Chromosome instability and kinetochore dysfunction

Histology and Histopathology

Volumn 22, Issue 1-3, 2007, Pages 191-197

  Tomonaga, Takeshi ^a   Nomura, F ^a  

^a CHIBA UNIVERSITY   (Japan)

Author keywords

Aneuploidy; Cancer; Chromosonal instability; Kinetochore

Indexed keywords

APC PROTEIN; AURORA A KINASE; AURORA B KINASE; CENTROMERE PROTEIN A; DNA; PROTEIN MAD2; SECURIN;

ANEUPLOIDY; CANCER; CARCINOGENESIS; CENTROMERE; CHROMOSOMAL INSTABILITY; CHROMOSOME ABERRATION; CHROMOSOME CONDENSATION; CHROMOSOME SEGREGATION; COLORECTAL CANCER; GENE INACTIVATION; GENE MUTATION; GENE OVEREXPRESSION; HETEROZYGOSITY LOSS; HUMAN; MICROTUBULE; MITOSIS; MITOSIS SPINDLE; NONHUMAN; REVIEW; SISTER CHROMATID EXCHANGE; STOMACH CANCER; TUMOR SUPPRESSOR GENE;

CHROMOSOMAL INSTABILITY; HUMANS; KINETOCHORES; MUTATION; NEOPLASMS;

EID: 33846286456     PISSN: 02133911     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (50)

