Morphological changes and apoptosis in bone marrow from patients with myelodysplastic syndromes treated with granulocyte-CSF and erythropoietin

Leukemia Research

Volumn 21, Issue 5, 1997, Pages 415-425

  Hellström Lindberg, Eva ^a   Kanter Lewensohn, Lena ^a   Ost A ^a  

^a KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Apoptosis; EPO; G CSF; MDS

Indexed keywords

ERYTHROPOIETIN; GRANULOCYTE COLONY STIMULATING FACTOR; HEMOGLOBIN;

APOPTOSIS; ARTICLE; BONE MARROW; ERYTHROID PRECURSOR CELL; FEMALE; HEMATOPOIESIS; HEMOGLOBIN DETERMINATION; HUMAN; HUMAN CELL; MAJOR CLINICAL STUDY; MALE; MYELOBLAST; MYELODYSPLASTIC SYNDROME; PRIORITY JOURNAL; REFRACTORY ANEMIA;

APOPTOSIS; BONE MARROW; ERYTHROPOIETIN; FEMALE; GRANULOCYTE COLONY-STIMULATING FACTOR; HEMATOPOIETIC STEM CELLS; HUMANS; MALE; MYELODYSPLASTIC SYNDROMES; RETROSPECTIVE STUDIES;

EID: 18344401654     PISSN: 01452126     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0145-2126(96)00110-5     Document Type: Article

References (33)

