Naphtho[2,1-b][1,5] and [1,2-f][1,4]oxazocines as selective NK1 antagonists

Bioorganic and Medicinal Chemistry

Volumn 12, Issue 10, 2004, Pages 2653-2669

  Ohnmacht, Cyrus J ^a   Albert, Jeffrey S ^a   Bernstein, Peter R ^a   Rumsey, William L ^a,b   Masek, Brian B ^a,c   Dembofsky, Bruce T ^a   Koether, Gerard M ^a   Andisik, Donald W ^a   Aharony, David ^a  

^a ASTRAZENECA   (United Kingdom)

^b GLAXOSMITHKLINE   (United States)

^c Optive Research Inc   (United States)

Author keywords

Antagonist; Atropisomers; NK1; Tachykinin

Indexed keywords

2 [2 (3,4 DICHLOROPHENYL) 4 (DIMETHYLAMINO)BUTYL] 1 OXO 1,3,4,6 TETRAHYDRO 2H NAPHTHO[1,2 F][1,4]OXAZINE 7 CARBONITRILE; 2 [2 (3,4 DICHLOROPHENYL) 4 (DIMETHYLAMINO)BUTYL] 4 METHYL 1 OXO 1,3,4,6 TETRAHYDRO 2H NAPHTHO[1,2 F][1,4]OXAZINE 7 CARBONITRILE; 2 [2 (3,4 DICHLOROPHENYL) 4 [4 [2 (METHYLSULFINYL)PHENYL]PIPERIDIN 1 YL]BUTYL] 1 OXO 2,3,5 TETRAHYDRO 1H NAPHTHO[2,1 B][1,5]OXAZINE 7 CARBONITRILE; NAPHTHOL DERIVATIVE; NEUROKININ 1 RECEPTOR ANTAGONIST; OXAZOCINE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; CYCLIZATION; DRUG ACTIVITY; DRUG FORMULATION; DRUG POTENCY; DRUG SELECTIVITY; DRUG SYNTHESIS; ISOMER; METHYLATION; MOLECULAR INTERACTION; NONHUMAN; PHARMACOPHORE; REACTION ANALYSIS; REACTION OPTIMIZATION; RECEPTOR INTRINSIC ACTIVITY; RING OPENING; SUBSTITUTION REACTION;

ANIMALS; CELL LINE; ISOMERISM; MAGNETIC RESONANCE SPECTROSCOPY; MICE; MOLECULAR CONFORMATION; MOLECULAR STRUCTURE; OXAZOCINES; RECEPTORS, NEUROKININ-1;

EID: 2142698576     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2004.03.015     Document Type: Article

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