long-term marrow cultures established from myelodysplastic patients
    • Abstr.
    • Holmberg L, Seidel K, Leisenring W, Torok-Storb B. Cytokine production by long-term marrow cultures established from myelodysplastic patients. Exp Hematol 1994; 22: 741 (Abstr.).
    • (1994) Exp Hematol , vol.22 , pp. 741
    • Holmberg, L.1    Seidel, K.2    Leisenring, W.3    Torok-Storb, B.4
  • 54
    • 0029957664 scopus 로고    scopus 로고
    • Altered oncoprotein expression and apoptosis in myelodysplastic syndrome marrow cells
    • Rajapaksa R, Ginzton N, Rott LS, Greenberg PL. Altered oncoprotein expression and apoptosis in myelodysplastic syndrome marrow cells. Blood 1996; 88: 4275-4287.
    • (1996) Blood , vol.88 , pp. 4275-4287
    • Rajapaksa, R.1    Ginzton, N.2    Rott, L.S.3    Greenberg, P.L.4
  • 56
    • 0031863816 scopus 로고    scopus 로고
    • Ineffective haemopoiesis and apoptosis in myelodysplastic syndromes
    • Parker JE, Mufti GJ. Ineffective haemopoiesis and apoptosis in myelodysplastic syndromes. Br J Haematol 1998; 101: 220-230.
    • (1998) Br J Haematol , vol.101 , pp. 220-230
    • Parker, J.E.1    Mufti, G.J.2
  • 57
    • 0031971385 scopus 로고    scopus 로고
    • Spontaneous intramedullary apoptosis is present in disorders other than myelodysplasia
    • Irvine AE, Magill MK, Somerville LE, McMullin MF. Spontaneous intramedullary apoptosis is present in disorders other than myelodysplasia. Exp Hematol 1998; 26: 455-439.
    • (1998) Exp Hematol , vol.26 , pp. 455-1439
    • Irvine, A.E.1    Magill, M.K.2    Somerville, L.E.3    McMullin, M.F.4
  • 59
    • 0032945317 scopus 로고    scopus 로고
    • Fas ligand expression in the bone marrow in myelodysplastic syndromes correlates with FAB subtype and anemia, and predicts survival
    • Gupta P, Niehans GA, LeRoy SC, Gupta K, Morrison VA, Schultz C, Knapp DJ, Kratzke RA. Fas ligand expression in the bone marrow in myelodysplastic syndromes correlates with FAB subtype and anemia, and predicts survival. Leukemia 1999; 13: 44-53.
    • (1999) Leukemia , vol.13 , pp. 44-53
    • Gupta, P.1    Niehans, G.A.2    LeRoy, S.C.3    Gupta, K.4    Morrison, V.A.5    Schultz, C.6    Knapp, D.J.7    Kratzke, R.A.8
  • 61
    • 0032171391 scopus 로고    scopus 로고
    • Bcl-2 expression by myeloid precursors in myelodysplastic syndrome: Relation to progression
    • Davis RE, Greenberg PL. Bcl-2 expression by myeloid precursors in myelodysplastic syndrome: relation to progression. Leukemia Res 1998; 22: 767-777.
    • (1998) Leukemia Res , vol.22 , pp. 767-777
    • Davis, R.E.1    Greenberg, P.L.2
  • 63
    • 0003289159 scopus 로고    scopus 로고
    • Amifostine suppresses apoptosis in myelodysplastic CD34+ cells and promotes progenitor cell growth via polyamine-like effects
    • Abstr.
    • Klimecki W, Heaton K, Gibson BG, List AF. Amifostine suppresses apoptosis in myelodysplastic CD34+ cells and promotes progenitor cell growth via polyamine-like effects. Blood 1997; 90 (Suppl. 1): 520a (Abstr.).
    • (1997) Blood , vol.90 , Issue.SUPPL. 1
    • Klimecki, W.1    Heaton, K.2    Gibson, B.G.3    List, A.F.4
  • 66
    • 2642697857 scopus 로고    scopus 로고
    • cAMP increasing agents attenuate the generation of apoptosis by etoposide in promonocytic leukemia cells
    • Garcia-Bermejo L, Pérez C, Vilaboa N, de Blas E, Aller P. cAMP increasing agents attenuate the generation of apoptosis by etoposide in promonocytic leukemia cells. J Cell Sci 1998, 111: 637-644.
