Attenuation of scopolamine-induced and age-associated memory impairments by the sigma and 5-hydroxytryptamine1A receptor agonist OPC-14523 (1-{3-[4-(3-chlorophenyl)-1-piperazinyl] propyl}-5-methoxy-3,4-dihydro-2[1H]-quinolinone monomethanesulfonate)

Journal of Pharmacology and Experimental Therapeutics

Volumn 301, Issue 1, 2002, Pages 249-257

  Tottori, Katsura ^a   Nakai, Masami ^a   Uwahodo, Yasufumi ^a   Miwa, Takashi ^a   Yamada, Sakiko ^a   Oshiro, Yasuo ^a   Kikuchi, Tetsuro ^a   Anthony Altar, C ^b,c  

^a OTSUKA PHARMACEUTICAL CO LTD   (Japan)

^b OTSUKA PHARMACEUTICAL DEVELOPMENT AND COMMERCIALIZATION INC   (United States)

^c Psychiatric Genomics Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1 [3 [4 (3 CHLOROPHENYL) 1 PIPERAZINYL]PROPYL] 5 METHOXY 3,4 DIHYDRO 2(1H) QUINOLINE METHANESULFONATE; 2 [4 METHOXY 3 (2 PHENYLETHOXY)PHENYL] N,N DIPROPYLETHYLAMINE; ACETYLCHOLINE; ACETYLCHOLINESTERASE; CHOLINERGIC RECEPTOR STIMULATING AGENT; DONEPEZIL; MESYLIC ACID DERIVATIVE; OPC 14523; SCOPOLAMINE; SEROTONIN 1A AGONIST; TACRINE; UNCLASSIFIED DRUG;

ACETYLCHOLINE RELEASE; AMNESIA; ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ARTICLE; AVOIDANCE BEHAVIOR; CHOLINERGIC ACTIVITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG POTENTIATION; ENZYME ACTIVITY; HIPPOCAMPUS; LEARNING; LOCOMOTION; MALE; MAZE TEST; MOUSE; NONHUMAN; PRIORITY JOURNAL; RAT; SWIMMING; TASK PERFORMANCE;

ACETYLCHOLINE; ACETYLCHOLINESTERASE; AGING; ANIMALS; ANISOLES; AVOIDANCE LEARNING; BRAIN CHEMISTRY; CHOLINERGIC AGENTS; CHOLINESTERASE INHIBITORS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; MALE; MAZE LEARNING; MEMORY DISORDERS; MICRODIALYSIS; MUSCARINIC ANTAGONISTS; PIPERAZINES; PROPYLAMINES; QUINOLONES; RATS; RATS, WISTAR; RECEPTORS, SEROTONIN; RECEPTORS, SEROTONIN, 5-HT1; RECEPTORS, SIGMA; SCOPOLAMINE; SEROTONIN AGONISTS;

EID: 0036196175     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: 10.1124/jpet.301.1.249     Document Type: Article

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