Atropisomeric property of 1-(2,6-difluorobenzyl)-3-[(2R)-amino-2-phenethyl] -5-(2-fluoro-3-methoxyphenyl)-6-methyluracil

Chirality

Volumn 17, Issue 9, 2005, Pages 559-564

  Tucci, Fabio C ^a   Hu, Tao ^a   Mesleh, Michael F ^a   Bokser, Allan ^a   Allsopp, Eric ^a   Gross, Timothy D ^a   Guo, Zhiqiang ^a   Zhu, Yun Fei ^a   Struthers, R Scott ^a   Ling, Nicholas ^a   Chen, Chen ^a,b  

^a NEUROCRINE BIOSCIENCES INC   (United States)

^b Neurocrine Biosciences ^*  (United States)

Author keywords

Atropisomers; Chiral HPLC; GnRH antagonists; NMR spectroscopy

Indexed keywords

1 (2,6 DIFLUOROBENZYL) 3 (AMINO 2 PHENETHYL) 5 (2 FLUORO 3 METHOXYPHENYL) 6 METHYLURACIL; BENZYLAMINE; GONADORELIN RECEPTOR ANTAGONIST; HORMONE RECEPTOR BLOCKING AGENT; NBI 42902; UNCLASSIFIED DRUG; URACIL;

AQUEOUS SOLUTION; ARTICLE; CHIRALITY; DRUG STRUCTURE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; STEREOISOMERISM;

CHROMATOGRAPHY, HIGH PRESSURE LIQUID; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; MOLECULAR STRUCTURE; RECEPTORS, LHRH; STEREOISOMERISM; THYMINE; URACIL;

EID: 27344459800     PISSN: 08990042     EISSN: None     Source Type: Journal    
DOI: 10.1002/chir.20198     Document Type: Article

References (25)

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25. # value of 97.4 kJ/mol obtained at 25°C from the NMR experiments in aqueous solution.