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Volumn 22, Issue 12, 1998, Pages 1123-1136

Apoptosis and its role in the myelodysplastic syndromes: Implications for disease natural history and treatment

Author keywords

Apoptosis; Hematopoiesis; MDS; Myelodysplastic syndrome; Oncogenes

Indexed keywords

AMIFOSTINE; CIPROFLOXACIN; CYTOKINE; DEXAMETHASONE; ERYTHROPOIETIN; GENE PRODUCT; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; ONCOPROTEIN; PENTOXIFYLLINE; PROTEIN BCL 2;

EID: 0032408713     PISSN: 01452126     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0145-2126(98)00112-X     Document Type: Article
Times cited : (109)

References (164)
  • 1
    • 0000347726 scopus 로고
    • The myelodysplastic syndromes
    • In: Hoffman R, Benz E, Shattil S, Furie B, Cohen H, editors. New York: Churchill Livingstone
    • Greenberg PL. The myelodysplastic syndromes. In: Hoffman R, Benz E, Shattil S, Furie B, Cohen H, editors. Hematology: Basic Principles and Practice, 2nd ed. New York: Churchill Livingstone, 1994:1098-1121.
    • (1994) Hematology: Basic Principles and Practice, 2nd Ed. , pp. 1098-1121
    • Greenberg, P.L.1
  • 2
    • 0029932590 scopus 로고    scopus 로고
    • Biologic and clinical implications of marrow culture studies in the myelodysplastic syndromes
    • Greenberg P.L. Biologic and clinical implications of marrow culture studies in the myelodysplastic syndromes. Semin Hematol. 33:1996;163-175.
    • (1996) Semin Hematol , vol.33 , pp. 163-175
    • Greenberg, P.L.1
  • 3
    • 0022791937 scopus 로고
    • Myelodysplastic syndromes (preleukemia)
    • Koeffler H. Myelodysplastic syndromes (preleukemia). Semin Haematol. 23:1986;284.
    • (1986) Semin Haematol , vol.23 , pp. 284
    • Koeffler, H.1
  • 5
    • 0024402407 scopus 로고
    • Two regression models and a scoring system for predicting survival and planning treatment in myelodysplastic syndromes: A multivariate analysis of prognostic factors in 370 patients
    • Sanz G.F., Sanz M.A., Vallespi T., Canizo M. Two regression models and a scoring system for predicting survival and planning treatment in myelodysplastic syndromes: A multivariate analysis of prognostic factors in 370 patients. Blood. 74:1989;395-408.
    • (1989) Blood , vol.74 , pp. 395-408
    • Sanz, G.F.1    Sanz, M.A.2    Vallespi, T.3    Canizo, M.4
  • 7
    • 0022538534 scopus 로고
    • Prognostic implications of morphology and karyotype in primary myelodysplastic syndromes
    • Jacobs R.A., Cornbleet M., Vardiman J., Larson R., LeBeau M.M., Rowley J.D. Prognostic implications of morphology and karyotype in primary myelodysplastic syndromes. Blood. 67:1986;1765.
    • (1986) Blood , vol.67 , pp. 1765
    • Jacobs, R.A.1    Cornbleet, M.2    Vardiman, J.3    Larson, R.4    Lebeau, M.M.5    Rowley, J.D.6
  • 8
    • 0023851340 scopus 로고
    • Refined chromosome study helps define prognostic subgroups in most patients with primary myelodysplastic syndrome and acute myelogenous leukaemia
    • Yunis J.J., Lobell M., Arnesen M.A., Oken M.M., Mayer M.G., Rydell R.E., Brunning R.D. Refined chromosome study helps define prognostic subgroups in most patients with primary myelodysplastic syndrome and acute myelogenous leukaemia. Br J Haematol. 68:1988;189.
    • (1988) Br J Haematol , vol.68 , pp. 189
    • Yunis, J.J.1    Lobell, M.2    Arnesen, M.A.3    Oken, M.M.4    Mayer, M.G.5    Rydell, R.E.6    Brunning, R.D.7
  • 9
    • 0025366372 scopus 로고
    • Molecular genetic aspects of myelodysplastic syndromes: Clinical and molecular study of the chronic phase of the disease
    • Bartram C.R. Molecular genetic aspects of myelodysplastic syndromes: clinical and molecular study of the chronic phase of the disease. Br J Haematol. 74:1990;408.
    • (1990) Br J Haematol , vol.74 , pp. 408
    • Bartram, C.R.1
  • 10
    • 0031438734 scopus 로고    scopus 로고
    • The molecular basis of myelodysplastic syndromes
    • Gallagher A., Darley R., Padua R. The molecular basis of myelodysplastic syndromes. Haematologica. 82:1997;191.
    • (1997) Haematologica , vol.82 , pp. 191
    • Gallagher, A.1    Darley, R.2    Padua, R.3
  • 11
    • 0025645740 scopus 로고
    • Apoptosis is a common histopathological finding in myelodysplasia: The correlate of ineffective haematopoiesis
    • Clark D.M., Lampert I.A. Apoptosis is a common histopathological finding in myelodysplasia: the correlate of ineffective haematopoiesis. Leuk Lymphoma. 2:1990;415.
    • (1990) Leuk Lymphoma , vol.2 , pp. 415
    • Clark, D.M.1    Lampert, I.A.2
  • 14
    • 0029957664 scopus 로고    scopus 로고
    • Altered oncoprotein expression and apoptosis in myelodysplastic syndrome marrow cells
    • Rajapaksa R., Ginzton N., Rott L., Greenberg P.L. Altered oncoprotein expression and apoptosis in myelodysplastic syndrome marrow cells. Blood. 88:1996;4275.
    • (1996) Blood , vol.88 , pp. 4275
    • Rajapaksa, R.1    Ginzton, N.2    Rott, L.3    Greenberg, P.L.4
  • 18
    • 0344140118 scopus 로고
    • Glucocoticoid activation of a calcium-dependent endonuclease in thymocyte nuclei leads to cell death
    • Cohen J.J., Duke R.C. Glucocoticoid activation of a calcium-dependent endonuclease in thymocyte nuclei leads to cell death. J Immuol. 123:1984;3842.
    • (1984) J Immuol , vol.123 , pp. 3842
    • Cohen, J.J.1    Duke, R.C.2
  • 19
    • 0018830636 scopus 로고
    • Glucocorticoid-induced thymocyte apoptosis is associated with endonuclease activation
    • Wyllie A.H. Glucocorticoid-induced thymocyte apoptosis is associated with endonuclease activation. Nature. 284:1980;555.
    • (1980) Nature , vol.284 , pp. 555
    • Wyllie, A.H.1
  • 20
    • 0027535559 scopus 로고
    • Toward understanding of the molecular mechanism of physiological cell death
    • Vaux D. Toward understanding of the molecular mechanism of physiological cell death. Proc Natl Acad Sci USA. 90:1993;786.
    • (1993) Proc Natl Acad Sci USA , vol.90 , pp. 786
    • Vaux, D.1
  • 21
    • 0024501122 scopus 로고
    • The bcl-2 candidate protooncogene product is a 24-kilodalton integral membrane protein highly expressed in lymphoid cell lines and lymphoma carrying the t(14;18) translocation
    • Chen-Levy Z., Nourse J., Cleary M.L. The bcl-2 candidate protooncogene product is a 24-kilodalton integral membrane protein highly expressed in lymphoid cell lines and lymphoma carrying the t(14;18) translocation. Mol Cell Biol. 9:1989;701.
    • (1989) Mol Cell Biol , vol.9 , pp. 701
    • Chen-Levy, Z.1    Nourse, J.2    Cleary, M.L.3
  • 22
    • 0025204548 scopus 로고
    • Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death
    • Hockenbery D., Nunez G., Milliman C., Schreiber R.D., Korsmeyer S.J. Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death. Nature. 348:1990;334.
    • (1990) Nature , vol.348 , pp. 334
    • Hockenbery, D.1    Nunez, G.2    Milliman, C.3    Schreiber, R.D.4    Korsmeyer, S.J.5
  • 23
    • 0025255538 scopus 로고
    • Deregulated bcl-2 gene expression selectively prolongs survival of growth factor-deprived hemopoietic cells lines
    • Nunez G., London L., Korsmeyer S. Deregulated bcl-2 gene expression selectively prolongs survival of growth factor-deprived hemopoietic cells lines. J Immunol. 144:1990;3602.