1. Adams R.R., Eckley D.M., Vagnarelli P., Wheatley S.P., Gerloff D.L., Mackay A.M., Svingen P.A., Kaufmann S.H. and Earnshaw W.C. (2001). Human INCENP colocalizes with the Aurora-B/AIRK2 kinase on chromosomes and is overexpressed in tumour cells. Chromosoma 110, 65-74.
2. Bischoff J.R., Anderson L., Zhu Y., Mossie K., Ng L., Souza B., Schryver B., Flanagan P., Clairvoyant F., Ginther C., Chan C.S., Novotny M., Slamon D.J. and Plowman G.D. (1998). A homologue of Drosophila aurora kinase is oncogenic and amplified in human colorectal cancers. EMBO J. 17, 3052-3065.
3. Bishop J.M. (1987). The molecular genetics of cancer. Science 235, 305-311.
4. Cahill D.P., Lengauer C., Yu J., Riggins G.J., Willson J.K., Markowitz S.D., Kinzler K.W. and Vogelstein B. (1998). Mutations of mitotic checkpoint genes in human cancers. Nature 392, 300-303.
5. Boveri T. (1914) Zur frage der entstehung maligner tumoren. Gustav Fisher Verlag. Jena, Germany.
6. Clark G.M., Allred D.C., Hilsenbeck S.G., Chamness G.C., Osborne C.K., Jones D. and Lee W.H. (1997). Mitosin (a new proliferation marker) correlates with clinical outcome in node-negative breast cancer. Cancer Res. 57, 5505-5508.
7. de la Guardia C., Casiano C.A., Trinidad-Pinedo J. and Baez A. (2001). CENP-F gene amplification and overexpression in head and neck squamous cell carcinomas. Head Neck 23, 104-112.
8. Erlanson M., Casiano C.A., Tan E.M., Lindh J., Roos G., and Landberg G. (1999). Immunohistochemical analysis of the proliferation associated nuclear antigen CENP-F in non-Hodgkin's lymphoma. Mod. Pathol. 12, 69-74.
9. Esguerra R.L., Jia L., Kaneko T., Sakamoto K., Okada N. and Takagi M. (2004). Immunohistochemical analysis of centromere protein F expression in buccal and gingival squamous cell carcinoma. Pathol. Int. 54, 82-89.
10. Fodde R., Kuipers J., Rosenberg C., Smits R., Kielman M., Gaspar C., van Es J.H., Breukel C., Wiegant J., Giles R.H., and Clevers H. (2001). Mutations in the APC tumour suppressor gene cause chromosomal instability. Nat. Cell. Biol. 3, 433-438.
11. Gemma A., Seike M., Seike Y., Uematsu K., Hibino S., Kurimoto F., Yoshimura A., Shibuya M., Harris C.C., and Kudoh S. (2000). Somatic mutation of the hBUB1 mitotic checkpoint gene in primary lung cancer. Genes Chromosomes Cancer 29, 213-218.
12. Green R.A. and Kaplan K.B. (2003). Chromosome instability in colorectal tumor cells is associated with defects in microtubule plus-end attachments caused by a dominant mutation in APC. J. Cell Biol. 163, 949-961.
13. Hanks S., Coleman K., Reid S., Plaja A., Firth H., Fitzpatrick D., Kidd A., Mehes K., Nash R., Robin N., Shannon N., Tolmie J., Swansbury J., and Inthum M. (2004). Constitutional aneuploidy and cancer predisposition caused by biallelic mutations in BUB1B. Nat. Genet. 36, 1159-1161.
14. Hartwell L.H., Szankasi P., Roberts C.J., Murray A.W., and Friend S.H. (1997). Integrating genetic approaches into the discovery of anticancer drugs. Science 278, 1064-1068.
15. Hauseman D. (1890). Ueber asymmetrische Zelltheilung in Epithelkrebsen und deren biologische Bedeutung. Virschows Arch. Pathol. Anat. 119, 299-326.
16. Hernando E., Nahle Z., Juan G., Diaz-Rodriguez E., Alaminos M., Hemann M., Michel L., Mittal V., Gerald W., Benezra R., Lowe S.W. and Cordon-Cardo C. (2004). Rb inactivation promotes genomic instability by uncoupling cell cycle progression from mitotic control. Nature 430, 797-802.
17. Heun P., Erhardt S., Blower M.D., Weiss S., Skora A.D. and Karpen, G.H. (2006). Mislocalization of the Drosophila centromere-specific histone CID promotes formation of functional ectopic kinetochores. Dev. Cell 10, 303-315.
18. Kaplan K.B., Burds A.A., Swedlow J.R., Bekir S.S., Sorger P.K. and Nathke I.S. (2001). A role for the Adenomatous Polyposis Coli protein in chromosome segregation. Nat. Cell Biol. 3, 429-432.
19. Kim H.S., Park K.H., Kim S.A., Wen J., Park S.W., Park B., Gham C.W., Hyung W.J., Noh S.H., Kim H.K. and Song S.Y. (2005). Frequent mutations of human Mad2, but not Bub1, in gastric cancers cause defective mitotic spindle checkpoint. Mutat. Res. 578, 187-201.
20. Kronenwett U., Huwendiek S., Ostring C., Portwood N., Roblick U.J., Pawitan Y., Alaiya A., Sennerstam R., Zetterberg A. and Auer G. (2004). Improved grading of breast adenocarcinomas based on genomic instability. Cancer Res. 64, 904-909.
21. Lengauer C., Kinzler K.W. and Vogelstein B. (1997). Genetic instability in colorectal cancers. Nature 386, 623-627.
22. Lengauer C., Kinzler K.W. and Vogelstein B. (1998). Genetic instabilities in human cancers. Nature 396, 643-649.
23. Li Y. and Benezra R. (1996). Identification of a human mitotic checkpoint gene: hsMAD2. Science 274, 246-248.
24. Li R., Yerganian G., Duesberg P., Kraemer A., Willer A., Rausch C. and Hehlmann R. (1997). Aneuploidy correlated 100% with chemical transformation of Chinese hamster cells. Proc. Natl. Acad. Sci. USA 94, 14506-14511.
25. Liu S.C., Sauter E.R., Clapper M.L., Feldman R.S., Levin L., Chen S.Y., Yen T.J., Ross E., Engstrom P.F., and Klein-Szanto A.J. (1998). Markers of cell proliferation in normal epithelia and dysplastic leukoplakias of the oral cavity. Cancer Epidemiol. Biomarkers Prev 7, 597-603.
26. Michel L.S., Liberal V., Chatterjee A., Kirchwegger R., Pasche B., Gerald W., Dobles M., Sorger P.K., Murty V.V. and Benezra R. (2001). MAD2 haplo-insufficiency causes premature anaphase and chromosome instability in mammalian cells. Nature 409, 355-359.
