Intratumoral Distribution of Tritiated-FDG in Breast Carcinoma: Correlation between Glut-1 Expression and FDG Uptake

Journal of Nuclear Medicine

Volumn 37, Issue 6, 1996, Pages 1042-1047

  Brown, Raya S ^b   Leung, Jennifer Y ^b   Fisher, Susan J ^b   Frey, Kirk A ^b   Ethier, Stephen P ^b   Wahl, Richard L ^a  

^a UNIVERSITY OF MICHIGAN   (United States)

^b NONE

Author keywords

Autoradiography; Breast carcinoma; FDG uptake; Glut 1 expression

Indexed keywords

DEOXYGLUCOSE; DRUG DERIVATIVE; FLUORINE; FLUORODEOXYGLUCOSE F 18; GLUCOSE TRANSPORTER;

ANIMAL; ARTICLE; AUTORADIOGRAPHY; EXPERIMENTAL NEOPLASM; FEMALE; IMMUNOHISTOCHEMISTRY; LEWIS RAT; METABOLISM; RAT;

ANIMALS; AUTORADIOGRAPHY; DEOXYGLUCOSE; FEMALE; FLUORINE RADIOISOTOPES; FLUORODEOXYGLUCOSE F18; IMMUNOHISTOCHEMISTRY; MAMMARY NEOPLASMS, EXPERIMENTAL; MONOSACCHARIDE TRANSPORT PROTEINS; RATS; RATS, INBRED LEW;

EID: 0030160492     PISSN: 01615505     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (51)