    • (1990) J Immunol , vol.144 , pp. 3602
    • Nunez, G.1    London, L.2    Korsmeyer, S.3
  • 24
    • 0028565965 scopus 로고
    • The bcl-2 gene: Prototype of a gene family that controls programmed cell death (apoptosis)
    • Larsen C.J. The bcl-2 gene: prototype of a gene family that controls programmed cell death (apoptosis). Ann Genet. 37:1994;121.
    • (1994) Ann Genet , vol.37 , pp. 121
    • Larsen, C.J.1
  • 25
    • 0031464448 scopus 로고    scopus 로고
    • Bcl-2 family proteins: Regulators of apoptosis and chemoresistance in hematologic malignancies
    • Reed J.C. Bcl-2 family proteins: regulators of apoptosis and chemoresistance in hematologic malignancies. Semin Hematol. 34:1997;9.
    • (1997) Semin Hematol , vol.34 , pp. 9
    • Reed, J.C.1
  • 27
    • 0025937489 scopus 로고
    • Constitutive c-myc expression in IL-3 dependent myeloid cell line suppresses cell cycle arrest and accelerates apoptosis
    • Askew D.S., Ashmun R.A., Simmons B.C., Cleveland J.L. Constitutive c-myc expression in IL-3 dependent myeloid cell line suppresses cell cycle arrest and accelerates apoptosis. Oncogene. 6:1991;1915.
    • (1991) Oncogene , vol.6 , pp. 1915
    • Askew, D.S.1    Ashmun, R.A.2    Simmons, B.C.3    Cleveland, J.L.4
  • 28
    • 0027319521 scopus 로고
    • P53 is required for radiation-induced apoptosis in mouse thymocytes
    • Lowe S.W., Schmitt E.M., Smith S.W., Osborne B.A., Jacks T. p53 is required for radiation-induced apoptosis in mouse thymocytes. Nature. 362:1993;847.
    • (1993) Nature , vol.362 , pp. 847
    • Lowe, S.W.1    Schmitt, E.M.2    Smith, S.W.3    Osborne, B.A.4    Jacks, T.5
  • 29
    • 0029066697 scopus 로고
    • Contenders in FasL/TNF signaling
    • Cleveland J.L., Ihle J.N. Contenders in FasL/TNF signaling. Cell. 81:1995;479.
    • (1995) Cell , vol.81 , pp. 479
    • Cleveland, J.L.1    Ihle, J.N.2
  • 30
    • 0028927607 scopus 로고
    • The fas death factors
    • Nagata S., Golstein P. The fas death factors. Science. 267:1995;1499.
    • (1995) Science , vol.267 , pp. 1499
    • Nagata, S.1    Golstein, P.2
  • 31
    • 0001703988 scopus 로고    scopus 로고
    • Dysregulation of apoptosis in non-Hodgkins lymphoma: Toward a molecular understanding of Bcl-2
    • Reed J.C. Dysregulation of apoptosis in non-Hodgkins lymphoma: Toward a molecular understanding of Bcl-2. Adv Leuk Lymphoma. 7:1997;3.
    • (1997) Adv Leuk Lymphoma , vol.7 , pp. 3
    • Reed, J.C.1
  • 32
    • 0025163927 scopus 로고
    • Regulation of apoptosis in interleukin-3 dependent hemopoietic cells by interleukin-3 and calcium ionophores
    • Rodriguez-Tarduchy G., Collins M., Lopez-Rivas A. Regulation of apoptosis in interleukin-3 dependent hemopoietic cells by interleukin-3 and calcium ionophores. EMBO J. 9:1990;2997.
    • (1990) EMBO J , vol.9 , pp. 2997
    • Rodriguez-Tarduchy, G.1    Collins, M.2    Lopez-Rivas, A.3
  • 33
    • 0025091773 scopus 로고
    • Haemopoietic colony stimulating factors promote cell survival by suppressing apoptosis
    • Williams G.T., Smith C.A., Spooncer E., Dexter T.M., Taylor D.R. Haemopoietic colony stimulating factors promote cell survival by suppressing apoptosis. Nature. 343:1990;76.
    • (1990) Nature , vol.343 , pp. 76
    • Williams, G.T.1    Smith, C.A.2    Spooncer, E.3    Dexter, T.M.4    Taylor, D.R.5
  • 34
    • 0026533515 scopus 로고
    • Programmed cell death (apoptosis) in hematopoiesis
    • Koury M. Programmed cell death (apoptosis) in hematopoiesis. Exp Hematol. 20:1992;391.
    • (1992) Exp Hematol , vol.20 , pp. 391
    • Koury, M.1
  • 35
    • 0028910524 scopus 로고
    • Modulation of apoptosis in human myeloid leukemic cells by granulocyte-macrophage colony-stimulating factor
    • Han J.H., Gileadi C., Rajapaksa R., Kosek J., Greenberg P.L. Modulation of apoptosis in human myeloid leukemic cells by granulocyte-macrophage colony-stimulating factor. Exp Hematol. 23:1995;265.
    • (1995) Exp Hematol , vol.23 , pp. 265
    • Han, J.H.1    Gileadi, C.2    Rajapaksa, R.3    Kosek, J.4    Greenberg, P.L.5
  • 36
    • 0027988155 scopus 로고
    • Immunohistochemical analysis of in vivo patterna of Bcl-X expression
    • Krajewski S., Krajewska M., Shabaik A.et al. Immunohistochemical analysis of in vivo patterna of Bcl-X expression. Cancer Res. 54:1994;5501.
    • (1994) Cancer Res , vol.54 , pp. 5501
    • Krajewski, S.1    Krajewska, M.2    Shabaik, A.3
  • 37
    • 0029043811 scopus 로고
    • Immunohistochemical analysis of Mcl-1 protein in human tissues. Differential regulation of Mcl-1 and Bcl-2 protein production suggests a unique role for Mcl-1 in control of programmed cell death in vivo
    • Krajewski S., Bodrug S., Krajewska M.et al. Immunohistochemical analysis of Mcl-1 protein in human tissues. Differential regulation of Mcl-1 and Bcl-2 protein production suggests a unique role for Mcl-1 in control of programmed cell death in vivo. Am J Pathol. 146:1995;1309.
    • (1995) Am J Pathol , vol.146 , pp. 1309
    • Krajewski, S.1    Bodrug, S.2    Krajewska, M.3
  • 38
    • 0029848765 scopus 로고    scopus 로고
    • Structure-function comparisons of the proapoptotic protein Bax in yeast and mammalian cells
    • Zhia H., Fisk H.A., Yaffe M.P., Mahajan N., Herman B., Reed J.C. Structure-function comparisons of the proapoptotic protein Bax in yeast and mammalian cells. Mol Cell Biol. 16:1996;6494.
    • (1996) Mol Cell Biol , vol.16 , pp. 6494
    • Zhia, H.1    Fisk, H.A.2    Yaffe, M.P.3    Mahajan, N.4    Herman, B.5    Reed, J.C.6
  • 39
    • 0343199181 scopus 로고    scopus 로고
    • Bax- And Bak-induced cell death in the fission yeast Schizosaccharomyces pombe
    • Jurgensmeier J.M., Krajesski S., Armstrong R.C.et al. Bax- and Bak-induced cell death in the fission yeast Schizosaccharomyces pombe. Mol Biol Cell. 8:1997;325.
    • (1997) Mol Biol Cell , vol.8 , pp. 325
    • Jurgensmeier, J.M.1    Krajesski, S.2    Armstrong, R.C.3
  • 40
    • 0027260656 scopus 로고
    • Epstein-Barr virus-coded BHRF1 protein, a viral homologue of Bcl-2, protects human B cells from programmed cell death
    • Henderson, Huen D., Rowe M., Dawson C., Johnson G., Rickinson A. Epstein-Barr virus-coded BHRF1 protein, a viral homologue of Bcl-2, protects human B cells from programmed cell death. Proc Nat Acad Sci USA. 90:1993;8479.