    • (1998) J Cell Sci , vol.111 , pp. 637-644
    • Garcia-Bermejo, L.1    Pérez, C.2    Vilaboa, N.3    De Blas, E.4    Aller, P.5
  • 67
    • 0029980564 scopus 로고    scopus 로고
    • Down regulation of NM23.H1, NM23.H2 and c-myc genes during differentiation induced by 1,25 dihydroxyvitamin D3
    • Caligo MA, Cipollini G, Petrini M, Valentini P, Bevilacqua G. Down regulation of NM23.H1, NM23.H2 and c-myc genes during differentiation induced by 1,25 dihydroxyvitamin D3. Leukemia Res 1996; 20: 161-167.
    • (1996) Leukemia Res , vol.20 , pp. 161-167
    • Caligo, M.A.1    Cipollini, G.2    Petrini, M.3    Valentini, P.4    Bevilacqua, G.5
  • 69
    • 0029932590 scopus 로고    scopus 로고
    • Biologic and clinical implications of marrow culture studies in the myelodysplastic syndromes
    • Greenberg PL. Biologic and clinical implications of marrow culture studies in the myelodysplastic syndromes. Semin Hematol 1996; 33: 163-175.
    • (1996) Semin Hematol , vol.33 , pp. 163-175
    • Greenberg, P.L.1
  • 70
    • 0026765476 scopus 로고
    • Comparison of in vitro growth characteristics of blast cell progenitors (CFU-L) in patients with myelodysplastic syndromes and acute myeloid leukemia
    • Aul C, Gattermann N, Schneider W. Comparison of in vitro growth characteristics of blast cell progenitors (CFU-L) in patients with myelodysplastic syndromes and acute myeloid leukemia. Blood 1992; 80: 625-633.
    • (1992) Blood , vol.80 , pp. 625-633
    • Aul, C.1    Gattermann, N.2    Schneider, W.3
  • 72
    • 0031694754 scopus 로고    scopus 로고
    • Differentiation therapy of myelodysplastic syndromes: Fact or fiction?
    • Santini V, Ferrim PR. Differentiation therapy of myelodysplastic syndromes: fact or fiction? Br J Haematol 1998; 102: 1124-1138.
    • (1998) Br J Haematol , vol.102 , pp. 1124-1138
    • Santini, V.1    Ferrim, P.R.2
  • 74
    • 0032877418 scopus 로고    scopus 로고
    • Calcitriol in myelodysplastic syndromes
    • Howard MR, Bond LR. Calcitriol in myelodysplastic syndromes. Br J Haematol 1999; 106: 569-574.
    • (1999) Br J Haematol , vol.106 , pp. 569-574
    • Howard, M.R.1    Bond, L.R.2
  • 75
    • 0027433888 scopus 로고
    • Serum stem cell factor concentration in patients with myelodysplastic syndromes
    • Bowen D, Yancik S, Bennett L, Culligan D, Resser K. Serum stem cell factor concentration in patients with myelodysplastic syndromes. Br J Haematol 1993; 85: 53-66.
    • (1993) Br J Haematol , vol.85 , pp. 53-66
    • Bowen, D.1    Yancik, S.2    Bennett, L.3    Culligan, D.4    Resser, K.5
  • 76
    • 0027053196 scopus 로고
    • Endogenous serum levels and surface receptor expression of GM-CSF and IL-3 in patients with myelodysplastic syndromes
    • Zwierzina H, Schöllenberger S, Herold M, Schmalzl F, Besemer J. Endogenous serum levels and surface receptor expression of GM-CSF and IL-3 in patients with myelodysplastic syndromes. Leukemia Res 1992; 16: 1181-1186.
