Dyskeratosis congenita and cancer in mice deficient in ribosomal RNA modification

Science

Volumn 299, Issue 5604, 2003, Pages 259-262

  Ruggero, Davide ^a   Grisendi, Silvia ^a   Piazza, Francesco ^a   Rego, Eduardo ^a,b   Mari, Francesca ^a   Rao, Pulivarthi H ^c   Cordon Cardo, Carlos ^a   Pandolfi, Pier Paolo ^a  

^a MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^b UNIVERSITY OF SÃO PAULO   (Brazil)

^c BAYLOR COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DISEASES; GENES; MUTAGENESIS; PROTEINS; RNA;

TELOMERES;

TUMORS;

RIBOSOME RNA; SMALL NUCLEOLAR RNA; TELOMERASE;

AGING; CANCER; RNA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER SUSCEPTIBILITY; CLINICAL FEATURE; CONTROLLED STUDY; DISEASE EXACERBATION; DYSKERATOSIS CONGENITA; GENE MUTATION; MOUSE; NONHUMAN; ONSET AGE; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN FUNCTION; PROTEIN MODIFICATION; TELOMERE;

ANEMIA; ANIMALS; APOPTOSIS; BONE MARROW CELLS; CELL CYCLE PROTEINS; COLONY-FORMING UNITS ASSAY; DISEASE MODELS, ANIMAL; DYSKERATOSIS CONGENITA; FEMALE; GENETIC PREDISPOSITION TO DISEASE; HEMATOPOIETIC STEM CELLS; IN SITU HYBRIDIZATION, FLUORESCENCE; MALE; MICE; MUTATION; NEOPLASMS; NUCLEAR PROTEINS; PSEUDOURIDINE; RIBOSOMES; RNA, RIBOSOMAL; TELOMERASE; TELOMERE;

ANIMALIA;

EID: 0037428129     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.1079447     Document Type: Article

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25. We thank M. Barna for helpful discussion and critical reading of the manuscript; A. Di Cristofano, M. S. Jiao, and W. Xu for assistance with several experiments; P. Lansdorp and E. Chavez for critical advice and re-agents; K. Manova and M. Leversha for assistance with microscopy; and P. Salomoni and L. Luzzatto for helpful discussion. S. G. is supported by the American Italian Cancer Foundation. P.P.P. is a Scholar of the Leukemia and Lymphoma Society.