    • (1993) Proc Nat Acad Sci USA , vol.90 , pp. 8479
    • Henderson1    Huen, D.2    Rowe, M.3    Dawson, C.4    Johnson, G.5    Rickinson, A.6
  • 41
    • 0026639932 scopus 로고
    • The adenovirus E1A proteins induce apoptosis, which is inhibited by the E1B 19-kDa and Bcl-2 proteins
    • Rao L., Debbas M., Sabbatini P., Hockenberry D., Korsmeyer S., White E. The adenovirus E1A proteins induce apoptosis, which is inhibited by the E1B 19-kDa and Bcl-2 proteins. Proc Natl Acad Sci USA. 89:1992;9974.
    • (1992) Proc Natl Acad Sci USA , vol.89 , pp. 9974
    • Rao, L.1    Debbas, M.2    Sabbatini, P.3    Hockenberry, D.4    Korsmeyer, S.5    White, E.6
  • 42
    • 0031017578 scopus 로고    scopus 로고
    • A Bcl-2 homologue encoded by Kaposi sarcoma-associated virus, human herpesvirus 8, inhibits apoptosis but does not heterodimerize with Bax or Bak
    • Cheng E.H., Nicholas J., Bellows D.S.et al. A Bcl-2 homologue encoded by Kaposi sarcoma-associated virus, human herpesvirus 8, inhibits apoptosis but does not heterodimerize with Bax or Bak. Proc Natl Acad Sci USA. 94:1997;690.
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 690
    • Cheng, E.H.1    Nicholas, J.2    Bellows, D.S.3
  • 43
    • 0028288277 scopus 로고
    • Elegans cell survival gene ced-9 encodes a functional homodimer of the mammalian proto-oncogene bcl-2
    • Hengartner M.O., Horvitz H.R.C. elegans cell survival gene ced-9 encodes a functional homodimer of the mammalian proto-oncogene bcl-2. Cell. 76:1994;665.
    • (1994) Cell , vol.76 , pp. 665
    • Hengartner, M.O.1    Horvitz, H.R.C.2
  • 44
    • 0031020227 scopus 로고    scopus 로고
    • Interaction and regulation of subcellular localization of Ced4 by Ced9
    • Wu D., Waller H., Nunez G. Interaction and regulation of subcellular localization of Ced4 by Ced9. Science. 275:1997;1126.
    • (1997) Science , vol.275 , pp. 1126
    • Wu, D.1    Waller, H.2    Nunez, G.3
  • 45
    • 0028883179 scopus 로고
    • Tumor suppressor p53 is a direct transcriptional activator of the human bax gene
    • Miyashita T., Reed J. Tumor suppressor p53 is a direct transcriptional activator of the human bax gene. Cell. 80:1995;293.
    • (1995) Cell , vol.80 , pp. 293
    • Miyashita, T.1    Reed, J.2
  • 46
    • 0031038137 scopus 로고    scopus 로고
    • Bax suppresses tumorigenesis and stimulates apoptosis in vivo
    • Yin C., Knudson C., Korsmeyer S., Van Dyke T. Bax suppresses tumorigenesis and stimulates apoptosis in vivo. Nature. 385:1997;637.
    • (1997) Nature , vol.385 , pp. 637
    • Yin, C.1    Knudson, C.2    Korsmeyer, S.3    Van Dyke, T.4
  • 47
    • 0027362667 scopus 로고
    • Investigation of the subcellular distribution of the bcl-2 oncoprotein: Residence in the nuclear envelope, endoplasmic reticulum, and outher mitochondrial membranes
    • Krajewski S., Tanaka S., Takayama S., Schibler M.J., Fenton W., Reed J.C. Investigation of the subcellular distribution of the bcl-2 oncoprotein: residence in the nuclear envelope, endoplasmic reticulum, and outher mitochondrial membranes. Cancer Res. 53:1993;4701.
    • (1993) Cancer Res , vol.53 , pp. 4701
    • Krajewski, S.1    Tanaka, S.2    Takayama, S.3    Schibler, M.J.4    Fenton, W.5    Reed, J.C.6
  • 50
    • 9544246860 scopus 로고    scopus 로고
    • Mitochondrial permeability transition is a central coordinating event of apoptosis
    • Marchetti P, Castedo M, Susin SA et al., Mitochondrial permeability transition is a central coordinating event of apoptosis. J Exp Med 184:1155.
    • J Exp Med , vol.184 , pp. 1155
    • Marchetti, P.1    Castedo, M.2    Susin, S.A.3
  • 51
    • 0028053663 scopus 로고
    • Recent progress on regulation of the mitochondrial permeability transition pore; A cyclosporin-sensitive pore in the inner mitochondrial membrane
    • Bernardi P., Borekemeier K.M., Pfeiffer D.R. Recent progress on regulation of the mitochondrial permeability transition pore; a cyclosporin-sensitive pore in the inner mitochondrial membrane. J Bioeng Biomembr. 26:1994;509.
    • (1994) J Bioeng Biomembr , vol.26 , pp. 509
    • Bernardi, P.1    Borekemeier, K.M.2    Pfeiffer, D.R.3
  • 53
    • 0030581151 scopus 로고    scopus 로고
    • Induction of apoptotic program in cell-free extracts: Requirement for dATP and cytochrome c
    • Liu X., Kim C.N., Yang J., Jemmerson T., Wang X. Induction of apoptotic program in cell-free extracts: requirement for dATP and cytochrome c. Cell. 86:1996;147.
    • (1996) Cell , vol.86 , pp. 147
    • Liu, X.1    Kim, C.N.2    Yang, J.3    Jemmerson, T.4    Wang, X.5
  • 54
    • 0029950290 scopus 로고    scopus 로고
    • Bcl-2 inhibits the mitochondrial release of an apoptogenic protease
    • Susin S.A., Zamzami N., Castedo M.et al. Bcl-2 inhibits the mitochondrial release of an apoptogenic protease. J Exp Med. 184:1996;1331.
    • (1996) J Exp Med , vol.184 , pp. 1331
    • Susin, S.A.1    Zamzami, N.2    Castedo, M.3
  • 55
    • 0030745646 scopus 로고    scopus 로고
    • Apaf-1, a human protein homologous to C. elegans CED-4, participates in cytochrome c-dependent activation of caspase-3
    • Zou H., Henzel W.J., Liu X., Lutschg A., Wang X. Apaf-1, a human protein homologous to C. elegans CED-4, participates in cytochrome c-dependent activation of caspase-3. Cell. 90:1997;405.
    • (1997) Cell , vol.90 , pp. 405
    • Zou, H.1    Henzel, W.J.2    Liu, X.3    Lutschg, A.4    Wang, X.5
  • 56
    • 0027166048 scopus 로고
    • Bcl-2 heterodimerizes in vivo with a conserved homolog, bax, that accelerates programed cell death
    • Oltvai Z., Milliman C., Korsmeyer S. Bcl-2 heterodimerizes in vivo with a conserved homolog, bax, that accelerates programed cell death. Cell. 74:1993;609.
    • (1993) Cell , vol.74 , pp. 609
    • Oltvai, Z.1    Milliman, C.2    Korsmeyer, S.3
  • 57
    • 0029917541 scopus 로고    scopus 로고
    • Proapoptotic protein Bax heterodimerizes with Bcl-2 and homodimerizes with Bax via a novel domain (BH3) distinct from BH1 and BH2
    • Zha H., Aime-Sempe C., Sato T., Reed J.C. Proapoptotic protein Bax heterodimerizes with Bcl-2 and homodimerizes with Bax via a novel domain (BH3) distinct from BH1 and BH2. J Biol Chem. 271:1996;7440.
    • (1996) J Biol Chem , vol.271 , pp. 7440
    • Zha, H.1    Aime-Sempe, C.2    Sato, T.3    Reed, J.C.4
  • 58
    • 0028956550 scopus 로고
    • Regulators of cell death
    • Korsmeyer S.J. Regulators of cell death. Trends Genet. 11:1995;101.
    • (1995) Trends Genet , vol.11 , pp. 101
    • Korsmeyer, S.J.1
  • 59
    • 0031048545 scopus 로고    scopus 로고
    • Bcl-2 and the ICE family of apoptotic regulators: Making a connection
    • Rao L., White E. Bcl-2 and the ICE family of apoptotic regulators: making a connection. Curr Opin Genet Dev. 7:1997;52.