    • (1992) Leukemia Res , vol.16 , pp. 1181-1186
    • Zwierzina, H.1    Schöllenberger, S.2    Herold, M.3    Schmalzl, F.4    Besemer, J.5
  • 77
    • 0029784432 scopus 로고    scopus 로고
    • Blast colony forming cell-binding capacity of bone marrow stroma from myelodysplastic patients
    • Gidáli J, Fehér I, Hollán S. Blast colony forming cell-binding capacity of bone marrow stroma from myelodysplastic patients. Stem Cell 1996; 14: 577-583.
    • (1996) Stem Cell , vol.14 , pp. 577-583
    • Gidáli, J.1    Fehér, I.2    Hollán, S.3
  • 78
    • 4243696598 scopus 로고    scopus 로고
    • Myelodysplastic bone marrow stroma is detective in its ability to sustain normal stem cell growth
    • Abstr.
    • Tennant GB, Truran LN, Kell WJ, Burnett AK. Myelodysplastic bone marrow stroma is detective in its ability to sustain normal stem cell growth. Blood 1997; 90 (Suppl. 1): 582a (Abstr.).
    • (1997) Blood , vol.90 , Issue.SUPPL. 1
    • Tennant, G.B.1    Truran, L.N.2    Kell, W.J.3    Burnett, A.K.4
  • 79
    • 0345702914 scopus 로고
    • Production of granulocyte colony stimulating factor (G-CSF) by normal and myelodysplastic syndrome (MDS) peripheral blood (PB) cells
    • Abstr.
    • Greenberg PL, Mackichan ML, Negrin R, Renick M, Ginzton N. Production of granulocyte colony stimulating factor (G-CSF) by normal and myelodysplastic syndrome (MDS) peripheral blood (PB) cells. Blood 1990; 76: (Suppl. 1) 146a (Abstr.).
    • (1990) Blood , vol.76 , Issue.SUPPL. 1
    • Greenberg, P.L.1    Mackichan, M.L.2    Negrin, R.3    Renick, M.4    Ginzton, N.5
  • 81
    • 0031462140 scopus 로고    scopus 로고
    • Clinical use of hematopoietic growth factors in the myelodysplastic syndromes
    • Ganser A, Karthaus M. Clinical use of hematopoietic growth factors in the myelodysplastic syndromes. Leuk Lymphoma 1997; 26 (Suppl. 1): 13-29.
    • (1997) Leuk Lymphoma , vol.26 , Issue.SUPPL. 1 , pp. 13-29
    • Ganser, A.1    Karthaus, M.2
  • 82
    • 0029665164 scopus 로고    scopus 로고
    • Production of tumor necrosis factor and granulocyte colony stimulating factor by bone marrow accessory cells in myelodysplastic patients
    • Mencoboni M, Castello G, Lerza R, Haupt E, Ballarine P, Cerruti A, Bogliolo G, Pannacciulli I. Production of tumor necrosis factor and granulocyte colony stimulating factor by bone marrow accessory cells in myelodysplastic patients. Eur J Haematol 1996; 56: 148-152.
    • (1996) Eur J Haematol , vol.56 , pp. 148-152
    • Mencoboni, M.1    Castello, G.2    Lerza, R.3    Haupt, E.4    Ballarine, P.5    Cerruti, A.6    Bogliolo, G.7    Pannacciulli, I.8
  • 84
    • 0024350196 scopus 로고
    • Regulatory abnormalities in the marrow of patients with myelodysplastic syndromes
    • Merchav S, Nagler A, Fleischer-Kurtz G, Tatarsky I. Regulatory abnormalities in the marrow of patients with myelodysplastic syndromes. Br J Haematol 1989; 73: 158-164.
    • (1989) Br J Haematol , vol.73 , pp. 158-164
    • Merchav, S.1    Nagler, A.2    Fleischer-Kurtz, G.3    Tatarsky, I.4
  • 85
    • 0032916076 scopus 로고    scopus 로고
    • Endogenous FLT-3 ligand serum levels are associated with disease stage in patients with myelodysplastic syndromes
    • Zwierzina H, Anderson JE, Rollinger-Holzinger I, Torok-Storb B, Nuessler V, Lyman SD. Endogenous FLT-3 ligand serum levels are associated with disease stage in patients with myelodysplastic syndromes. Leukemia 1999; 13: 553-557.
