Convenient synthesis of 7-aryl-3,4,5,6-tetrahydro-2H-pyrido[4,5-b]- and [2,3-b]-1,5-oxazocine-6-ones

Tetrahedron Letters

Volumn 45, Issue 46, 2004, Pages 8475-8478

  Seto, Shigeki ^a  

^a KYORIN PHARMACEUTICAL CO LTD   (Japan)

Author keywords

Nucleophilic aromatic substitution; Pyrido 2,3 b 1,5 oxazocine 6 one; Pyrido 4,5 b 1,5 oxazocine 6 one; S NAr; Suzuki coupling

Indexed keywords

AROMATIC COMPOUND; TACHYKININ RECEPTOR ANTAGONIST;

ARTICLE; CYCLIZATION; DRUG STRUCTURE; DRUG SYNTHESIS; SUZUKI REACTION;

LATEOLABRAX JAPONICUS;

EID: 5644229648     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tetlet.2004.09.104     Document Type: Article

References (16)

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10. 3 (2.12 g, 15.3 mmol) was added, and the mixture was stirred under reflux for 6 h. Following the work-up procedure as described above afforded compound 11 (950 mg, 71%)
11. +) 438.0570, found 438.0571
12. +) 529.9926, found 529.9907
13. 4. The solvent was evaporated, and the residue was purified by recrystallization from isopropanol to give compound 2a (729 mg, 80%)
14. J.S. Albert, C. Ohnmacht, P.R. Bernstein, W.L. Rumsey, D. Aharony, B.B. Masek, B.T. Dembofsky, G.M. Koether, W. Potts, and J.L. Evenden Tetrahedron 60 2004 4337
15. +) 480.1272, found 480.1261
16. +) 480.1272, found 480.1286