    • (1997) Curr Opin Genet Dev , vol.7 , pp. 52
    • Rao, L.1    White, E.2
  • 60
    • 0029790857 scopus 로고    scopus 로고
    • Induction of apoptosis by human Nbk/Bik, a BH3 containing E1B 19K interacting protein
    • Han J., Sabbatini P., White E. Induction of apoptosis by human Nbk/Bik, a BH3 containing E1B 19K interacting protein. Mol Cell Biol. 16:1996;5857.
    • (1996) Mol Cell Biol , vol.16 , pp. 5857
    • Han, J.1    Sabbatini, P.2    White, E.3
  • 63
    • 0030047365 scopus 로고    scopus 로고
    • Functional dissection of the human Bcl-2 protein: Sequence requirements for inhibition of apoptosis
    • Hunter J., Bond B., Parslow T. Functional dissection of the human Bcl-2 protein: Sequence requirements for inhibition of apoptosis. Mol Cell Biol. 16:1996;877.
    • (1996) Mol Cell Biol , vol.16 , pp. 877
    • Hunter, J.1    Bond, B.2    Parslow, T.3
  • 64
    • 0345002596 scopus 로고
    • C-myc and bcl-2 modulate p53 subcellular function by altering p53 trafficking during the cell cycle
    • Ryan J., Prochownik E., Gottlieb C.et al. c-myc and bcl-2 modulate p53 subcellular function by altering p53 trafficking during the cell cycle. Proc Natl Acad Sci USA. 91:1994;5857.
    • (1994) Proc Natl Acad Sci USA , vol.91 , pp. 5857
    • Ryan, J.1    Prochownik, E.2    Gottlieb, C.3
  • 66
    • 0027948205 scopus 로고
    • Induction of apoptosis by a dominant negative H-ras mutant (116y) in K562 cells
    • Sakai N., Ogiso Y., Fujita H., Watari H.J., Koike T., Kuzumaki N. Induction of apoptosis by a dominant negative H-ras mutant (116y) in K562 cells. Exp Cell Res. 37:1994;121.
    • (1994) Exp Cell Res , vol.37 , pp. 121
    • Sakai, N.1    Ogiso, Y.2    Fujita, H.3    Watari, H.J.4    Koike, T.5    Kuzumaki, N.6
  • 67
    • 0028144848 scopus 로고
    • Apoptosis regulation by interaction of Bcl-2 protein and Raf-1 kinase
    • Wang H.G., Miyashita T., Takayama S.et al. Apoptosis regulation by interaction of Bcl-2 protein and Raf-1 kinase. Oncogene. 9:1994;2751.
    • (1994) Oncogene , vol.9 , pp. 2751
    • Wang, H.G.1    Miyashita, T.2    Takayama, S.3
  • 68
    • 0029029743 scopus 로고
    • R-Ras promotes apoptosis caused by growth factor deprivation via a Bcl-2 suppressible mechanism
    • Wang H.G., Millan J.A., Cox A.D.et al. R-Ras promotes apoptosis caused by growth factor deprivation via a Bcl-2 suppressible mechanism. J Cell Biol. 129:1995;1103.
    • (1995) J Cell Biol , vol.129 , pp. 1103
    • Wang, H.G.1    Millan, J.A.2    Cox, A.D.3
  • 69
    • 85058247584 scopus 로고    scopus 로고
    • Regulation and function of Fas and Fas ligand expression in human myeloid leukemia cells
    • Rajapaksa R., Bhatia S., Alluri N., Greenberg P.L. Regulation and function of Fas and Fas ligand expression in human myeloid leukemia cells. Blood. 90(Suppl. 1):1997;196b.
    • (1997) Blood , vol.90 , Issue.SUPPL. 1
    • Rajapaksa, R.1    Bhatia, S.2    Alluri, N.3    Greenberg, P.L.4
  • 70
    • 0027246692 scopus 로고
    • Regulation by bcl-2, c-myc, and p53 of susceptibility to induction of apoptosis by heat shock and cancer chemotheraphy compounds in differentiation-competent and -defective myeloid leukemic cells
    • Lotem J., Sachs L. Regulation by bcl-2, c-myc, and p53 of susceptibility to induction of apoptosis by heat shock and cancer chemotheraphy compounds in differentiation-competent and -defective myeloid leukemic cells. Cell Growth Diff. 4:1993;41.
    • (1993) Cell Growth Diff. , vol.4 , pp. 41
    • Lotem, J.1    Sachs, L.2
  • 71
    • 0023786047 scopus 로고    scopus 로고
    • Bcl-2 gene promotes haematopoietic cell survival and cooperates with c-myc to immortalize pre-B cells
    • Vaux D.L., Cory S., Adams J.M. Bcl-2 gene promotes haematopoietic cell survival and cooperates with c-myc to immortalize pre-B cells. Nature. 335:1999;440.
    • (1999) Nature , vol.335 , pp. 440
    • Vaux, D.L.1    Cory, S.2    Adams, J.M.3
  • 72
    • 0026722655 scopus 로고
    • Interaction between c-myc and bcl-2 protooncogenes: A noval paradigm for oncogene cooperation
    • Fanidi A., Harrington E.A., Evan G.I. Interaction between c-myc and bcl-2 protooncogenes: A noval paradigm for oncogene cooperation. Nature. 359:1992;554.
    • (1992) Nature , vol.359 , pp. 554
    • Fanidi, A.1    Harrington, E.A.2    Evan, G.I.3
  • 73
  • 75
    • 0028222955 scopus 로고
    • Bcl-2 blocks p53-dependent apoptosis
    • Chiou S., Rao L., White E. Bcl-2 blocks p53-dependent apoptosis. Mol Cell Biol. 14:1994;2556.
    • (1994) Mol Cell Biol , vol.14 , pp. 2556
    • Chiou, S.1    Rao, L.2    White, E.3
  • 76
    • 0027258466 scopus 로고
    • Thymocyte apoptosis induced by p53-dependent and independent pathways
    • Clarke A.R., Purdie C.A., Harrison D.J.et al. Thymocyte apoptosis induced by p53-dependent and independent pathways. Nature. 362:1993;849.
    • (1993) Nature , vol.362 , pp. 849
    • Clarke, A.R.1    Purdie, C.A.2    Harrison, D.J.3
  • 77
    • 0027999617 scopus 로고
    • Structure and function of p53 in normal cells and their aberrations in cancer cells: Projection on the hematologic cell lineages
    • Prokocimer M., Rotter V. Structure and function of p53 in normal cells and their aberrations in cancer cells: projection on the hematologic cell lineages. Blood. 84:1994;2391.
    • (1994) Blood , vol.84 , pp. 2391
    • Prokocimer, M.1    Rotter, V.2
  • 78
    • 0025784539 scopus 로고
    • Wild-type p53 induces apoptosis of myeloid leukemic cells that is inhibited by interleukin-6
    • Yonish-Rouach E., Resnitzky D., Lotem J., Sachs L., Kimchi A., Oren M. Wild-type p53 induces apoptosis of myeloid leukemic cells that is inhibited by interleukin-6. Nature. 352:1991;345.
    • (1991) Nature , vol.352 , pp. 345
    • Yonish-Rouach, E.1    Resnitzky, D.2    Lotem, J.3    Sachs, L.4    Kimchi, A.5    Oren, M.6
  • 79
    • 0028294898 scopus 로고
    • Down-regulation of wild-type p53 activity interferes with apoptosis of IL-3-dependent hematopoietic cells following IL-3 withdrawal
    • Gottlieb E., Haffner R., von Ruden T., Wagner E.F., Oren M. Down-regulation of wild-type p53 activity interferes with apoptosis of IL-3-dependent hematopoietic cells following IL-3 withdrawal. EMBO J. 13:1994;1368.
    • (1994) EMBO J , vol.13 , pp. 1368
    • Gottlieb, E.1    Haffner, R.2    Von Ruden, T.3    Wagner, E.F.4    Oren, M.5
  • 80
    • 0029972806 scopus 로고    scopus 로고
    • P53: Puzzle and paradigm
    • Ko L.J., Prives C. p53: puzzle and paradigm. Genes Dev. 10:1996;1054.