1. Warburg O. The metabolism of tumors. New York: Richard R. Smith, Inc., 1931:29-169.
2. Watanabe A, Tatiaka R, Takeda N, Washiyama K. DNA synthesis, blood flow and glucose utilization in experimental rat brain tumors. J Neurosurg 1989;70:86-91.
3. Flier JS, Mueckler MM, Usher P, Lodish HF. Elevated levels of glucose transport and transporter messenger RNA are induced by ras or src oncogenes. Science 1987;235: 1492-1495.
4. Birnbaum MJ, Haspel HC, Rosen OM. Transformation of rat fibroblasts by FSV rapidly increases glucose transporter gene transcription. Science 1987;235:1495-1498.
5. Yamamoto T, Seino Y, Fukumoto H, et al. Overexpression of facilitative glucose transporter genes in human cancer. Biochem Biophys Res Commun 1990;170:223-230.
6. Su TS, Tsai TF, Chi CW, Han SH, Chou CK. Elevation of facilitated glucose-transporter messenger RNA in human hepatocellular carcinoma. Hepatology 1990;11: 118-122.
7. Brown RS, Wahl RL. Overexpression of Glut-1 glucose transporter in human breast cancer: an immunohistochemical study. Cancer 1993;72:2979-2985.
8. Ahn YS, Zerban H, Bannasch P. Expression of glucose transporter isoforms (Glut-1, Glut-2) and activities of hexokinase, pyruvate kinase and malic enzyme in preneoplastic and neoplastic rat renal basophilic cell lesions. Virchows Arch B Cell Pathol 1993;63:351-357.
9. Nagamatsu S, Sawa H, Wakizaka A, Hoshino T. Expression of facilitative glucose transporter isoforms in human brain tumors. J Neurochem 1993;61:2048-2053.
10. Mellanen P, Minn H, Grenman R, Harkunen P. Expression of glucose transporters in head-and-neck tumors. Int J Cancer 1994;56:622-629.
11. Weber G. Enzymology of cancer cells (second of two parts). N Engl J Med 1977;296:541-551.
12. 18F): nontoxic tracer for rapid tumor detection. J Nucl Med 1980;21:670-675.
13. Fischer G, Ruschenburg I, Eigenbrodt E, Katz N. Decrease in glucokinase and glucose-6-phosphatase and increase in hexokinase in putative preneoplastic lesions of rat liver. J Cancer Res Clin Oncal 1987;113:430-436.
14. Goldberg MA, Lee MJ, Fischman AJ, Mueller PR, Alpert NM, Thrall JH. Fluorodeoxyglucose PET of abdominal and pelvic neoplasms: potential role in oncologic imaging. Radiographics 1993;13:1047-1062.
15. Ahn YS, Zerban H, Grobholz R, Bannasch P. Sequential changes in glycogen content, expression of glucose transporters and enzymic patterns during development of clear/acidophilic cell tumors in rat kidney. Carcinogenesis 1992;13:2329-2334.
16. Brown RS, Fisher SJ, Wahl RL. Autoradiographic evaluation of the intra-tumoral distribution of 2-deoxy-D-glucosc and monoclonal antibodies in xenografts of human ovarian adenocarcinoma. J Nucl Med 1993;34:75-82.
17. Clavo A, Brown R, Wahl R. 2-Fluoro-2-deoxy-D-glucose (FDG) uptake into human cancer cell lines is increased by Hypoxia. J Nucl Med 1995;36:1625-1632.
18. Ethier SP, Cundiff KC. Importance of extended growth potential and growth factor independence on in vivo neoplastic potential of primary rat mammary carcinoma cells. Cancer Res 1987;47:5316-5322.
19. Brown RS, Leung JY, Fisher SJ, Frey KA, Ethier SP, Wahl RL. Intratumoral distribution of tritiated fluorodeoxy-glucose in breast carcinoma: I. Are inflammatory cells important? J Nucl Med 1995;36:1854-1861.
20. Wahl RL, Hutchins GD, Buchsbaum DJ, Liebert M, Grossman HB, Fisher S. Fluorine-18-2-deoxy-2-fluoro-D-glucose uptake into human tumor xenografts. Feasibility studies for cancer imaging with positron-emission tomography. Cancer 1991; 67:1544-1550.
21. Karnovsky MJ. A formaldehyde-glutaraldehyde fixative of high osmolality for use in electron microscopy. J Cell Biol 1965;27:137A.
22. Birnbaum MI, Haspel HC, Rosen OM. Cloning and characterization of a cDNA encoding the rat brain glucose-transporter protein. Proc Natl Acad Sci USA 1986;83: 5784-5788.
23. Haspel MC, Rosenfeld MG, Rosen OM. Characterization of antisera to a synthetic carboxyl-terminal peptide of the glucose transporter protein. J Biol Chem 1988;263: 398-403.
24. Hsu SM, Raine L, Fanger H. Use of avidin-biotin-peroxidase complex (ABC) in immunoperoxidase techniques: a comparison between ABC and unlabeled antibody (PAP) procedures. J Histochem Cytochem 1981;29:577-580.
25. Rogers AW. Techniques of autoradiography, 3rd ed. New York: Elsevier/North-Holland Biomedical Press; 1979:429.