    • (1999) Leukemia , vol.13 , pp. 553-557
    • Zwierzina, H.1    Anderson, J.E.2    Rollinger-Holzinger, I.3    Torok-Storb, B.4    Nuessler, V.5    Lyman, S.D.6
  • 86
    • 0032902504 scopus 로고    scopus 로고
    • Telomere stability is frequently impaired in high-risk groups of patients with myelodysplastic syndromes
    • Ohyashiki JH, Iwama H, Yahata N, Ando K, Hayashi, Shay JW, Ohyashiki K. Telomere stability is frequently impaired in high-risk groups of patients with myelodysplastic syndromes. Clin Cancer Res 1999; 5: 1155-1160.
    • (1999) Clin Cancer Res , vol.5 , pp. 1155-1160
    • Ohyashiki, J.H.1    Iwama, H.2    Yahata, N.3    Ando, K.4    Shay, J.W.5    Ohyashiki, K.6
  • 89
    • 0031717905 scopus 로고    scopus 로고
    • Tumor-suppressor p53: Implications for tumor development and prognosis
    • Kirsch DG, Kastan MB. Tumor-suppressor p53: implications for tumor development and prognosis. J Clin Ontol 1998; 16: 3158-3168.
    • (1998) J Clin Ontol , vol.16 , pp. 3158-3168
    • Kirsch, D.G.1    Kastan, M.B.2
  • 91
    • 0028172868 scopus 로고
    • p 53 Mutations are associated with resistance to chemotherapy and short survival in hematologic malignancies
    • Wattel E, Preudhomme C, Hecquet B, Vanrumbeke M, Quesnel B, Dervite I, Morel P, Fenaux. p 53 mutations are associated with resistance to chemotherapy and short survival in hematologic malignancies. Blood 1994; 84: 3148-3157.
    • (1994) Blood , vol.84 , pp. 3148-3157
    • Wattel, E.1    Preudhomme, C.2    Hecquet, B.3    Vanrumbeke, M.4    Quesnel, B.5    Dervite, I.6    Morel, P.7    Fenaux8
  • 94
    • 0030987513 scopus 로고    scopus 로고
    • The clinical significance of mutations of the p 53 tumour suppressor gene in haematological malignancies
    • Preudhomme C, Fenaux P. The clinical significance of mutations of the p 53 tumour suppressor gene in haematological malignancies. Br J Haematol 1997; 98: 502-511.
    • (1997) Br J Haematol , vol.98 , pp. 502-511
    • Preudhomme, C.1    Fenaux, P.2
  • 95
    • 0031608678 scopus 로고    scopus 로고
    • p 53 tumor suppressor gene therapy for cancer
    • Nielsen LL, Maneval DC. p 53 tumor suppressor gene therapy for cancer. Cancer Gene Ther 1998; 5: 52-63.
    • (1998) Cancer Gene Ther , vol.5 , pp. 52-63
    • Nielsen, L.L.1    Maneval, D.C.2
  • 100
    • 0031892481 scopus 로고    scopus 로고
    • DNA methylation as a target for drug design
    • Bender CM, Zingg JM, Jones PA. DNA methylation as a target for drug design. Pharm Res 1998; 15: 175-187.
    • (1998) Pharm Res , vol.15 , pp. 175-187
    • Bender, C.M.1    Zingg, J.M.2    Jones, P.A.3
  • 101
    • 0031045307 scopus 로고    scopus 로고
    • Pharmacological approach for optimization of the dose schedule of 5-Aza-2′-deoxycytidine (Decitahine) for the therapy of leukemia
    • Momparler RL, Cote S, Eliopoulos N. Pharmacological approach for optimization of the dose schedule of 5-Aza-2′-deoxycytidine (Decitahine) for the therapy of leukemia. Leukemia 1997; 11: 175-180.