    • (1996) Genes Dev , vol.10 , pp. 1054
    • Ko, L.J.1    Prives, C.2
  • 81
    • 0030046508 scopus 로고    scopus 로고
    • Life, death and the pursuit of apoptosis
    • White E. Life, death and the pursuit of apoptosis. Genes Dev. 10:1996;1.
    • (1996) Genes Dev , vol.10 , pp. 1
    • White, E.1
  • 82
    • 0029125701 scopus 로고
    • Protease activation during apoptosis: Death by a thousand cuts?
    • Martin S., Green D. Protease activation during apoptosis: death by a thousand cuts? Cell. 82:1995;349.
    • (1995) Cell , vol.82 , pp. 349
    • Martin, S.1    Green, D.2
  • 83
    • 0029927422 scopus 로고    scopus 로고
    • The role of proteases during apoptosis
    • Patel T., Gores G., Kaufman S. The role of proteases during apoptosis. FASEB J. 10:1996;587.
    • (1996) FASEB J , vol.10 , pp. 587
    • Patel, T.1    Gores, G.2    Kaufman, S.3
  • 84
    • 0027525104 scopus 로고
    • The C. elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin-1β-converting enzyme
    • Yuan J., Shaham S., Ledoux S., Ellis H.M., Horvitz J.R. The C. elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin-1β-converting enzyme. Cell. 75:1993;641.
    • (1993) Cell , vol.75 , pp. 641
    • Yuan, J.1    Shaham, S.2    Ledoux, S.3    Ellis, H.M.4    Horvitz, J.R.5
  • 86
    • 0028920863 scopus 로고
    • Altered cytokine export and apoptosis in mice deficient in interleukin-1β converting enzyme
    • Kuida K., Lippke J.A., Ku G., Harding M.W., Livingston D.J., Su M.S., Flavell R.A. Altered cytokine export and apoptosis in mice deficient in interleukin-1β converting enzyme. Science. 267:1995;2000.
    • (1995) Science , vol.267 , pp. 2000
    • Kuida, K.1    Lippke, J.A.2    Ku, G.3    Harding, M.W.4    Livingston, D.J.5    Su, M.S.6    Flavell, R.A.7
  • 91
    • 0030011398 scopus 로고    scopus 로고
    • Involvement of MACH, a novel MORT1/FADD-interacting protease, in Fas/APO-1 and TNF receptor-induced cell death
    • Boldin M.P., Goncharov T.M., Goltsev Y.V., Wallach D. Involvement of MACH, a novel MORT1/FADD-interacting protease, in Fas/APO-1 and TNF receptor-induced cell death. Cell. 85:1996;803.
    • (1996) Cell , vol.85 , pp. 803
    • Boldin, M.P.1    Goncharov, T.M.2    Goltsev, Y.V.3    Wallach, D.4
  • 93
    • 0031587883 scopus 로고    scopus 로고
    • Daxx, a novel Fas-binding protein that activates JNK and apoptosis
    • Yang X., Khosravi-Far R., Chang H., Baltimore D. Daxx, a novel Fas-binding protein that activates JNK and apoptosis. Cell. 89:1997;1067.
    • (1997) Cell , vol.89 , pp. 1067
    • Yang, X.1    Khosravi-Far, R.2    Chang, H.3    Baltimore, D.4
  • 94
    • 0030465544 scopus 로고    scopus 로고
    • Lamin proteolysis facilitates nuclear events during apoptosis
    • Rao L., Perez D., White E. Lamin proteolysis facilitates nuclear events during apoptosis. J Cell Biol. 135:1996;1441.
    • (1996) J Cell Biol , vol.135 , pp. 1441
    • Rao, L.1    Perez, D.2    White, E.3
  • 95
    • 0031037897 scopus 로고    scopus 로고
    • The release of cytochrome c from mitochrondia: A primary site for Bcl-2 regulation of apoptosis
    • Kluck R.M., Bossy-Wetzel E., Green D.R., Newmeyer D.D. The release of cytochrome c from mitochrondia: A primary site for Bcl-2 regulation of apoptosis. Science. 275:1997;1132.
    • (1997) Science , vol.275 , pp. 1132
    • Kluck, R.M.1    Bossy-Wetzel, E.2    Green, D.R.3    Newmeyer, D.D.4
  • 97
    • 0029976817 scopus 로고    scopus 로고
    • An essential role for NF-KB in preventing TNF-α induced cell death
    • Beg A.A., Baltimore D. An essential role for NF-KB in preventing TNF-α induced cell death. Science. 274:1996;782.
    • (1996) Science , vol.274 , pp. 782
    • Beg, A.A.1    Baltimore, D.2
  • 99
    • 0029858387 scopus 로고    scopus 로고
    • TNF and cancer therapy-induced apoptosis: Potentiation by inhibition of NF-KB
    • Wang C.Y., Mayo M.W., Baldwin A.S. Jr. TNF and cancer therapy-induced apoptosis: Potentiation by inhibition of NF-KB. Science. 274:1996;784.
    • (1996) Science , vol.274 , pp. 784
    • Wang, C.Y.1    Mayo, M.W.2    Baldwin A.S., Jr.3
  • 100
    • 0002800018 scopus 로고
    • Analysis of DNA. General methods
    • In: Ormerod MG, editor. Oxford: IRL press at Oxford University Press
    • Ormerod MG. Analysis of DNA. General methods. In: Ormerod MG, editor. Flow Cytometry. A Practical Approach. Oxford: IRL press at Oxford University Press, 1990:69.
    • (1990) Flow Cytometry. a Practical Approach , pp. 69
    • Ormerod, M.G.1
  • 101
    • 0031985647 scopus 로고    scopus 로고
    • Annexin V-affinity assay: A review on an apoptosis detection system based on phosphatidylserine exposure
    • Van Engeland M., Nieland L.J., Ramaekers F.C., Schutte B., Reutelingsperger C.P. Annexin V-affinity assay: a review on an apoptosis detection system based on phosphatidylserine exposure. Cytometry. 31:1998;1.
    • (1998) Cytometry , vol.31 , pp. 1
    • Van Engeland, M.1    Nieland, L.J.2    Ramaekers, F.C.3    Schutte, B.4    Reutelingsperger, C.P.5
  • 103
    • 0025835716 scopus 로고
    • Bcl-2 protein is topographically restricted in tissues characterized by apoptotic cell death
    • Hockenbery D., Zutter M., Hickey W., Nahm M. Bcl-2 protein is topographically restricted in tissues characterized by apoptotic cell death. Proc Natl Acad Sci USA. 88:1991;6961.
    • (1991) Proc Natl Acad Sci USA , vol.88 , pp. 6961
    • Hockenbery, D.1    Zutter, M.2    Hickey, W.3    Nahm, M.4
  • 105
    • 0026696155 scopus 로고
    • Growth- And differentiation-associated expression of bcl-2 in B-chronic lymphocytic leukemia cells
    • Schena M., Larsson L.-G., Gottardi D., Gaidano G. Growth- and differentiation-associated expression of bcl-2 in B-chronic lymphocytic leukemia cells. Blood. 79:1992;2981.
    • (1992) Blood , vol.79 , pp. 2981
    • Schena, M.1    Larsson, L.-G.2    Gottardi, D.3    Gaidano, G.4
  • 106
    • 0024521441 scopus 로고
    • Bcl-2-immunoglobulin transgenic mice demonstrate extended B cell survival and follicular lymphoproliferation
    • McDonnell T.J., Deane N., Platt F.M., Nunez G., Jaeger U., McKearn J.P., Korsmeyer S.J. Bcl-2-immunoglobulin transgenic mice demonstrate extended B cell survival and follicular lymphoproliferation. Cell. 57:1989;79.
    • (1989) Cell , vol.57 , pp. 79
    • McDonnell, T.J.1    Deane, N.2    Platt, F.M.3    Nunez, G.4    Jaeger, U.5    McKearn, J.P.6    Korsmeyer, S.J.7
  • 107
    • 0026053958 scopus 로고
    • Progression from lymphoid hyperplasia to high- grade malignant lymphoma in mice transgenic for the t(14;18)
    • McDonnell T., Korsmeyer S. Progression from lymphoid hyperplasia to high- grade malignant lymphoma in mice transgenic for the t(14;18). Nature. 349:1991;254.