1. Bennett J. M., Catovsky D., Daniel M. T., Flandrin G., Galton D. A. G., Gralnick H. R., Sultan C. and The French-American-British (FAB) Co-operative Group (1982) Proposals for the classification of the myelodysplastic syndromes. British Journal of Haematology 51, 189.
2. May, S. J., Smith, S. A., Jacobs, A., Williams, A. and Bailey-Wood, R., The myelodysplastic syndromes: analysis of laboratory characteristics in relation to the FAB classification. British Journal of Haematology, 1985, 59, 311.
3. Dörmer, P., Schalhorn, A., Wilmanns, W. and Hershko, C., Erythroid and myeloid maturation patterns related to progenitor assessment in the myelodysplastic syndromes. British Journal of Haematology, 1987, 67, 61.
4. Dörmer, P., Hershko, C. and Wilmanns, W., Mechanisms and prognostic value of cell kinetics in the myelodysplastic syndromes. British Journal of Haematology, 1987, 67, 147.
5. 59Fe. British Journal of Haematology, 1975, 31, 65.
6. Cazzola, M., Barosi, G., Berzuini, C., Dacco, M., Orlandi, E., Stefanelli, M. and Ascari, E., Quantitative evaluation of erythropoietic activity in dysmyelopoietic syndromes. British Journal of Haematology, 1982, 50, 55.
7. Ohmori, M., Ohmori, S., Ueda, Y., Yoshida, Y. and Okuma, M., Ineffective hemopoiesis in the myelodysplastic syndromes (MDS) as studied by daily in situ observation of colony-cluster formation. International Journal of Cell Cloning, 1991, 9, 521.
8. Clark, D. M. and Lampert, I. A., Apoptosis is a common histopathological finding in myelodysplasia: the correlate of ineffective haematopoiesis. Leukemia and Lymphoma, 1990, 2, 415.
9. Yoshida, Y., Hypothesis: Apoptosis may be the mechanism responsible for the premature intramedullary cell death in the myelodysplastic syndromes. Leukemia, 1995, 7, 144.
10. Yoshida, Y., Anzai, N. and Kawabata, H., Apoptosis in myelodysplasia: a paradox or a paradigm. Leukemia Research, 1995, 19, 887.
11. Isaacs, J. T., Advances and controversies in the study of programmed cell death/apoptosis in the development of and therapy for cancer. Current Opinions in Oncology, 1994, 6, 82.
12. Eastman, A. and Barry, M. A., The origins of DNA breaks: A consequence of DNA damage, DNA repair or apoptosis? Cancer Investigations, 1992, 10, 229.
13. Gavrieli, Y., Sherman, Y. and Ben-Sasson, S. A., Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation. Journal of Cell Biology, 1992, 119, 493.
14. Wijsman, J. H., Jonker, R. R., Keijzer, R., van der Velde, C. J. H., Cornelisse, C. J. and van Dierendonck, J. H., A new method to detect apoptosis in paraffin section: in situ end-labeling of fragmented DNA. Journal of Histochemistry and Cytochemistry, 1993, 41, 7.
15. Mundle, S., Iftikhar, A., Shetty, V., Alvi, S., Dameron, S., Gregory, S., Marcus, B., Khan, S. and Raza, A., In situ end labeling of DNA to detect apoptotic cell death in a variety of tumors. Cell Death Differentiation, 1994, 1, 117.
16. Raza, A., Mundle, S., Iftikhar, A., Gregory, S., Marcus, B., Khan, Z., Alvi, S., Shetty, V., Dameron, S., Wright, V., Adler, S., Loew, J. M., Shott, S., Nadir Ali, S. and Preisler, H., Simultaneous assessment of cell kinetics and programmed cell death in bone marrow biopsies of myelodysplastics reveals extensive apoptosis as the probable basis for ineffective hematopoiesis. American Journal of Hematology, 1995, 48, 143.
17. Raza, A., Gezer, S., Mundle, S., Gao, X. Z., Alvi, S., Borok, R., Rifkin, S., Iftikhar, A., Shetty, V. and Parcharidou, A., Apoptosis in bone marrow biopsy samples involving stromal and hematopoietic cells in 50 patients with myelodysplastic syndromes. Blood, 1995, 86, 268.
18. Hellström-Lindberg, E., Birgegård, G., Carlsson, M., Carneskog, J., Dahl, I. M., Dybedal, I., Grimfors, G., Merk, K., Tangen, J. M., Winqvist, I. and Öst, Å., A combination of granulocyte-colony-stimulating factor and erythropoietin may synergistically improve the anaemia in patients with myelodysplastic syndromes. Leukemia and Lymphoma, 1993, 11, 221.
19. Hellström-Lindberg, E., Efficacy of erythropoietin in the myelodysplastic syndromes. An analysis of 205 patients in 17 studies. British Journal of Haematology, 1995, 89, 67.
20. Hogge, D. E., Cashman, J. D., Humphries, K. and Eaves, C., Differential and synergistic effects of human granulocyte-macrophage colony-stimulating factor and human granulocyte colony-stimulating factor on hematopoiesis in human long-term marrow cultures. Blood, 1991, 77, 493.
21. Greenberg P. L., Negrin R. S. & Ginzton N. (1991) G-CSF synergizes with erythropoietin for enhancing erythroid colony-formation in myelodysplastic syndromes. Blood 77, 141a (abstr).
22. Negrin, R. S., Stein, R., Vardiman, J., Doherty, K., Cornwell, J., Krantz, S. and Greenberg, P. L., Treatment of the anaemia of myelodysplastic syndromes using human granulocyte-CSF in combination with erythropoietin. Blood, 1993, 82, 737.
23. Hellström-Lindberg E., Negrin R., Stein R., Krantz S., Vardiman J., Öst A. & Greenberg P. (1995) Prediction of response to G-CSF and epo treatment for the anaemia of myelodysplastic syndromes. Blood 86, 53a (abstr).
24. Öst, Å., Lagerlöf, B., Sundström, C., Lindström, P., Gyllenhammar, H., Engstedt, L. and Skoog, L., A study of the reproducibility of the diagnostic criteria for acute leukemia. Scandinavian Journal of Haematology, 1983, 31, 257.
25. Tuzuner, N., Cox, C., Rowe, J. M., Watrous, D. and Bennett, J., Hypocellular myelodysplastic syndromes (MDS): new proposals. British Journal of Haematology, 1995, 91, 612.
26. Hellström-Lindberg E. for the Scandinavian MDS group (1994) Synergistic effect of G-CSF and Epo on the anaemia in patients with MDS. Evidence for increased erythropoietic effectiveness rather than expansion. Blood 84, 1253a (abstr).
27. Aoki, A. and Shibata, A., In vitro studies of eryhtropoiesis in patients with aplastic anemia and myelodysplastic syndromes: a possible tool for the prospective determination of the clinical effectiveness of growth factors. Hematology and Pathology, 1992, 6, 143.
28. Amano, Y., Koike, K. and Nakahata, T., Stem cell factor enhances the growth of primitive erythroid progenitors to a greater extent than interleukin 3 in patients with aplastic anemia. British Journal of Haematology, 1993, 85, 663.
29. Backx, B., Broeders, L. and Löwenberg, B., Kit ligand improves in vitro erythropoiesis in myelodysplastic syndromes. Blood, 1992, 80, 1213.
30. Greenberg P. L., Ginzton N., Rajapaksa R., Tong C. R. & Han J. H. Apoptosis in myelodysplastic syndrome (MDS) (1994). Blood 84, 159a (abstr).
31. Kelley, L. L., Green, W. F., Hicks, G. G., Bondurant, M. C., Koury, M. J. and Ruley, H. E., Apoptosis in the erythroid progenitors deprived of erythropoietin occurs during the G1 and S phases of the cell cycle without growth arrest or stabilization of wild-type p53. Molecular Cell Biology, 1994, 14, 4183.
32. Hellström-Lindberg, E., Robèrt, K. H., Ånséhn, B., Elmhorn-Rosenberg, A., Kock, Y. and Öst, Å., In vitro suspension culture reactions to 1,25 dihydroxy-vitamin D3 in relation to bone marrow morphology and prognosis in patients with myelodysplastic syndromes. Leukemia Research, 1992, 16, 529.
33. Philpott, N. J., Scopes, J., Marsch, J. C. W., Gordon-Smith, E. C. and Gibson, F. M., Increased apoptosis in aplastic anemia bone marrow progenitor cells: Possible pathophysiologic significance. Experimental Hematology, 1995, 23, 1642.