Axially chiral N-benzyl-n,7-dimethyl-5-phenyl-1,7-naphthyridine-6- carboxamide derivatives as tachykinin NK1 receptor antagonists: Determination of the absolute stereochemical requirements

Journal of Medicinal Chemistry

Volumn 41, Issue 22, 1998, Pages 4232-4239

  Ikeura, Yoshinori ^a   Ishichi, Yuji ^a   Tanaka, Toshimasa ^a   Fujishima, Akira ^a   Murabayashi, Mika ^a   Kawada, Mitsuru ^a   Ishimaru, Takenori ^a   Kamo, Izumi ^a   Doi, Takayuki ^a   Natsugari, Hideaki ^a  

^a TAKEDA PHARMACEUTICAL COMPANY LIMITED   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

N [1 [3,5 BIS(TRIFLUOROMETHYL)PHENYL]ETHYL] 7,8 DIHYDRO N,7 DIMETHYL 5 (4 METHYLPHENYL) 8 OXO 1,7 NAPHTHYRIDINE 6 CARBOXAMIDE; N [3,5 BIS(TRIFLUOROMETHYL)BENZYL] 7,8 DIHYDRO N,7 DIMETHYL 5 (4 METHYLPHENYL) 8 OXO 1,7 NAPHTHYRIDINE 6 CARBOXAMIDE; TACHYKININ RECEPTOR ANTAGONIST; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG STRUCTURE; DRUG SYNTHESIS; GUINEA PIG; NONHUMAN; STRUCTURE ACTIVITY RELATION;

ADMINISTRATION, ORAL; ANIMALS; CAPILLARY PERMEABILITY; CAPSAICIN; CELL LINE; CRYSTALLOGRAPHY, X-RAY; GUINEA PIGS; HUMANS; INJECTIONS, INTRAVENOUS; MODELS, MOLECULAR; MOLECULAR CONFORMATION; NAPHTHYRIDINES; RECEPTORS, NEUROKININ-1; STEREOISOMERISM; TRACHEA;

EID: 15644372975     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm980042m     Document Type: Article

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