    • (1991) Nature , vol.349 , pp. 254
    • McDonnell, T.1    Korsmeyer, S.2
  • 108
    • 0029970093 scopus 로고    scopus 로고
    • Bcl-2, Bax and p53 expression in B-CLL in relation to in vitro survival and clinical progression
    • Aguilar-Santelises M., Rottenberg M., Lwein N., Mellstedt H., Jondal M. Bcl-2, Bax and p53 expression in B-CLL in relation to in vitro survival and clinical progression. Int J Cancer. 69:1996;114.
    • (1996) Int J Cancer , vol.69 , pp. 114
    • Aguilar-Santelises, M.1    Rottenberg, M.2    Lwein, N.3    Mellstedt, H.4    Jondal, M.5
  • 109
    • 0024436583 scopus 로고
    • Nuclear oncoprotein expression as a function of lineage, differentiation stage and proliferative status of normal human hematopoietic cells
    • Kastan M.B., Stone K.D., Civin C.I. Nuclear oncoprotein expression as a function of lineage, differentiation stage and proliferative status of normal human hematopoietic cells. Blood. 74:1989;1517.
    • (1989) Blood , vol.74 , pp. 1517
    • Kastan, M.B.1    Stone, K.D.2    Civin, C.I.3
  • 112
    • 0026565933 scopus 로고
    • Bcl-2 proto-oncogene expression in normal and neoplastic human myeloid cells
    • Delia D., Aiello A., Soligo D., Fontanella E. Bcl-2 proto-oncogene expression in normal and neoplastic human myeloid cells. Blood. 79:1992;1291.
    • (1992) Blood , vol.79 , pp. 1291
    • Delia, D.1    Aiello, A.2    Soligo, D.3    Fontanella, E.4
  • 113
    • 0029111391 scopus 로고
    • Bcl-2 protein expression in normal human bone marrow precursors and in acute myelogenous leukemia
    • Porwit-MacDonald A., Ivory K., Wilkinson S., Wheatley K., Wong L., Janossy G. Bcl-2 protein expression in normal human bone marrow precursors and in acute myelogenous leukemia. Leukemia. 9:1995;1191.
    • (1995) Leukemia , vol.9 , pp. 1191
    • Porwit-Macdonald, A.1    Ivory, K.2    Wilkinson, S.3    Wheatley, K.4    Wong, L.5    Janossy, G.6
  • 114
    • 0027164144 scopus 로고
    • High expression of bcl-2 protein in acute myeloid leukemia cells is associated with poor response to chemotherapy
    • Campos L., Rouault J.-P., Sabiolo O., Oriol P., Roubi N., Vasselan C., Archimbaud E. High expression of bcl-2 protein in acute myeloid leukemia cells is associated with poor response to chemotherapy. Blood. 81:1993;3091.
    • (1993) Blood , vol.81 , pp. 3091
    • Campos, L.1    Rouault, J.-P.2    Sabiolo, O.3    Oriol, P.4    Roubi, N.5    Vasselan, C.6    Archimbaud, E.7
  • 115
    • 0028881958 scopus 로고
    • Comparative quantitative expression of bcl-2 by normal and leukemic myeloid cells
    • Bradbury D.A., Russell N.H. Comparative quantitative expression of bcl-2 by normal and leukemic myeloid cells. Br J Haematol. 91:1995;374.
    • (1995) Br J Haematol , vol.91 , pp. 374
    • Bradbury, D.A.1    Russell, N.H.2
  • 116
    • 0028284281 scopus 로고
    • Effects of bcl-2 antisense oligodeoxynucleotides on in vitro proliferation and survival of normal marrow progenitors and leukemic cells
    • Campos L., Sabido O., Rouault J.-P., Guyotat D. Effects of bcl-2 antisense oligodeoxynucleotides on in vitro proliferation and survival of normal marrow progenitors and leukemic cells. Blood. 84:1994;595.
    • (1994) Blood , vol.84 , pp. 595
    • Campos, L.1    Sabido, O.2    Rouault, J.-P.3    Guyotat, D.4
  • 117
    • 0031030034 scopus 로고    scopus 로고
    • Measurement of spontaneous and therapeutic agent-induced apoptosis with bcl-2 protein expression in acute myeloid leukemia
    • Banker D.E., Groudine M., Norwood T., Appelbaum F.R. Measurement of spontaneous and therapeutic agent-induced apoptosis with bcl-2 protein expression in acute myeloid leukemia. Blood. 89:1997;243.
    • (1997) Blood , vol.89 , pp. 243
    • Banker, D.E.1    Groudine, M.2    Norwood, T.3    Appelbaum, F.R.4
  • 120
    • 0030985486 scopus 로고    scopus 로고
    • In leukemic hematopoiesis CD34 antigen does not have the same significance as it does in normal hematopoiesis
    • Del Canizo M.C., Galende J., Mota A., Orfao A., Martinez A., Almeida J., San Miguel J.F. In leukemic hematopoiesis CD34 antigen does not have the same significance as it does in normal hematopoiesis. Leuk Res. 21:1997;651.
    • (1997) Leuk Res , vol.21 , pp. 651
    • Del Canizo, M.C.1    Galende, J.2    Mota, A.3    Orfao, A.4    Martinez, A.5    Almeida, J.6    San Miguel, J.F.7
  • 123
    • 0025332227 scopus 로고
    • Effects of recombinant human granulocyte colony stimulating factor and granulocyte-monocyte colony-stimulating factor on in vitro hemopoiesis in the myelodysplastic syndromes
    • Nagler A., Ginzton N., Negrin R., Bangs D., Donlon T., Greenberg P. Effects of recombinant human granulocyte colony stimulating factor and granulocyte-monocyte colony-stimulating factor on in vitro hemopoiesis in the myelodysplastic syndromes. Leukemia. 4:1993;193.
    • (1993) Leukemia , vol.4 , pp. 193
    • Nagler, A.1    Ginzton, N.2    Negrin, R.3    Bangs, D.4    Donlon, T.5    Greenberg, P.6
  • 124
    • 0021972565 scopus 로고
    • Immunologic selection of hemopoietic precursor cells utilizing antibody-mediated plate binding ('panning')
    • Greenberg P.L., Baker S., Link M., Minowada J. Immunologic selection of hemopoietic precursor cells utilizing antibody-mediated plate binding ('panning'). Blood. 65:1985;190.
    • (1985) Blood , vol.65 , pp. 190
    • Greenberg, P.L.1    Baker, S.2    Link, M.3    Minowada, J.4
  • 125
    • 4244090615 scopus 로고    scopus 로고
    • Apoptosis in patients with myelodysplastic syndromes: Differential involvement of marrow cells in early versus advanced cases and correlation with the expression of apoptosis-related genes
    • Tsoplou P., Kourakli-Symeonidis A., Thanopoulou E., Orphanos V., Zoumbos N. Apoptosis in patients with myelodysplastic syndromes: Differential involvement of marrow cells in early versus advanced cases and correlation with the expression of apoptosis-related genes. Blood. 90(Suppl 1):1997;203a.
    • (1997) Blood , vol.90 , Issue.SUPPL. 1
    • Tsoplou, P.1    Kourakli-Symeonidis, A.2    Thanopoulou, E.3    Orphanos, V.4    Zoumbos, N.5
  • 127
    • 18344401654 scopus 로고    scopus 로고
    • Morphological changes and apoptosis in bone marrow from patients with myelodysplastic syndromes treated with granulocyte-CSF and erythropoietin
    • Hellstrom-Lindberg E., Kanter-Lewensohn L., Ost A. Morphological changes and apoptosis in bone marrow from patients with myelodysplastic syndromes treated with granulocyte-CSF and erythropoietin. Leuk Res. 21:1997;415.
    • (1997) Leuk Res , vol.21 , pp. 415
    • Hellstrom-Lindberg, E.1    Kanter-Lewensohn, L.2    Ost, A.3
  • 128
    • 0029804412 scopus 로고    scopus 로고
    • Is apoptosis a massive process in myelodysplastic syndromes?