26. 3H]muscimol binding in substantia nigra, entopeduneular nucleus, globus pallidus and thalamus after striatal lesions as demonstrated by quantitative receptor autoradiography. J Neurosci 1983;3: 1189-1198.
27. Dermietzel R, Krause D, Kremer M, Wang C, Stevenson B, Pattern of glucose transporter (Glut-1) expression in embryonic brains is related to maturation of blood-brain barrier tightness. Dev Dyn 1992;193:152-163.
28. Dominguez JH, Camp K, Maianu L, Garvey WT. Glucose transporters of rat proximal tubule: differential expression and subcellular distribution. Am J Physiol 1992;262: F807-812.
29. Tal M, Schneider DL, Thorens B, Lodish HF. Restricted expression of the erythroid/brain glucose transporter isoform to perivenous hepatocytes in rats. Modulation by glucose. J Clin Invest 1990;86:986-992
30. Ismail-Beigi F. Metabolic regulation of glucose transport. J Membrane Biol 1993;135: 1-40.
31. Merrall NW, Plevin R, Gould GW. Growth factors, mitogens, oncogens and the regulation of glucose transport. Cell Signal 1993;5:667-675.
32. Bramwell ME, Davies A, Baldwin SA. Heterogeneity of the glucose transporter in malignant and suppressed hybrid cells. Exp Cell Res 1990;188:97-104.
33. Tanti JF, Gautier N, Cormont M, Baron V, Van Obberghen E, Le Marchand-Brustel Y. Potential involvement of the carboxy-terminus of the Glut-1 transporter in glucose transport. Endocrinology 1992;131:2319-2324.
34. Wheeler TJ. Translocation of glucose transporters in response to anoxia in heart. J Biol Chem 1988;263:19447-19454.
35. Rollins BJ, Morrison ED, Usher P, Flier JS, Platelet-derived growth factor regulates glucose transporter expression J Biol Chem 1988;263:16523-16526.
36. Vaupel P, Kallinowski F, Okunieff P. Blood flow, oxygen and nutrient supply and metabolic microenvironment of human tumors: a review. Cancer Res 1989;49:6449 6465.
37. Zasadny KR, Wahl RL, Regional FDG uptake versus blood flow in untreated primary breast cancers [Abstract]. J Nucl Med 1993;34(suppl):74P.
38. Threadgold LC, Kuhn NJ. Monosaccharide transport in the mammary gland of the intact laclating rat. Biochem J 1984;218:213-219.
39. Burnol AF, Leturque A, Loizeau M, Postic C, Girard J. Glucose transporter expression in rat mammary gland. Biochem J 1990;270:277-279.
40. Madon RJ, Martin S, Davies A, Fawcett HA, Flint DJ, Baldwin SA. Identification and characterization of glucose transport proteins in plasma membrane- and Golgi vesicle-enriched fractions prepared from lactating rat mammary gland. Biochem J 1990;272:99-105.
41. Camps M, Vilaro S, Testar X, Palacin M, Zorzano A. High and polarized expression of Glut-1 glucose transporters in epithelial cells from mammary gland: acute down-regulation of Glut-1 carriers by weaning. Endocrinology 1994;134:924-934.
42. 13N-ammonia. Circulation 1983;67:766-778.
43. Brosius FCI, Sun D, England R, Nguyen N, Schwaiger M. Altered glucose transporter mRNA levels in cardiac ischemia. Circulation 1993;88:1-542.
44. Kubota R, Kubota K, Yamada S, Tada M, Ido T, Tamahashi N. Active and passive mechanisms of fluorine-18-fluorodeoxyglucose uptake by proliferating and prenecrotic cancer cells in vivo: a microautoradiographic study. J Nucl Med 1994;35:1067-1075.
45. 14C]deoxyglucose. Brain 1979;102:653-668.
46. Reeves JP. Stimulation of 3-O-methylglucose transport by anaerobiosis in rat thymocytes. J Biol Chem 1975;250:9413-9420.
47. Kalff V, Schwaiger M, Nguyen N, McClanahan TB, Gallagher KP. The relationship between myocardial blood flow and glucose uptake in ischemic canine myocardium determined with fluorine-18-deoxyglucose. J Nucl Med 1992;33:1346-1353.
48. Opie LH, Camici PG. Myocardial blood flow, deoxyglucose uptake and myocyte viability in ischemia [Editorial]. J Nucl Med 1992;33:1353-1356.
49. Opie LH. Glycolitic rates control cell viability in ischemia. J Appl Cardiol 1988;3: 407-414.
50. Tamaki N, Ohtani H, Yonekura Y. et al. Viable myocardium identified by reinjection thallium-201 imaging: comparison with regional wall motion and metabolic activity on FDG-PET. J Cardiol 1992;22:283-293.
51. Yaoita H, Fischman AJ, Strauss HW, Saito T, Sato E, Maruyama Y. Uridine: a marker of myocardial viability after coronary occlusion and reperfusion. Int J Cardiac Imaging 1993;9:273-280.