    • (1997) Leukemia , vol.11 , pp. 175-180
    • Momparler, R.L.1    Cote, S.2    Eliopoulos, N.3
  • 104
    • 0031042482 scopus 로고    scopus 로고
    • Continuous infusion of low-dose 5-Aza-2′-deoxycytidine in elderly patients with high-risk myelodysplastic syndrome
    • Wijermans PW, Krulder JWM, Huijgens PC, Neve P. Continuous infusion of low-dose 5-Aza-2′-deoxycytidine in elderly patients with high-risk myelodysplastic syndrome. Leukemia 1997; 11: 1-5.
    • (1997) Leukemia , vol.11 , pp. 1-5
    • Wijermans, P.W.1    Krulder, J.W.M.2    Huijgens, P.C.3    Neve, P.4
  • 105
    • 4244194095 scopus 로고    scopus 로고
    • Cytogenetic response to low-dose 5-Aza-2′-deoxycytidine (DAC) in poor-risk myelodysplastic syndromes (MDS)-phase II study results
    • Abstr.
    • Lubbert M, Haak HL, Kunzmann R, Danzer-Driessen S, Verhoef G, Mertelsmann R, Wijermans P. Cytogenetic response to low-dose 5-Aza-2′-deoxycytidine (DAC) in poor-risk myelodysplastic syndromes (MDS)-phase II study results. Blood 1997; 90: 582a (Abstr.)
    • (1997) Blood , vol.90
    • Lubbert, M.1    Haak, H.L.2    Kunzmann, R.3    Danzer-Driessen, S.4    Verhoef, G.5    Mertelsmann, R.6    Wijermans, P.7
  • 107
    • 0026723762 scopus 로고
    • Interferon-γ gene expression in unstimulated bone marrow mononuclear cells predicts a good response to cyclosporine therapy in aplastic anaemia
    • Nakao S, Yamaguchi M, Shiobara S, Yokoi T, Miyawaki T, Taniguichi T, Matsuda T. Interferon-γ gene expression in unstimulated bone marrow mononuclear cells predicts a good response to cyclosporine therapy in aplastic anaemia. Blood 1992; 79: 2532-2535.
    • (1992) Blood , vol.79 , pp. 2532-2535
    • Nakao, S.1    Yamaguchi, M.2    Shiobara, S.3    Yokoi, T.4    Miyawaki, T.5    Taniguichi, T.6    Matsuda, T.7
  • 109
    • 0030912049 scopus 로고    scopus 로고
    • The pathophysiology of acquired aplastic anemia
    • Young NS, Maciejewski J. The pathophysiology of acquired aplastic anemia. New Engl J Med 1997; 336: 1365-1372.
    • (1997) New Engl J Med , vol.336 , pp. 1365-1372
    • Young, N.S.1    Maciejewski, J.2
  • 110
    • 0029609759 scopus 로고
    • Increased apoptosis in aplastic anemia bone marrow progenitor cells: Possible pathophysiologic significance
    • Philpolt NJ, Scopes J, Marsh JC, Gordon-Smith EC, Gibson FM. Increased apoptosis in aplastic anemia bone marrow progenitor cells: possible pathophysiologic significance. Exp Hematol 1995; 23: 1642-1648.
    • (1995) Exp Hematol , vol.23 , pp. 1642-1648
    • Philpolt, N.J.1    Scopes, J.2    Marsh, J.C.3    Gordon-Smith, E.C.4    Gibson, F.M.5
  • 111
    • 0030805088 scopus 로고    scopus 로고
    • Increased apoptotic cells in bone marrow biopsies from patients with aplastic anaemia
    • Callera F, Falcao RP. Increased apoptotic cells in bone marrow biopsies from patients with aplastic anaemia. Br J Haematol 1997; 98: 18-20.
    • (1997) Br J Haematol , vol.98 , pp. 18-20
    • Callera, F.1    Falcao, R.P.2
  • 113
    • 0026630951 scopus 로고
    • Hematopoietic growth factors released by marrow stromal cells from patients with aplastic anemia
    • Kojima S, Matsuyama T, Kodera Y. Hematopoietic growth factors released by marrow stromal cells from patients with aplastic anemia. Blood 1992: 79: 2256-2261.
    • (1992) Blood , vol.79 , pp. 2256-2261
    • Kojima, S.1    Matsuyama, T.2    Kodera, Y.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.