    • Lepelley P., Campergue L., Grardel N.et al. Is apoptosis a massive process in myelodysplastic syndromes? Br J Haematol. 95:1996;368.
    • (1996) Br J Haematol , vol.95 , pp. 368
    • Lepelley, P.1    Campergue, L.2    Grardel, N.3
  • 129
    • 0027196547 scopus 로고
    • Control of programmed cell death in normal and leukemic cells: New implications for therapy
    • Sachs L., Lotem J. Control of programmed cell death in normal and leukemic cells: new implications for therapy. Blood. 82:1993;15.
    • (1993) Blood , vol.82 , pp. 15
    • Sachs, L.1    Lotem, J.2
  • 130
    • 4243828680 scopus 로고    scopus 로고
    • Leukemic progression in myelodysplastic syndromes decreased apoptosis and a reduced ratio of pro- versus anti-apoptosis related proteins
    • Parker J.E., Fishlock K.L., Mijovic A., Pagliucca A., Mufti G. Leukemic progression in myelodysplastic syndromes decreased apoptosis and a reduced ratio of pro- versus anti-apoptosis related proteins. Blood. 90(Suppl 1):1997;520a.
    • (1997) Blood , vol.90 , Issue.SUPPL. 1
    • Parker, J.E.1    Fishlock, K.L.2    Mijovic, A.3    Pagliucca, A.4    Mufti, G.5
  • 131
    • 0026659995 scopus 로고
    • Proto-oncogene expression in subpopulations of cells from leukemia patients
    • Hulette B.C., Banavali S.D., Finke D.P., Gopal V., Preisler H.D. Proto-oncogene expression in subpopulations of cells from leukemia patients. Cytometry. 13:1992;653.
    • (1992) Cytometry , vol.13 , pp. 653
    • Hulette, B.C.1    Banavali, S.D.2    Finke, D.P.3    Gopal, V.4    Preisler, H.D.5
  • 132
    • 0032171391 scopus 로고    scopus 로고
    • Bcl-2 expression by myeloid precursors in myelodysplastic syndromes: Immunostaining of bone marrow biopsies
    • Davis RE, Greenberg PL. Bcl-2 expression by myeloid precursors in myelodysplastic syndromes: Immunostaining of bone marrow biopsies. Leuk Res 1998;22:767.
    • (1998) Leuk Res , vol.22 , pp. 767
    • Davis, R.E.1    Greenberg, P.L.2
  • 134
    • 0026096185 scopus 로고
    • P53 gene mutations in acute myeloid leukemia with 17p monosomy
    • Fenaux P., Jonveaux P., Quiquandon I.et al. p53 gene mutations in acute myeloid leukemia with 17p monosomy. Blood. 78:1991;1652.
    • (1991) Blood , vol.78 , pp. 1652
    • Fenaux, P.1    Jonveaux, P.2    Quiquandon, I.3
  • 135
    • 0028928283 scopus 로고
    • Myelodysplastic syndromes and acute myeloid leukemia with 17p deletion. An entity characterized by specific dysgranulopoiesis and a high incidence of p53 mutations
    • Lai J.L., Preudhomme C., Zandecki M.et al. Myelodysplastic syndromes and acute myeloid leukemia with 17p deletion. An entity characterized by specific dysgranulopoiesis and a high incidence of p53 mutations. Leukemia. 9:1995;370.
    • (1995) Leukemia , vol.9 , pp. 370
    • Lai, J.L.1    Preudhomme, C.2    Zandecki, M.3
  • 136
    • 0026336513 scopus 로고
    • Mutations in the p53 gene in myelodysplastic syndromes
    • Jonveaux P., Fenaux P., Quiquandon I.et al. Mutations in the p53 gene in myelodysplastic syndromes. Oncogene. 6:1991;2243.
    • (1991) Oncogene , vol.6 , pp. 2243
    • Jonveaux, P.1    Fenaux, P.2    Quiquandon, I.3
  • 137
    • 0027162048 scopus 로고
    • Occurrence of point mutations in p53 gene is not increased in patients with acute myeloid leukemia carrying an activating N-ras mutation
    • Buhler-Leclere M., Graswohl A., Senn J.P. Occurrence of point mutations in p53 gene is not increased in patients with acute myeloid leukemia carrying an activating N-ras mutation. Br J Haematol. 84:1993;443.
    • (1993) Br J Haematol , vol.84 , pp. 443
    • Buhler-Leclere, M.1    Graswohl, A.2    Senn, J.P.3
  • 138
    • 0026690447 scopus 로고
    • Mutations of the p53 tumour suppressor gene in hematologic neoplasms
    • Mori N., Wada M., Yokota J.et al. Mutations of the p53 tumour suppressor gene in hematologic neoplasms. Br J Haematol. 81:1992;235.
    • (1992) Br J Haematol , vol.81 , pp. 235
    • Mori, N.1    Wada, M.2    Yokota, J.3
  • 139
    • 0008424994 scopus 로고
    • The presence of apoptosis in refractory anemia of myelodysplasia
    • In: Abraham N, editor. Andover, MD: Intercept
    • Hatake K, Tomizuka H, Ikeda M et al. The presence of apoptosis in refractory anemia of myelodysplasia. In: Abraham N, editor. Molecular Biology of Haematopoiesis, vol 3. Andover, MD: Intercept, 1994:127.
    • (1994) Molecular Biology of Haematopoiesis , vol.3 , pp. 127
    • Hatake, K.1    Tomizuka, H.2    Ikeda, M.3
  • 141
    • 0029090167 scopus 로고
    • Direct evidence for tumor necrosis factor-induced mitochondrial reactive oxygen intermediates and their involvement in cytotoxicity
    • Goossens V., Grooten J., De Vos K., Fiers W. Direct evidence for tumor necrosis factor-induced mitochondrial reactive oxygen intermediates and their involvement in cytotoxicity. Proc Natl Acad Sci USA. 92:1995;8115.
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 8115
    • Goossens, V.1    Grooten, J.2    De Vos, K.3    Fiers, W.4
  • 142
    • 0028946386 scopus 로고
    • DNA damage induced by tumour necrosis factor-alpha in L929 cells is mediated by mitochondrial oxygen radical formation
    • Shoji Y., Uedono Y., Ishikura H., Takeyama N., Tanaka T. DNA damage induced by tumour necrosis factor-alpha in L929 cells is mediated by mitochondrial oxygen radical formation. Immunology. 84:1995;543.
    • (1995) Immunology , vol.84 , pp. 543
    • Shoji, Y.1    Uedono, Y.2    Ishikura, H.3    Takeyama, N.4    Tanaka, T.5
  • 143
    • 0030664927 scopus 로고    scopus 로고
    • + myelodysplastic cells is associated with intracellular redox changes and elevated plasma tumour necrosis factor-α concentration
    • + myelodysplastic cells is associated with intracellular redox changes and elevated plasma tumour necrosis factor-α concentration. Br J Haematol. 99:1997;625.
    • (1997) Br J Haematol , vol.99 , pp. 625
    • Peddie, C.1    Wolf, R.2    McLellan, L.3    Collins, A.R.4    Bowen, T.5
  • 144
    • 0029016931 scopus 로고
    • Fas antigen expression in CD34+ human marrow cells is induced by interferon-γ And tumor necrosis factor-α And potentiates cytokine-mediated hematopoietic suppression in vitro
    • Maciejewski J.P., Selleri C., Anderson S., Young N. Fas antigen expression in CD34+ human marrow cells is induced by interferon-γ and tumor necrosis factor-α and potentiates cytokine-mediated hematopoietic suppression in vitro. Blood. 85:1995;3183.
    • (1995) Blood , vol.85 , pp. 3183
    • MacIejewski, J.P.1    Selleri, C.2    Anderson, S.3    Young, N.4
  • 145
    • 0029763467 scopus 로고    scopus 로고
    • Fas (CD95) receptor and Fas-ligand expression in bone marrow cells from patients with myelodysplastic syndrome
    • Gersuk G.M., Lee J.W., Beckham C.A., Anderson J., Deeg J.H. Fas (CD95) receptor and Fas-ligand expression in bone marrow cells from patients with myelodysplastic syndrome. Blood. 88:1996;1122.
