Design and synthesis of novel 9-substituted-7-aryl-3,4,5,6-tetrahydro-2H- pyrido[4,3-b]- and [2,3-b]-1,5-oxazocin-6-ones as NK1 antagonists

Bioorganic and Medicinal Chemistry Letters

Volumn 15, Issue 5, 2005, Pages 1479-1484

  Seto, Shigeki ^a   Tanioka, Asao ^a   Ikeda, Makoto ^a   Izawa, Shigeru ^a  

^a KYORIN PHARMACEUTICAL CO LTD   (Japan)

Author keywords

Meisenheimer reaction; Pyrido 2,3 b 1,5 oxazocin 6 one; Pyrido 4,3 b 1,5 oxazocin 6 one

Indexed keywords

NEUROKININ 1 RECEPTOR ANTAGONIST; OXAZOCINE DERIVATIVE; PYRIDONE DERIVATIVE;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG DESIGN; DRUG MECHANISM; DRUG STABILITY; DRUG SYNTHESIS; GUINEA PIG; NONHUMAN; RAT; REACTION ANALYSIS; STRUCTURE ACTIVITY RELATION;

EID: 13944275182     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2004.12.091     Document Type: Article

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