27. Ohshima K., Haraoka S., Yoshioka S., Hamasaki M., Fujiki T., Suzumiya J., Kawasaki C., Kanda M. and Kikuchi M. (2000). Mutation analysis of mitotic checkpoint genes (hBUB1 and hBUBR1) and microsatellite instability in adult T-cell leukemia/lymphoma. Cancer Lett. 158, 141-150.
28. Ota T., Suto S., Katayama H., Han Z.B., Suzuki F., Maeda M., Tanino M., Terada Y. and Tatsuka M. (2002). Increased mitotic phosphorylation of histone H3 attributable to AIM-1/Aurora-B overexpression contributes to chromosome number instability. Cancer Res. 62, 5168-5177.
29. Rajagopalan H. and Lengauer C. (2004). Aneuploidy and cancer. Nature 432, 338-341.
30. Rajagopalan H., Jallepalli P.V., Rago C., Velculescu V.E., Kinzler K.W., Vogelstein B. and Lengauer C. (2004). Inactivation of hCDC4 can cause chromosomal instability. Nature 428, 77-81.
31. Rajagopalan H., Nowak M.A., Vogelstein B. and Lengauer C. (2003). The significance of unstable chromosomes in colorectal cancer. Nat. Rev. Cancer 3, 695-701.
32. Ru H.Y., Chen R.L., Lu W.C. and Chen J.H. (2002). hBUB1 defects in leukemia and lymphoma cells. Oncogene 21, 4673-4679.
33. Sawyers C.L. (2001). Research on resistance to cancer drug Gleevec. Science 294, 1834.
34. Shichiri M., Yoshinaga K., Hisatomi H., Sugihara K., and Hirata Y. (2002). Genetic and epigenetic inactivation of mitotic checkpoint genes hBUB1 and hBUBR1 and their relationship to survival. Cancer Res. 62, 13-17.
35. Shigeishi H., Mizuta K., Higashikawa K., Yoneda S., Ono S. and Kamata N. (2005). Correlation of CENP-F gene expression with tumor-proliferating activity in human salivary gland tumors. Oral Oncol. 41, 716-722.
36. Shih I.M., Zhou W., Goodman S.N., Lengauer C., Kinzler K.W. and Vogelstein B. (2001). Evidence that genetic instability occurs at an early stage of colorectal tumorigenesis. Cancer Res. 61, 818-822.
37. Sorrentino R., Libertini S., Pallante P.L., Troncone G., Palombini L., Bavetsia V., Spalletti-Cernia D., Laccetti P., Linardopoulos S., Chieffi P., Fusco A. and Portella G. (2005). Aurora B overexpression associates with the thyroid carcinoma undifferentiated phenotype and is required for thyroid carcinoma cell proliferation. J. Clin. Endocrinol. Metab. 90, 928-935.
38. Tatsuka M., Katayama H., Ots T., Tanaka T., Odashima S., Suzuki F. and Terada Y. (1998). Multinuclearity and increased ploidy caused by overexpression of the aurora- and Ipl1-like midbody-associated protein mitotic kinase in human cancer cells. Cancer Res. 58, 4811-4816.
39. Tomonaga T., Matsushita K., Yamaguchi S., Oohashi T., Shimada H., Ochiai T., Yoda K. and Nomura F. (2003). Overexpression and mistargeting of centromere protein-A in human primary colorectal cancer. Cancer Res. 63, 3511-3516.
40. Tomonaga T., Matsushita K., Ishibashi M., Nezu M., Shimada H., Ochiai T., Yoda K. and Nomura F. (2005). Centromere protein H is up-regulated in primary human colorectal cancer and its overexpression induces aneuploidy. Cancer Res. 65, 4683-4689.
41. Van Hooser A.A., Ouspenski II, Gregson H.C., Starr D.A., Yen TJ., Goldberg M.L., Yokomori K., Earnshaw W.C., Sullivan K.F. and Brinkley B.R. (2001). Specification of kinetochore-forming chromatin by the histone H3 variant CENP-A. J. Cell. Sci. 114, 3529-3542.
42. Wang T.L., Diaz L.A. Jr., Romans K., Bardelli A., Saha S., Galizia G., Choti M., Donehower R., Parmigiani G., Shih le M., Iacobuzio-Donahue C., Kinzler K.W., Vogelstein B., Lengauer C. and Velculescu V.E. (2004). Digital karyotyping identifies thymidylate synthase amplification as a mechanism of resistance to 5-fluorouracil in metastatic colorectal cancer patients. Proc. Natl. Acad. Sci. USA 101, 3089-3094.
43. Wang X., Jin D.Y., Wong, Y.C., Cheung A.L., Chun A.C., Lo A.K., Liu Y. and Tsao S.W. (2000). Correlation of defective mitotic checkpoint with aberrantly reduced expression of MAD2 protein in nasopharyngeal carcinoma cells. Carcinogenesis 21, 2293-2297.
44. Wang X., Jin D.Y., Ng R.W., Feng H., Wong Y.C., Cheung A.L. and Tsao S.W. (2002). Significance of MAD2 expression to mitotic checkpoint control in ovarian cancer cells. Cancer Res. 62, 1662-1668.
45. Wang Z., Cummins J.M., Shen D., Cahill D.P., Jallepalli P.V., Wang T.L., Parsons D.W., Traverso G., Awad M., Silliman N., Ptak J., Szabo S., Willson J.K., Markowitz S.D., Goldberg M.L., Karess R., Kinzler K.W., Vogelstein B., Velculescu V.E. and Lengauer C. (2004). Three classes of genes mutated in colorectal cancers with chromosomal instability. Cancer Res. 64, 2998-3001.
46. Watanabe T., Wu T.T., Catalano P.J., Ueki T., Satriano R., Haller D.G., Benson A.B. 3rd and Hamilton S.R. (2001). Molecular predictors of survival after adjuvant chemotherapy for colon cancer. N. Engl. J. Med. 344, 1196-1206.
47. Yuen K.W., Montpetit B. and Hieter P. (2005). The kinetochore and cancer: what's the connection? Curr. Opin. Cell Biol. 17, 576-582.
48. Zhou H., Kuang J., Zhong L., Kuo W.L., Gray J.W., Sahin A., Brinkley B.R. and Sen S. (1998). Tumour amplified kinase STK15/BTAK induces centrosome amplification, aneuploidy and transformation. Nat. Genet. 20, 189-193.
49. Zhou W., Goodman S.N., Galizia G., Lieto E., Ferraraccio F., Pignatelli C., Purdie C.A., Piris J., Morris R., Harrison D.J., Paty P.B., Culliford A., Romans K.E., Montgomery E.A., Choti M.A., Kinzler K.W. and Vogelstein B. (2002). Counting alleles to predict recurrence of early-stage colorectal cancers. Lancet 359, 219-225.
50. Zou H., McGarry T.J., Bernal T. and Kirschner M.W. (1999). Identification of a vertebrate sister-chromatid separation inhibitor involved in transformation and tumorigenesis. Science 285, 418-422.