    • (1996) Blood , vol.88 , pp. 1122
    • Gersuk, G.M.1    Lee, J.W.2    Beckham, C.A.3    Anderson, J.4    Deeg, J.H.5
  • 146
    • 0009690259 scopus 로고    scopus 로고
    • Increased expression of Fas antigen and apoptosis in patients myelodysplastic syndromes
    • Okada M., Okamoto T., Saheki K., Fuimo Y., Takemoto, Kakisista E. Increased expression of Fas antigen and apoptosis in patients myelodysplastic syndromes. Blood. 90(Suppl 1):1997;202a.
    • (1997) Blood , vol.90 , Issue.SUPPL. 1
    • Okada, M.1    Okamoto, T.2    Saheki, K.3    Fuimo, Y.4    Takemoto5    Kakisista, E.6
  • 148
    • 0015209133 scopus 로고
    • Granulopoiesis in acute myeloid leukemia and preleukemia
    • Greenberg P.L., Nichols W.C., Schrier S.L. Granulopoiesis in acute myeloid leukemia and preleukemia. New Engl J Med. 284:1971;1225-1232.
    • (1971) New Engl J Med , vol.284 , pp. 1225-1232
    • Greenberg, P.L.1    Nichols, W.C.2    Schrier, S.L.3
  • 149
    • 4243260133 scopus 로고    scopus 로고
    • Implication of ICE and CPP32 in the in vitro growth defects of committed progenitors from myelodysplastic syndromes
    • Campos L., Sabido O., Viallet A., Piselli S., Guyotat D. Implication of ICE and CPP32 in the in vitro growth defects of committed progenitors from myelodysplastic syndromes. Blood. 90(Suppl 1):1997;521a.
    • (1997) Blood , vol.90 , Issue.SUPPL. 1
    • Campos, L.1    Sabido, O.2    Viallet, A.3    Piselli, S.4    Guyotat, D.5
  • 152
    • 0025370701 scopus 로고
    • Maintenance treatment of patients with myelodysplastic syndromes using recombinant human granulocyte colony stimulating factor
    • Negrin R.S., Haeuber D.H., Nagler A., Kobayashi Y., Sklar J., Donlon T., Vincent M., Greenberg P.L. Maintenance treatment of patients with myelodysplastic syndromes using recombinant human granulocyte colony stimulating factor. Blood. 76:1990;36.
    • (1990) Blood , vol.76 , pp. 36
    • Negrin, R.S.1    Haeuber, D.H.2    Nagler, A.3    Kobayashi, Y.4    Sklar, J.5    Donlon, T.6    Vincent, M.7    Greenberg, P.L.8
  • 153
    • 0027304592 scopus 로고
    • Treatment of the anemia of myelodysplastic syndromes using recombinant human granulocyte colony-stimulating factor in combination with erythropoietin
    • Negrin R.S., Stein R., Vardiman J., Doherty K., Cornwell J., Krantz S., Greenberg P.L. Treatment of the anemia of myelodysplastic syndromes using recombinant human granulocyte colony-stimulating factor in combination with erythropoietin. Blood. 82:1993;737.
    • (1993) Blood , vol.82 , pp. 737
    • Negrin, R.S.1    Stein, R.2    Vardiman, J.3    Doherty, K.4    Cornwell, J.5    Krantz, S.6    Greenberg, P.L.7
  • 154
    • 0027361750 scopus 로고
    • A combination of granulocyte colony-stimulating factor and erythropoietin may synergistically improve the anemia in patients with myelodysplastic syndromes
    • Hellstrom-Lindberg E., Birgegard G., Carlsson M.et al. A combination of granulocyte colony-stimulating factor and erythropoietin may synergistically improve the anemia in patients with myelodysplastic syndromes. Leuk Lymphoma. 11:1993;221-228.
    • (1993) Leuk Lymphoma , vol.11 , pp. 221-228
    • Hellstrom-Lindberg, E.1    Birgegard, G.2    Carlsson, M.3
  • 155
    • 0028174141 scopus 로고
    • Regulation of bcl-2 expression and apoptosis in acute myeloblastic leukemia cells by granulocyte-macrophage colony-stimulating factor
    • Bradbury D., Zhu Y.-M., Russell N. Regulation of bcl-2 expression and apoptosis in acute myeloblastic leukemia cells by granulocyte-macrophage colony-stimulating factor. Leukemia. 8:1994;786.
    • (1994) Leukemia , vol.8 , pp. 786
    • Bradbury, D.1    Zhu, Y.-M.2    Russell, N.3
  • 156
    • 0029022737 scopus 로고
    • Human interleukin-3 receptor modulates bcl-2 mRNA and protein levels through protein kinase C in TF-1 cells
    • Rinaudo M.S., Su K., Falk L.A., Halder S., Mufson R.A. Human interleukin-3 receptor modulates bcl-2 mRNA and protein levels through protein kinase C in TF-1 cells. Blood. 86:1995;80.
    • (1995) Blood , vol.86 , pp. 80
    • Rinaudo, M.S.1    Su, K.2    Falk, L.A.3    Halder, S.4    Mufson, R.A.5
  • 157
    • 0024448197 scopus 로고
    • Circulating erythropoietin in patients with myelodysplastic syndrome
    • Jacobs A., Janowska A., Caro J.et al. Circulating erythropoietin in patients with myelodysplastic syndrome. Br J Haematol. 73:1989;36.
    • (1989) Br J Haematol , vol.73 , pp. 36
    • Jacobs, A.1    Janowska, A.2    Caro, J.3
  • 159
    • 0345702914 scopus 로고
    • Production of granulocyte colony stimulating factor by normal and myelodysplastic syndrome peripheral blood cells
    • Greenberg P.L., MacKichan M.L., Negrin R., Renick M., Ginzton N. Production of granulocyte colony stimulating factor by normal and myelodysplastic syndrome peripheral blood cells. Blood. 76(Suppl 1):1990;146.
    • (1990) Blood , vol.76 , Issue.SUPPL. 1 , pp. 146
    • Greenberg, P.L.1    MacKichan, M.L.2    Negrin, R.3    Renick, M.4    Ginzton, N.5
  • 160
    • 0023225857 scopus 로고
    • Regulation of bcl-2 proto-oncogene expression during normal human lymphocyte proliferation
    • Reed J.C., Tsujimoto Y., Alpers J.D., Croce C.M., Nowell P.C. Regulation of bcl-2 proto-oncogene expression during normal human lymphocyte proliferation. Science. 236:1987;1298.
    • (1987) Science , vol.236 , pp. 1298
    • Reed, J.C.1    Tsujimoto, Y.2    Alpers, J.D.3    Croce, C.M.4    Nowell, P.C.5
  • 162
    • 0003289159 scopus 로고    scopus 로고
    • + progenitor growth and promotes progenitor cell growth via polyamine-like effects
    • + progenitor growth and promotes progenitor cell growth via polyamine-like effects. Blood. 90(Suppl 1):1997;520a.
    • (1997) Blood , vol.90 , Issue.SUPPL. 1
    • Klimecki, W.1    Heaton, R.2    Glinsmann-Ygibson, W.3    List, A.F.4
  • 163
    • 0030735082 scopus 로고    scopus 로고
    • Stimulation of hemopoiesis by amifostine in patients with myelodysplastic syndrome
    • List A., Brasfield F., Heaton R.et al. Stimulation of hemopoiesis by amifostine in patients with myelodysplastic syndrome. Blood. 90:1997;3364.
    • (1997) Blood , vol.90 , pp. 3364
    • List, A.1    Brasfield, F.2    Heaton, R.3
  • 164
    • 24844458575 scopus 로고    scopus 로고
    • Combination of pentoxyfylline, ciprofloxacine and dexamethasone with amifostine improves the ineffective hemopoiesis in patients with myelodysplastic syndromes
    • Raza A., Andric T., Qawi P.et al. Combination of pentoxyfylline, ciprofloxacine and dexamethasone with amifostine improves the ineffective hemopoiesis in patients with myelodysplastic syndromes. Blood. 90(Suppl 1):1997;84a.
    • (1997) Blood , vol.90 , Issue.SUPPL. 1
    • Raza, A.1    Andric, T.2    Qawi, P.3


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